Does the Gut Microbiome Contribute to Frailty via Oxidative Stress?
The challenge in understanding degenerative aging is at this point less a matter of identifying mechanisms, and more a matter of establishing which of the many mechanisms involved in every specific aspect of aging are actually important. Cellular biochemistry is a complex interconnected web, and it is very hard to make changes to just one mechanism in isolation, so as to establish exactly its contribution. Now that biotechnology has advanced to the point at which near every biological mechanism is a viable target for intervention, it matters whether or not the research and development communities focus on the right targets...
Source: Fight Aging! - November 16, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Monitoring Congestive Heart Failure Through Speech: Interview with Tamir Tal, CEO of Cordio Medical
Cordio Medical, a medtech company based in Israel, has developed HearO, an app that can assist in monitoring congestive heart failure. The technology is based on the phenomenon whereby congestive heart failure patients demonstrate changes in their voice as their disease progresses or in advance of disease exacerbation. This includes lung sounds, such as wheezing and crackling. Indeed, some cardiologists report that they can hear changes in their patient’s voice, but that this typically occurs relatively late during disease exacerbation, making it less useful.
This phenomenon inspired Cordio Medical to develop an AI-po...
Source: Medgadget - November 11, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Diagnostics Exclusive CHF Congestive Heart Failure Source Type: blogs
What Are the Symptoms of High Blood Pressure in Women?
ConclusionThe Common Symptoms Of High Blood Pressure In Women
Numerous signs and symptoms in women can point to increased blood pressure. Visit your doctor immediately to check your blood pressure if you experience any of the following signs or symptoms.
Or read our article on Complete Blood Pressure Chart to understand the elevations.
Excessive fatigue
One of the major symptoms of high blood pressure is fatigue. Women with this condition often report feeling tired all the time, even when they get a full night’s sleep.
Fatigue can make it difficult to concentrate, and simple tasks seem overwhelming.
Thi...
Source: The EMT Spot - November 11, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs
The Med List: ACE Inhibitors
Today I’m starting a new series called The Med List. Once or twice a month, I’d like take a closer look at a single class of home medications and explore the medical implications for our patients who take these meds.
The patient’s medications list holds a wealth of information. Prescribed medications tell us about the patient’s medical history. They also give us clues to the patient’s possible current condition and presentation. Some medicines can better explain the clinical picture in front of us and others can be red flags regarding treatment options and the patients likely response.
Let’s kic...
Source: The EMT Spot - November 9, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Treating Hypertension with Diuretics
This article will explore the types, uses and side effects of treating hypertension with diuretics as a supplement to other ways to lower blood pressure.
Quick Summary
Diuretics are prescribed to encourage kidney function and vascular health and regulate blood pressure.
There are several forms of diuretics with possible side effects and interactions with other drugs and supplements.
Doctors often prescribe them to complement medication or a combination for effective hypertension treatment.
Treating Hypertension and More with Diuretics
Diuretics are the most common medication to manage high b...
Source: The EMT Spot - November 8, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs
Does High Blood Pressure Make You Tired, Sleepy?
This article will help shed light on the link.
Quick Summary
There is a strong link between feeling tired or sleepy with high blood pressure due to underlying conditions or medication.
Kidney disease, arterial disease, and sleep apnea are possible explanations for lethargy with hypertension.
Proper treatment and control can reduce the risk of fatigue caused by elevated blood pressure.
So, Does High Blood Pressure Make You Feel Tired, Sleepy, or Fatigued?
Fatigue and high blood pressure are connected, but they could also be a symptom of underlying causes—for example, hypertension medication...
Source: The EMT Spot - November 8, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs
Investigating the Ability of Type 2 Diabetes Treatments to Modestly Slow Aging Extends to SGLT-2 Inhibitors
There is something of a trend towards picking over the landscape of type 2 diabetes medication in search of therapies that can modestly slow aging, at least in animal models. If metformin is anything to go by, we shouldn't be at all optimistic that this will result in useful outcomes in humans. "Useful" in this context means reliable gains in late life health and life expectancy in metabolically normal people, where those gains are larger than those that can be achieved with exercise, and with minimal side-effects. Otherwise, this seems like time and effort that could be directed to more productive areas of research and de...
Source: Fight Aging! - November 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamm...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What is ascites precox?
The early occurrence of ascites in chronic constrictive pericarditis even before the appearance of generalised edema has been called ‘ascites precox’. Though ascites can occur in any severe long standing heart failure, it is most likely to occur in constrictive pericarditis and severe tricuspid valve disease. (Source: Cardiophile MD)
Source: Cardiophile MD - November 5, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Reviewing Approaches to Treating Transthyretin Amyloidosis
Transthyretin amyloidosis may be a primary component of the present limit on human longevity. Transthyretin is one of the few proteins in the human body that can misfold in ways that encourage other molecules of the same protein to misfold in the same way, joining together form solid aggregates that disrupt cell and tissue function. This is particularly an issue in the cardiovascular system, and while it is presently thought that transthyretin amyloidosis only contributes to a minority of fatal cardiovascular disease in younger old age, autopsies of supercentenarians suggested that it is the major cause of death in the old...
Source: Fight Aging! - November 3, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why is angina not a typical symptom of left ventricular aneurysm?
Angina pectoris indicates viable but ischemic myocardium. In ventricular aneurysm, it is usually a non-viable scarred area of myocardium, due to poorly collateralized chronically occluded coronary artery. The border zone of the aneurysm is vulnerable to form re-entrant circuits which can trigger ventricular tachycardia. As the aneurysmal segment bulges out in systole instead of contracting, the systolic effort of the left ventricle is wasted. Part of the effort of the remaining left ventricular muscle is wasted in moving blood in and out of the aneurysm pouch. This leads to heart failure. Mural thrombi can form in th...
Source: Cardiophile MD - November 3, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What are the mechanical complications of acute myocardial infarction?
Typical mechanical complications of acute myocardial infarction are rupture of papillary muscle, rupture of interventricular septum and rupture of left ventricular free wall. Mechanical complications are more life threatening and seldom respond to medical management. They need early high risk surgery. Rupture of papillary muscle causes severe acute mitral regurgitation and pulmonary edema. Rupture of interventricular septum produces an acquired ventricular septal defect and leads to severe heart failure. Rupture of ventricular free wall causes hemopericardium and cardiac tamponade. (Source: Cardiophile MD)
Source: Cardiophile MD - November 3, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, October 31st 2022
This study used mice to evaluate how their lifestyles - eating fatty foods vs. healthy and exercising vs. not - affected the metabolites of their offspring. Metabolites are substances made or used when the body breaks down food, drugs or chemicals, or its own fat or muscle tissue. "We have previously shown that maternal and paternal exercise improve health of offspring. Tissue and serum metabolites play a fundamental role in the health of an organism, but how parental exercise affects offspring tissue and serum metabolites has not yet been investigated."
Researchers used targeted metabolomics - the study of metaboli...
Source: Fight Aging! - October 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Direct Reprogramming of Heart Fibroblasts into Cardiomyocytes
A promising approach to inducing regeneration from injury and age-related fibrosis in the heart is the reprogramming of fibroblast cells into heart muscle cells, cardiomyocytes. Like all such efforts, much of the work lies in establishing the recipe of regulatory signals needed to produce the desired outcome. The research results reported here are an illustrative example, representative of programs taking place in many laboratories, in which scientists are attempting to improve on the discovered forms of reprogramming in order to make them efficient enough to be useful as a basis for regenerative therapies.
Mammal...
Source: Fight Aging! - October 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
