Harnessing the supremacy of MEG3 LncRNA to defeat gastrointestinal malignancies
Pathol Res Pract. 2024 Feb 23;256:155223. doi: 10.1016/j.prp.2024.155223. Online ahead of print.ABSTRACTEvidence suggests that long non-coding RNAs (lncRNAs) play a pivotal role in the carcinogenesis and progression of various human malignancies including gastrointestinal malignancies. This comprehensive review reports the functions and mechanisms of the lncRNA maternally expressed gene 3 (MEG3) involved in gastrointestinal malignancies. It summarizes its roles in mediating the regulation of cellular proliferation, apoptosis, migration, invasiveness, epithelial-to-mesenchymal transition, and drug resistance in several gast...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: H H Rashwan A M Taher H A Hassan A A Awaji C J Kiriacos R A Assal R A Youness Source Type: research
Adjuvant Chemoradiation in Resected Biliary Adenocarcinoma: Evaluation of SWOG S0809 with a Large National Database
CONCLUSION: Using a large national database, we support the findings of SWOG S0809 with a similar median OS in patients receiving chemoradiation. These data further support the consideration of adjuvant multimodal therapy in resected biliary cancers.PMID:38443700 | DOI:10.1245/s10434-024-15117-y (Source: Ann Oncol)
Source: Ann Oncol - March 5, 2024 Category: Cancer & Oncology Authors: Dana A Dominguez Paul Wong Yi-Jen Chen Gagandeep P Singh Yuman Fong Daneng Li Philip H G Ituarte Laleh G Melstrom Source Type: research
Adjuvant Chemoradiation in Resected Biliary Adenocarcinoma: Evaluation of SWOG S0809 with a Large National Database
CONCLUSION: Using a large national database, we support the findings of SWOG S0809 with a similar median OS in patients receiving chemoradiation. These data further support the consideration of adjuvant multimodal therapy in resected biliary cancers.PMID:38443700 | DOI:10.1245/s10434-024-15117-y (Source: Ann Oncol)
Source: Ann Oncol - March 5, 2024 Category: Cancer & Oncology Authors: Dana A Dominguez Paul Wong Yi-Jen Chen Gagandeep P Singh Yuman Fong Daneng Li Philip H G Ituarte Laleh G Melstrom Source Type: research
Comparing robotic and open surgical techniques in gallbladder cancer management: a detailed systematic review and meta-analysis
This study has been registered with PROSPERO under the identifier CRD42023476686. Our final meta-analysis incorporated 5 cohort studies, encompassing a total of 353 patients. Compared to the Open Group (OG), the Robotic Group (RG) had reduced intraoperative blood loss (WMD − 217.72 ml, 95% CI − 371.08 to − 64.35;p = 0.005), shorter hospital stay (WMD − 1.80 days, 95% CI − 2.66 to − 0.95;p < 0.0001), and fewer overall complications (OR 0.31, 95% CI 0.10–0.97;p = 0.04). However, there was no significant difference between the two groups in terms of operation duration, postoperative...
Source: Journal of Robotic Surgery - March 5, 2024 Category: Surgery Source Type: research
The prognostic value of combined preoperative PLR and CA19-9 in patients with resectable gallbladder cancer
AbstractThe platelet to lymphocyte ratio (PLR) is the marker of host inflammation and it is a potential significant prognostic indicator in various different tumors. The serum carbohydrate antigen 19 –9 (CA19-9) is a tumor-associated antigen and it is associated with poor prognosis of gallbladder cancer (GBC). We aimed to analyze the prognostic value of the combination of preoperative PLR and CA19-9 in patients with GBC. A total of 287 GBC patients who underwent curative surgery in our institu tion was included. To analyze the relationship between PLR and CA19-9 and clinicopathological features. A receiver operating char...
Source: Updates in Surgery - March 4, 2024 Category: Surgery Source Type: research
Metabolomics and miRNA profiling reveals feature of gallbladder cancer-derived biliary extracellular vesicles
CONCLUSIONS: Our findings demonstrate that the contents of exosomes are disease-specific, particularly in gallbladder cancer, and that altered metabolites convey critical information regarding their phenotype. We believe that our metabolomic and miRNA profiling results may provide important insights into the development of gallbladder cancer.PMID:38432111 | DOI:10.1016/j.bbrc.2024.149724 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 3, 2024 Category: Biochemistry Authors: Mingyu Kong Da Hee Hong Sanjita Paudel Na Eun Yoon Byung Hwa Jung Myounghoi Kim Tae Hun Kim Jaemin Jeong Dongho Choi Hyunbeom Lee Source Type: research
Metabolomics and miRNA profiling reveals feature of gallbladder cancer-derived biliary extracellular vesicles
CONCLUSIONS: Our findings demonstrate that the contents of exosomes are disease-specific, particularly in gallbladder cancer, and that altered metabolites convey critical information regarding their phenotype. We believe that our metabolomic and miRNA profiling results may provide important insights into the development of gallbladder cancer.PMID:38432111 | DOI:10.1016/j.bbrc.2024.149724 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 3, 2024 Category: Biochemistry Authors: Mingyu Kong Da Hee Hong Sanjita Paudel Na Eun Yoon Byung Hwa Jung Myounghoi Kim Tae Hun Kim Jaemin Jeong Dongho Choi Hyunbeom Lee Source Type: research
Metabolomics and miRNA profiling reveals feature of gallbladder cancer-derived biliary extracellular vesicles
CONCLUSIONS: Our findings demonstrate that the contents of exosomes are disease-specific, particularly in gallbladder cancer, and that altered metabolites convey critical information regarding their phenotype. We believe that our metabolomic and miRNA profiling results may provide important insights into the development of gallbladder cancer.PMID:38432111 | DOI:10.1016/j.bbrc.2024.149724 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 3, 2024 Category: Biochemistry Authors: Mingyu Kong Da Hee Hong Sanjita Paudel Na Eun Yoon Byung Hwa Jung Myounghoi Kim Tae Hun Kim Jaemin Jeong Dongho Choi Hyunbeom Lee Source Type: research
Increased Prostate-Specific Membrane Antigen Uptake in a Gallbladder Stone
Clin Nucl Med. 2024 Apr 1;49(4):344-345. doi: 10.1097/RLU.0000000000005121. Epub 2024 Feb 28.ABSTRACTAn Al 18F-prostate-specific membrane antigen (PSMA) Q PET/CT scan was performed in a 67-year-old man to identify any potential recurrent prostate cancer lesions, which revealed no recurrent or metastatic lesions. However, a large gallbladder stone with increased PSMA uptake was incidentally detected, which could be a potential pitfall in the interpretation of PSMA PET imaging.PMID:38427958 | DOI:10.1097/RLU.0000000000005121 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Hui Li Le Song Meixin Zhao Weifang Zhang Source Type: research
Haematologic biomarkers and survival in gallbladder cancer: a systematic review and meta-analysis
CONCLUSION: High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, monocyte-lymphocyte ratio, PC and SII are associated with worse OS in gallbladder cancer and are potential biomarkers for prognostication. Prospective studies are recommended to further evaluate their use.PMID:38425767 | PMC:PMC10901636 | DOI:10.3332/ecancer.2024.1660 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - March 1, 2024 Category: Cancer & Oncology Authors: Rogelio N Velasco Harold Nathan C Tan Michael D San Juan Source Type: research
Decoding the role of long non-coding RNAs in gallbladder cancer pathogenesis: A review focus on signaling pathways interplay
Int J Biol Macromol. 2024 Feb 28:130426. doi: 10.1016/j.ijbiomac.2024.130426. Online ahead of print.ABSTRACTGallbladder cancer (GBC) is one of the most aggressive types of biliary tree cancers and the commonest despite its rarity. It is infrequently diagnosed at an early stage, further contributing to its poor prognosis and low survival rate. The lethal nature of the disease has underlined a crucial need to discern the underlying mechanisms of GBC carcinogenesis which are still largely unknown. However, with the continual evolution in the research of cancer biology and molecular genetics, studies have found that non-coding...
Source: International Journal of Biological Macromolecules - March 1, 2024 Category: Biochemistry Authors: Ahmed S Doghish Abdullah F Radwan Mohamed Bakr Zaki Nourhan Elfar Rewan Moussa Zahraa Walash Nora A A Alhamshry Osama A Mohammed Mustafa Ahmed Abdel-Reheim Hanan Elimam Source Type: research
Increased Prostate-Specific Membrane Antigen Uptake in a Gallbladder Stone
Clin Nucl Med. 2024 Apr 1;49(4):344-345. doi: 10.1097/RLU.0000000000005121. Epub 2024 Feb 28.ABSTRACTAn Al 18F-prostate-specific membrane antigen (PSMA) Q PET/CT scan was performed in a 67-year-old man to identify any potential recurrent prostate cancer lesions, which revealed no recurrent or metastatic lesions. However, a large gallbladder stone with increased PSMA uptake was incidentally detected, which could be a potential pitfall in the interpretation of PSMA PET imaging.PMID:38427958 | DOI:10.1097/RLU.0000000000005121 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Hui Li Le Song Meixin Zhao Weifang Zhang Source Type: research
Haematologic biomarkers and survival in gallbladder cancer: a systematic review and meta-analysis
CONCLUSION: High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, monocyte-lymphocyte ratio, PC and SII are associated with worse OS in gallbladder cancer and are potential biomarkers for prognostication. Prospective studies are recommended to further evaluate their use.PMID:38425767 | PMC:PMC10901636 | DOI:10.3332/ecancer.2024.1660 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - March 1, 2024 Category: Cancer & Oncology Authors: Rogelio N Velasco Harold Nathan C Tan Michael D San Juan Source Type: research
Increased Prostate-Specific Membrane Antigen Uptake in a Gallbladder Stone
Clin Nucl Med. 2024 Apr 1;49(4):344-345. doi: 10.1097/RLU.0000000000005121. Epub 2024 Feb 28.ABSTRACTAn Al 18F-prostate-specific membrane antigen (PSMA) Q PET/CT scan was performed in a 67-year-old man to identify any potential recurrent prostate cancer lesions, which revealed no recurrent or metastatic lesions. However, a large gallbladder stone with increased PSMA uptake was incidentally detected, which could be a potential pitfall in the interpretation of PSMA PET imaging.PMID:38427958 | DOI:10.1097/RLU.0000000000005121 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Hui Li Le Song Meixin Zhao Weifang Zhang Source Type: research
Haematologic biomarkers and survival in gallbladder cancer: a systematic review and meta-analysis
CONCLUSION: High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, monocyte-lymphocyte ratio, PC and SII are associated with worse OS in gallbladder cancer and are potential biomarkers for prognostication. Prospective studies are recommended to further evaluate their use.PMID:38425767 | PMC:PMC10901636 | DOI:10.3332/ecancer.2024.1660 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - March 1, 2024 Category: Cancer & Oncology Authors: Rogelio N Velasco Harold Nathan C Tan Michael D San Juan Source Type: research
