A Law and Economics Perspective on Dermatological Disease
Brian S. Haney, A Law and Economics Perspective on Dermatological Disease, SSRN: The human population is infested with dermatological diseases. For example, at a global scale, 95% of people are infected with the Herpes Simplex Virus (HSV) and 90% of... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - July 31, 2020 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Alphaherpesviruses
A new book on Alphaherpesviruses: Molecular Biology, Host Interactions and Control Since the last edition of this volume in 2011, our understanding of the alphaherpesviruses has significantly advanced creating the need for this new book that distils the most important new information to provide a timely overview. Chapters are written by well-respected researchers, each offering their perspectives on the current state of the field, using herpes simplex virus as the main focus. Topics covered include: genomics; entry into the cell; genome delivery from the cell periphery to the nucleus; the fate of the genome in the nucleus;...
Source: Microbiology Blog: The weblog for microbiologists. - July 17, 2020 Category: Microbiology Source Type: blogs
Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation.
Lin28 as a Target for Nerve Regeneration
https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/
Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondr...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Better Vaccines for Older People are a Poor Alternative to Better Immune Systems for Older People
The paper here offers a good overview of recent research and development aimed at improving the effectiveness of vaccines in old people. Vaccines are only poorly effective in the old because of the age-related decline of the immune system. A great deal of effort, with only some success, has gone into trying to improve vaccine effectiveness in older populations. Even if tinkering with vaccines boosts the percentage of patients who exhibit an immune response, however, that response is always going to be more anemic than that of a younger person, given the effects of aging on the immune system. This time and funding would per...
Source: Fight Aging! - May 20, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
CRISPR-ing herpes simplex virus
by Gertrud U. Rey Herpes simplex viruses establish lifelong persistent infection in sensory neurons of infected individuals, a phenomenon called latency. Latent viral genomes are “dormant” but can sporadically reactivate and begin replicating in a phase called lytic replication, which is often accompanied by shedding of virus particles and the appearance of painful lesions. There […] (Source: virology blog)
Source: virology blog - February 7, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information cold sore crispr genome editing herpes simplex virus herpesvirus latency reactivation viral viruses Source Type: blogs
Fight Aging! Newsletter, December 30th 2019
This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts. BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence-associated β-galactosidase (SA-β-gal)-positive cell rates of late PD cells grown in the BBR-containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically, BBR im...
Source: Fight Aging! - December 29, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Refuting the Link Between Persistent Herpesvirus Infection and Alzheimer's Disease
There is a reasonable mechanism by which persistent viral infections might raise the risk of Alzheimer's disease: amyloid-β is an antimicrobial peptide, a part of the innate immune system. The presence of viral particles will contribute to greater production of amyloid-β, which will accelerate the pace at which amyloid-β might aggregate in older individuals due to an imbalance between production and clearance. The aggregates then cause the usual progression to neural inflammation, damage, and cognitive decline. Does the epidemiological data support a role for persistent herpes viruses in Alzheimer's risk, however? Previ...
Source: Fight Aging! - December 26, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Sexually transmitted infections are on the rise: Should you worry?
In 2018, the number of bacterial sexually transmitted infections (STIs) reported in the United States reached an all-time high. This is worrisome for many reasons. Having an STI can raise risks for HIV, infertility, pregnancy complications, and infant death. Fortunately, all of these outcomes can be avoided if people receive appropriate treatment.
What are STIs?
STIs are illnesses caused by microorganisms passed between people during sex. An STI can affect anyone who is exposed to it. Syphilis, gonorrhea, and chlamydia are the most common bacterial infections. Trichomoniasis, a protozoan infection, is also diagnosed freque...
Source: Harvard Health Blog - December 11, 2019 Category: Consumer Health News Authors: Eric A. Meyerowitz, MD Tags: Adolescent health HIV Men's Health Relationships Sexual Conditions Women's Health Source Type: blogs
The Numbered Pediatric Rashes Revisited
I have been seeing a lot of second disease and fifth disease—it's that time of year. School is back in session, and winter is just around the corner.The rash-numbering system for these diseases is now a historical footnote, but fifth disease is still commonly used by physicians to refer to erythema infectiosum, a parvovirus. I suspect that this system was created as a memory device for similar names and the obscure Latin terms used for these diseases. Erythema infectiosum is also easy to confuse with the many other erythema rashes such as erythema migrans, erythema marginatum, erythema toxicum, and erythema multiforme...
Source: M2E Too! Mellick's Multimedia EduBlog - December 2, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
TWiV 570: Aarhus viral
At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS. Click arrow to play Download TWiV 570 (61 MB .mp3, 101 min) Subscribe (free): iTunes, Google Podcasts, RSS, email […] (Source: virology blog)
Source: virology blog - October 20, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Aarhus University AIDS AIDS cure cGAS DNA sensor herpes simplex virus HIV-1 HIV-1 latent reservoir host genetics polIII polio poliomyelitis poliovirus STING TLR9 varicella-zoster virus viral viruse Source Type: blogs
Prepubertal Dysuria Not as Simple as a UTI
Prepubertal boys who present to the emergency department with dysuria are uncommon. The adult with burning on urination is assumed to have a sexually transmitted disease, but of course that diagnosis should not be high on your list for boys.In fact, infectious urethritis in children is quite uncommon unless there is premature sexual activity or sexual abuse by an adult. Unfortunately, a variety of noninfectious urethral pathologies may mimic infectious urethritis in children. A urinary tract infection in a prepubertal boy is an infectious cause of dysuria. Those infections, however, rarely present with the isolated symp...
Source: M2E Too! Mellick's Multimedia EduBlog - September 3, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, June 24th 2019
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age.
Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - June 23, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Infection Induced Systemic Inflammation as a Contributing Cause of Alzheimer's Disease
The big question regarding Alzheimer's disease has always been why only some people suffer this form of dementia. While being overweight clearly increases the risk of dementia, and it is easy to argue that this is because of the chronic inflammation generated by visceral fat tissue, not every overweight individual progresses to the point of Alzheimer's disease. Some people who are not overweight suffer Alzheimer's disease. The condition starts with rising levels of amyloid-β aggregates forming in the brain, thought to be a progressive process occurring over a decade or more prior to any clinical symptoms, but why does thi...
Source: Fight Aging! - June 20, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
5 Surprising Things Stress Can Do to Your Body
You're reading 5 Surprising Things Stress Can Do to Your Body, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
You just
got off a terrible meeting, your boss gave you an impossible deadline for the
next project, your team is pushing you to make extra hours, and you still need
to pick up the kids at school. Your body is in a “fight or flight response.”
Your stress levels are high, you feel your breath get quicker and even feel
your heart beating faster than usual. Although this is all a natural response
from your brai...
Source: PickTheBrain | Motivation and Self Improvement - June 18, 2019 Category: Consumer Health News Authors: annabelle Tags: featured health and fitness self improvement stress Source Type: blogs
