Herpesviridae and Atypical Bacteria Co-Detections in Lower Respiratory Tract Samples of SARS-CoV-2-Positive Patients Admitted to an Intensive Care Unit
Microorganisms. 2024 Mar 31;12(4):714. doi: 10.3390/microorganisms12040714.ABSTRACTShortly after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cases of viral, bacterial, and fungal coinfections in hospitalized patients became evident. This retrospective study investigates the prevalence of multiple pathogen co-detections in 1472 lower respiratory tract (LRT) samples from 229 SARS-CoV-2-positive patients treated in the largest intensive care unit (ICU) in Slovenia. In addition to SARS-CoV-2, (rt)RT-PCR tests were used to detect cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex ...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Ga šper Grubelnik Mi ša Korva Rok Kogoj Tina Polanc Matej Mavri č Monika Jev šnik Virant Tina Ur šič Darja Ke še Katja Seme Miroslav Petrovec Matja ž Jereb Tatjana Av šič-Županc Source Type: research
Clinical and Demographic Characteristics of Herpetic Keratitis Patients-Tertiary Centre Experience
Conclusions: To the best of our knowledge, this is the first prospective study in Croatia, and one of the few in Europe, to describe the demographic and clinical features of HSK patients. We found that HSK is most common in the elderly population, with its dendritic form as a clinical presentation. We have shown that HSK is prone to recurrence and secondary complications, with a worryingly long time between symptom and treatment, indicating the need for diagnostic testing in routine practice.PMID:38674223 | PMC:PMC11052461 | DOI:10.3390/medicina60040577 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Petra Grube šić Igor Jurak Tea Čaljkušić-Mance Andrej Belan čić Aron Grube šić Source Type: research
Lack of Direct Effects of Neurotrophic Factors in an In Vitro Model of Neuroinflammation
Int J Mol Sci. 2024 Apr 9;25(8):4160. doi: 10.3390/ijms25084160.ABSTRACTNeuroinflammation is associated with several neurological disorders including temporal lobe epilepsy. Seizures themselves can induce neuroinflammation. In an in vivo model of epilepsy, the supplementation of brain-derived neurotropic factor (BDNF) and fibroblast growth factor-2 (FGF-2) using a Herpes-based vector reduced epileptogenesis-associated neuroinflammation. The aim of this study was to test whether the attenuation of the neuroinflammation obtained in vivo with BDNF and FGF-2 was direct or secondary to other effects, for example, the reduction ...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Nimra Aziz Chiara Ruzza Chiara Falcicchia Annunziata Guarino Marie Soukupova Laila Asth Valentina Aleotti Barbara Bettegazzi Michele Simonato Silvia Zucchini Source Type: research
Polyphenols from < em > Maackia amurensis < /em > Heartwood Protect Neuronal Cells from Oxidative Stress and Prevent Herpetic Infection
Int J Mol Sci. 2024 Apr 9;25(8):4142. doi: 10.3390/ijms25084142.ABSTRACTHere, we continued the investigation of anti-HSV-1 activity and neuroprotective potential of 14 polyphenolic compounds isolated from Maackia amurensis heartwood. We determined the absolute configurations of asymmetric centers in scirpusin A (13) and maackiazin (10) as 7R,8R and 1″S,2″S, respectively. We showed that dimeric stilbens maackin (9) and scirpusin A (13) possessed the highest anti-HSV-1 activity among polyphenols 1-14. We also studied the effect of polyphenols 9 and 13 on the early stages of HSV-1 infection. Direct interaction with the vi...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Darya V Tarbeeva Evgeny A Pislyagin Ekaterina S Menchinskaya Dmitrii V Berdyshev Natalya V Krylova Olga V Iunikhina Anatoliy I Kalinovskiy Mikhail Y Shchelkanov Natalia P Mishchenko Dmitry L Aminin Sergey A Fedoreyev Source Type: research
Reactivation of Varicella-Zoster Virus in Patients with Lung Cancer Receiving Immune Checkpoint Inhibitors: Retrospective Nationwide Population-Based Cohort Study from South Korea
CONCLUSIONS: In these real-world data from an Asian population with lung cancer, ICIs treatment might be associated with a reduced risk of HZ compared to that without ICIs treatment.PMID:38672581 | PMC:PMC11048333 | DOI:10.3390/cancers16081499 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Jiyun Jung Seong-Yeon Park Jae-Yoon Park Dalyong Kim Kyoungmin Lee Sungim Choi Source Type: research
Disseminated Histoplasmosis in a Patient with Myelofibrosis on Ruxolitinib: A Case Report and Review of the Literature on Ruxolitinib-Associated Invasive Fungal Infections
In this report, we present the case of a 59-year-old woman with MF who developed disseminated histoplasmosis after seven months of ruxolitinib use. The patient clinically improved after ten weeks of combined amphotericin B and azole therapy, and ruxolitinib was discontinued. Later, the patient received fedratinib, a relatively JAK2-selective inhibitor, without relapse of histoplasmosis. We also reviewed the literature on published cases of proven IFIs in patients with MF who received ruxolitinib. Including ours, we identified 28 such cases, most commonly due to Cryptococcus species (46%). IFIs were most commonly disseminat...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Chia-Yu Chiu Teny M John Takahiro Matsuo Sebastian Wurster Rachel S Hicklen Raihaan Riaz Khattak Ella J Ariza-Heredia Prithviraj Bose Dimitrios P Kontoyiannis Source Type: research
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity
PLoS Pathog. 2024 Apr 26;20(4):e1012146. doi: 10.1371/journal.ppat.1012146. eCollection 2024 Apr.ABSTRACTApoptosis is a critical host antiviral defense mechanism. But many viruses have evolved multiple strategies to manipulate apoptosis and escape host antiviral immune responses. Herpesvirus infection regulated apoptosis; however, the underlying molecular mechanisms have not yet been fully elucidated. Hence, the present study aimed to study the relationship between herpesvirus infection and apoptosis in vitro and in vivo using the pseudorabies virus (PRV) as the model virus. We found that mitochondria-dependent apoptosis w...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Qiongqiong Zhou Deshi Shi Yan-Dong Tang Longfeng Zhang Boli Hu Chunfu Zheng Li Huang Changjiang Weng Source Type: research
Disseminated Histoplasmosis in a Patient with Myelofibrosis on Ruxolitinib: A Case Report and Review of the Literature on Ruxolitinib-Associated Invasive Fungal Infections
In this report, we present the case of a 59-year-old woman with MF who developed disseminated histoplasmosis after seven months of ruxolitinib use. The patient clinically improved after ten weeks of combined amphotericin B and azole therapy, and ruxolitinib was discontinued. Later, the patient received fedratinib, a relatively JAK2-selective inhibitor, without relapse of histoplasmosis. We also reviewed the literature on published cases of proven IFIs in patients with MF who received ruxolitinib. Including ours, we identified 28 such cases, most commonly due to Cryptococcus species (46%). IFIs were most commonly disseminat...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Chia-Yu Chiu Teny M John Takahiro Matsuo Sebastian Wurster Rachel S Hicklen Raihaan Riaz Khattak Ella J Ariza-Heredia Prithviraj Bose Dimitrios P Kontoyiannis Source Type: research
An Assessment of a New Rapid Multiplex PCR Assay for the Diagnosis of Meningoencephalitis
Conclusions: A high correlation of the QIAstat-Dx ME panel with reference methods was shown. QIAstat-Dx ME is a rapid-PCR technique to be applied in patients with suspected ME with a high accuracy.PMID:38667448 | DOI:10.3390/diagnostics14080802 (Source: Herpes)
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Genoveva Cuesta Pedro Puerta-Alcalde Andrea Vergara Enric Roses Jordi Bosch Climent Casals-Pascual Alex Soriano M ª Ángeles Marcos Sergi Sanz Jordi Vila Source Type: research
RETRACTION: A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation
Am J Hematol. 2024 Apr 26. doi: 10.1002/ajh.27353. Online ahead of print.ABSTRACTRetraction: Feng, C-J. , Zhao, P. , Fu, H-X. , Yan, C-H. , Wang, C-C. , Zhu, X-L. , He, Y. , Wang, F-R. , Zhang, Y-Y. , Mo, X-D. , Kong, Y. , Han, W. , Wang, J-Z. , Wang, Y. , Chen, H. , Chen, Y-H. , Zhao, X-Y. , Chang, Y-J. , Xu, L-P. , Liu, K-Y. , Huang, X-J. , Zhang, X-H. (2023) A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation. American Journal of Hematology. https://doi.org/10.1002/ajh.27090. The above article, published online on ...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Source Type: research
Effect of acyclovir therapy on the outcome of mechanically ventilated patients with lower respiratory tract infection and detection of herpes simplex virus in bronchoalveolar lavage: protocol for a multicentre, randomised controlled trial (HerpMV)
BMJ Open. 2024 Apr 25;14(4):e082512. doi: 10.1136/bmjopen-2023-082512.ABSTRACTINTRODUCTION: Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients and is associated with a worse outcome. The aim of this study is to determine whether antiviral therapy in HSV-positive patients improves outcome.METHODS AND ANALYSIS: Prospective, multicentre, open-label, randomised, controlled trial in parallel-group design. Adult, mechanically ventilated patients with pneumonia and HSV type 1 detected in bronchoalveolar lavage (≥105 copies/mL) are eligible for participation and will be...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Stefan Hagel Nicole Brillinger Sebastian Decker Maria Deja Christian Ertmer Sandra Fiedler Philipp Franken Markus Heim Markus A Weigand Alexander Zarbock Mathias W Pletz SepNet Critical Care Trials Group Source Type: research
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity
PLoS Pathog. 2024 Apr 26;20(4):e1012146. doi: 10.1371/journal.ppat.1012146. eCollection 2024 Apr.ABSTRACTApoptosis is a critical host antiviral defense mechanism. But many viruses have evolved multiple strategies to manipulate apoptosis and escape host antiviral immune responses. Herpesvirus infection regulated apoptosis; however, the underlying molecular mechanisms have not yet been fully elucidated. Hence, the present study aimed to study the relationship between herpesvirus infection and apoptosis in vitro and in vivo using the pseudorabies virus (PRV) as the model virus. We found that mitochondria-dependent apoptosis w...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Qiongqiong Zhou Deshi Shi Yan-Dong Tang Longfeng Zhang Boli Hu Chunfu Zheng Li Huang Changjiang Weng Source Type: research
Disseminated Histoplasmosis in a Patient with Myelofibrosis on Ruxolitinib: A Case Report and Review of the Literature on Ruxolitinib-Associated Invasive Fungal Infections
In this report, we present the case of a 59-year-old woman with MF who developed disseminated histoplasmosis after seven months of ruxolitinib use. The patient clinically improved after ten weeks of combined amphotericin B and azole therapy, and ruxolitinib was discontinued. Later, the patient received fedratinib, a relatively JAK2-selective inhibitor, without relapse of histoplasmosis. We also reviewed the literature on published cases of proven IFIs in patients with MF who received ruxolitinib. Including ours, we identified 28 such cases, most commonly due to Cryptococcus species (46%). IFIs were most commonly disseminat...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Chia-Yu Chiu Teny M John Takahiro Matsuo Sebastian Wurster Rachel S Hicklen Raihaan Riaz Khattak Ella J Ariza-Heredia Prithviraj Bose Dimitrios P Kontoyiannis Source Type: research
An Assessment of a New Rapid Multiplex PCR Assay for the Diagnosis of Meningoencephalitis
Conclusions: A high correlation of the QIAstat-Dx ME panel with reference methods was shown. QIAstat-Dx ME is a rapid-PCR technique to be applied in patients with suspected ME with a high accuracy.PMID:38667448 | PMC:PMC11048994 | DOI:10.3390/diagnostics14080802 (Source: Herpes)
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Genoveva Cuesta Pedro Puerta-Alcalde Andrea Vergara Enric Roses Jordi Bosch Climent Casals-Pascual Alex Soriano M ª Ángeles Marcos Sergi Sanz Jordi Vila Source Type: research
RETRACTION: A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation
Am J Hematol. 2024 Apr 26. doi: 10.1002/ajh.27353. Online ahead of print.ABSTRACTRetraction: Feng, C-J. , Zhao, P. , Fu, H-X. , Yan, C-H. , Wang, C-C. , Zhu, X-L. , He, Y. , Wang, F-R. , Zhang, Y-Y. , Mo, X-D. , Kong, Y. , Han, W. , Wang, J-Z. , Wang, Y. , Chen, H. , Chen, Y-H. , Zhao, X-Y. , Chang, Y-J. , Xu, L-P. , Liu, K-Y. , Huang, X-J. , Zhang, X-H. (2023) A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation. American Journal of Hematology. https://doi.org/10.1002/ajh.27090. The above article, published online on ...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Source Type: research
