Central Agonists For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In summary, central agonists, a notable class of hypertension medications, offer an alternative modality when other first-line antihypertensive treatments fail to show desired results or cause intolerable side effects.
They operate via a unique neurocentric mechanism that primarily functions centrally in the brain, impacting blood pressure regulation by decreasing systemic arterial pressure and heart rate.
Despite their potential side effects and potential for interactions with other drugs, their therapeutic utility in the context of hypertension management remains undiminished.
Moreover, certain cen...
Source: The EMT Spot - July 27, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Beta-Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In conclusion, beta-blockers serve as an indispensable tool in the realm of modern medical treatment, particularly in managing a broad range of cardiovascular conditions.
Their unique mechanism of action, which includes decreasing heart rate and blood pressure, confers a significant cardio-protective effect.
This, combined with their versatility and the extensive clinical experience with their use, has cemented beta-blockers as a first-line treatment for various conditions, from hypertension and heart failure to anxiety and migraines.
Although beta-blockers present unique benefits, it’s crucial...
Source: The EMT Spot - July 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Thinking on Your Feet Well: Building Adaptive Expertise in Learners Using Simulation
On this episode of the Academic Medicine Podcast, Sam Clarke, MD, MAS, and Jon Ilgen, MD, PhD, join host Toni Gallo to discuss the importance of teaching adaptive expertise to prepare learners for the types of complex cases they will encounter in clinical practice. This conversation also covers what adaptive expertise is, how simulation can be used to foster this skill in learners, and the complementary relationship between performance-oriented cases and adaptive cases in health professions education.
This episode is now available through Apple Podcasts, Spotify, and anywhere else podcasts are available.
...
Source: Academic Medicine Blog - July 24, 2023 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast adaptive expertise medical education medical students residents simulation Source Type: blogs
Zilebesiran: A Promising Leap Forward In Hypertension Management
Conclusion
As we draw the curtain on this insightful dive into Zilebesiran, a couple of takeaways stand out. Zilebesiran, the promising twice-yearly shot, is opening new frontiers in hypertension management.
With its ability to suppress angiotensin production, it offers a fresh approach that could alleviate the burden of daily pill regimens. But the shot is still in its developmental phase, and further research is crucial to fully understand its capabilities and limitations.
Still, it’s important to remember that medications are only a part of the solution. The enduring message from health professionals is ...
Source: The EMT Spot - July 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Alpha-Beta-Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In conclusion, the advent of alpha-beta-blockers has marked a significant advancement in cardiovascular treatment.
These medications, combining the properties of both alpha and beta blockers, have demonstrated superiority in managing various cardiovascular conditions.
They offer the potential for enhanced blood pressure control, cardiovascular protection, and versatility in the management of several cardiovascular conditions.
The choice of using alpha-beta-blockers, however, must be tailored to the individual patient. Considerations such as past medical records, present health conditions, concurrent ...
Source: The EMT Spot - July 20, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Pulmonary Arterial Hypertension: Unraveling Its Impact On Heart And Lungs
Conclusion
Navigating the complexities of Pulmonary Arterial Hypertension (PAH) might seem daunting. However, with the right knowledge and proactive approach, it’s possible to manage the condition and maintain a good quality of life.
PAH, a unique type of high blood pressure affecting the arteries in the lungs, can put extra strain on the heart. Over time, this can lead to heart failure. The condition’s root cause may vary, from genetic factors to other health issues like heart defects, liver disease, or autoimmune diseases. Remember, sometimes the cause remains unknown, resulting in idiopathic pulmonary ...
Source: The EMT Spot - July 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Late Life Rapamycin Treatment Reverses Diastolic Dysfunction in Mice
Inhibitors of mTOR such as rapamycin are increasingly well studied. This class of drug stimulates cellular stress responses, principally autophagy, and thus produces outcomes that are broadly similar to the long-term improvement of health resulting from calorie restriction, exercise, or other demonstrated means of upregulating autophagy. This results in benefits to health, such as those noted in today's open access paper.
It is one thing to demonstrate that a drug improves measures of autophagy known to decline with age, and note that many of the interventions shown to modestly slow aging in laboratory species are c...
Source: Fight Aging! - July 14, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing Efforts to Use Cells and Scaffolds to Regenerate the Heart
The heart is one of the least regenerative tissues in the body. Damage resulting from loss of blood flow during a heart attack leads to scarring and loss of function, rather than any meaningful degree of regeneration. While preventing the atherosclerosis that causes occlusion of blood vessels is the most desirable goal, finding ways to repair a damaged heart is also a high priority for the research community. Many groups have worked towards regenerative therapies based on delivery of cells and scaffolding material, even layers of artificial tissue made by combining the two, but progress has been frustratingly slow.
...
Source: Fight Aging! - July 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Angiotensin II Receptor Blockers (ARBs) For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
Cardiovascular disease (CVD) has become a leading cause of death globally, necessitating the adoption of preventive measures, early detection, and effective management strategies.
Hypertension, a significant risk factor for CVD, requires active management to mitigate associated risks.
Angiotensin II Receptor Blockers (ARBs) have emerged as a favored choice among healthcare professionals due to their effectiveness and unique benefits.
ARBs offer several advantages compared to other blood pressure medications. They effectively control blood pressure, protect vital organs such as the heart and kidneys, ...
Source: The EMT Spot - July 11, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
ACE Inhibitors For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In conclusion, the rising utilization of blood pressure medications reflects a growing awareness of the importance of managing hypertension for overall health.
ACE inhibitors, among other drug classes, are widely used due to their effectiveness in lowering blood pressure and providing additional benefits for heart and kidney health.
It’s essential to consult your doctor before starting or adjusting ACE inhibitor treatment to ensure personalized care and monitor for potential side effects or drug interactions.
Taking ACE inhibitors as prescribed, following consistent dosing schedules, and attend...
Source: The EMT Spot - July 9, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Poor Long Term Outcome With Subsequent Pregnancies After Peripartum Cardiomyopathy
This study was from a single centre where mortality in women with peripartum cardiomyopathy was higher than in other studies from the United Studies. Most of the patients were African American and of low socioeconomic status. Earlier studies have clearly demonstrated a different phenotypic presentation and outcome in African American women with peripartum cardiomyopathy compared to non-African American women. African American women had been shown to be diagnosed later, present lower LVEF, larger LV volume and more severe heart failure symptoms. The rate of recovery was lower and time for recovery markedly longer in that pa...
Source: Cardiophile MD - June 28, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Senescent Cardiomyocytes Increase the Damage Following a Heart Attack
If a heart attack is survived, it leads to long-term damage to heart tissue. Scarring, detrimental remodeling of heart muscle, and other dysfunctions result. Researchers here show that a raised burden of cellular senescence in cardiomyocytes specifically predisposes the aged heart to greater harm following a heart attack. This well illustrates that periodic senolytic treatments or related strategies that can minimize the presence of senescent cells in aged tissues are highly desirable. The presence of lingering senescent cells is harmful in many ways, directly causing organs to become less functional and more vulnerable.
...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
