Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00343.2023. Online ahead of print.ABSTRACTVasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involve...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: H éctor Carbajal-Contreras Adrian Rafael Murillo-de-Ozores Germ án Magaña-Avila Alejandro Marquez-Salinas Laurent Bourqui Michelle Tellez-Sutterlin Jessica P Bahena-Lopez Eduardo Cortes-Arroyo Sebasti án González-Behn-Eschemburg Alejandro Lopez-Saave Source Type: research
A step towards tuning the jute fiber structure and properties by employing sodium periodate oxidation and coating with alginate
Int J Biol Macromol. 2023 Dec 11:128668. doi: 10.1016/j.ijbiomac.2023.128668. Online ahead of print.ABSTRACTThis paper outlines a novel simple protocol for tuning the structure and properties of jute using sodium periodate (NaIO4) oxidation and coating with alginate. When compared to the raw jute, fabrics oxidized with a 0.2 or 0.4 % NaIO4 solution for 30-120 min exhibited an increased aldehyde group content (0.185 vs. 0.239-0.398 mmol/g), a significantly increased negative zeta potential (from -8.57 down to -20.12 mV), a slight disruption of fiber crystallinity, 15.1-37.5 % and 27.9-49.8 % lower fabric maximum force and s...
Source: International Journal of Biological Macromolecules - December 13, 2023 Category: Biochemistry Authors: Aleksandra Ivanovska Marija Milo šević Jelena La đarević Maja Jankoska Tamara Mati ć Zorica Svir čev Mirjana Kosti ć Source Type: research
New insights on diagnosis and treatment of AVP deficiency
AbstractArginine vasopressin deficiency (AVP-D) is one of the main entities of the polyuria-polydipsia syndrome. Its correct diagnosis and differentiation from the other two causes - AVP resistance and primary polydipsia – is crucial as this determines the further management of these patients.Over the last years, several new diagnostic tests using copeptin, the stable surrogate marker of AVP, have been introduced. Among them, hypertonic saline stimulated copeptin was confirmed to reliably and safely improve the diagnostic accuracy to diagnose AVP-D. Due to its simplicity, arginine stimulated copeptin was put forward as a...
Source: Reviews in Endocrine and Metabolic Disorders - December 13, 2023 Category: Endocrinology Source Type: research
Water-responsive supercontractile polymer films for bioelectronic interfaces
Nature, Published online: 13 December 2023; doi:10.1038/s41586-023-06732-yWater-responsive supercontractile polymer films composed of poly(ethylene oxide) and poly(ethylene glycol)-α-cyclodextrin inclusion complex contract by more than 50% of their original length within seconds after wetting and become soft and stretchable hydrogel thin films that can be used in bioelectronic interfaces. (Source: Nature AOP)
Source: Nature AOP - December 13, 2023 Category: Research Authors: Junqi Yi Guijin Zou Jianping Huang Xueyang Ren Qiong Tian Qianhengyuan Yu Ping Wang Yuehui Yuan Wenjie Tang Changxian Wang Linlin Liang Zhengshuai Cao Yuanheng Li Mei Yu Ying Jiang Feilong Zhang Xue Yang Wenlong Li Xiaoshi Wang Yifei Luo Xian Jun Loh Guan Source Type: research
Hollow Filaments from Coaxial Dry-Jet Wet Spinning of a Cellulose Solution in an Ionic Liquid: Wet-Strength and Water Interactions
Biomacromolecules. 2023 Dec 12. doi: 10.1021/acs.biomac.3c00984. Online ahead of print.ABSTRACTHollow tubing and tubular filaments are highly relevant to membrane technologies, vascular tissue engineering, and others. In this context, we introduce hollow filaments (HF) produced through coaxial dry-jet wet spinning of cellulose dissolved in an ionic liquid ([emim][OAc]). The HF, developed upon regeneration in water (23 °C), displays superior mechanical performance (168 MPa stiffness and 60% stretchability) compared to biobased counterparts, such as those based on collagen. The results are rationalized by the effects of cry...
Source: Biomacromolecules - December 12, 2023 Category: Biochemistry Authors: Shiying Zhang Guillermo Reyes Alexey Khakalo Orlando J Rojas Source Type: research
New insights on diagnosis and treatment of AVP deficiency
Rev Endocr Metab Disord. 2023 Dec 13. doi: 10.1007/s11154-023-09862-w. Online ahead of print.ABSTRACTArginine vasopressin deficiency (AVP-D) is one of the main entities of the polyuria-polydipsia syndrome. Its correct diagnosis and differentiation from the other two causes - AVP resistance and primary polydipsia - is crucial as this determines the further management of these patients.Over the last years, several new diagnostic tests using copeptin, the stable surrogate marker of AVP, have been introduced. Among them, hypertonic saline stimulated copeptin was confirmed to reliably and safely improve the diagnostic accuracy ...
Source: ENDOCR REV - December 12, 2023 Category: Endocrinology Authors: Julie Refardt Cihan Atila Mirjam Christ-Crain Source Type: research
Hollow Filaments from Coaxial Dry-Jet Wet Spinning of a Cellulose Solution in an Ionic Liquid: Wet-Strength and Water Interactions
Biomacromolecules. 2023 Dec 12. doi: 10.1021/acs.biomac.3c00984. Online ahead of print.ABSTRACTHollow tubing and tubular filaments are highly relevant to membrane technologies, vascular tissue engineering, and others. In this context, we introduce hollow filaments (HF) produced through coaxial dry-jet wet spinning of cellulose dissolved in an ionic liquid ([emim][OAc]). The HF, developed upon regeneration in water (23 °C), displays superior mechanical performance (168 MPa stiffness and 60% stretchability) compared to biobased counterparts, such as those based on collagen. The results are rationalized by the effects of cry...
Source: Biomacromolecules - December 12, 2023 Category: Biochemistry Authors: Shiying Zhang Guillermo Reyes Alexey Khakalo Orlando J Rojas Source Type: research
New insights on diagnosis and treatment of AVP deficiency
Rev Endocr Metab Disord. 2023 Dec 13. doi: 10.1007/s11154-023-09862-w. Online ahead of print.ABSTRACTArginine vasopressin deficiency (AVP-D) is one of the main entities of the polyuria-polydipsia syndrome. Its correct diagnosis and differentiation from the other two causes - AVP resistance and primary polydipsia - is crucial as this determines the further management of these patients.Over the last years, several new diagnostic tests using copeptin, the stable surrogate marker of AVP, have been introduced. Among them, hypertonic saline stimulated copeptin was confirmed to reliably and safely improve the diagnostic accuracy ...
Source: ENDOCR REV - December 12, 2023 Category: Endocrinology Authors: Julie Refardt Cihan Atila Mirjam Christ-Crain Source Type: research
Spontaneous imbibition of a liquid film wetting a wall-mounted cylinder corner
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Si Suo Spontaneous imbibition flows within confined geometries are commonly encountered in both natural phenomena and industrial applications. A profound knowledge of the underlying flow dynamics benefits a broad spectrum of engineering... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)
Source: RSC - Soft Matter latest articles - December 12, 2023 Category: Chemistry Authors: Si Suo Source Type: research
Hyponatremia Promotes Cancer Growth in a Murine Xenograft Model of Neuroblastoma
Int J Mol Sci. 2023 Nov 23;24(23):16680. doi: 10.3390/ijms242316680.ABSTRACTIn cancer patients, hyponatremia is detected in about 40% of cases at hospital admission and has been associated to a worse outcome. We have previously observed that cancer cells from different tissues show a significantly increased proliferation rate and invasion potential, when cultured in low extracellular [Na+]. We have recently developed an animal model of hyponatremia using Foxn1nu/nu mice. The aim of the present study was to compare tumor growth and invasivity of the neuroblastoma cell line SK-N-AS in hyponatremic vs. normonatremic mice. Ani...
Source: Cancer Control - December 9, 2023 Category: Cancer & Oncology Authors: Giada Marroncini Laura Naldi Benedetta Fibbi Alice Errico Simone Polvani Marco Brogi Alessandra Fanelli Mario Maggi Alessandro Peri Source Type: research
Reduced tear fluid production in neurological diseases: a cohort study in 708 patients
ConclusionWL was altered in many neurological diseases compared to healthy controls. Most importantly, we observed a reduction of WL in NDDs, independent of age or sex. This study highlights the potential of WL as an easily obtainable parameter and suggests functional alterations in the autonomic innervation in various neurological disorders. (Source: Journal of Neurology)
Source: Journal of Neurology - December 8, 2023 Category: Neurology Source Type: research
Desmopressin Dose Requirements in Adults with Congenital and Acquired
Central Diabetes Insipidus
Horm Metab Res DOI: 10.1055/a-2198-7207Central diabetes insipidus is a rare disorder characterized by a deficiency of
vasopressin. The first line drug to treat this disorder is a synthetic analogue
of vasopressin, desmopressin.The primary aim of this retrospective register
study was to compare desmopressin dose requirements in patients with acquired
and congenital DI, and secondly to assess the influence of BMI on dose
requirement and risk of hyponatremia with different drug administrations. We
included all patients with suspected DI attending the endocrine depart...
Source: Hormone and Metabolic Research - December 8, 2023 Category: Endocrinology Authors: Pedersen, Aslak Nykj ær Andreassen, Mikkel Rasmussen, Aase Krogh Krogh, Jesper Tags: Original Article: Endocrine Care Source Type: research
The role of interferential current electrical stimulation in pediatric urology: A systematic review of randomized controlled trials
CONCLUSION: IFC is a promising therapy for bladder dysfunction and enuresis in children. More comparative RCTs are required in the future to quantitatively determine the superiority of IFC to other alternatives. The safety aspects of the treatment should also be studied further before it can be used in a clinical setting as the standard and protocol for children are still unclear.PMID:38053700 | PMC:PMC10695463 | DOI:10.25259/SNI_615_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - December 6, 2023 Category: Neurosurgery Authors: None Barmadisatrio Illona Okvita Wiyogo Yudhistira Pradnyan Kloping Source Type: research
Not only enuresis: do not disregard organic disorders
We report a 7-year- old female with a history of recent onset of sphincter troubles and recurrent low urinary tract infections. She presented urinary urgency associated to daytime incontinence, bedwetting almost every night in the previous 3 months and sometimes encopresis. The physical and neurological examination was silent, no psychological or social problem intercurred. As first approach, she was treated with deamino-delta-D-arginine vasopressin (dDAVP) 120 mcg associated with oxybutynin 5 mg and educational therapy, for 3 months without benefits. So, she underwent a magnetic resonance imaging (MRI) of the spinal cord,...
Source: Acta Bio-Medica : Atenei Parmensis - December 6, 2023 Category: General Medicine Authors: Pietro Ferrara Giovanna Magli Elena Malavolta Emidio Procaccini Luca Massimi Antonio Gatto Source Type: research
The role of interferential current electrical stimulation in pediatric urology: A systematic review of randomized controlled trials
CONCLUSION: IFC is a promising therapy for bladder dysfunction and enuresis in children. More comparative RCTs are required in the future to quantitatively determine the superiority of IFC to other alternatives. The safety aspects of the treatment should also be studied further before it can be used in a clinical setting as the standard and protocol for children are still unclear.PMID:38053700 | PMC:PMC10695463 | DOI:10.25259/SNI_615_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - December 6, 2023 Category: Neurosurgery Authors: None Barmadisatrio Illona Okvita Wiyogo Yudhistira Pradnyan Kloping Source Type: research
