Mitotech and Clinical Progress for Mitochondrially Targeted Antioxidants
The path from laboratory to clinic is a lengthy one. It helps to keep an eye on specific projects across the years to better calibrate one's expectations for new lines of research. Today's example of the mitochondrially targeted antioxidant molecule SkQ1, a form of plastiquinone, has been under development for quite the long time, starting with Russian lab work that first attracted my notice ten years ago - and of course had been going on for quite some time prior to that, stuck on the wrong side of the language barrier to catch the best opportunities for investment and interest. Following years of animal studies of variou...
Source: Fight Aging! - September 8, 2016 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Is Charlotte Tilbury Multi-Miracle cream really miraculous? Episode 149
Is Charlotte Tilbury Multi-miracle cream really worth it?
Jo asks…I love Charlotte Tilbury’s Multi-Miracle Glow product but I’m afraid I spent too much and I worry that it really provides any benefits. Can you tell me if it has any special properties and if not is there a more budget conscious version?
Thanks for the question, Jo. It sounds like you’re really torn about using this product so let’s see if we can help.
First of all, don’t be confused if you decide to look for this product because in addition to Mult-miracle glow she also sells a “Magic Cream.” Apparently Charlotte went to the “Harry Po...
Source: thebeautybrains.com - September 6, 2016 Category: Consumer Health News Authors: Randy Schueller Tags: Podcast Source Type: blogs
Drug Eluting Contact Lenses Treat Glaucoma
Latanoprost (Xalatan) pressure reducing eye drops are the first line of defense against glaucoma. They’re unpleasant enough for a lot of patients to the point that the burning effect leads to poor adherence. What if there were contact lenses that release the drug slowly right onto the eyeball in a precise amount? Well, researchers at Boston Children’s Hospital and Massachusetts Eye and Ear have been successfully testing just such devices on monkeys with glaucoma in one eye.
Published in journal Ophthalmology, the team describes the creation of high and low dose contact lenses using latanoprost-polymer film. The...
Source: Medgadget - September 1, 2016 Category: Medical Equipment Authors: Editors Tags: Ophthalmology Source Type: blogs
Fight Aging! Newsletter, August 8th 2016
In conclusion, spermidine inhibits lipid accumulation and necrotic core formation through stimulation of cholesterol efflux, albeit without changing plaque size or cellular composition. These effects, which are driven by autophagy in VSMCs, support the general idea that autophagy induction is potentially useful to prevent vascular disease.
Intestinal Autophagy Important in Calorie Restriction and Longevity in Nematodes
https://www.fightaging.org/archives/2016/08/intestinal-autophagy-important-in-calorie-restriction-and-longevity-in-nematodes/
Based on the evidence accumulated from many years of studies of...
Source: Fight Aging! - August 7, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CyPass Micro-Stent, an Implant for Glaucoma, Approved by FDA
The FDA has approved the CyPass Micro-Stent from Transcend Medical (Menlo Park, CA), a device for treatment of mild to moderate primary open-angle glaucoma that is intended to be implanted along with cataract surgery. The stent creates a channel for liquids to flow out from the anterior chamber of the eye, thereby reducing the intraocular pressure.
The device rests in the supraciliary space between the sclera and the ciliary body. It’s in the shape of a cylinder that has an entry port on one end and a series of holes throughout its body that diffuse the liquid flowing through. The size of the device and the hol...
Source: Medgadget - August 2, 2016 Category: Medical Equipment Authors: Editors Tags: Ophthalmology Source Type: blogs
In Search of a Foundation for Therapies to Block and Reverse Fibrosis
Fibrosis is a form of inappropriate scarring, connective tissue forming where it should not inside organs, destroying the structures necessary for correct function. Fibrosis is involved in many age-related diseases, notably in liver conditions, for example. Researchers have in the last couple of years made a few initial inroads in targeting cell behavior to reduce fibrosis in some organs, but there is still comparatively little that can be done for patients suffering fibrotic conditions. Better and more universal approaches to block the mechanisms of fibrosis are needed, but as the publicity materials here indicate, the pr...
Source: Fight Aging! - August 1, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 1st 2016
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 31, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Stem Cell Therapy as a Potential Glaucoma Treatment
Researchers here provide evidence in mice to suggest that stem cell treatments could be used to address some forms of glaucoma, usually caused by an increase in pressure in the eye that can damage the optic nerve and other structures. The types of glaucoma of interest here are those in which the drainage channels for aqueous humour deteriorate, as those channels might be induced to regenerate via the transplantation of stem cells produced from the patient's own tissues:
Researchers injected stem cells into the eyes of mice with glaucoma. The influx of cells regenerated the tiny, delicate patch of tissue known as t...
Source: Fight Aging! - July 27, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Would You Inhale?
We know Bill Clinton did not inhale but Barak Obama did inhale (because that was the whole point). I might have inhaled in the past but would never consider it now. All my past experiences involved smoking and occasional batches of brownies. < br / > < br / > One friend told me that she asked her doctor about it and he told her it wasn ' t appropriate for her. She thinks she could go off all her other medications if she could go to pot. Another blogger recently revealed her problems trying to determine how much marijuana was contained in cookies she purchased. < br / > < br / > Medical marijuana has been looming outside of...
Source: Caroline's Breast Cancer Blog - July 26, 2016 Category: Cancer & Oncology Tags: ailments medical marijuana medications pain relief Source Type: blogs
Fight Aging! Newsletter, July 18th 2016
In this study, a PET camera was used to examine individual differences in the D2 system in a group consisting of 181 healthy individuals between the age of 64 and 68. All participants also had to take part in an all-inclusive performance test of the long-term episodic memory, working memory and processing speed along with an MRI assessment (which was used to measure the size of various parts of the brain). Researchers could see that the D2 system was positively linked to episodic memory, but not to working memory or to processing speed by relating PET registrations to the cognitive data. Researchers could also see that the...
Source: Fight Aging! - July 17, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Optic Nerve Regeneration and Partial Vision Restoration Achieved in Mice
In what seems an important incremental advance in nerve regeneration, researchers have demonstrated regrowth of damaged portions of the optic nerve in mice, and partial vision restoration as a result. Once past the initial point of provoking regeneration of nerve tissue, the challenge here is as much to identify the degree to which vision is restored as it is to actually repair damaged nerves. Mice cannot be walked through a standard eye exam, and they cannot tell you in detail just how good or bad their vision is. Determining how well they can see after the processes of damage and regeneration is a difficult undertaking, ...
Source: Fight Aging! - July 12, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Rethinking MACRA Part II
By JOHN HALAMKA
In my blog posts, I speak from the heart without a specific political or economic motivation. Although I’ve not written about highly controversial subjects such as religion, gun control, or reproductive policy, some of the topics in my posts can be polarizing. Such as was the case with MACRA.
Some agreed with my initial analysis that clinicians will have a hard time translating complex MACRA payment processes into altered clinical behavior. Others felt I was overharsh, negative and inappropriate. It’s never my intent to criticize people, instead I want encourage dialog about ideas. In that spi...
Source: The Health Care Blog - May 16, 2016 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized John Halamaka MACRA Source Type: blogs
Rethinking MACRA, a follow up
In my blog posts, I speak from the heart without a specific political or economic motivation. Although I’ve not written about highly controversial subjects such as religion, gun control, or reproductive policy, some of the topics in my posts can be polarizing. Such as was the case with MACRA. Some agreed with my initial analysis that clinicians will have a hard time translating complex MACRA payment processes into altered clinical behavior. Others felt I was overharsh, negative and inappropriate. It’s never my intent to criticize people, instead I want encourage dialog about ide...
Source: Life as a Healthcare CIO - May 11, 2016 Category: Information Technology Source Type: blogs
Fight Aging! Newsletter, May 2nd 2016
This study is the first CAR T-cell trial to infuse patients with an even mixture of two types of T cells (helper and killer cells, which work together to kill cancer). With the assurance that each patient gets the same mixture of cells, the researchers were able to come to conclusions about the effects of administering different doses of cells.
In 27 of 29 participants whose responses were evaluated a few weeks after the infusion, a high-sensitivity test could detect no trace of their cancer in their bone marrow. The CAR T cells eliminated cancers anywhere in the body they appeared. Of the two participants who did n...
Source: Fight Aging! - May 1, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
It Looks Like UNITY Biotechnology is Taking the Drug Development Path to Senescent Cell Clearance
UNITY Biotechnology and Oisin Biotechnologies are both early stage startups working on commercial development of therapies capable of clearance of senescent cells. Since accumulation of senescent cells is one of the root causes of aging and age-related disease, periodic removal of these cells is a narrowly focused form of rejuvenation. There are a number of other forms of damage and disarray that contribute to degenerative aging, and all will have to be fixed if aging is to be controlled by medicine, but an individual with fewer senescent cells is absolutely better off than one with more senescent cells regardless of the s...
Source: Fight Aging! - April 26, 2016 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
