Fight Aging! Newsletter, January 17th 2022
In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment. (Source: Fight Aging!)
Source: Fight Aging! - January 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Life Biosciences Raises a Sizable Round of Funding
I'll note the recent Life Biosciences capital raise as an example of the dramatic increase in funding flowing into the longevity industry in the past year or so. The companies that started earlier, many of which are running multiple distinct programs aimed at various approaches to the treatment of aging, are reaching the point at which they need to pull in significant funding to prepare for and undertake their first clinical trials. That funding is increasingly available. This remains a young industry, yet to obtain regulatory approval for any of the therapies under development, but it is clearly a field of growing interes...
Source: Fight Aging! - January 12, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 20th 2021
In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development.
CYTOR Upregulation as a Path to Improved Muscle Function in Later Life
https://www.fightaging.org/archives/2021/12/cytor-...
Source: Fight Aging! - December 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cataract Surgery Correlates with Reduced Risk of Dementia
Today's research materials report on a solid correlation between cataract surgery to restore vision and lower risk of later dementia. This provides support for the view that a reduced flow of sensory information to the brain accelerates the onset of neurodegeneration and loss of function with age. This is quite distinct from the usual set of underlying biochemical processes that are investigation in connection with cognitive decline and dementia: the accumulation of molecular waste in the brain; the chronic inflammation of brain tissue; the loss of mitochondrial function; the dysfunction of the vascular system leading to l...
Source: Fight Aging! - December 13, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exercise Slows Retinal Aging, but Which of the Many Mechanisms Involved are Important?
As researchers note here, there is evidence for exercise to slow retinal aging and the progression of conditions involving retinal degeneration. Exercise affects many aspects of aging, not to the same degree as the practice of calorie restriction, but likely through an overlapping set of mechanisms related to cellular stress response upregulation, including increased autophagy and mitochondrial quality control. There is is a vast forest of interacting metabolic changes to explore, however, and the research community has yet to come to a solid grasp of which of the effects of exercise are the most relevant in any given tiss...
Source: Fight Aging! - December 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Eyevensys Electrotransfection System for Ocular Disease: Interview with Patricia Zilliox, CEO
Eyevensys, a medtech company based in France, has developed the Eyevensys Electrotransfection System, a non-viral transfection system for the treatment of ocular diseases. So far, the firm has demonstrated the safety of the technique in treating noninfectious uveitis and is developing treatments for geographic atrophy, retinitis pigmentosa, and wet age-related macular degeneration (AMD).
The technology delivers DNA plasmids to the ciliary muscle in the eye, leading to long-term production of proteins in the back of the eye for therapeutic benefit. The electricity is delivered in short pulses and helps to drive the genet...
Source: Medgadget - September 27, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Genetics Ophthalmology Source Type: blogs
Is There A Place For Facebook In Healthcare?
Data privacy scandals, help in rigging elections, spreading fake news on COVID and vaccines: Facebook has been through a lot and users are not happy with the social media giant’s performance. However, Mark Zuckerberg’s company does not only have a political and social impact, but it’s also getting quite relevant in healthcare.
We looked around what Facebook currently does in healthcare and evaluated whether those are viable ways to follow in the future.
Facebook: from trust issues to healthcare
The social media machine built on “sophisticated, computer-driven engines for extracting users’ person...
Source: The Medical Futurist - September 7, 2021 Category: Information Technology Authors: berci.mesko Tags: Bioethics Security & Privacy AI facebook future Health Healthcare Innovation social media technology VR fake news smart healthcare Mark Zuckerberg Source Type: blogs
Robotic Scanner for Automated Eye Imaging
Researchers at Duke University created a robotic eye scanner that can detect signs of several eye diseases, including glaucoma and diabetic retinopathy. The system includes several 3D cameras that track the location of the patient, who merely has to stand in front of the robot, while a robotic arm containing the scanning hardware tracks and scans the patient’s eyes. In less than a minute the system produces images that are as clear as those obtained by currently used technologies, which require a patient to use a head and chin rest to avoid any head movement.
Currently, highly trained technicians can identify vario...
Source: Medgadget - August 16, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Ophthalmology Source Type: blogs
Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated.
Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
https://www.fightaging.org/archi...
Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
Researchers here attempted a combination gene therapy using BDNF and TrkB in order to provoke growth of axons in the mouse optic nerve and brain. The hope is to produce enough repair and regrowth to outpace for a time the disease process that causes damage. This seemed to have positive results in the optic nerve, but less so when applied to a mouse model of tauopathy. The regenerative medicine community might argue that sufficiently comprehensive regenerative will help, and functional recovery following treatment is a matter of the balance between degree of regeneration versus degree of harm caused by the disease process. ...
Source: Fight Aging! - May 14, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 3rd 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 2, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Retinal Cells that Can Integrate into Tissue and Survive Following Transplantation
One of the biggest challenges in regenerative medicine is ensuring the long-term survival and integration into tissue of any meaningful fraction of transplanted cells. Most transplanted cells simply die. Most early cell therapies achieve benefits via the signaling generated by transplanted cells, in the short period of time before they die. Numerous approaches are under development to try to ensure long-term survival of transplanted cells, but successes have so far been few and far between. Here, researchers report on one of these successes, generating retinal cells that integrate into the retina to produce tissue regenera...
Source: Fight Aging! - April 26, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Want healthy eyes? What to know at 40 and beyond
Did the print on that label suddenly shrink? If you’re in your 40s or beyond, you may have asked yourself that question as you struggled to read something that you used to be able to see clearly with no problem.
Blame your aging eyes. Much like our joints, our eyes undergo age-related changes. While eye problems can affect people of any age, some conditions become more common after age 40.
Getting older? Three common eye conditions
Presbyopia. The lens of the eye gets stiffer with age, which makes it harder to focus on objects nearby — hence your label-reading struggles. Many people find satisfaction with inexpensive r...
Source: Harvard Health Blog - April 20, 2021 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Diabetes Eye Health Healthy Aging Source Type: blogs
Electrodiagnosis of Ocular Diseases Using Sensor-Enabled Contacts
Electroretinography is a common technique for diagnosing and following up on eye conditions such as glaucoma, diabetic retinopathy, and retinitis pigmentosa. To perform an electroretinography exam, a device is placed against the eye that projects light onto it and measures the resulting electrical signals that are generated by the retina. Commercial electroretinography devices are rigid and require electrodes, often in the form of a hard contact lens, to touch the eye or the bulbar conjunctiva just underneath. This is irritating and unpleasant, and often requires general anesthesia or sedation to be administered, in additi...
Source: Medgadget - March 18, 2021 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Ophthalmology Source Type: blogs
