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Safety Profile of Upadacitinib up to 5 Years in Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis: An Integrated Analysis of Clinical Trials
CONCLUSION: Higher rates of serious infection, HZ, lymphopenia, and NMSC were observed with upadacitinib versus adalimumab in PsA; slightly elevated rates for most of these TEAEs were seen with upadacitinib in PsA versus axSpA. Upadacitinib 15 mg demonstrated a generally consistent safety profile across disease states with no new safety signals identified.TRIAL REGISTRATION: SELECT-AXIS 1: NCT03178487; SELECT-AXIS 2: NCT04169373; SELECT-PsA 1: NCT03104400; SELECT-PsA 2: NCT03104374.PMID:38683479 | DOI:10.1007/s40744-024-00671-4 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Gerd R Burmester Jayne Stigler Andrea Rubbert-Roth Yoshiya Tanaka Valderilio F Azevedo Derek Coombs Ivan Lagunes Ralph Lippe Peter Wung Lianne S Gensler Source Type: research

Anything that can go wrong: cytotoxic cells and their control of Epstein-Barr virus
Rev Alerg Mex. 2024 Feb 1;71(1):29-39. doi: 10.29262/ram.v71i1.1276.ABSTRACTEpstein-Barr virus (EBV) is an gamma of herpes virus affecting exclusively humans, was the first oncogenic virus described and is associated with over seven different cancers. Curiously, the exchange of genes during viral infections has enabled the evolution of other cellular organisms, favoring new functions and the survival of the host. EBV has been co-evolving with mammals for hundreds of millions of years, and more than 95% of adults have been infected in one moment of their life. The infection is acquired primarily during childhood, in most ca...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Arturo Guti érrez-Guerrero Sara Elva Espinosa-Padilla Sa úl Oswaldo Lugo-Reyes Source Type: research

A systematic review and meta-analysis of herpes zoster occurrence/recurrence after COVID-19 infection and vaccination
J Med Virol. 2024 May;96(5):e29629. doi: 10.1002/jmv.29629.ABSTRACTTo inform surveillance, prevention, and management strategies for the varicella zoster virus (VZV) during the COVID-19 pandemic, this study aimed to evaluate the risk of herpes zoster (HZ) occurrence/recurrence following COVID-19 infection and vaccination. A comprehensive search across seven databases was conducted up to January 31, 2024, to identify studies relevant to the occurrence of HZ following COVID-19 infection and vaccination. The meta-analysis included five studies on postinfection HZ and 13 studies on postvaccination HZ. Patients infected with CO...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Fengge Wang Yidan Gao Abram L Wagner Yihan Lu Source Type: research

Bilateral non-necrotizing herpetic retinopathy: Unusual initial presentation of ocular HSV-1 infection
J Med Virol. 2024 May;96(5):e29633. doi: 10.1002/jmv.29633.NO ABSTRACTPMID:38682539 | DOI:10.1002/jmv.29633 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Ashok Kumar Ananya Chatterji Vijay Kumar Sharma Vikas Ambiya Sushil Kumar Kundan Tandel Source Type: research

In vitro evaluation of inhibitory effect of Lactobacillus reuteri supernatant on the replication of herpes simplex virus type 1 and expression of UL54, UL52 and UL27 genes
CONCLUSION: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1 infection.PMID:38682053 | PMC:PMC11055432 | DOI:10.18502/ijm.v16i1.14877 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Faezeh Ebneali Mohammad Shayestehpour Ahmad Piroozmand Hossein Sedaghat Shaghayegh Yazdani Zahrasadat Fateminasab Source Type: research

Ethnopharmacological uses of fauna among the people of central Punjab, Pakistan
This study focuses on investigating the utilization of animal-based traditional medicine by the people of Pakistan, specifically in the Gujranwala area.METHODS: Data collection took place from January to September 2019 through interviews with local communities. Ethnomedicinal applications of animal products were analyzed using several indices, including Relative Frequency of Citation (RFC), Relative Popularity Level (RPL), Folk Use Value (FL), and Relative Occurrence Percentage (ROP).RESULTS: The study identified the use of different body parts of 54 species of animals in treating various diseases and health issues. These ...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Abdul Majid Khan Muhammad Altaf Tanveer Hussain M Haroon Hamed Umaira Safdar Amina Ayub Zaibun-Nisa Memon Adnan Hafiz Sana Ashraf Muhammad Shoaib Amjad Muhammad Majeed Musheerul Hassan Rainer W Bussmann Arshad Mahmood Abbasi Mohamed Al-Yafrsi Hosam O Elan Source Type: research

Enhanced therapeutic efficacy for glioblastoma immunotherapy with an oncolytic herpes simplex virus armed with anti-PD-1 antibody and IL-12
In this study, we developed a new generation of oncolytic herpes simplex virus C5252 by deletion of a 15-kb internal repeat region and both copies of γ34.5 genes. Additionally, C5252 was armed with anti-programmed cell death protein 1 antibody and interleukin-12 to enhance its therapeutic efficacy for glioblastoma immune-virotherapy. In vitro and in vivo experiments demonstrate that C5252 has a remarkable safety profile and potent anti-tumor activity against glioblastoma. Mechanistic studies demonstrated that C5252 specifically induces cell apoptosis by caspase-3/7 activation via downregulating ciliary neurotrophic factor...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Lei Wang Xusha Zhou Xiaoqing Chen Yuanyuan Liu Yue Huang Yuan Cheng Peigen Ren Jing Zhao Grace Guoying Zhou Source Type: research

Results of Autologous Hematopoietic Stem Cell Transplantation in Patients with Multiple Myeloma(MM) and Renal Impairment: A Retrospective Single-Center Study
Conclusion: Auto-HSCT is a safe and effective treatment for patients with MM complicated by acute kidney injury. Fourteen of 23 (61%) patients became dialysis-independent.PMID:38680711 | PMC:PMC11055427 | DOI:10.18502/ijhoscr.v18i1.14745 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Maiia Soloveva Maxim Solovev Daria Mironova Larisa Mendeleeva Source Type: research

In vitro evaluation of inhibitory effect of Lactobacillus reuteri supernatant on the replication of herpes simplex virus type 1 and expression of UL54, UL52 and UL27 genes
CONCLUSION: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1 infection.PMID:38682053 | PMC:PMC11055432 | DOI:10.18502/ijm.v16i1.14877 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Faezeh Ebneali Mohammad Shayestehpour Ahmad Piroozmand Hossein Sedaghat Shaghayegh Yazdani Zahrasadat Fateminasab Source Type: research

Ligand-based drug design against Herpes Simplex Virus-1 capsid protein by modification of limonene through in silico approaches
Sci Rep. 2024 Apr 29;14(1):9828. doi: 10.1038/s41598-024-59577-4.ABSTRACTThe pharmacological effects of limonene, especially their derivatives, are currently at the forefront of research for drug development and discovery as well and structure-based drug design using huge chemical libraries are already widespread in the early stages of therapeutic and drug development. Here, various limonene derivatives are studied computationally for their potential utilization against the capsid protein of Herpes Simplex Virus-1. Firstly, limonene derivatives were designed by structural modification followed by conducting a molecular doc...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Md Rezaul Islam Md Shafiqul Islam Sovon Ummy Amena Miadur Rahman Md Eram Hosen Ajoy Kumer Mohammed Bourhia Yousef A Bin Jardan Samir Ibenmoussa Gezahign Fentahun Wondmie Source Type: research