GSE197489 Group B Streptococcal transcriptome when interacting with brain endothelial cells
Contributors : Bailey E Bridgers ; Madelyn L Armstrong ; Eric R Espinal ; Mustafa Divyapicigil ; Thomas A Hooven ; Alexander J Westermann ; Till Sauerwein ; Konrad U Foerstner ; Alexandra Schubert-Unkmeir ; Brandon J Kim ; Nadine Vollmuth ; Abigail Gildea ; Jacob Wood ; Guilia BarbieriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Streptococcus sp. 'group B'We have conducted RNA-seq analysis on Group B Streptococcus (GBS) when interacting with human stem-cell (hSC) derived BECs. The study contains a control group for GBS and a control group for BECs each with three biologic...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Streptococcus sp. 'group B' Source Type: research
Changes in serum inflammatory factors in group B streptococcal infection and their predictive value for premature rupture of membranes complicated by chorioamnionitis
Conclusion: Joint prediction of IL-6, TNF-α, PCT and hs-CRP has the best predictive value for PROM complicating CS and adverse pregnancy outcomes.PMID:38623925 | DOI:10.2217/bmm-2023-0588 (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 16, 2024 Category: Internal Medicine Authors: Xiaorui Dong Xixi Chen Mengling Xue Yina Zhang Source Type: research
Antibody kinetics between birth and three months of life in healthy infants with natural exposure to Group B streptococcus: A UK cohort study
CONCLUSION: Our results provide a basis for future investigations into the use of antibody kinetics in defining a serocorrelate of protection against late-onset iGBS disease.PMID:38627147 | DOI:10.1016/j.vaccine.2024.04.014 (Source: Vaccine)
Source: Vaccine - April 16, 2024 Category: Allergy & Immunology Authors: Konstantinos Karampatsas Tom Hall Merryn Voysey Clara Carreras-Abad Madeleine Cochet Laxmee Ramkhelawon Elisabeth Peregrine Nick Andrews Paul T Heath Kirsty Le Doare Source Type: research
Development and validation of a 6-plex Luminex-based assay for measuring human serum antibodies to group B streptococcus capsular polysaccharides
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 12, 2024 Category: Allergy & Immunology Authors: Michelle A. GaylordMelissa LarrierDonna Giordano-SchmidtChristopher D. GrubeSuddham SinghHa H. NguyenAndrew McKeenCharles Y. TanAnnaliesa S. AndersonWarren V. KalinaDanka PavliakovaPeter C. Giardinaa Vaccine Research and Development, Pfizer Inc, Pearl Riv Source Type: research
Interlaboratory comparison of a multiplex immunoassay that measures human serum IgG antibodies against six-group B streptococcus polysaccharides
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 12, 2024 Category: Allergy & Immunology Authors: Kirsty Le DoareMichelle A. GaylordAnnaliesa S. AndersonNick AndrewsCarol J. BakerShanna BolcenArif FelekPeter C. GiardinaChristopher D. GrubeTom HallBassam HallisAlane IzuShabir A. MadhiPete ManiatisMary MathesonFatme MawasAndrew McKeenJulia RhodesBailey Source Type: research
Group B Streptococcus Brain Abscess in a Neonate with Bilateral Otorrhea
Conclusion Brain abscess can occur as a sequela of GBS meningitis in neonates, but they are rare. Otogenic infections require prompt evaluation and treatment as they can progress to serious central nervous infections in neonates. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 4, 2024 Category: Perinatology & Neonatology Authors: Spencer, Emily E. Nostrand, Sarah Van Arya, Shreyas Tags: Case Report Source Type: research
Risk factors for infection and outcomes in infants with neonatal encephalopathy: a cohort study
CONCLUSIONS: Infants with NE exposed to risk factors for early-onset infection did not have worse short-term adverse outcomes.IMPACT: Risk factors for early-onset neonatal infection, including rupture of membranes >18 h, maternal group B streptococcus colonization, chorioamnionitis, maternal pyrexia or antepartum antibiotics, were not associated with death or short-term morbidity after cooling for NE. Despite exposure to risk factors for early-onset neonatal infection, infants with NE reached oral feeds earlier and needed fewer anti-seizure medications for a shorter duration than infants with NE but without such risk fa...
Source: Pediatric Research - April 2, 2024 Category: Pediatrics Authors: David Odd Hemmen Sabir Simon A Jones Chris Gale Ela Chakkarapani Source Type: research
Specific interaction between Group B Streptococcus CC17 hypervirulent clone and phagocytes
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - March 22, 2024 Category: Infectious Diseases Authors: Anne-Sophie BourrelAmandine PicartJose-Carlos FernandezConstantin HaysVirginie MignonBruno Saubam éaClaire PoyartAgnès FouetAsmaa TaziJulie Guignot1Université Paris Cité, Institut Cochin, INSERM, U1016, CNRS, UMR8104, Paris, France2Hôpitaux Universit Source Type: research
A decade of neonatal sepsis in Stockholm, Sweden: Gram-positive pathogens were four times as common as Gram-negatives
ConclusionGPB-BSI was four times more common than Gram-negative BSI in neonates but resulted in lower mortality rate. GBS was the most common pathogen in full-term infants and in EOS. CoNS was the most common pathogen in LOS and infants born very preterm, and the AMR rate was high in these isolates. The increasing trend ofS. aureus BSI indicates a need of further investigation. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 22, 2024 Category: Microbiology Source Type: research
Risk factors and genetic characteristics of the carriage of hypervirulent and carbapenem-resistant Acinetobacter baumannii among pregnant women
ConclusionThe significant carriage rate and enhanced virulence of CRAB during pregnancy emphasize the imperative for routine surveillance to forestall dissemination within this high-risk group, especially in Guangdong for ClusterRS 13 isolates. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 20, 2024 Category: Microbiology Source Type: research
Incidence of invasive infections with Group B streptococcus in adults in Norway 1996-2019: a nationwide registry-based case-control study
CONCLUSIONS: The incidence of invasive GBS disease in adults increased significantly from 1996 to 2019. The increasing age of the population with accompanying underlying comorbid conditions might contribute to the increasing burden of invasive GBS disease. Interestingly, type 1 diabetes was also associated with the occurrence of invasive GBS disease.PMID:38483786 | DOI:10.1007/s15010-024-02210-3 (Source: Cancer Control)
Source: Cancer Control - March 14, 2024 Category: Cancer & Oncology Authors: Elise Uggen Camilla Olaisen Randi Vals ø Lyng Gunnar Skov Simonsen Roar Magne B ævre-Jensen Frode Width Gran Bj ørn Olav Åsvold Tom Ivar Lund Nilsen Jan Kristian Dam ås Jan Egil Afset Source Type: research
Incidence of invasive infections with Group B streptococcus in adults in Norway 1996 –2019: a nationwide registry-based case–control study
ConclusionsThe incidence of invasive GBS disease in adults increased significantly from 1996 to 2019. The increasing age of the population with accompanying underlying comorbid conditions might contribute to the increasing burden of invasive GBS disease. Interestingly, type 1 diabetes was also associated with the occurrence of invasive GBS disease. (Source: Infection)
Source: Infection - March 14, 2024 Category: Infectious Diseases Source Type: research
Group B Streptococcus Infection and Obstetric Hemorrhage Risk
Conclusions for PracticeGBS infection at the time of delivery was not associated with increased risk for OBH or OBH-M. Further research is needed to further explore the relationship between peripartum infections and OBH risk. (Source: Maternal and Child Health Journal)
Source: Maternal and Child Health Journal - March 10, 2024 Category: Health Management Source Type: research
Engagement of α3β1 and α2β1 integrins by hypervirulent Streptococcus agalactiae in invasion of polarized enterocytes
The gut represents an important site of colonization of the commensal bacterium Streptococcus agalactiae (group B Streptococcus or GBS), which can also behave as a deadly pathogen in neonates and adults. Invasion of the intestinal epithelial barrier is likely a crucial step in the pathogenesis of neonatal infections caused by GBS belonging to clonal complex 17 (CC17). We have previously shown that the prototypical CC17 BM110 strain invades polarized enterocyte-like cells through their lateral surfaces using an endocytic pathway. By analyzing the cellular distribution of putative GBS receptors in human enterocyte-like Caco-...
Source: Frontiers in Microbiology - March 6, 2024 Category: Microbiology Source Type: research
Re-framing the importance of Group B Streptococcus as a gut-resident pathobiont
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - March 4, 2024 Category: Infectious Diseases Authors: Joie LingAndrew J. Hryckowian1Department of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA2Department of Medical Microbiology and Immunology, University of Wisco Source Type: research
