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Analysis of carbapenem-resistant < em > Acinetobacter baumannii < /em > carbapenemase gene distribution and biofilm formation
CONCLUSION: The clinical strains have a high resistance rate to carbapenems, and the CRAB with blaOXA-51 and blaOXA-23 genes has a high resistance to antibiotics and a strong biofilm.PMID:38505565 | PMC:PMC10944714 (Source: International Journal of Molecular Epidemiology and Genetics)
Source: International Journal of Molecular Epidemiology and Genetics - March 20, 2024 Category: Genetics & Stem Cells Authors: Lin Wang Qi-Wei Chen Yan-Chun Qin Xue-Li Yi Hong Zeng Source Type: research

Conditional expression of FumA in < em > Aspergillus niger < /em > enhances synthesis of L-malic acid
This study focuses on enhancing L-malic acid synthesis by modifying the tricarboxylic acid cycle within the mitochondria of Aspergillus niger. We emphasize the significant role of fumarase in converting fumaric acid into L-malic acid, enhancing our understanding of metabolic pathways in A. niger. The precise regulation of fumA is highlighted as a key factor in enhancing L-malic acid production. Furthermore, this research introduces a stringent conditional promoter (PmfsA), exclusively activated by CaCO3. The utilization of PmfsA for fumA expression resulted in heightened L-malic acid titers. The progress in metabolic engin...
Source: Applied and Environmental Microbiology - March 20, 2024 Category: Microbiology Authors: Chi Zhang Man Shi Yingyan Xu Dongdong Yang Ling Lu Feng Xue Qing Xu Source Type: research