Intramucosal Extent as a Marker for Advanced Disease and Survival in Gallbladder Adenocarcinoma
DISCUSSION: Patients with diffuse involvement of the gallbladder mucosa likely represent a subset with aggressive biology and worse overall survival compared to focal disease. These findings may aid surgeons in subsequent surgical and medical decision-making for patients with GBC.PMID:38174690 | DOI:10.1177/00031348231220581 (Source: The American Surgeon)
Source: The American Surgeon - January 4, 2024 Category: Surgery Authors: Robert Naples Breanna C Perlmutter Haiyan Lu Daniela Allende Chao Tu Asif Hitawala Pravallika Chadalavada Vinay Padbidri Abdo Haddad Robert Simon R Matthew Walsh Toms Augustin Source Type: research
Intramucosal Extent as a Marker for Advanced Disease and Survival in Gallbladder Adenocarcinoma
DISCUSSION: Patients with diffuse involvement of the gallbladder mucosa likely represent a subset with aggressive biology and worse overall survival compared to focal disease. These findings may aid surgeons in subsequent surgical and medical decision-making for patients with GBC.PMID:38174690 | DOI:10.1177/00031348231220581 (Source: The American Surgeon)
Source: The American Surgeon - January 4, 2024 Category: Surgery Authors: Robert Naples Breanna C Perlmutter Haiyan Lu Daniela Allende Chao Tu Asif Hitawala Pravallika Chadalavada Vinay Padbidri Abdo Haddad Robert Simon R Matthew Walsh Toms Augustin Source Type: research
Intramucosal Extent as a Marker for Advanced Disease and Survival in Gallbladder Adenocarcinoma
DISCUSSION: Patients with diffuse involvement of the gallbladder mucosa likely represent a subset with aggressive biology and worse overall survival compared to focal disease. These findings may aid surgeons in subsequent surgical and medical decision-making for patients with GBC.PMID:38174690 | DOI:10.1177/00031348231220581 (Source: The American Surgeon)
Source: The American Surgeon - January 4, 2024 Category: Surgery Authors: Robert Naples Breanna C Perlmutter Haiyan Lu Daniela Allende Chao Tu Asif Hitawala Pravallika Chadalavada Vinay Padbidri Abdo Haddad Robert Simon R Matthew Walsh Toms Augustin Source Type: research
Response to capmatinib in a patient with neuroendocrine carcinoma of the gallbladder origin harboring MET amplification
AbstractNeuroendocrine carcinoma (NEC) of the gallbladder origin is particularly rare, accounting for only 0.38% of primary malignancies of the gallbladder, and standard therapies are limited. TheMET gene encodes the tyrosine kinase receptor, c-Met. Pathogenic variants ofMET, such asMET exon 14 skipping andMET amplification, result in excessive downstream signaling that promotes tumor progression. A MET inhibitor, capmatinib, blocks signaling of c-Met and has been approved by the Food and Drug Administration for non-small cell lung cancer withMET exon 14 skipping. The effectiveness of capmatinib has been reported in other ...
Source: International Cancer Conference Journal - January 2, 2024 Category: Cancer & Oncology Source Type: research
Germline genetic associations for hepatobiliary cancers
Cell Mol Gastroenterol Hepatol. 2023 Dec 30:S2352-345X(23)00226-6. doi: 10.1016/j.jcmgh.2023.12.010. Online ahead of print.ABSTRACTHepatobiliary cancers (HBC) include hepatocellular carcinoma, cholangiocarcinoma, and gallbladder carcinoma, which originate from the liver, bile ducts, and gallbladder. They are responsible for a substantial burden of cancer-related deaths worldwide. Despite knowledge of risk factors and advancements in therapeutics and surgical interventions, the prognosis for most patients with HBC remains bleak. There is evidence from familial aggregation and case-control studies to suggest a familial risk ...
Source: Cancer Control - January 1, 2024 Category: Cancer & Oncology Authors: Perapa Chotiprasidhi Angela Karina Sato-Espinoza Kirk J Wangensteen Source Type: research
GSE192577 Glutaminase (GLS) was a target gene downstream of lithocholic acid inhibiting gallbladder cancer
Conclusion: GLS was a downstream effector of LCA treatment in gallbladder cancer. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Supragastric lesser sac: an insidious site for surgical exploration during the debulking surgery in advanced ovarian cancer
CONCLUSION: Metastases to the SGLS are not uncommon in advanced ovarian cancer, particularly those with widely disseminated disease. Disease in this recess is rarely identified by preoperative imaging and deserves systematic surgical exploration to attain complete cytoreduction.PMID:38130134 | DOI:10.3802/jgo.2024.35.e25 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 22, 2023 Category: OBGYN Authors: Yulian Chen Zhuozhen Sun Songqi Cai Yan Hu Rong Jiang Libing Xiang Rongyu Zang Source Type: research
