Group B Streptococcus Infection and Obstetric Hemorrhage Risk
Conclusions for PracticeGBS infection at the time of delivery was not associated with increased risk for OBH or OBH-M. Further research is needed to further explore the relationship between peripartum infections and OBH risk. (Source: Maternal and Child Health Journal)
Source: Maternal and Child Health Journal - March 10, 2024 Category: Health Management Source Type: research
Engagement of α3β1 and α2β1 integrins by hypervirulent Streptococcus agalactiae in invasion of polarized enterocytes
The gut represents an important site of colonization of the commensal bacterium Streptococcus agalactiae (group B Streptococcus or GBS), which can also behave as a deadly pathogen in neonates and adults. Invasion of the intestinal epithelial barrier is likely a crucial step in the pathogenesis of neonatal infections caused by GBS belonging to clonal complex 17 (CC17). We have previously shown that the prototypical CC17 BM110 strain invades polarized enterocyte-like cells through their lateral surfaces using an endocytic pathway. By analyzing the cellular distribution of putative GBS receptors in human enterocyte-like Caco-...
Source: Frontiers in Microbiology - March 6, 2024 Category: Microbiology Source Type: research
Re-framing the importance of Group B Streptococcus as a gut-resident pathobiont
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - March 4, 2024 Category: Infectious Diseases Authors: Joie LingAndrew J. Hryckowian1Department of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA2Department of Medical Microbiology and Immunology, University of Wisco Source Type: research
Can the administration of probiotics in pregnant mothers reduce Group B streptococcus maternal colonization and mother-to-infant vertical transmission?
Group B streptococcus (GBS), also known as Streptococcus agalactiae, is a Gram-positive bacterium that colonizes the vagina and gastrointestinal tract in 10% –30% of women and can cause life-threatening diseases in pregnant women and neonates (1). Without intervention, the risk of vertical transmission occurs in approximately 50% of infants born to GBS-colonized mothers and approximately 1%–2% of them develop clinical infection. Maternal colonization of GBS is a major risk factor for early- and late-onset diseases, including GBS sepsis, pneumonia, and meningitis, which result in considerable morbidity and mortality wor...
Source: Pediatrics and Neonatology - February 27, 2024 Category: Perinatology & Neonatology Authors: Shiuh-Bin Fang Tags: Editorial Source Type: research
Establishment and application of a rapid molecular diagnostic platform for the isothermal visual amplification of group B Streptococcus based on recombinase polymerase
In conclusion, this study successfully established a combined RPA and LFS GBS in situ detection platform, with short reaction time, high sensitivity, high specificity, portability, and device independence, providing a feasible strategy for clinical GBS screening. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 23, 2024 Category: Microbiology Source Type: research
Analytical performances of a point-of-care loop-mediated isothermal amplification (LAMP) assay to detect Group B Streptococcus in intrapartum pregnant women living in the Democratic Republic of the Congo
Infection is an important cause of maternal, foetal, and infant mortality in resource-constrained settings [1]. Children living in sub-Saharan Africa are ten-fold more likely to die at and/or around birth compared to high-income countries [2]. Worldwide, Streptococcus agalactiae, commonly referred to as Group B Streptococcus (GBS), is the leading infectious cause of stillbirth, and neonatal morbidity and mortality [3,4]. GBS colonizes the gastrointestinal and/or genital tract of 15% to 40% of healthy adults, the rectum being the reservoir [5]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 19, 2024 Category: Infectious Diseases Authors: Serge Tonen-Wolyec, Noel Labana Otuli, Monde Otsatre-Okuti, Raelle Atenyi-Kasemire, Raphael Dupont, Laurent B élec Source Type: research
Analytical performances of a point-of-care loop-mediated isothermal amplification assay to detect Group B Streptococcus in intrapartum pregnant women living in the Democratic Republic of the Congo
Infection is an important cause of maternal, fetal, and infant mortality in resource-constrained settings [1]. Children living in sub-Saharan Africa are ten-fold more likely to die at and/or around birth compared to high-income countries [2]. Worldwide, Streptococcus agalactiae, commonly referred to as Group B Streptococcus (GBS), is the leading infectious cause of stillbirth, and neonatal morbidity and mortality [3,4]. GBS colonizes the gastrointestinal and/or genital tract of 15% to 40% of healthy adults, the rectum being the reservoir [5]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 19, 2024 Category: Infectious Diseases Authors: Serge Tonen-Wolyec, Noel Labana Otuli, Monde Otsatre-Okuti, Raelle Atenyi-Kasemire, Raphael Dupont, Laurent B élec Source Type: research
Urinary Tract Infection and Progression to Pyelonephritis: Group B Streptococcus versus E. coli
Conclusion Escherichia coli infections progress to pyelonephritis in pregnancy at markedly higher rates than GBS, although obstetric outcomes are similar. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 18, 2024 Category: Perinatology & Neonatology Authors: Sachdeva, Sarika Rosett, Heather A. Krischak, Madison K. Weaver, Kristin E. Heine, R. Phillips Denoble, Anna E. Dotters-Katz, Sarah K. Tags: Original Article Source Type: research
Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonisation (OPSiP trial): study protocol for a double-blind parallel group randomised placebo trial
This study protocol received ethics approval from the University of British Columbia’s Clinical Research Ethics Board, Dublin City University and Health Canada. Findings will be presented at research rounds, conferences and in peer-reviewed publications.
Trial registration number
NCT03407157. (Source: BMJ Open)
Source: BMJ Open - February 5, 2024 Category: General Medicine Authors: Hayes, K., Janssen, P., Payne, B. A., Jevitt, C., Johnston, W., Johnson, P., Butler, M. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Neonatal Group B < em > Streptococcus < /em > infection at a single center in Al-Madinah Al-Munawarah, Saudi Arabia
CONCLUSION: Neonatal GBS infection is prevalent in Al-Madinah Al-Munawarah. Several risk factors may contribute to the occurrence of GBS infection including preterm labor, higher body temperature during delivery, prolonged premature rupture of membranes for more than 18 hours, and GBS bacteriuria. We recommend that larger multi-centric studies are needed in Al-Madinah Al-Munawarah, to study the magnitude of neonatal GBS infection and risk factors to develop a screening protocol in maternity and children's hospital.PMID:38309734 | DOI:10.15537/smj.2024.45.2.20230533 (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - February 3, 2024 Category: Middle East Health Authors: Amal M Surrati Khulood M Alharbi Walaa Mohammedsaeed Hanaa F Almohammadi Source Type: research
