Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Gallbladder Cancer
Gallbladder cancer is the most common biliary tract malignancy, often detected incidentally post-cholecystectomy or at an advanced stage, historically linked to a poor prognosis. Advances in minimally invasive surgery and systemic therapies have improved outcomes. Global incidence varies, with risk factors including gender, age, gallbladder disease history, and polyp size influencing malignancy risks. Management involves cross-sectional imaging, staging laparoscopy in select cases, and radical cholecystectomy with lymphadenectomy and adjuvant therapy, though its use is limited. Trials are ongoing assessing the role of neoa...
Source: Surgical Clinics of North America - April 24, 2024 Category: Surgery Authors: Giacomo C. Waller, Umut Sarpel Source Type: research
Pancreatobiliary reflux increases macrophage-secreted IL-8 and activates the PI3K/NF κB pathway to promote cholangiocarcinoma progression
CONCLUSIONS: PBR is one of the primary causes of biliary disease. IL-8 secreted by macrophages or bile duct epithelial cells stimulated by high-amylase bile promotes cholangiocarcinoma progression.PMID:38653100 | DOI:10.1016/j.tranon.2024.101967 (Source: Translational Oncology)
Source: Translational Oncology - April 23, 2024 Category: Cancer & Oncology Authors: Tingting Wu Ruiqian Gao Xiaowei Wang Dong Guo Yuwei Xie Bingzi Dong Xiwei Hao Chengzhan Zhu Source Type: research
Gallbladder cancer: surgical treatment, immunotherapy, and targeted therapy
Postgrad Med. 2024 Apr 18. doi: 10.1080/00325481.2024.2345585. Online ahead of print.ABSTRACTGallbladder cancer is a common type of biliary tract tumor. Optimal management for early stage cases typically involves radical excision as the primary treatment modality. Various surgical techniques, including laparoscopic, robotic, and navigational surgery, have demonstrated favorable clinical outcomes in radical gallbladder excision. Unfortunately, most patients are ineligible for surgical intervention because of the advanced stage of the disease upon diagnosis. Consequently, non-surgical interventions, such as chemotherapy, rad...
Source: Postgraduate Medicine - April 18, 2024 Category: Internal Medicine Authors: Yanjun Sun Junfeng Gong Zhuang Li Lin Han Dengqun Sun Source Type: research
Gallbladder cancer: surgical treatment, immunotherapy, and targeted therapy
Postgrad Med. 2024 Apr 23:1-14. doi: 10.1080/00325481.2024.2345585. Online ahead of print.ABSTRACTGallbladder cancer is a common type of biliary tract tumor. Optimal management for early stage cases typically involves radical excision as the primary treatment modality. Various surgical techniques, including laparoscopic, robotic, and navigational surgery, have demonstrated favorable clinical outcomes in radical gallbladder excision. Unfortunately, most patients are ineligible for surgical intervention because of the advanced stage of the disease upon diagnosis. Consequently, non-surgical interventions, such as chemotherapy...
Source: Postgraduate Medicine - April 18, 2024 Category: Internal Medicine Authors: Yanjun Sun Junfeng Gong Zhuang Li Lin Han Dengqun Sun Source Type: research
[Corrigendum] miR ‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway
Oncol Rep. 2024 Mar;51(3):40. doi: 10.3892/or.2024.8699. Epub 2024 Jan 12.ABSTRACTFollowing the publication of the article, the authors drew to the Editor's attention that, in Fig. 4D on p. 7, the data correctly shown to represent the E‑cadherin bands for the "NOZ" experiment had inadvertently been used to show the Vimentin bands. However, the authors retained their original data, and the corrected version of Fig. 4, now showing the correct data for the Vimentin bands in Fig. 4D for the "NOZ" experiment, is shown on the next page. Note that this error did not grossly affect either the results or the conclusions reported ...
Source: Oncology Reports - April 16, 2024 Category: Cancer & Oncology Authors: Bin Ouyang Ningfeng Pan Haifeng Zhang Chuanming Xing Wu Ji Source Type: research
Trends in mortality from gastrointestinal, hepatic, and pancreatic cancers in the United States: A comprehensive analysis (1999-2020)
CONCLUSION: While overall gastrointestinal cancer-related mortality declined significantly in the United States from 1999 to 2020, mortality from some cancers increased. Furthermore, differences between sexes and racial groups underscore crucial differences in gastrointestinal cancer mortality, highlighting areas for future research.PMID:38623490 | PMC:PMC11017855 | DOI:10.1002/jgh3.13064 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Hassam Ali Rizwan Ishtiaq Brandon Tedder Joshua Zweigle Romina Nomigolzar Dushyant S Dahiya Vishali Moond Amir Humza Sohail Pratik Patel Debargha Basuli Hans L Tillmann Source Type: research
[Corrigendum] miR ‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway
Oncol Rep. 2024 Mar;51(3):40. doi: 10.3892/or.2024.8699. Epub 2024 Jan 12.ABSTRACTFollowing the publication of the article, the authors drew to the Editor's attention that, in Fig. 4D on p. 7, the data correctly shown to represent the E‑cadherin bands for the "NOZ" experiment had inadvertently been used to show the Vimentin bands. However, the authors retained their original data, and the corrected version of Fig. 4, now showing the correct data for the Vimentin bands in Fig. 4D for the "NOZ" experiment, is shown on the next page. Note that this error did not grossly affect either the results or the conclusions reported ...
Source: Oncology Reports - April 16, 2024 Category: Cancer & Oncology Authors: Bin Ouyang Ningfeng Pan Haifeng Zhang Chuanming Xing Wu Ji Source Type: research
[Corrigendum] miR ‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway
Oncol Rep. 2024 Mar;51(3):40. doi: 10.3892/or.2024.8699. Epub 2024 Jan 12.ABSTRACTFollowing the publication of the article, the authors drew to the Editor's attention that, in Fig. 4D on p. 7, the data correctly shown to represent the E‑cadherin bands for the "NOZ" experiment had inadvertently been used to show the Vimentin bands. However, the authors retained their original data, and the corrected version of Fig. 4, now showing the correct data for the Vimentin bands in Fig. 4D for the "NOZ" experiment, is shown on the next page. Note that this error did not grossly affect either the results or the conclusions reported ...
Source: Oncology Reports - April 16, 2024 Category: Cancer & Oncology Authors: Bin Ouyang Ningfeng Pan Haifeng Zhang Chuanming Xing Wu Ji Source Type: research
Fatty Acid Binding Protein 1 is an Independent Prognostic Biomarker for Gallbladder Cancer with Direct Hepatic Invasion
Conclusions: Elevated expression of FABP1 in DI region serves as a potential prognostic biomarker for advanced GBC with DI.PMID:38617005 | PMC:PMC11008480 | DOI:10.7150/ijms.93413 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Shimei Qiu Zhaonan Liu Jun Hu Ziyi Wang Zhuying Yue Ziheng Jia Wenhua Zhang Ziru Xue Zebing Liu Yingbin Liu Source Type: research
