A Selection of Mechanisms Relevant to Atherosclerosis
Atherosclerosis is the growth of fatty lesions in blood vessel walls, leading eventually to a rupture and blockage to cause a heart attack or stroke, and along the way causing narrowing of blood vessels sufficient to lead to heart failure and dysfunction elsewhere in the body as the supply of blood to tissues is reduced. Today's paper on this topic is a little disorganized, something of a random assembly of thoughts on mechanisms relevant to the development of atherosclerosis. Atherosclerosis is the single largest cause of human mortality, and attempts to treat contributing mechanisms have so far not stopped it from being ...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Epigenetics in Age-Related Mitochondrial Dysfunction
The hundreds of mitochondria present in every cell in the body undertake the essential duty of producing chemical energy store molecules, adenosine triphosphate (ATP), used to power the cell. With age, mitochondria become less efficient and more damaged, generating oxidative stress and triggering inflammation while producing less ATP than is optimal. This is thought to be a major contribution to degenerative aging, though as for all contributions to aging, it requires a highly targeted way to improve mitochondrial function in order to determine just how important it is. That highly targeted therapy doesn't yet exist in a u...
Source: Fight Aging! - September 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Study: High Blood Pressure While Lying Down Linked To Greater Heart Risks
Conclusion
The findings of this recent study are nothing short of a game-changer in how we understand and manage blood pressure. It’s clear that simply taking blood pressure readings while seated might not give the full picture.
High blood pressure while lying down has been linked to a heightened risk of serious heart health complications, including heart attack, stroke, and even premature death.
Therefore, a more comprehensive approach to blood pressure monitoring is crucial. One that considers different body positions could offer deeper insights into an individual’s cardiovascular health.
This n...
Source: The EMT Spot - September 9, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
DNA Damage and Consequent Inflammation in Heart Failure
One of the ways in which cell damage characteristic of aging can provoke inflammation is via the mislocalization of DNA. Either nuclear DNA or mitochondrial DNA can find its way to the cytosol, where it can trigger responses evolved to detect bacterial or viral infection, or severe cell damage. This creates a cascade of downstream signaling leading to an inflammatory response. In youth these events occur comparatively rarely, and in circumstances wherein immune response and potentially even cell death are beneficial. With age, however, there is a continued mild but growing level of dysfunction and consequent sustained infl...
Source: Fight Aging! - September 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How Cold Weather Affects Blood Pressure? New Study Reveals Surprising Facts
Conclusion
In the vast tapestry of medical research, the recent study on seasonal trends in high blood pressure is a particularly illuminating thread. It’s shown us that something as seemingly benign as the changing of the seasons can impact a major health metric – our blood pressure.
This isn’t just about statistics and numbers. It’s about lives. Recognizing and anticipating these patterns means healthcare providers can be better equipped to offer timely, effective care. And for those living with high blood pressure? It offers a roadmap. A guide to navigate the challenges of each season, with...
Source: The EMT Spot - September 8, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
New ESC 2023 Cardiomyopathy guidelines: Truths trail by 17 years!
It was 2006
Allow me to recount an unassuming piece of a PowerPoint presentation from my institute, Madras Medical College, at the annual Cardiological Society meeting in New Delhi. The paper was categorized under miscellaneous sessions. I vividly remember the day. I have to admit, It was a nearly empty hall E, located in the basement of Hotel Ashoka. After the talk, I looked up to find that neither the chairman nor the handful of kind academic souls had any questions or comments to make. Pausing for a few moments, I quietly walked down the podium with an inexplicable silent pain.
The title of the presentation was &#...
Source: Dr.S.Venkatesan MD - August 27, 2023 Category: Cardiology Authors: dr s venkatesan Tags: cardiomyopathy Dilated cardiomyopathy hypertrophic cardiomyopathy ischemic cardiomyopathy Uncategorized drsvenkatesan ESC 2023 new cardiomyopathy guideline ndlvc non dilated cardiomyopathy Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Longevity-Associated Variant of BPIFB4 Reduces Heart Disease Severity
Few human longevity-associated gene variants are replicated in multiple patient populations. One of those is a variant of BPIFB4, that appears to improve immune function and lower inflammation by adjusting the behavior of macrophage cells of the innate immune system. Delivering the variant to mice using a gene therapy has similar effects. It may well operate via other mechanisms as well, however. Few proteins in a living cell turn out to have only one purpose.
In today's open access paper, researchers report that the BPIFB4 variant reduces the severity of coronary artery disease in humans and mice. Delivering the va...
Source: Fight Aging! - August 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Progress Towards Therapies for Transthyretin Amyloidosis
Transthyretin is one of the few proteins in the body that can misfold in a way that encourages other copies of the protein to also misfold, forming solid aggregates called amyloid that disrupt tissue structure and function. The resulting condition, transthyretin amyloidosis, clogs up cardiac tissue and thereby contributes to a fraction of all heart failure cases. It is thought to be a major cause of mortality in supercentenarians. Approved therapies targeting a more aggressive form of the condition resulting from a mutated transthyretin gene will not be useful against the much more common version of the condition, as they ...
Source: Fight Aging! - August 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Best Blood Pressure Monitors For Apple Health
In conclusion, Apple Health and compatible blood pressure monitors represent the synergy between technology and healthcare, redefining health management’s future.
This amalgamation fosters a detailed and proactive perspective toward personal health, emphasizing the need for maintaining awareness and making educated health choices.
As technological advancements persist, our capacity to control and comprehend our health will likewise expand, heralding a new age of customized healthcare.
Reference
Central-acting agents – Drugs.com. (n.d.). Retrieved July 24, 2023, from https://www.drugs.com/mca/central-ac...
Source: The EMT Spot - August 14, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Monitors Source Type: blogs
What does the ECG show in this patient with chest pain, hypotension, dyspnea, and hypoxemia?
Written by Pendell Meyers, with some edits by SmithA man in his 40s with many comorbidities presented to the ED with chest pain, hypotension, dyspnea, and hypoxemia.The bedside echo showed a large RV (Does this mean there is a pulmonary embolism as the etiology?)Here is his triage ECG:What do you think? Lots of info here.The rhythm is 2:1 atrial flutter. The flutter waves can conceal or mimic ischemic repolarization findings, but here I don ' t see any obvious findings of OMI or subendocardial ischemia.The QRS is around 100 msec wide (narrow), but with very abnormal morphology including a large R-wave in V1, dee...
Source: Dr. Smith's ECG Blog - August 14, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
Vasodilators For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In summary, vasodilators play a pivotal role in managing cardiovascular conditions, including hypertension, which is rapidly becoming a global health concern.
By expanding the body’s blood vessels, these unique medications can improve blood flow and decrease the pressure exerted by the heart, thereby providing relief to numerous patients worldwide.
Their applications are diverse, extending beyond hypertension to conditions like angina, heart failure, and even erectile dysfunction.
However, these medications should be taken carefully and always under the supervision of a doctor due to the potent...
Source: The EMT Spot - July 27, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
