Fight Aging! Newsletter, November 11th 2019
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health.
Towards a Rigorous Definition of Cellular Senescence
https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/
The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the producti...
Source: Fight Aging! - November 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards a Rigorous Definition of Cellular Senescence
The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the production of rejuvenation therapies based on clearance of senescent cells, it is still the case that much remains to be settled when it comes to the biochemistry of these errant cells. More rigorous consensus definitions relating to the mechanisms, manifestations, and tissue specificity of senescence have ye...
Source: Fight Aging! - November 5, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How to Take Care of Your Eyes as You Age: be aware of GMC: Glaucoma, Macular degeneration, Cataract
FromConsumer Reports:GlaucomaMore than 2 million Americans have glaucoma, but 50% know it. Glaucoma often goes undiagnosed because it causes no symptoms until vision declines, at which point treatment no longer helps.People aged 40-60 should be examined by an optometrist every 3-5 years; those older than 60 need an eye exam every 1-2 years.Many eye doctors screen for glaucoma with tonometry (measures eye pressure) but that ’s not enough. Relying only on intraocular pressure (IOP) when screening for glaucoma could miss up to 50% of all cases. Theexam should also include an ophthalmoscopy, which involves examining your opt...
Source: Clinical Cases and Images - Blog - October 2, 2019 Category: Universities & Medical Training Tags: Ophthalmology Source Type: blogs
8 Nootropics to Stimulate Your Brain This Fall
You're reading 8 Nootropics to Stimulate Your Brain This Fall, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
Nootropics is a term coined by Dr. Corneliu E. Giurgea
to describe a class of drugs, supplements, and other synthetic and naturally
occurring compounds that improve cognitive function in our brains. They’re
often called “smart drugs,” as they can help us think faster and more
efficiently.
Although used by pretty much everyone, these nootropic supplements are especially
popular among younger and olde...
Source: PickTheBrain | Motivation and Self Improvement - September 26, 2019 Category: Consumer Health News Authors: Nadav Dakner Tags: featured health and fitness self improvement nootropics pickthebrain Source Type: blogs
Fight Aging! Newsletter, September 16th 2019
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial.
People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - September 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
LEAF Interviews David Sinclair
David Sinclair recently published a new book to assist in publicizing his present research directions, companies, and thinking on aging, and is here interviewed by the Life Extension Advocacy Foundation (LEAF) volunteers. The work presently underway includes supplements to increase levels of NAD+ in mitochondria and, separately, partial reprogramming of cells in a living individual in order to gain some of the effects of full reprogramming, particularly restoration of mitochondrial function. Fully reprogramming cells into induced pluripotent stem cells has been shown to clear out dysfunctional mitochondria and reset epigen...
Source: Fight Aging! - September 12, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 9th 2019
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling.
Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity
https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/
Researchers he...
Source: Fight Aging! - September 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Work on Senolytic Rejuvenation Therapies Begins to Attract More Mainstream Notice
This popular science piece on the development of senolytic therapies capable of clearing harmful senescent cells from aging tissues is a cut above the average. It is important to see more publicity for this line of work. Not because it will aid the industry, but because the more attention that is given to the field, the faster that existing senolytic treatments such as the dasatinib and quercetin combination will become available through off-label prescription and physician networks. Tens of millions of patients with inflammatory age-related diseases caused in part by senescent cells, and the many cancer survivors with hig...
Source: Fight Aging! - September 4, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
New Roads for Marijuana Research
News that the DEA ismoving forward to improve access to marijuana for research purposes should be cause for celebration. But, if history is any guide, marijuana advocates should remain cautious. It has beenthree years since the process of increasing the number of entities registered under the Controlled Substances Act to “facilitate research involving marijuana and its chemical constituents” began.Prior to the2016announcement, the DEA had a monopoly on growing marijuana for research purposes. That no progress has been made in the past three years is outrageous, yet not unexpected from the prohibitionist bureaucracy of ...
Source: Cato-at-liberty - September 3, 2019 Category: American Health Authors: Jeffrey Miron, Erin Partin Source Type: blogs
Everyone Is Having the Wrong Healthcare Debate
By STEVEN MERAHN, MD
In 1807, in an effort to spite the British and French for shipping interference (and forced recruitment of American citizens into military service), the United States Congress passed an Embargo Act, effectively shutting down trade with these two countries. Britain and France quickly found other trading partners; the US, then limited in our capacity to sell products outside our borders, was left with a devastated economy and a gaping hole in our face. It took only weeks before Congress passed a loophole; they repealed the act within 15 months of its passing. It was a great lesson in unintended co...
Source: The Health Care Blog - August 16, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Politics Uncategorized Health care debate Health Care Reform Steven Merahn universal healthcare Source Type: blogs
Fight Aging! Newsletter, August 5th 2019
In conclusion, with study of the frailty syndrome still in its infancy, frailty analysis remains a major challenge. It is a challenge that needs to be overcome in order to shed light on the multiple mechanisms involved in the pathogenesis of this syndrome. Although several mechanisms contribute to frailty, immune system alteration seems to play a central role: this syndrome is characterized by increased levels of pro-inflammatory markers and the resulting pro-inflammatory status can have negative effects on various organs. Future studies should aim to better clarify the immune system alteration in frailty, and seek to esta...
Source: Fight Aging! - August 4, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Vivo Reprogramming of Cells to a Pluripotent, Partially Rejuvenated State Continues to Forge Ahead in the Lab
It has for some years now been possible to reprogram adult somatic cells into pluripotent stem cells that are functionally equivalent to embryonic stem cells. This is achieved by overexpressing some or all of the Yamanaka transcription factors, Oct4, Sox2, Klf4, and c-Myc (OSKM) proteins. One of the most interesting outcomes of this process is that cells so treated reverse epigenetic markers of aging to some degree, and repair their mitochondrial damage. Thus the research community has started to induce this same reprogramming in living animals to observe the results. If done haphazardly, the outcome is unrestrained cancer...
Source: Fight Aging! - August 2, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Can an eye exam reveal Alzheimer ’s risk?
Looking for clues about the health of your brain? You might want to pay a visit to your eye doctor. Research increasingly links common eye conditions — glaucoma, age-related macular degeneration, and diabetic retinopathy — to risk for Alzheimer’s and other forms of dementia.
What’s interesting about the study results, says Dr. Albert Hofman, chair of epidemiology at the Harvard T.H. Chan School of Public Health, is that cataracts, another common age-related eye condition, had no apparent connection to dementia risk. This gives scientists an important clue about the cause of dementia and Alzheimer’s disease, h...
Source: Harvard Health Blog - June 7, 2019 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Alzheimer's Disease Brain and cognitive health Eye Health Source Type: blogs
5 Yoga Poses to Help You Relieve Stress and Anxiety
You're reading 5 Yoga Poses to Help You Relieve Stress and Anxiety, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
Ice-cream , cookies, wine – tried and tested but not working ? Then a great stress buster like no other, yoga, is said to work wonders for both mind and body and bring about holistic healing and increase your resistance to the stress triggers.
In general, while yoga is said to calm the senses , there are certain poses or asanas of yoga that work on letting go of stress and tension. Try these out.
Eagl...
Source: PickTheBrain | Motivation and Self Improvement - May 21, 2019 Category: Consumer Health News Authors: himalayan yoga Tags: featured health and fitness self improvement anxiety pickthebrain stress yoga Source Type: blogs
