Fight Aging! Newsletter, May 2nd 2016
This study is the first CAR T-cell trial to infuse patients with an even mixture of two types of T cells (helper and killer cells, which work together to kill cancer). With the assurance that each patient gets the same mixture of cells, the researchers were able to come to conclusions about the effects of administering different doses of cells. In 27 of 29 participants whose responses were evaluated a few weeks after the infusion, a high-sensitivity test could detect no trace of their cancer in their bone marrow. The CAR T cells eliminated cancers anywhere in the body they appeared. Of the two participants who did not go into complete remission, one eventually reenrolled in the trial and went into complete remission after receiving a higher dose of cells. Not all patients stayed in complete remission: some relapsed and were treated again with CAR T cell
Publication date: Available online 28 March 2020Source: Stem Cell ResearchAuthor(s): Josef Večeřa, Jiřina Procházková, Veronika Šumberová, Veronika Pánská, Hana Paculová, Martina Kohutková Lánová, Jan Mašek, Dáša Bohačiaková, Emma Rachel Andersson, Jiří Pacherník
Publication date: Available online 28 March 2020Source: Materials Today: ProceedingsAuthor(s): S. Godwin Barnabas, S. Valai Ganesh, V. Sivakumar, P. Muthukumar, A. Dhinesh Raja, K. Hariharan
Publication date: Available online 29 March 2020Source: CytotherapyAuthor(s): Helena Debiazi Zomer, Talita da Silva Jeremias, Buddy Ratner, Andrea Goncalves Trentin
Publication date: Available online 28 March 2020Source: Journal of Clinical NeuroscienceAuthor(s): Akemi Hioka, Yoshiteru Tada, Keiko Kitazato, Naoki Akazawa, Yasushi Takagi, Shinji Nagahiro
Erratum: P130cas is required for TGF-β1-mediated epithelial-mesenchymal transition in lung cancer. Oncol Lett. 2020 Apr;19(4):3358 Authors: Deng B, Tan QY, Wang RW, Jiang YG, Zhou JH, Huang W Abstract [This corrects the article DOI: 10.3892/ol.2014.2123.]. PMID: 32218871 [PubMed - as supplied by publisher]
Authors: Wang S, Meng C, Jiang Z, Gonzalez-Rivas D, Ruan J, Xu W, Liu C, Zhang L, Gao G, Yu G, Teng H, Ju J Abstract [This corrects the article DOI: 10.3892/ol.2019.10030.]. PMID: 32218870 [PubMed - as supplied by publisher]
Authors: Lu F, Cui D, Mu B, Zhao L, Mu P Abstract Tropomodulin-1 (TMOD1) is a key regulator of actin dynamics, which caps the pointed end of actin filaments. TMOD1 has been reported to be involved in several cellular processes, including neurite outgrowth, spine formation and cell migration. Increasing evidence demonstrates that TMOD1 is implicated in several aspects of cancer development. The present study aimed to investigate the role of TMOD1 in cervical cancer. HeLa and CaSki cell lines, derived from human cervical cancer, were used to evaluate the function of TMOD1. Cell motility was measured via a wound-heali...
Authors: Tian X, Wang N Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a major cause of cancer-associated mortality, with poor patient outcome. The present study aimed to identify key candidate genes and investigate the potential molecular mechanisms associated with the progression of PDAC. The GSE46234 dataset was downloaded from the Gene Expression Omnibus database, in order to identify the upregulated differentially expressed genes (DEGs) in PDAC. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to determine the biological functions and pathways of the upreg...
Authors: Zhang Y, Bi L, Hu Z, Cao W, Zhuang D Abstract It has been found that>90% of oral cancer patients suffer from squamous cell carcinoma (SCC). The 5-year survival rate of SCC is ~50%, despite the availability of different treatments. Sonodynamic therapy (SDT) has been developed as a novel therapy for cancer, resisting bacterial infection and inhibiting atherosclerotic plaque progression. The present study investigated the efficacy of hematoporphyrin monomethyl ether (HMME)-mediated SDT on the A-253 epidermoid cancer cell line. The cytotoxicity of HMME and the survival rate of cells following SDT were exami...
Authors: Liang H Abstract The aim of the present study was to determine the mechanism by which advanced glycation end products (AGEs) induce proliferation, invasion and epithelial-mesenchymal transition (EMT) of human colon cancer SW480 cells. SW480 cells were divided into groups as follows: i) Control; ii) cells treated with AGEs alone; and iii) cells treated with AGEs combined with LY294002. Proliferation, cell cycle progression, apoptosis, invasion and migration of SW480 cells were assessed using an MTT assay, flow cytometry, Transwell assays and a wound healing assay, respectively. The protein expression levels...
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