A case of bacteremia and meningitis in a neonate infected with Group B Streptococcus via breastfeeding who survived without neurological sequelae: A case report
In this report, we describe a case of late-onset bacteremia/meningitis in a neonate suspected to have been infected with GBS via breastfeeding. A vaginal culture test of the mother at 35 weeks' gestation was negative for GBS. Since she had symptoms of mastitis, breast milk and nipple cultures were also tested and found to be positive for the strain of GBS identified in the neonate on genetic analysis. Diagnosis of trans-mammary GBS infection is challenging because breastfeeding-related events are difficult to identify. In our case, the diagnosis was based on the mother's history of mastitis, and the patient was treated wit...
Source: Journal of Nippon Medical School - June 4, 2023 Category: Universities & Medical Training Authors: Ryohei Fukunaga Takeshi Asano Ryosuke Matsui Masanori Abe Naruhiko Ishiwada Yoshio Shima Source Type: research
A case of bacteremia and meningitis in a neonate infected with Group B Streptococcus via breastfeeding who survived without neurological sequelae: A case report
In this report, we describe a case of late-onset bacteremia/meningitis in a neonate suspected to have been infected with GBS via breastfeeding. A vaginal culture test of the mother at 35 weeks' gestation was negative for GBS. Since she had symptoms of mastitis, breast milk and nipple cultures were also tested and found to be positive for the strain of GBS identified in the neonate on genetic analysis. Diagnosis of trans-mammary GBS infection is challenging because breastfeeding-related events are difficult to identify. In our case, the diagnosis was based on the mother's history of mastitis, and the patient was treated wit...
Source: Journal of Nippon Medical School - June 4, 2023 Category: Universities & Medical Training Authors: Ryohei Fukunaga Takeshi Asano Ryosuke Matsui Masanori Abe Naruhiko Ishiwada Yoshio Shima Source Type: research
GSE230856 Group B Streptococcus drives major transcriptomic changes in the colonic epithelium
Contributors : Kristen Dom ínguez ; April K Lindon ; Justin A Gibbons ; Sophie E Darch ; Tara M RandisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGroup B Streptococcus (GBS) is a leading cause of infant sepsis worldwide. Colonization of the gastrointestinal tract is a critical precursor to late-onset disease in exposed newborns. Neonatal susceptibility to GBS intestinal translocation stems from intestinal immaturity; however, the mechanisms by which GBS exploits the immature host remain unclear. β-hemolysin/cytolysin (βH/C) is a highly conserved toxin produced by GBS capable o...
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes
To evaluate the choice of antibiotic used for intrapartum Group B Streptococcus (GBS) prophylaxis in pregnant individuals with reported penicillin allergies compared to those without reported penicillin allerg... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - May 30, 2023 Category: OBGYN Authors: Josephine B. Snider, Leena B. Mithal, Jason H. Kwah, Nathaniel J. Rhodes and Moeun Son Tags: Research Source Type: research
Genomic characterization of emerging invasive Streptococcus agalactiae serotype VIII in Alberta, Canada
Abstract
Invasive Group B Streptococcus (GBS) can infect pregnant women, neonates, and older adults. Invasive GBS serotype VIII is infrequent in Alberta; however, cases have increased in recent years. Here, genomic analysis was used to characterize fourteen adult invasive serotype VIII isolates from 2009 to 2021. Trends in descriptive clinical data and antimicrobial susceptibility results were evaluated for invasive serotype VIII isolates from Alberta. Isolate genomes were sequenced and subjected to molecular sequence typing, virulence and antimicrobial resistance gene identification, phylogenetic analysis, and pangenom...
Source: European Journal of Clinical Microbiology and Infectious Diseases - May 29, 2023 Category: Microbiology Source Type: research
Variable resistance to zinc intoxication among Streptococcus agalactiae reveals a novel IS1381 insertion element within the zinc efflux transporter gene czcD
Streptococcus agalactiae, also known as group B Streptococcus, is an important human and animal pathogen. Zinc (Zn) is an essential trace element for normal bacterial physiology but intoxicates bacteria at high concentrations. Molecular systems for Zn detoxification exist in S. agalactiae, however the degree to which Zn detoxification may vary among different S. agalactiae isolates is not clear. We measured resistance to Zn intoxication in a diverse collection of clinical isolates of S. agalactiae by comparing the growth of the bacteria in defined conditions of Zn stress. We found significant differences in the ability of ...
Source: Frontiers in Immunology - May 26, 2023 Category: Allergy & Immunology Source Type: research
Self-collected versus health-care professional taken swab for identification of vaginal-rectal colonisation with group B streptococcus in late pregnancy: a systematic review
CONCLUSION: This study provides reassuring evidence that self-collected swabs for maternal GBS colonisation are highly accurate relative to swabs collected by health-care professionals. Women requiring a swab for GBS colonisation can self-swab with appropriate instructions if they choose.FUNDING: Personal fellowship from the University of Nottingham for KFW.PMID:37229964 | DOI:10.1016/j.ejogrb.2023.05.027 (Source: Reproductive Biology)
Source: Reproductive Biology - May 25, 2023 Category: Reproduction Medicine Authors: Kenny Odubamowo Maria Garcia Francis Muriithi Reuben Ogollah Jane P Daniels Kate F Walker Source Type: research
Self-collected versus health-care professional taken swab for identification of vaginal-rectal colonisation with group B streptococcus in late pregnancy: a systematic review
Testing for group B streptococcus (GBS) requires a vaginal-rectal swab in late pregnancy. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - May 22, 2023 Category: OBGYN Authors: Kenny Odubamowo, Maria Garcia, Francis Muriithi, Reuben Ogollah, Jane P Daniels, Kate F Walker Tags: Full length article Source Type: research
Population genetics of group B Streptococcus from maternal carriage in an ethnically diverse community in London
ConclusionOur study showed high prevalence of GBS vaccine targets among isolates from pregnant women in London. However, the observed serotype diversity in CC1 and high prevalence of MLSB resistance genes in CC19 demonstrates presence of high risk lineages, which might act as a reservoir of non-vaccine strains and antimicrobial resistance determinants. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - May 18, 2023 Category: Microbiology Source Type: research
Determination of pilus-islands profile and antibiotic susceptibility of < em > Streptococcus agalactiae < /em > isolated from urine of pregnant women
CONCLUSION: Most of the GBS urine isolates examined carried the PI-1+PI-2a gene, which increases bacterial potency in colonization and resistance to the immune system. Penicillin was best choice for prevention.PMID:37193229 | PMC:PMC10183068 | DOI:10.18502/ijm.v15i2.12473 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - May 16, 2023 Category: Microbiology Authors: Susan Panahi Mohammad Bagher Khalili Maryam Sadeh Mahmood Vakili Source Type: research
