Establishment of 6 pediatric rhabdomyosarcoma patient's derived xenograft models closely recapitulating patients' tumor characteristics
CONCLUSION: Our findings increase the number of available RMS PDX models and strengthen the role of PDXs as useful preclinical tools for patients with unmet medical needs and to develop personalized therapies.PMID:36114629 | DOI:10.1177/03008916221110266 (Source: Tumori)
Source: Tumori - September 17, 2022 Category: Cancer & Oncology Authors: Patrizia Gasparini Michela Casanova Giovanni Centonze Cristina Borzi Luca Bergamaschi Paola Collini Adele Testi Stefano Chiaravalli Maura Massimino Gabriella Sozzi Andrea Ferrari Massimo Moro Source Type: research

Hypercholesterolemia diagnosis, treatment patterns and target achievement in patients with acute coronary syndromes in Germany
CONCLUSIONS: This study provides a contemporary picture of the treatment of hyperlipidemia after ACS in patients in Germany. Despite treatment with lipid-lowering therapy, many patients did not achieve recommended lipid targets by 12 months after an ACS event.PMID:36114838 | DOI:10.1007/s00392-022-02108-w (Source: Clin Med Res)
Source: Clin Med Res - September 17, 2022 Category: Research Authors: Anselm K Gitt Klaus G Parhofer Ulrich Laufs Winfried M ärz W Dieter Paar Peter Bramlage Nikolaus Marx Source Type: research

Metabolic rates, feed intake, appetite control, and gut transit of clownfish Amphiprion ocellaris exposed to increased temperature and limited feed availability
Comp Biochem Physiol A Mol Integr Physiol. 2022 Sep 14:111318. doi: 10.1016/j.cbpa.2022.111318. Online ahead of print.ABSTRACTEpisodes of elevated temperature, combined with lower feed availability, are among the predicted scenarios of climate change representing a challenge for coral reef fish. We investigated the response of clownfish (Amphiprion ocellaris) to a scenario in which it received a single meal to satiety after 48 h fasting at 32 °C (climate change scenario) and 28 °C (control). We analysed the metabolic rate (MR), feed intake, gut transit, and expression of selected brain neuropeptides and one receptor beli...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - September 17, 2022 Category: Physiology Authors: Linh P Pham Minh V Nguyen Ann-Elise Olderbakk Jordal Ivar R ønnestad Source Type: research

Establishment of 6 pediatric rhabdomyosarcoma patient's derived xenograft models closely recapitulating patients' tumor characteristics
CONCLUSION: Our findings increase the number of available RMS PDX models and strengthen the role of PDXs as useful preclinical tools for patients with unmet medical needs and to develop personalized therapies.PMID:36114629 | DOI:10.1177/03008916221110266 (Source: Tumori)
Source: Tumori - September 17, 2022 Category: Cancer & Oncology Authors: Patrizia Gasparini Michela Casanova Giovanni Centonze Cristina Borzi Luca Bergamaschi Paola Collini Adele Testi Stefano Chiaravalli Maura Massimino Gabriella Sozzi Andrea Ferrari Massimo Moro Source Type: research

Hypercholesterolemia diagnosis, treatment patterns and target achievement in patients with acute coronary syndromes in Germany
CONCLUSIONS: This study provides a contemporary picture of the treatment of hyperlipidemia after ACS in patients in Germany. Despite treatment with lipid-lowering therapy, many patients did not achieve recommended lipid targets by 12 months after an ACS event.PMID:36114838 | DOI:10.1007/s00392-022-02108-w (Source: Clin Med Res)
Source: Clin Med Res - September 17, 2022 Category: Research Authors: Anselm K Gitt Klaus G Parhofer Ulrich Laufs Winfried M ärz W Dieter Paar Peter Bramlage Nikolaus Marx Source Type: research

Hypercholesterolemia diagnosis, treatment patterns and target achievement in patients with acute coronary syndromes in Germany
ConclusionsThis study provides a contemporary picture of the treatment of hyperlipidemia after ACS in patients in Germany. Despite treatment with lipid-lowering therapy, many patients did not achieve recommended lipid targets by 12  months after an ACS event.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - September 17, 2022 Category: Cardiology Source Type: research

Viruses, Vol. 14, Pages 2068: Complete Genome and Molecular Characterization of a New Cyprinid Herpesvirus 2 (CyHV-2) SH-01 Strain Isolated from Cultured Crucian Carp
In this study, we analyzed the genomic characteristics of a new strain, CyHV-2 SH-01, isolated during outbreaks in crucian carp at a local fish farm near Shanghai, China. CyHV-2 SH-01 exhibited a high sensitivity to goldfish and crucian carp in our previous research. The complete genome of SH-01 is 290,428 bp with 154 potential open reading frames (ORFs) and terminal repeat (TR) regions at both ends. Compared to the sequenced genomes of other CyHVs, Carassius auratus herpesvirus (CaHV) and Anguillid herpesvirus 1 (AngHV-1), several variations were found in SH-01, including nucleotide mutations, deletions, and insertions, a...
Source: Viruses - September 17, 2022 Category: Virology Authors: Jia Yang Jinxuan Wen Simin Xiao Chang Wei Fei Yu Patarida Roengjit Liqun Lu Hao Wang Tags: Article Source Type: research

IJERPH, Vol. 19, Pages 11743: Impact of Low-Head Dam Removal on River Morphology and Habitat Suitability in Mountainous Rivers
This study provides a research basis for habitat assessment after dam removal and a new perspective for the subsequent adaptive management strategy of the project. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - September 17, 2022 Category: Environmental Health Authors: Yun Lu Wan-Yi Zhu Qing-Yuan Liu Yong Li Hui-Wu Tian Bi-Xin Cheng Ze-Yu Zhang Zi-Han Wu Jie Qing Gan Sun Xin Yan Tags: Article Source Type: research

Hypercholesterolemia diagnosis, treatment patterns and target achievement in patients with acute coronary syndromes in Germany
ConclusionsThis study provides a contemporary picture of the treatment of hyperlipidemia after ACS in patients in Germany. Despite treatment with lipid-lowering therapy, many patients did not achieve recommended lipid targets by 12  months after an ACS event.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - September 17, 2022 Category: Cardiology Source Type: research

Long-term effects of adolescent exposure to olanzapine in C57BL/6  J mice and the impact of dietary fish oil supplementation
ConclusionsThe current results suggest that adolescent olanzapine exposure can produce long-term alterations in weight and metabolic function in male mice and that dietary fish oil can reduce adverse effects of lifelong consumption of an HF-HS diet. Because expected adverse effects of adolescent olanzapine treatment were not observed, the potential beneficial effects of dietary fish oil for SGA-induced weight gain and metabolic dysfunction could not be evaluated. (Source: Psychopharmacology)
Source: Psychopharmacology - September 16, 2022 Category: Psychiatry Source Type: research

Effect of extraction methods on the properties of tilapia scale gelatins
Int J Biol Macromol. 2022 Sep 13:S0141-8130(22)02025-6. doi: 10.1016/j.ijbiomac.2022.09.094. Online ahead of print.ABSTRACTThree types of tilapia scale gelatins (hot water-pretreated gelatin, HWG; acetic acid-pretreated gelatin, AAG; and pepsin enzyme-pretreated gelatin, PEG) were extracted and their gel strength, foaming properties, and emulsifying properties were analyzed. They had different gel strength values: AAG (370 ± 10 g Bloom) > HWG (320 ± 10 g Bloom) > PEG (280 ± 10 g Bloom). The creaming index values of tilapia scale gelatin-stabilized fish oil-loaded emulsions were dependent on gelatin type (HWG ≈ A...
Source: International Journal of Biological Macromolecules - September 16, 2022 Category: Biochemistry Authors: Jiawei Peng Ye Zi Jiamin Xu Yulu Zheng Shudan Huang Yaxue Hu Bolin Liu Xichang Wang Jian Zhong Source Type: research

Sharks Provide Evidence for a Highly Complex TNFSF Repertoire in the Jawed Vertebrate Ancestor
In this study, we perform detailed bioinformatic, phylogenetic, and syntenic analyses of five cartilaginous fish genomes to identify their TNFSF repertoires. Strikingly, we find that shark genomes harbor ∼30 TNFSF genes, more than any other vertebrate examined to date and substantially more than humans. This is due to better retention of the ancestral jawed vertebrate TNFSF repertoire than any other jawed vertebrate lineage, combined with lineage-specific gene family expansions. All human TNFSFs appear in shark genomes, except for lymphotoxin-α (LTA; TNFSF1) and TNF (TNFSF2), and CD70 (TNFSF7) and 4-1BBL (TNFSF9), which...
Source: Journal of Immunology - September 16, 2022 Category: Allergy & Immunology Authors: Anthony K Redmond Rita Pettinello Fiona K Bakke Helen Dooley Source Type: research

Control of ribosomal RNA synthesis by hematopoietic transcription factors
Mol Cell. 2022 Sep 9:S1097-2765(22)00847-4. doi: 10.1016/j.molcel.2022.08.027. Online ahead of print.ABSTRACTRibosomal RNAs (rRNAs) are the most abundant cellular RNAs, and their synthesis from rDNA repeats by RNA polymerase I accounts for the bulk of all transcription. Despite substantial variation in rRNA transcription rates across cell types, little is known about cell-type-specific factors that bind rDNA and regulate rRNA transcription to meet tissue-specific needs. Using hematopoiesis as a model system, we mapped about 2,200 ChIP-seq datasets for 250 transcription factors (TFs) and chromatin proteins to human and mous...
Source: Cancer Control - September 16, 2022 Category: Cancer & Oncology Authors: Charles Antony Subin S George Justin Blum Patrick Somers Chelsea L Thorsheim Dexter J Wu-Corts Yuxi Ai Long Gao Kaosheng Lv Michel G Tremblay Tom Moss Kai Tan Jeremy E Wilusz Austen R D Ganley Maxim Pimkin Vikram R Paralkar Source Type: research

Sharks Provide Evidence for a Highly Complex TNFSF Repertoire in the Jawed Vertebrate Ancestor
In this study, we perform detailed bioinformatic, phylogenetic, and syntenic analyses of five cartilaginous fish genomes to identify their TNFSF repertoires. Strikingly, we find that shark genomes harbor ∼30 TNFSF genes, more than any other vertebrate examined to date and substantially more than humans. This is due to better retention of the ancestral jawed vertebrate TNFSF repertoire than any other jawed vertebrate lineage, combined with lineage-specific gene family expansions. All human TNFSFs appear in shark genomes, except for lymphotoxin-α (LTA; TNFSF1) and TNF (TNFSF2), and CD70 (TNFSF7) and 4-1BBL (TNFSF9), which...
Source: Journal of Immunology - September 16, 2022 Category: Allergy & Immunology Authors: Anthony K Redmond Rita Pettinello Fiona K Bakke Helen Dooley Source Type: research

Immunological and hemato-biochemical effects on catfish (Clarias gariepinus) exposed to dexamethasone
In conclusion, dexamethasone at concentrations present in water bodies causes deleterious effects on blood biomarkers, biochemical, and antioxidant as well as immune upregulation in catfish until after depuration period. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - September 16, 2022 Category: Physiology Source Type: research