Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology.
Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Dysfunction in Alzheimer's Disease
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology.
Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - May 31, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Is there Intracellular edema in congestive heart failure ?
I am unable to answer this question confidently even after spending 25 years in the specialty of cardiology. I thought, the answer was yes. Reality is definitely different. Such is the complexity in the biology of the fluid and circulatory systems. The heart’s function doesn’t seem to end with just pumping 6 liters of blood every minute, ultimately, it has to handle a huge load of water as well with delicate coordination with the kidney. (ANP,& RASS feedback). It is fascinating to note, that the heart transforms into a powerful endocrine organ as and when it is necessary.
Read further, with a caution: (The...
Source: Dr.S.Venkatesan MD - May 31, 2022 Category: Cardiology Authors: dr s venkatesan Tags: cardiac failure edema in heart failure Source Type: blogs
Shame can no longer be accepted as a rite of passage in medicine
“Then why did this patient come to the hospital? You haven’t done anything to help this patient,” the attending physician said angrily during our morning rounds, upset that the patient had not met their urination output goals during treatment for heart failure exacerbation. A hot flush crept up my face. Tightness clenching my chest andRead more …Shame can no longer be accepted as a rite of passage in medicine originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 19, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/ni-cheng-liang-patricia-luck" rel="tag" data-wpel-link="internal" > Ni-Cheng Liang, MD and Dr. Patricia Lück < /a > < /span > Tags: Physician Primary Care Source Type: blogs
New Study Finds that Switching from Smoking to Vaping Reduces Heart Disease Risk by 34%
This study should cause the FDA to stop everything they are doing and re-assess the balance between the benefits and costs of making vaping products available to adult smokers. Rather than ban 99% of these products, which the agency seems poised to do, it should allow most of these products to remain on the market. However, I believe that the agency should also promulgate a rule that limits the sale of all tobacco and nicotine products to stores that exclusively sell these products and are only open to adults ages 21 and older. This is the best way to balance the risks and benefits of vaping.Unfortunately, I have little do...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - May 11, 2022 Category: Addiction Source Type: blogs
Empowering Trainees to be Leaders and Change Agents
We described several wellness initiatives that were done at individual campuses. The University of Illinois where I attend, we had a wellness committee that we formed led by students. We were able to partner with local companies to bring in more healthy food options. We were able to set up a counseling center dedicated specifically towards medical trainees.
Joe Geraghty:
And so that’s at the institutional level, but then in our local community, we had several letters from places like the University of Chicago. We had a medical student who wrote about how they were developing kind of like easy to digest infograp...
Source: Academic Medicine Blog - April 25, 2022 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Annual Call for Trainee-Authored Letters to the Editor ATLAS Trainee Perspective leadership medical education scholarship medical students residents scholarly publishing trainee engagement Source Type: blogs
It ’s not your heart that’s failing. It’s our medical jargon.
A little over two years ago, my elderly mother was admitted to the hospital. Almost 90, she’d been short of breath for days — uncomfortable, perspiring, unable to sleep properly. Blood tests, a chest X-ray, and an echocardiogram followed, whereupon her doctor pronounced:“You have congestive heart failure, Mrs. Les.” I arrived on the sceneRead more …It’s not your heart that’s failing. It’s our medical jargon. originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 16, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/j-edward-les" rel="tag" data-wpel-link="internal" > J. Edward Les, MD < /a > < /span > Tags: Physician Cardiology Source Type: blogs
A man in his 50s with acute chest pain and history of prior MI
Written by Pendell MeyersA man in his 50s with prior history of anterior MI with LAD stent presented with acute chest pain similar but more intense than his last MI. He presented around midnight with pain that had started around 9pm the night before. He had taken NTG at home with no improvement, and immediately received morphine on arrival at the ED for severe chest pain (a very bad idea if your accuracy for finding OMI on ECG is low, since ongoing pain will be your last chance to identify those with ongoing untreated OMI).Here is his triage ECG at 0012:What do you think? What is the differential of this ECG?There is sinus...
Source: Dr. Smith's ECG Blog - April 13, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
vMap Mapping Technology for Cardiac Arrhythmias: Interview with Mike Monko, CEO of Vektor Medical
Vektor Medical, a medtech company based in San Diego, created the vMap system, a mapping solution for cardiac arrhythmias. The system is the first to identify arrhythmia sources anywhere in the heart, including the septal wall, outflow tracts, and all four chambers. The company reports that the technology takes less than three minutes to provide a result.
The system uses 12-lead electrocardiogram (ECG) data to pin-point the location of an arrythmia, and so is non-invasive. Accurate mapping of arrythmia sources is important in ensuring that subsequent treatment is successful. In the case of ablation for atrial fibrillati...
Source: Medgadget - April 4, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Exclusive Radiology afib vektormedical Source Type: blogs
MedPAC Got It Wrong (pt 2)
By GEORGE HALVORSON
This is the second part of former Kaiser Permanente CEO George Halvorson’s critique of Medpac’s new analysis of Medicare Advantage.Part 1 is here. The final part will be published on THCB later this week. Eventually I’ll be doing a summary article about all the back and forth about what Medicare Advantage really costs!-Matthew Holt
We clearly do have significant levels of quality data about the MA plans because we have extensive levels of quality programs and recognitions that exist in MA . Those programs get better every year — and MedPac should be reporting and even celeb...
Source: The Health Care Blog - March 31, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Policy The Business of Health Care George Halvorson Medicare Advantage MedPAC Source Type: blogs
Discovering Better Ways to Build Medicinal Molecules
Dr. Phil Baran. Credit: Scripps Research.
“I love the mystery of chemistry. It explores the great unknown of the universe,” says Phil Baran, Ph.D., a professor of chemistry at Scripps Research, La Jolla, California. His passion for the subject catalyzed a successful career in organic synthesis—building molecules that are the foundation of living things and can be developed as medicines.
Setting His Sights on Science
School didn’t interest Dr. Baran until he found chemistry in 10th grade. “From there, the mission was clear: do whatever was required to do chemistry for the rest of my life,” he says. At t...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 30, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Medicines Profiles Source Type: blogs
MedPAC Got It Wrong (pt 1)
By GEORGE HALVORSON
This is the first part of former Kaiser Permanente CEO George Halvorson’s critique of Medpac’s new analysis of Medicare Advantage. The rest will be published on THCB later this week. Eventually I’ll be doing a summary article about all the back and forth about what Medicare Advantage really costs!-Matthew Holt
MedPac just did their annual report on Medicare Advantage (MA) and they were extremely wrong on several key points.
The MedPac staff has a long tradition of being critical of MA, and they also, unfortunately, have a long tradition of being inaccurate, misleading, and...
Source: The Health Care Blog - March 30, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Policy The Business of Health Care George Halvorson Medicare Advantage MedPAC Source Type: blogs
Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Evidence for Mitochondrial Transfusion to Require Matched Mitochondrial DNA
Researchers here suggest that mixing mitochondrial DNA haplotypes in the same individual has long-term negative consequences to health, though the precise mechanisms by which this happens have yet to be determined. This has the most relevance to ongoing work on mitochondrial transplants as a way to restore mitochondrial function in old people. Fortunately mitochondrial DNA is not completely unique to the individual. There is a large but limited number of haplotypes, so matching to a patient would be more akin to blood type matching for transfusions than having to produce a distinct set of material for each patient. It does...
Source: Fight Aging! - March 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Role of Cellular Senescence in Cardiovascular Disease
Senescent cells are created and destroyed constantly in the body, but their numbers accumulate with age, an imbalance that is a consequence of raised rates of creation due to an age-damaged environment, and the failure of the immune system to rapidly clear these errant cells. Senescent cells actively secrete a pro-inflammatory, pro-growth mix of signals, useful in the short term in contexts such as suppression of precancerous lesions and coordination of wound healing. When present for the long term, senescent cell signaling is very harmful to cell and tissue function, however. It is an important contributing cause of chron...
Source: Fight Aging! - March 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
