The Challenge of Achieving Healthy Human Longevity
The big sea change of the past 10 to 15 years in aging research is that the scientific community is now near entirely behind the idea that aging is a viable target for therapy, and that we should be working towards greater healthy human longevity. Prior to this time, aging was near entirely a "look but don't touch" field, in which any talk of medical intervention in aging was strongly discouraged. Making this change come about was a battle of years of patient advocacy (such as by the SENS Research Foundation and Methuselah Foundation), argument, and incremental advances in the science funded by small sums of hard-to-find r...
Source: Fight Aging! - October 23, 2020 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Cough and cold season is arriving: Choose medicines safely
With the summer winding down and fall moving in, colder weather will arrive soon — along with cold and flu season. Millions of Americans get the common cold each year, often more than once. To counter coughs and runny noses, many will turn to over-the-counter (OTC) medications available for relief without a prescription.
Heading to the pharmacy for some relief? Read this first
While OTC medicines do not cure or shorten the common cold or flu, they can ease some symptoms. Finding a product that fits your needs, however, may not be so straightforward. A recent study evaluated brand-name OTC medications marketed as cold, al...
Source: Harvard Health Blog - September 22, 2020 Category: Consumer Health News Authors: Katsiaryna Bykov, PharmD, ScD Tags: Cold and Flu Drugs and Supplements Health Infectious diseases Source Type: blogs
Fight Aging! Newsletter, June 22nd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 21, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Loss of Visual Acuity Correlates with Dementia Risk
Many aspects of aging correlate with one another, even those with quite different underlying mechanisms and proximate causes. The various forms of root cause damage that result in the aging process, as well as their downstream consequences, all interact with one another. So whether or not any specific correlation teaches us anything about the way in which aging works under the hood is very dependent on the details. That loss of vision and hearing correlate with dementia risk is known, but the relative contribution of different mechanisms is up for debate. How much is due to similar biochemical mechanisms of damage in nervo...
Source: Fight Aging! - June 15, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 4th 2020
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease.
Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus
https://www.fightaging.org/archives/2020/04/notes-on-self-experi...
Source: Fight Aging! - May 3, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Implicating Glymphatic System Dysfunction in Glaucoma
There is growing interest in the systems of drainage that carry away cerebrospinal fluid and molecular waste from the brain. The failure of these systems due to the damage and dysfunction of aging may be an important cause of neurodegenerative conditions, allowing protein aggregates such as amyloid-β to build up to pathological levels in brain tissue. One branch of this work is focused on drainage through the cribriform plate, while another is focused on the comparatively recently discovered glymphatic system. Here, researchers note that a portion of the glymphatic system is implicated in glaucoma, a retinal degeneration ...
Source: Fight Aging! - April 27, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 20th 2020
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum.
Blood Metabolites as a Marker of Frailty
https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/
Frailty in older people is usually diagnosed in a symptomatic...
Source: Fight Aging! - April 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in Diseases of the Eye
Cellular senescence contributes to many age-related diseases. Senescent cells arise naturally as a result of the Hayflick limit on cellular replication, as well as injury, or due to molecular damage or a toxic environment that might give rise to cancer. A senescent cell ceases replication and secretes a potent mix of signals that produce inflammation and disrupt nearby tissue structure and function. In youth, senescent cells are near all quickly removed, via programmed cell death or the actions of the immune system, but these removal mechanisms falter with age. Senescent cells accumulate as a result, and the more of them t...
Source: Fight Aging! - April 13, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
MiSight 1 day Contacts to Slow Myopia: Interview with Michele Andrews of CooperVision
CooperVision, a contact lens developer based in San Ramon, California, recently received FDA approval for its MiSight 1 day contact lens. The lens is the first to slow the progression of myopia when worn by children aged 8-12 years old.
Myopia is very common, but it doesn’t just affect the way someone sees objects at a distance, and can trigger other conditions such as detached retina and cataracts. The condition typically develops during childhood, and can makes things like seeing the blackboard at school difficult for kids.
Myopia occurs when the eyeball grows too long, meaning that light rays are focused at a p...
Source: Medgadget - February 14, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Ophthalmology Source Type: blogs
From Ophthalmology Clinic to At-Home Device: Disrupting OTC Testing | Helge Sudkamp, Visotec
By JESSICA DaMASSA, WTF HEALTH
Optical coherence tomography, otherwise known as OCT testing, gives eye doctors a glimpse of the retina to help detect eye diseases like glaucoma, macular degeneration, retinopathy, and more. So, what’s wrong with current methods of testing? Helge Sudkamp, CEO & co-founder of Visotec, explains how traditional OCT machines are huge, bulky and expensive — limiting scanning to infrequent visits at the doctor’s office. His company has a new take on OCT tech that puts the scanning into patients’ hands with a small, portable device that can be used daily AT HOME. What...
Source: The Health Care Blog - February 14, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Jessica DaMassa WTF Health Bayer G4A Bayer G4A Signing Day eye disease Helge Sudkamp OCT opthalmology optical coherence tomography Visotech Source Type: blogs
Lack of timely monitoring of patients with glaucoma
Healthcare Safety Investigation Branch - This national investigation identified that there is inadequate hospital eye services capacity to meet demand for glaucoma services, and that better, smarter ways of working should be implemented to maximise the current capacity. The report highlights that there are innovative measures implemented by some trusts that have reduced the risk, but this good practice is yet to be implemented more widely.ReportPress release (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - January 12, 2020 Category: UK Health Authors: The King ' s Fund Information & Knowledge Service Tags: Patient safety Source Type: blogs
Fight Aging! Newsletter, January 6th 2020
Conclusion
A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - January 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senolytic Therapies as Preventative Medicine for Glaucoma
Lingering populations of senescent cells grow with age, and cause considerable harm via their inflammatory secretions. They are a tool to promote regeneration and resistance to cancer in the short term, but like many short term systems, they become damaging when left switched on for the long term. As I noted just yesterday, even looking at only the past year of studies of senolytic therapies to selectively destroy senescent cells, there is strong evidence in animal models for their ability to prevent or reverse a score of common age-related conditions, a broad range from Alzheimer's disease and other forms of neurodegenera...
Source: Fight Aging! - January 1, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The eyes have it
Eyes are a worry aren’t they? I use mine a lot…but I have all these little floater things bobbing about, I see them when I use my PC, when I’m on the phone, when I’m outside on a sunny day, sitting reading, watching TV, playing guitar, taking photos, singing.
All the time, actually.
They’re always there. I was getting worried.
Couple that to the need to find my glasses to read anything at all or look at an object any smaller than an inch across, and it’s all a bit worrying.
So, nice to have an eye test where nothing truly untoward is revealed, just a slight and inevitably sliding into a...
Source: David Bradley Sciencebase - Songs, Snaps, Science - November 28, 2019 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Eyevensys Non-Viral Gene Therapy for Ocular Diseases: Interview with Patricia Zilliox, CEO of Eyevensys
Eyevensys, a clinical-stage biotechnology company based in France, has developed a method to perform non-viral gene therapy in the eye, with the aim of treating ocular diseases. The system uses ocular electrotransfection to deliver therapeutic genes into the eye. Consisting of an ocular device and an electrical pulse generator, the system can deliver DNA plasmids into the ciliary muscle. The idea is that the transfected cells in the eye allow for sustained local production of therapeutic proteins, which can then produce effects in a variety of structures in the eye, including the retina and choroid.
To date, the co...
Source: Medgadget - November 12, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Genetics Ophthalmology Source Type: blogs
