Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis
CONCLUSION: TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α agents. Most relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off TOF. Special attention is needed for tapering and HZ.PMID:38659488 | PMC:PMC11036499 | DOI:10.3748/wjg.v30.i13.1871 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Source Type: research
Differential Utility Losses in Herpes Zoster Cases Between Vaccinated and Unvaccinated Subjects: A Meta-analysis of Three Clinical Trials
CONCLUSIONS: Recombinant zoster vaccine is effective in alleviating disease severity in breakthrough cases of herpes zoster. The results may be useful in distinguishing QALY losses between vaccinated and unvaccinated cohorts in health economics studies, particularly cost-effectiveness analyses.PMID:38662318 | DOI:10.1007/s40261-024-01355-1 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Nikolaos Giannelos Bernard Francq Desmond Curran Source Type: research
PD-L1 Expression in Nonbacterial Chronic Cystitis and Bladder Cancer
CONCLUSIONS: Expression of PD-L1 was detected in a cohort of NCC patients, although the PD-L1 positivity rate was lower than that in BC. Our results demonstrate that the degree of PD-L1 expression in bladder tissue is associated with the presence of viral infections and with the degree of inflammatory infiltration of the bladder wall in both NCC and BC.PMID:38662109 | DOI:10.1007/s00192-024-05782-8 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Inga Kosova Vagan Barsegian Lyudmila Gundorova Dmitriy Kolbasov Source Type: research
Systemic therapy for psoriasis and the risk of cutaneous infections
In conclusion, our study reveals that systemic therapies may increase the risk of cutaneous viral infections. Therefore, dermatologists should exercise caution in this regard.PMID:38660962 | DOI:10.1111/1346-8138.17245 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Yuko Higashi Shinichi Imafuku Noriko Tsuruta Kenta Murotani Western Japan Inflammatory Skin Disease Research Group Source Type: research
Case report: Shingles-associated probable Bickerstaff brainstem encephalitis with IgM anti-sulfatide positivity
CONCLUSIONS: We emphasize the importance of a careful medical history and assessment of clinical symptoms, performing MRI, testing autoimmune antibodies for rapid diagnosis, and ruling out differential diagnoses. Further studies involving more patients with BBE with IgM anti-sulfatide autoantibodies will increase the understanding of the clinical characteristics and advance the diagnosis and treatment of this syndrome. Meanwhile, it is crucial for dermatologists to know about this severe neurological complication following shingles.PMID:38660303 | PMC:PMC11041370 | DOI:10.3389/fimmu.2024.1358886 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Xiaoxue Fu Qianli Zhan Linjie Zhang Xiaoyan Tian Source Type: research
Gastrointestinal Kaposi: A Rare Case Unveiling the Presentation and Management Challenges of an Uncommon Neoplasm in the Digestive Tract
Cureus. 2024 Mar 25;16(3):e56892. doi: 10.7759/cureus.56892. eCollection 2024 Mar.ABSTRACTGastrointestinal Kaposi's sarcoma (GI-KS), which is frequently observed in individuals with HIV/AIDS, tends to manifest with vague symptoms or may not show any symptoms at all. These symptoms can include abdominal discomfort, nausea, vomiting, and low levels of iron in the blood, and they may worsen as the tumor enlarges, leading to more severe issues such as blockage or perforation of the bowel. Diagnosis usually requires an endoscopy to confirm the presence of GI-SK in individuals showing symptoms. In this case report, we describe a...
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Santiago Philibert-Rosas Ruth Rabago Escoto Ariosto H Hernandez Lara Ceriolith Tenorio Flores Edwin Ornelas Escobedo Source Type: research
Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis
CONCLUSION: TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α agents. Most relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off TOF. Special attention is needed for tapering and HZ.PMID:38659488 | PMC:PMC11036499 | DOI:10.3748/wjg.v30.i13.1871 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Source Type: research
Seroprevalence of sexually transmitted infections over 44 years - A cross-sectional study in Sweden
CONCLUSIONS: There was a decrease over time in Chlamydia trachomatis seroprevalence, probably due to contact tracing, testing and early treatment; this might also have affected Mycoplasma genitalium seroprevalence. Despite the reduction, seroprevalences are still high, so continued and new efforts to reduce STI incidence are essential.PMID:38659325 | DOI:10.1177/09564624241248874 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Nirina Andersson Tim Waterboer Elisabet Nylander Annika Idahl Source Type: research
Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis
CONCLUSION: TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α agents. Most relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off TOF. Special attention is needed for tapering and HZ.PMID:38659488 | PMC:PMC11036499 | DOI:10.3748/wjg.v30.i13.1871 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Source Type: research
Differential Utility Losses in Herpes Zoster Cases Between Vaccinated and Unvaccinated Subjects: A Meta-analysis of Three Clinical Trials
ConclusionsRecombinant zoster vaccine is effective in alleviating disease severity in breakthrough cases of herpes zoster. The results may be useful in distinguishing QALY losses between vaccinated and unvaccinated cohorts in health economics studies, particularly cost-effectiveness analyses. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - April 25, 2024 Category: Drugs & Pharmacology Source Type: research
PD-L1 Expression in Nonbacterial Chronic Cystitis and Bladder Cancer
ConclusionsExpression of PD-L1 was detected in a cohort of NCC patients, although the PD-L1 positivity rate was lower than that in BC. Our results demonstrate that the degree of PD-L1 expression in bladder tissue is associated with the presence of viral infections and with the degree of inflammatory infiltration of the bladder wall in both NCC and BC. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - April 25, 2024 Category: OBGYN Source Type: research
Effect of acyclovir therapy on the outcome of mechanically ventilated patients with lower respiratory tract infection and detection of herpes simplex virus in bronchoalveolar lavage: protocol for a multicentre, randomised controlled trial (HerpMV)
Introduction
Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients and is associated with a worse outcome. The aim of this study is to determine whether antiviral therapy in HSV-positive patients improves outcome.
Methods and analysis
Prospective, multicentre, open-label, randomised, controlled trial in parallel-group design. Adult, mechanically ventilated patients with pneumonia and HSV type 1 detected in bronchoalveolar lavage (≥105 copies/mL) are eligible for participation and will be randomly allocated (1:1) to receive acyclovir (10 mg/kg body weight every 8 ...
Source: BMJ Open - April 25, 2024 Category: General Medicine Authors: Hagel, S., Brillinger, N., Decker, S., Deja, M., Ertmer, C., Fiedler, S., Franken, P., Heim, M., Weigand, M. A., Zarbock, A., Pletz, M. W., SepNet Critical Care Trials Group, Ehler, Bloos, Bauer, Brenner, Meybohm, Kluge, Vogt, Lahmer, Fortenbach, John, Be Tags: Open access, Intensive care Source Type: research
Herpes zoster (HZ) vaccine coverage and confidence in Italy: a Nationwide cross-sectional study, the OBVIOUS project
CONCLUSION: In conclusion, this research emphasizes regional disparities in herpes zoster (HZ) vaccination uptake in Italy. Demographic, socioeconomic, and geographic factors impact individuals' willingness to receive the vaccine. The study highlights the importance of awareness of vaccine eligibility and accessible vaccination facilities in increasing uptake rates.PMID:38658871 | DOI:10.1186/s12879-024-09344-7 (Source: Herpes)
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Aurelia Salussolia Angelo Capodici Francesca Scognamiglio Giusy La Fauci Giorgia Sold à Marco Montalti Zeno Di Valerio Maria Pia Fantini Anna Odone Claudio Costantino Heidi J Larson Julie Leask Jacopo Lenzi Davide Gori OBVIOUS board Source Type: research
C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain
Commun Biol. 2024 Apr 24;7(1):494. doi: 10.1038/s42003-024-06178-6.ABSTRACTInflammatory monocytes (iMO) are recruited from the bone marrow to the brain during viral encephalitis. C-C motif chemokine receptor (CCR) 2 deficiency substantially reduces iMO recruitment for most, but not all encephalitic viruses. Here we show CCR7 acts synergistically with CCR2 to control this process. Following Herpes simplex virus type-1 (HSV-1), or La Crosse virus (LACV) infection, we find iMO proportions are reduced by approximately half in either Ccr2 or Ccr7 knockout mice compared to control mice. However, Ccr2/Ccr7 double knockouts elimin...
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Clayton W Winkler Alyssa B Evans Aaron B Carmody Justin B Lack Tyson A Woods Karin E Peterson Source Type: research
Serious neurological adverse events in immunocompetent children and adolescents caused by viral reactivation in the years following varicella vaccination
Rev Med Virol. 2024 May;34(3):e2538. doi: 10.1002/rmv.2538.ABSTRACTSerious adverse events following vaccination include medical complications that require hospitalisation. The live varicella vaccine that was approved by the Food and Drug Administration in the United States in 1995 has an excellent safety record. Since the vaccine is a live virus, adverse events are more common in immunocompromised children who are vaccinated inadvertently. This review includes only serious adverse events in children considered to be immunocompetent. The serious adverse event called varicella vaccine meningitis was first reported in a hospi...
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Prashanth Ramachandran Charles Grose Source Type: research
