Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Envisaging Blood Brain Barrier Dysfunction as Secondary to Reduced Blood Flow to the Brain
The blood-brain barrier is a layer of specialized cells that tightly control passage of cells and molecules from the vasculature to the central nervous system. When the blood-brain barrier becomes dysfunctional and leaky with age, this contributes to chronic inflammation in brain tissue. The paper here provides an interesting discussion of the degree to which blood-brain barrier dysfunction in aging is secondary to reduced blood flow to the brain. A combination of factors lead to reduced circulation in the brain: loss of capillary density; small vessel disease in which the vessels narrow and weaken; heart failure; loss of ...
Source: Fight Aging! - March 7, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
An elderly woman with shortness of breath and an ECG that helps understand it
Written by Pendell Meyers, edits by Smith and GrauerOne of my fantastic residents brought me an ECG on shift and asked for my interpretation without any context:What do you think?I responded that it looks like chronic right ventricular hypertrophy. This is due to the QRS morphology and axis including incomplete RBBB pattern in V1, precordial R wave progression reversal, matching deep S waves in leftward leads I and aVL, very rightward limb lead axis including R wave in aVR. See Ken Grauer ' s comments below where he points out that the tall P-wave in lead II is diagnostic of right atrial enlargement, which supp...
Source: Dr. Smith's ECG Blog - March 6, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
High Blood Pressure: The Best Time To Take Pills
Taking blood pressure pills at the right time halves the risk of heart failure, heart attack and stroke. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 5, 2022 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying r...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Missing ECG signs of OMI is associated with early death
Written by Sean Trostel MD, with edits by Smith and MeyersA man in his 80s with history of CAD, MI s/p PCI, HTN, HLD, Afib, and HFrEF, presented with sudden onset, aching, central chest pain radiating to the left arm and shortness of breath that began in the morning, 1 hour prior to arrival to the ED. This was his initial triage ECG, recorded one hour after onset of symptoms, and a baseline ECG below for comparison:What do you think?Baseline on file: This ECG was interpreted as sinus bradycardia with no acute ST or T wave changes compared to prior. Despite the very poor quality and wanderin...
Source: Dr. Smith's ECG Blog - February 25, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Late Life Exercise Lowers Risk of Cardiovascular Disease
There is plenty of evidence for moderate levels of exercise in late life to lower cardiovascular disease risk. When it comes to age-related disease, exercise remains better than most medicine for most people, a sad state of affairs that will hopefully change given technological progress in the years ahead. The study here offers yet another example of epidemiological data that supports the benefits of exercise in old age.
It's no secret that physical activity is associated with a lower risk of cardiovascular disease and a longer life, irrespective of gender and ethnicity, with the benefits accruing in tandem with t...
Source: Fight Aging! - February 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Links Between Cognitive Impairment and Cardiovascular Disease
Cognitive impairment and cardiovascular disease can have a bidirectional relationship, but much of the attention tends to focus on how cardiovascular aging can cause dysfunction in brain tissue. Mechanisms involved include a declining supply of nutrients to the brain, the rupture of small blood vessels due to hypertension, leakage of the blood-brain barrier that provokes neuroinflammation, and so forth. In principle, cognitive impairment can aggravate the situation via reduced the level of exercise, degree to which medical care is utilized, and so forth, making cardiovascular aging worse, and so the cycle progresses. Picki...
Source: Fight Aging! - February 21, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far.
Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy
https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/
In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and her...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting Matrix Vesicles in Vascular Calcification
This article aims to review the detailed role of MVs in the progression of VC and compare the difference with other major drivers of calcification, including aging, uremia, mechanical stress, oxidative stress, and inflammation. We will also bring attention to the novel findings in the isolation and characterization of MVs, and the therapeutic application of MVs in VC.
Link: https://doi.org/10.3389/fcell.2022.825622 (Source: Fight Aging!)
Source: Fight Aging! - February 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 31st 2022
In conclusion, the effects of MR on the gut barrier were likely related to alleviation of the oscillations of inflammation-related microbes. MR can enable nutritional intervention against age-related gut barrier dysfunction.
Clearing Senescent Cells from the Neural Stem Cell Niche Rapidly Improves Neurogenesis in Old Mice
https://www.fightaging.org/archives/2022/01/clearing-senescent-cells-from-the-neural-stem-cell-niche-rapidly-improves-neurogenesis-in-old-mice/
Neurogenesis is the generation of new neurons in the brain, and their integration into existing neural circuits. It is essential to learning a...
Source: Fight Aging! - January 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Failure of the Single Disease Paradigm in the Treatment of Aged Patients
Medical research and development in the context of aging has, like all other medicine, been dominated for a long time by a model in which a single disease is identified by symptoms and then treated. In the context of infectious disease and inherited conditions, this is a good way to go about the matter of investigation, treatment, and assignment of resources. A patient typically has one disease at a time, and the symptoms are distinct and clearly caused by the disease in question. Indeed, the disease paradigm arose from the modern era's long road towards ever more effective control of infectious disease. The institutions a...
Source: Fight Aging! - January 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Temporary Chimeric Antigen Receptor T Cells Produced in the Body via mRNA Gene Therapy
Chimeric antigen receptors applied to T cells, known as CAR-T therapies, are expensive. Isolating a patient's T cells, culturing them, engineering them, and then returning them to the body is an undertaking, particularly when it must be carried out with the very high level of reliability and quality control required by regulators. CAR-T therapies do well in attacking many types of cancer, but can have side-effects due to the lasting presence of engineered immune cells that have become too zealous. Few chimeric antigens are completely specific for cancer, and other cells will be destroyed as well. The approach noted here is...
Source: Fight Aging! - January 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Health Care Quality, Registries, and Artificial Intelligence at Q-Centrix
Many organizations have taken on the quest—and the enormous business opportunity—of measuring the quality of clinical care. For instance, health care registries collect data about procedures and outcomes for particular disciplines, such as oncology or heart failure. These registries don’t try to serve as a gigantic, general-purpose data repository like the failed Health Information Exchange […] (Source: EMR and HIPAA)
Source: EMR and HIPAA - January 13, 2022 Category: Information Technology Authors: Andy Oram Tags: Analytics/Big Data Healthcare IT Artificial Intelligence Brian Foy Clinical Coding Clinical Quality Computer Assisted Coding Healthcare AI Healthcare Automation Healthcare Data Healthcare NLP Healthcare Registries ICD-10 medical Source Type: blogs
