Phenotypes in Arrhythmogenic Cardiomyopathy
Arrhythmogenic Cardiomyopathy was better known as Arrhythmogenic Right Ventricular Dysplasia or ARVD and sometimes as Arrhythmogenic Right Ventricular Cardiomyopathy or ARVC earlier. When left ventricular [1] and biventricular involvement became increasingly recognized, the terminology has been revised to Arrhythmogenic Cardiomyopathy. A study published in JACC has compared the phenotypic expression and clinical outcomes in patients with arrhythmogenic cardiomyopathy [2]. Of the 446 patients, 44% had arrhythmogenic right ventricular cardiomyopathy, while 23% had arrhythmogenic left ventricular cardiomyopathy. 33% had bive...
Source: Cardiophile MD - February 24, 2024 Category: Cardiology Authors: Johnson Francis Tags: ECG / Electrophysiology Source Type: blogs
Signaling Between Cell Types is Vital to Heart Regeneration
A fair amount of the research and development work aimed at spurring greater regeneration of an injured heart is focused on cardiomyocytes, either by delivering new cells, or by encouraging existing cells to replicate or otherwise better resist the hostile environment following injury. As researchers here point out, regeneration is known to be an intricate dance between multiple different cell populations. Thus the signaling that facilitates coordination between those cell types may prove to be a better target for intervention than any single cell population, and single cell population approaches that have shown promise in...
Source: Fight Aging! - February 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Gene Therapy to Promote Cardiomyocyte Proliferation Improves Late Stage Heart Failure in Rats
In this study, we did something that had not been done before. We intervened with the same gene therapy but not during acute heart failure or early in the disease as in our previous experiments, but late in the disease during the chronic phase four weeks after cardiac injury had severely damaged the heart."
Four months after treating the animals, the researchers checked cardiac function and heart structure. "We were surprised to see evidence of significant heart cell proliferation, a marked reduction in scar size and a significant improvement in cardiac function. Although heart dilation and lung congestion associate...
Source: Fight Aging! - February 21, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why ICDs are less effective in Non Ischemic DCM ?
We wish, our understanding about cardiac contractile physiology is deep and nearly complete. Heart is an irreversibly coupled electro-mechanical organ , right from the fetal days until the final heart beat. In myocardial pathology, the genesis and sustainability of ventricular arrhythmia are intricately related to the degree of LV dysfunction of any cause.
SCD is the leading cause of mortality in heart failure. Tackling SCD was in God’s domain, until the brilliance of Dr. Michel Mirowski shrunk the defibrillator and implanted it under the chest in 1980. (Dr. MM’s s a unique and inspiring story, from Poland a...
Source: Dr.S.Venkatesan MD - February 20, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized crt device crt-p vs crt-d danish trial ischemic dcm madit trial non ischemic dcm Source Type: blogs
Potential options for reducing cardiotoxicity of anthracyclines
What are the potential options for reducing cardiotoxicity of anthracyclines?
Anthracyclines are an important group of medications useful in the treatment of solid tumours and hematological malignancies. An important limitation is their potential cardiotoxicity which can cause heart failure at varying time intervals, even decades later. Some methods which have been used to prevent cardiotoxicity are longer infusion times, use of liposomal preparations, dexrazoxane, beta blockers and renin-angiotensin system inhibitors, all with different success rates. These strategies have not been universally accepted as useful modalitie...
Source: Cardiophile MD - February 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Interactions Between Innervation, Vascular Aging, and Loss of Capillary Density in the Heart
One noted aspect of vascular aging is that the processes of angiogenesis become less effective with age, and as a consequence aged tissues lose capillary density. This harms function by reducing the supply of nutrients and oxygen to energy-hungry tissues such as muscles and brain, as well as putting stress on the remaining vasculature due to changes in the dynamics of blood flow. Accompanying this form of vascular aging is a progressive innervation, a loss of peripheral nervous system connections. These two complex processes interact strongly with one another, given the proximity of blood vessels and nerves, and signaling ...
Source: Fight Aging! - January 29, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A man in his 30s with chest pain. How was he managed? What if they had used the Queen of Hearts?
Written by Pendell MeyersA man in his late 30s with history of hypertension, tobacco use, and obesity presented to the Emergency Department for acute chest pain which started approximately 3 hours prior to arrival, in the setting of a very stressful situation. The pain radiated down both arms, 10/10 in severity. He stated it did not feel like his prior episodes of reflux. Vitals were within normal limits except some hypertension. Triage ECG:And here she explains her assessment:The ECG was read as simply " No ST elevation. " Which is true.The initial high sensitivity troponin I returned at around 3300 ng/L. No repeat E...
Source: Dr. Smith's ECG Blog - January 20, 2024 Category: Cardiology Authors: Pendell Source Type: blogs
A Novel Proteomic Aging Clock
By now there are most likely dozens of published aging clocks constructed from various omics databases. The proliferation of new clocks isn't helping to solve the fundamental problem with this approach to assessing biological age, which is that the predicted biological age produced by a clock isn't actionable, as no-one yet understands how the clocks relate to causative processes of aging. Thus factions within the research community are arguing for standardization to a single clock, followed by focused effort on understand how those clock measurements relate to underlying processes of aging.
Using a large proteomi...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Effects of LDLR Variants on Longevity via Lowered Cardiovascular Disease
This study suggests that LDLR is a promising genetic target for human longevity. Lipid-related gene targets, such as PCSK9, CETP, and APOC3, might potentially regulate human lifespan, thus offering promising prospects for developing newer nonstatin therapies.
Link: https://doi.org/10.1186/s12944-023-01983-0 (Source: Fight Aging!)
Source: Fight Aging! - January 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Patient Portals Improve Healthcare Outcomes. So, Why Don ’t Patients Use Them?
The following is a guest article by Oakkar Oakkar, Co-Founder and CEO at Keona Health
Imagine a tool that puts your health information right at your fingertips. That’s what patient portals promise – a simple, digital way to access medical records, book appointments, and chat with doctors. They’re designed to make life easier for patients, and studies show they can even help reduce hospital visits, like in 2020 when heart failure patients using these portals saw fewer hospital readmissions.
But there’s a catch. Despite their benefits, many patients aren’t using these portals. It’s not just a ...
Source: EMR and HIPAA - January 11, 2024 Category: Information Technology Authors: Guest Author Tags: Ambulatory Communication and Patient Experience EMR-EHR Health IT Company Healthcare IT Hospital - Health System Telemedicine and Remote Monitoring Digital Literacy Health Data Privacy Improving Patient Outcomes Keona Health Oakkar O Source Type: blogs
A fascinating electrophysiology case. What is this wide complex tachycardia, and how best to manage it?
The patient is female in her 80s with a medical hx of previous MI with PCI and stent placement. She also has a hx of paroxysmal atrial fibrillation and is on oral anticoagulant treatment. She had a single chamber ICD/Pacemaker implanted several years prior due to ventricular tachycardia. The last echocardiography 12 months ago showed HFmrEF.She presented to the emergency department after a couple of days of chest discomfort. The ECG below was recorded. What is your assessment? How would you manage this patient?The ECG was interpreted as showing atrial flutter with 2:1 conduction. The patient was deemed stable and...
Source: Dr. Smith's ECG Blog - January 10, 2024 Category: Cardiology Authors: Magnus Nossen Source Type: blogs
Value Based Care – 2024 Health IT Predictions
As we kick off 2024, we wanted to start the new year with a series of 2024 Health IT predictions. We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes. In fact, we got so many that we had to narrow them down to just the best and most interesting. Check out our community’s predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media.
All of this year’s 2024 health IT predictions (updated as they’re shared):
John and ...
Source: EMR and HIPAA - January 5, 2024 Category: Information Technology Authors: John Lynn Tags: Administration Ambulatory C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Regulations Revenue Cycle Management 2024 Health IT Predictions 9amHealth Andreessen Horowitz Anthony Hudson Anton Kittleberger Source Type: blogs
