Fight Aging! Newsletter, December 10th 2018
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging.
Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes
https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/
Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the co...
Source: Fight Aging! - December 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Immune System Aging and its Contribution to Cardiovascular Disease
Today's open access paper is a survey of the known ways in which the aged immune system contributes to disruption of function in the cardiovascular system. As the selected snippets illustrate, this is a relationship dominated by chronic inflammation. Raised and constant inflammation is characteristic of the systematic failure of the immune system in late life: it becomes both overactive and ineffective, and the consequent inflammation causes detrimental reactions in many important cell populations.
In the short term inflammation is useful, a necessary part of the response to infection and injury. When it runs withou...
Source: Fight Aging! - December 3, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
TWiV 519: Fishing for viruses in senile
The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles. Click arrow to play Download TWiV 519 (58 MB .mp3, 96 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 11, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology acyclovir alzheimer's disease amyloid plaque antiviral beta amyloid herpes simplex virus HSV-1 senile dementia viruses Source Type: blogs
Herpes simplex virus and Alzheimer ’s disease
Alois Alzheimer was the first to propose that an infection might play a role in the disease named after him. Herpes simplex virus type 1 (HSV-1) has been most frequently linked to Alzheimer’s Disease (AD), and a clinical trial is in progress to determine if antivirals ameliorate its development. What is the evidence that HSV-1 […] (Source: virology blog)
Source: virology blog - November 9, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Commentary Information alzheimer's disease amyloid beta amyloid plaque antiviral clinical trial herpes simplex virus viruses Source Type: blogs
Fight Aging! Newsletter, October 29th 2018
This study shows that some genetic changes linked to cancer are present in surprisingly large numbers of normal cells. We still have a long way to go to fully understand the implications of these new findings, but as cancer researchers, we can't underestimate the importance of studying healthy tissue."
Early Onset of Menopause Correlates with Shorter Life Expectancy
https://www.fightaging.org/archives/2018/10/early-onset-of-menopause-correlates-with-shorter-life-expectancy/
Aging is a phenomenon affecting all organs and systems throughout the body, driven by rising levels of molecular damage. The varia...
Source: Fight Aging! - October 28, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Evidence for HSV1 to Contribute to Alzheimer's Disease
Alzheimer's disease starts with a slow rise in levels of amyloid-β present in the brain, an imbalance between dynamic processes of creation and clearance. This produces a state of mild biochemical and cognitive dysfunction that sets the stage for the later, much more destructive phase characterized by chronic inflammation, deposition of altered tau protein, and cell death. The roots of Alzheimer's must lie in the early mechanisms, in the poorly studied initial years of the condition, that cause some people to accumulate amyloid-β at a faster pace. In recent years evidence has emerged for persistent viral infection to pla...
Source: Fight Aging! - October 22, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A cell protein that synthesizes an antiviral ribonucleotide
Some antiviral drugs, like acyclovir for treatment of herpes simplex virus infections, are chain terminators that block RNA or DNA synthesis. They are modified nucleotides that can be incorporated into a growing RNA strand, but no additional nucleotides can be added. Amazingly, a cell protein has been found that can synthesize antiviral chain terminators. Viperin* […] (Source: virology blog)
Source: virology blog - September 27, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information chain terminator CTP ddhCTP IFN ISG nucleoside polymerase rna synthesis viperin viral virus viruses Source Type: blogs
Fight Aging! Newsletter, July 23rd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 22, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Evidence for Herpesvirus Infection to be a Significant Cause of Alzheimer's Disease
A few recent papers have, collectively, added evidence for persistent viral infection to be a significant contributing cause of Alzheimer's disease. A number of viruses in the herpesvirus family are prevalent in the population but cause few obvious symptoms, such as HSV-1 and cytomegalovirus (CMV). Some of these, particularly CMV, are already under suspicion as being the cause of long-term dysfunction in the immune system. Viral infection is an attractive way to explain why only some of the people who exhibit all of the known risk factors for Alzheimer's disease actually go on to develop the full clinical manifestation of ...
Source: Fight Aging! - July 16, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
MKSAP: 24-year-old woman with atopic dermatitis
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 24-year-old woman with longstanding atopic dermatitis is evaluated for an acute worsening of her disease in the past week. She has had increased pruritus and now has multiple painful areas within the involved skin. She has been applying petrolatum jelly and triamcinolone ointment and washing with gentle cleansers without improvement. She is otherwise well and takes no medications.
On physical examination, vital signs are normal. She has eczematous plaques with scattered pustules in the involved areas. The rema...
Source: Kevin, M.D. - Medical Weblog - July 14, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Dermatology Infectious Disease Source Type: blogs
Tropical Travel Trouble 009 Humongous HIV Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 009
The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with a low ...
Source: Life in the Fast Lane - July 7, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
June issue of NIH News in Health Now Available!
Check out the June issue of NIH News in Health, the monthly newsletter bringing you practical health news and tips based on the latest NIH research.
In this issue:
Dealing With Trauma: Recovering From Frightening Events
Find healthy ways to cope after scary or dangerous events happen.
Herpes Can Happen to Anyone: Share Facts, Not Fears
Did you know that the virus that causes “cold sores” or “fever blisters” on or around the mouth can also infect other areas of the body? The infection is caused by the herpes simplex virus. And it’s very common.
Health Capsule: Healthy Habits Can Lengthen Life
Study underscores t...
Source: BHIC - June 6, 2018 Category: Databases & Libraries Authors: Kay Deeney Tags: All of Us General Source Type: blogs
A Live-Attenuated Herpes Simplex Virus Vaccine Candidate
By Gertrud U. Rey There is currently no vaccine to prevent infection with herpes simplex virus type 1 or type 2 (HSV-1 or HSV-2). Infection with either of these viruses results in life-long viral latency. Sporadic reactivation and viral shedding may lead to painful oral and genital disease and an increased risk of HIV transmission. […] (Source: virology blog)
Source: virology blog - May 25, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information guinea pig herpes simplex virus herpesvirus latency mouse reactivation vaccine viral viruses Source Type: blogs
Herpes zoster ophthalmicus
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - May 15, 2018 Category: Internal Medicine Tags: infectious disease Source Type: blogs
Celebrities get shingles, too
Follow me on Twitter @RobShmerling
Perhaps you heard the news recently that Lin-Manuel Miranda has shingles. Headlines announced this in a variety of ways:
Hamilton creator Lin-Manuel Miranda is suffering from shingles (NY DailyNews)
Lin-Manuel Miranda has shingles; must be quarantined from his baby (today.com)
Lin-Manuel Miranda has shingles, regrets joke about blurred vision (CBS News).
Without more information, these headlines might leave you wondering: is this a serious condition? Is it dangerous for children? Can it lead to blindness?
What is shingles?
The term “shingles” refers to a painful rash caused by infec...
Source: Harvard Health Blog - April 11, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Infectious diseases Skin and Hair Care Vaccines Source Type: blogs
