JMM Profile: Swine influenza A virus: a neglected virus with pandemic potential
J Med Microbiol. 2023 Jan;72(1). doi: 10.1099/jmm.0.001623.ABSTRACTSwine influenza is an acute respiratory disease of swine caused by swine influenza A virus (SwIAV). The ability of SwIAV to spread bidirectionally from animals to humans (zoonotic), and from humans to animals (reverse zoonotic), drives coinfection that can result in gene segment exchange and elevates the risk of generating viruses with pandemic potential. Compared to human-origin influenza A viruses, current data indicate a greater diversity amongst circulating SwIAVs, with three major subtypes (classified by haemagglutinin and neuraminidase) circulating gl...
Source: Journal of Medical Microbiology - February 7, 2023 Category: Microbiology Authors: Benjamin C Mollett Helen E Everett Pauline M van Diemen Alexander M P Byrne Andrew Ramsay Joe James Scott M Reid Rowena D E Hansen Nicola S Lewis Ian H Brown Ashley C Banyard Source Type: research
JMM Profile: Swine influenza A virus: a neglected virus with pandemic potential
J Med Microbiol. 2023 Jan;72(1). doi: 10.1099/jmm.0.001623.ABSTRACTSwine influenza is an acute respiratory disease of swine caused by swine influenza A virus (SwIAV). The ability of SwIAV to spread bidirectionally from animals to humans (zoonotic), and from humans to animals (reverse zoonotic), drives coinfection that can result in gene segment exchange and elevates the risk of generating viruses with pandemic potential. Compared to human-origin influenza A viruses, current data indicate a greater diversity amongst circulating SwIAVs, with three major subtypes (classified by haemagglutinin and neuraminidase) circulating gl...
Source: Journal of Medical Microbiology - February 7, 2023 Category: Microbiology Authors: Benjamin C Mollett Helen E Everett Pauline M van Diemen Alexander M P Byrne Andrew Ramsay Joe James Scott M Reid Rowena D E Hansen Nicola S Lewis Ian H Brown Ashley C Banyard Source Type: research
Viruses, Vol. 15, Pages 46: A Bivalent Live Attenuated Influenza Virus Vaccine Protects against Drifted H1N2 and H3N2 Clinical Isolates in Swine
In this study, we demonstrate that this vaccine extends protection in pigs to more current, drifted non-homologous H1N2 and H3N2 strains, A/Swine/MB/SD0467/2019 (H1N2) [SD467] and A/Swine/AB/SD0435/2019 (H3N2) [SD435]. The vaccine elicited a robust immune response in the serum and the lung and reduced viral replication as well as lung pathology associated with these strains. Therefore, this bivalent vaccine remains a strong candidate that would be beneficial to the swine influenza vaccine market in North America. (Source: Viruses)
Source: Viruses - December 23, 2022 Category: Virology Authors: Lauren Aubrey Ulises Barron-Castillo Susan Detmer Yan Zhou Tags: Article Source Type: research
Viruses, Vol. 14, Pages 2398: Interspecies Transmission from Pigs to Ferrets of Antigenically Distinct Swine H1 Influenza A Viruses with Reduced Reactivity to Candidate Vaccine Virus Antisera as Measures of Relative Zoonotic Risk
my L. Vincent Baker
During the last decade, endemic swine H1 influenza A viruses (IAV) from six different genetic clades of the hemagglutinin gene caused zoonotic infections in humans. The majority of zoonotic events with swine IAV were restricted to a single case with no subsequent transmission. However, repeated introduction of human-seasonal H1N1, continual reassortment between endemic swine IAV, and subsequent drift in the swine host resulted in highly diverse swine IAV with human-origin genes that may become a risk to the human population. To prepare for the potential of a future swine-origin IAV pandemic in human...
Source: Viruses - October 29, 2022 Category: Virology Authors: J. Brian Kimble Carine K. Souza Tavis K. Anderson Zebulun W. Arendsee David E. Hufnagel Katharine M. Young Nicola S. Lewis C. Todd Davis Sharmi Thor Amy L. Vincent Baker Tags: Article Source Type: research
Genetic characterization of a novel quadruple reassortant influenza A (H1N2) virus from swine, China, 2021
We read with interest a recent letter in the Journal of Infection, which reported the emergence of novel H5N6 reassortant and it's threat to both birds and humans (1). Pigs are susceptible to human, swine, and avian influenza A viruses (IAVs) and considered as intermediate hosts or “mixing vessels” for generating novel viruses with pandemic potential (2). Moreover, China has a complicated ecosystem of swine influenza viruses (SIVs) in which H1N1, H1N2, and H3N2 subtypes with classical swine (CS), North America triple-reassortant (TR), Eurasian avian-like (EA), and H1N1 pan demic/2009 (pdm/09) lineages are co-circulatin...
Source: Journal of Infection - September 10, 2022 Category: Infectious Diseases Authors: Hailiang Sun, Hanlin Liu, Yanwei Liu, Zifeng Pang, Yinglin Jiang, Quan Liu, Ming Liao Source Type: research
Alternating 3 different influenza vaccines for swine in Europe for a broader antibody response and protection
In this study, we have examined the efficacy of alternating 3 different European commercial swine influenza A virus (swIAV) vaccines: the trivalent Respiporc® FLU3 (TIV), the bivalent GRIPORK® (BIV) and the monovalent Respiporc® FLUpan H1N1 (MOV). Five groups of 6 pigs each received 3 vaccinations at 4 –6 week intervals in a homologous or heterologous prime-boost regimen. A sixth group served as a mock-vaccinated challenge control. Four weeks after the last vaccination, pigs were challenged intranasally with a European avian-like H1N1 (1C.2.1) swIAV, which was antigenically distinct from the va ccine strains. One het...
Source: Veterinary Research - June 15, 2022 Category: Veterinary Research Source Type: research
Determining Existing Human Population Immunity as Part of Assessing Influenza Pandemic Risk
Emerg Infect Dis. 2022 May;28(5):977-985. doi: 10.3201/eid2805.211965.ABSTRACTZoonotic influenza infections continue to threaten human health. Ongoing surveillance and risk assessment of animal viruses are needed for pandemic preparedness, and population immunity is an important component of risk assessment. We determined age-stratified hemagglutinin inhibition seroprevalence against 5 swine influenza viruses circulating in Hong Kong and Guangzhou in China. Using hemagglutinin inhibition seroprevalence and titers, we modeled the effect of population immunity on the basic reproduction number (R0) if each virus were to becom...
Source: Emerging Infectious Diseases - April 21, 2022 Category: Infectious Diseases Authors: Jonathan Tin Lai Cheung Tim K Tsang Hui-Ling Yen Ranawaka A P M Perera Chris Ka Pun Mok Yong Ping Lin Benjamin J Cowling Malik Peiris Source Type: research
Human infection with a reassortant swine-origin influenza A(H1N2)v virus in Taiwan, 2021
Influenza A virus infections occur in different species, causing mild-to-severe symptoms that lead to a heavy disease burden. H1N1, H1N2 and H3N2 are major subtypes of swine influenza A viruses in pigs and occ... (Source: Virology Journal)
Source: Virology Journal - April 7, 2022 Category: Virology Authors: Ji-Rong Yang, Chuan-Yi Kuo, I.-Ling Yu, Fang-Yen Kung, Fang-Tzy Wu, Jen-Shiou Lin and Ming-Tsan Liu Tags: Research Source Type: research
Retracted: Isolation of a Reassortant H1N2 Swine Flu Strain of Type "Swine-Human-Avian" and Its Genetic Variability Analysis
Biomed Res Int. 2022 Mar 18;2022:9860961. doi: 10.1155/2022/9860961. eCollection 2022.ABSTRACT[This retracts the article DOI: 10.1155/2018/1096079.].PMID:35342768 | PMC:PMC8956383 | DOI:10.1155/2022/9860961 (Source: Biomed Res)
Source: Biomed Res - March 28, 2022 Category: Research Authors: BioMed Research International Source Type: research
Retracted: Isolation of a Reassortant H1N2 Swine Flu Strain of Type "Swine-Human-Avian" and Its Genetic Variability Analysis
Biomed Res Int. 2022 Mar 18;2022:9860961. doi: 10.1155/2022/9860961. eCollection 2022.ABSTRACT[This retracts the article DOI: 10.1155/2018/1096079.].PMID:35342768 | PMC:PMC8956383 | DOI:10.1155/2022/9860961 (Source: Biomed Res)
Source: Biomed Res - March 28, 2022 Category: Research Authors: BioMed Research International Source Type: research
Viruses, Vol. 14, Pages 643: Prevalence, Genetics, and Evolutionary Properties of Eurasian Avian-Like H1N1 Swine Influenza Viruses in Liaoning
ang Song
Ying Zhang
Swine influenza virus (SIV) is an important zoonosis pathogen. The 2009 pandemic of H1N1 influenza A virus (2009/H1N1) highlighted the importance of the role of pigs as intermediate hosts. Liaoning province, located in northeastern China, has become one of the largest pig-farming areas since 2016. However, the epidemiology and evolutionary properties of SIVs in Liaoning are largely unknown. We performed systematic epidemiological and genetic dynamics surveillance of SIVs in Liaoning province during 2020. In total, 33,195 pig nasal swabs were collected, with an SIV detection rate of 2%. Our analysi...
Source: Viruses - March 20, 2022 Category: Virology Authors: Hailing Li Haoyu Leng Siqi Tang Chaofan Su Yina Xu Yongtao Wang Jiaming Lv Shiwei Zhang Yali Feng Shaokang Song Ying Zhang Tags: Article Source Type: research
Viruses, Vol. 14, Pages 643: Prevalence, Genetics and Evolutionary Properties of Eurasian Avian-like H1N1 Swine Influenza Viruses in Liaoning
ang Song
Ying Zhang
Swine influenza virus (SIV) is an important zoonosis pathogen. The 2009 pandemic of H1N1 influenza A virus (2009/H1N1) highlighted the importance of the role of pigs as intermediate hosts. Liaoning province, located in northeastern China, has become one of the largest pig-farming areas since 2016. However, the epidemiology and evolutionary properties of SIVs in Liaoning are largely unknown. We performed systematic epidemiological and genetic dynamics surveillance of SIVs in Liaoning province during 2020. In total, 33,195 pig nasal swabs were collected, with an SIV detection rate of 2%. Our analysi...
Source: Viruses - March 20, 2022 Category: Virology Authors: Hailing Li Haoyu Leng Siqi Tang Chaofan Su Yina Xu Yongtao Wang Jiaming Lv Shiwei Zhang Yali Feng Shaokang Song Ying Zhang Tags: Article Source Type: research
Viruses, Vol. 13, Pages 2346: Comparative Susceptibility of Madin & ndash;Darby Canine Kidney (MDCK) Derived Cell Lines for Isolation of Swine Origin Influenza A Viruses from Different Clinical Specimens
Viruses, Vol. 13, Pages 2346: Comparative Susceptibility of Madin–Darby Canine Kidney (MDCK) Derived Cell Lines for Isolation of Swine Origin Influenza A Viruses from Different Clinical Specimens
Viruses doi: 10.3390/v13122346
Authors:
Matthew Suderman
Mariko Moniwa
Tamiru N. Alkie
Davor Ojkic
Andre Broes
Neil Pople
Yohannes Berhane
Madin–Darby canine kidney (MDCK) cells are commonly used for the isolation of mammalian influenza A viruses. The goal of this study was to compare the sensitivity and suitability of the original MDCK cell line in comparison with MDCK-derived cell line...
Source: Viruses - November 23, 2021 Category: Virology Authors: Matthew Suderman Mariko Moniwa Tamiru N. Alkie Davor Ojkic Andre Broes Neil Pople Yohannes Berhane Tags: Article Source Type: research
Characterization of Swine Influenza A(H1N2) Variant, Alberta, Canada, 2020
Emerg Infect Dis. 2021;27(12):3045-3051. doi: 10.3201/eid2712.210298.ABSTRACTInfluenza strains circulating among swine populations can cause outbreaks in humans. In October 2020, we detected a variant influenza A subtype H1N2 of swine origin in a person in Alberta, Canada. We initiated a public health, veterinary, and laboratory investigation to identify the source of the infection and determine whether it had spread. We identified the probable source as a local pig farm where a household contact of the index patient worked. Phylogenetic analysis revealed that the isolate closely resembled strains found at that farm in 201...
Source: Emerging Infectious Diseases - November 22, 2021 Category: Infectious Diseases Authors: Jamil N Kanji Kanti Pabbaraju Matthew Croxen Susan Detmer Nathalie Bastien Yan Li Anna Majer Hussein Keshwani Nathan Zelyas Ifeoma Achebe Corinne Jones Maureen Rutz Angela Jacobs Keith Lehman Deena Hinshaw Graham Tipples Source Type: research
Characterization of Swine Influenza A(H1N2) Variant, Alberta, Canada, 2020
J. N. Kanji et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - November 1, 2021 Category: Infectious Diseases Source Type: research
