Wnt Signaling Inhibition Prevents Postnatal Inflammation and Disease Progression in Mouse Congenital Myxomatous Valve Disease
CONCLUSIONS: Wnt signaling is involved in the initiation of mitral valve abnormalities and inflammation but is not responsible for later-stage valve disease progression once it has been initiated. Thus, Wnt signaling contributes to MVD progression in a time-dependent manner and provides a promising therapeutic target for the early treatment of congenital MVD in Marfan syndrome.PMID:38660802 | DOI:10.1161/ATVBAHA.123.320388 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Na Xu Christina M Alfieri Yang Yu Minzhe Guo Katherine E Yutzey Source Type: research
Effect of Antimicrobial Agent Coating on Physicochemical and Biologic Properties of Implant Abutments: A Systematic Review
CONCLUSIONS: This review showed that there is still no consensus on which is the better antimicrobial agent and which coated materials have the better performance. However, the association of surface coating of abutments with antimicrobials is feasible and can benefit many patients, which can support their clinical use to favor the healing process and prevent infections that can lead to treatment failure with dental implants.PMID:38657216 | DOI:10.11607/jomi.9992 (Source: International Journal of Oral and Maxillofacial Implants)
Source: International Journal of Oral and Maxillofacial Implants - April 24, 2024 Category: ENT & OMF Authors: Murilo Rodrigues de Campos Andr éa Cândido Dos Reis Source Type: research
High cure rates of Mycoplasma genitalium following empiric treatment with azithromycin alongside frequent detection of macrolide resistance in Austria
ConclusionsMycoplasma genitalium was readily detected in this Austrian observational study, affected predominantly MSM and often presented as asymptomatic disease. We observed a worryingly high prevalence of AZM resistance mutations; however, empiric AZM treatment cleared twice as many MG infections as expected. (Source: Infection)
Source: Infection - April 22, 2024 Category: Infectious Diseases Source Type: research
Leptospira-specific immunoglobulin Y (IgY) is protective in infected hamsters
In conclusion, passive immunotherapy with specific IgY can be considered an effective treatment for leptospirosis, and may replace antibiotics regarding its therapeutic effects.PMID:38641497 | DOI:10.1016/j.vaccine.2024.04.010 (Source: Vaccine)
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Tianbao Lv Xufeng Xie Luteng Diao Shuang Jiang Yue Ding Xin Yuan Lingling Gong Xi Chen Wenlong Zhang Yongguo Cao Source Type: research
Case of Haemophilus influenzae urethritis in a male patient
We report a case of H. influenzae urethritis and describe a relatively novel treatment approach. A man presented to Melbourne Sexual Health Centre with a 3-day history of penile discharge and dysuria. He engaged in condomless oral and anal sex with casual male partners in preceding months. On examination, purulent urethral discharge was noted. Urethral microscopy showed Gram-positive bacilli and epithelial cells. Screening for chlamydia, gonorrhoea, Mycoplasma genitalium, Trichomonas vaginalis, HIV and syphilis was performed. He was treated for NGU with a 1-week course of doxycycline. Initial investigations were all negati...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Samra, R. S., Plummer, E. L., Vodstrcil, L., Bradshaw, C. S. Tags: PostScript Source Type: research
Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia
Conclusion: This report summarizes the clinical significance of macrolide-resistant and refractory MP pneumonia and discusses the efficacy and safety of alternative drugs, with a stepwise approach to the management of MP pneumonia recommended from the viewpoint of clinical practice.What is Known:•Although MP pneumonia is usually a benign self-limited infection with response macrolides as first line therapy,severe life-threatening cases may develop if additional treatment strategies are not effectively implemented.•Macrolide-resistant and refractory MP pneumonia are two conditions that may complicate the clinical cour...
Source: European Journal of Pediatrics - April 18, 2024 Category: Pediatrics Source Type: research
Directed Differentiation of Neurons from Human iPSCs for Modeling Neurological Disorders
Methods Mol Biol. 2024;2794:141-155. doi: 10.1007/978-1-0716-3810-1_12.ABSTRACTHuman-induced pluripotent stem cell (hiPSC) technology has enabled comprehensive human cell-based disease modeling in vitro. Due to limited accessibility of primary human neurons as well as species-specific divergence between human and rodent brain tissues, hiPSC-derived neurons have become a popular tool for studying neuronal biology in a dish. Here, we provide methods for transcription factor-driven directed differentiation of neurons from hiPSCs via a neural progenitor cell (NPC) intermediate. Doxycycline-inducible expression of neuron fate-d...
Source: Mol Biol Cell - April 17, 2024 Category: Molecular Biology Authors: Cheng Wang Jonas Cerneckis Yanhong Shi Source Type: research
Directed Differentiation of Neurons from Human iPSCs for Modeling Neurological Disorders
Methods Mol Biol. 2024;2794:141-155. doi: 10.1007/978-1-0716-3810-1_12.ABSTRACTHuman-induced pluripotent stem cell (hiPSC) technology has enabled comprehensive human cell-based disease modeling in vitro. Due to limited accessibility of primary human neurons as well as species-specific divergence between human and rodent brain tissues, hiPSC-derived neurons have become a popular tool for studying neuronal biology in a dish. Here, we provide methods for transcription factor-driven directed differentiation of neurons from hiPSCs via a neural progenitor cell (NPC) intermediate. Doxycycline-inducible expression of neuron fate-d...
Source: Mol Biol Cell - April 17, 2024 Category: Molecular Biology Authors: Cheng Wang Jonas Cerneckis Yanhong Shi Source Type: research
Peripheral ulcerative keratitis associated with tralokinumab therapy: a case report and review of IL-13 inhibitor-associated ocular surface disease
ConclusionThis case report documents ulcerative keratitis occurring in association with tralokinumab therapy for AD, which has previously been described with dupilumab but not tralokinumab. This report demonstrates the need for vigilant ocular surface monitoring for patients on tralokinumab and illustrates successful management and long-term control of adverse ocular events associated with this medication. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - April 16, 2024 Category: Opthalmology Source Type: research
Efficacy and safety of antibiotics for treatment of leptospirosis: a systematic review and network meta-analysis
ConclusionsFindings recommend that leptospirosis patients be treated with antibiotics, which significantly reduced the leptospirosis defervescence time. Cephalosporins, doxycycline, and penicillin are suggested, and azithromycin may be a suitable alternative for drug-resistant cases.Systematic review registrationPROSPERO CRD42022354938. (Source: Systematic Reviews)
Source: Systematic Reviews - April 16, 2024 Category: International Medicine & Public Health Source Type: research
Doxycycline-induced gastric injury
Hong Kong Med J. 2024 Apr 15. doi: 10.12809/hkmj2310708. Online ahead of print.NO ABSTRACTPMID:38618912 | DOI:10.12809/hkmj2310708 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 15, 2024 Category: General Medicine Authors: H H W Liu T W Ho N S K Tsang J T W Lam Y T Hui Source Type: research
Doxycycline-induced gastric injury
Hong Kong Med J. 2024 Apr 15. doi: 10.12809/hkmj2310708. Online ahead of print.NO ABSTRACTPMID:38618912 | DOI:10.12809/hkmj2310708 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 15, 2024 Category: General Medicine Authors: H H W Liu T W Ho N S K Tsang J T W Lam Y T Hui Source Type: research
High-sensitivity concentration detection of trace doxycycline in solution by molecular imprinting based on surface plasmon resonance technology
The abuse of doxycycline (DC) will lead to the presence of its residues in animals and water environments, which threatens human health. It ... (Source: Journal of the Optical Society of America B)
Source: Journal of the Optical Society of America B - April 15, 2024 Category: Physics Authors: Zhitao Yang Shijie Wang Sijia Han Lingzui Wei Source Type: research
Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection
ConclusionsIn this large prospective study in the US primary and urgent care setting, antibiotics had no measurable impact on the severity or duration of cough due to acute LRTI. Patients had unrealistic expectations regarding the duration of LRTI and the effect of antibiotics which should be the target of antibiotic stewardship efforts. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 15, 2024 Category: Internal Medicine Source Type: research
