Acute and continuation pharmacological treatment of children and adolescents with bipolar disorders; a summary of two previous studies.
We report the results of an acute-phase and continuation-phase study of the pharmacological treatment of children and adolescents with bipolar disorders. The acute phase study, with a duration of 6-8 weeks, aimed at developing effect sizes (ES) for lithium, divalproex sodium, and carbamazepine, in the acute phase treatment of Bipolar I or II children and adolescents during a mixed or manic episode. During the acute-phase of treatment, 42 outpatients with a mean age of 11.4 yr. (20 with Bipolar I Disorder and 22 with Bipolar II Disorder) were randomly assigned to 6-8 weeks of open treatment with either lithium, divalproex s...
Source: Acta Neuropsychiatrica - March 18, 2016 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
The Use of Antiepileptics in Migraine Prophylaxis.
CONCLUSIONS: Available AEDs to prophylactically treat migraine are few but of robust clinical efficacy. Special care needs to be exerted with respect to their side effects. Future research is needed for a better understanding of their mechanisms of action in migraine. Such research has the potential of providing some insight into the pathophysiology of migraine.
PMID: 26935348 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - March 3, 2016 Category: Neurology Authors: Bagnato F, Good J Tags: Headache Source Type: research
Development of fixed dose combination tablets of aripiprazole plus divalproex sodium and their simultaneous determination using HPLC-UV.
Authors: Ahmed Z, Subhan F, Ahmed S, Abdur Rasheed Q, Ahmed S, Shahid M, Farooq S
Abstract
A vast majority of psychiatric patients are effectively treated with combination of drugs to improve efficacy and adherence, but due to limited research and development in fixed dose combination (FDC) in psychiatry, these products are not commonly available. The aim of this study is to prepare cost effective FDC tablets containing aripiprazole and divalproex sodium. Two batches of fixed dose combination tablets, FDC1 and FDC2, were successfully prepared using wet granulation technique. Furthermore, aripiprazole table...
Source: Drug Development and Industrial Pharmacy - February 16, 2016 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Treatment-resistant panic disorder: a systematic review.
Authors: Freire RC, Zugliani MM, Garcia RF, Nardi AE
Abstract
INTRODUCTION: The prevalence of panic disorder (PD) in the population is high and these patients have work impairment, high unemployment rates, seek medical treatment more frequently and have more hospitalizations than people without panic symptoms. Despite the availability of pharmacological, psychological and combined treatments, approximately one-third of all PD patients have persistent panic attacks and other PD symptoms after treatment.
AREAS COVERED: MEDLINE/Pubmed, CENTRAL, PsycINFO and Web of Science databases were searched for c...
Source: Expert Opinion on Pharmacotherapy - February 14, 2016 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
The Use of Antiepileptics in Migraine Prophylaxis
ConclusionsAvailable AEDs to prophylactically treat migraine are few but of robust clinical efficacy. Special care needs to be exerted with respect to their side effects. Future research is needed for a better understanding of their mechanisms of action in migraine. Such research has the potential of providing some insight into the pathophysiology of migraine. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - February 1, 2016 Category: Neurology Authors: Francesca Bagnato, Janine Good Tags: Headache Currents Source Type: research
Heroin Withdrawal: QT Prolongation & Torsade de Pointes
This is the case of a 61 year old male who presented to the emergency department with a chief complaint of nausea and vomiting. The patient was alert and oriented, reporting intermittent chest pressure for the last 12 hours that he rated as a 9/10 pain level. He also reported multiple syncopal episodes within the last 24 hrs.
Previous Medical History:
Hypertension
Previous MI
Coronary artery disease
2 coronary stents
No known allergies
Medications:
Lisinopril
Plavix
Pravachol
Depakote
Methadone
Initial Vital Signs:
Heart Rate: 72 beats/min
Respiratory Rate: 22 breaths/min
Non-invasive Blood Pressure: 142/78...
Source: EMS 12-Lead - October 29, 2015 Category: Cardiology Authors: Ivan Rios Tags: 12 lead ecg Torsade de Pointes Source Type: research
Treatment of Early-Age Mania: Outcomes for Partial and Nonresponders to Initial Treatment
This report evaluates the benefit of either an add-on or a switch of antimanic medications for an 8-week trial period in partial responders and nonresponders, respectively. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 7, 2015 Category: Psychiatry Authors: John T. Walkup, Karen Dineen Wagner, Leslie Miller, Gayane Yenokyan, Joan L. Luby, Paramjit T. Joshi, David A. Axelson, Adelaide Robb, Jay A. Salpekar, Dwight Wolf, Abanti Sanyal, Boris Birmaher, Benedetto Vitiello, Mark A. Riddle Tags: New research Source Type: research
The Treatment of Early Age Mania: Outcomes for Partial and Non-Responders to Initial Treatment
This report evaluates the benefit of either an add-on or switch of anti-manic medications for an 8-week trial period in partial and non-responders, respectively. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 7, 2015 Category: Psychiatry Authors: John Walkup, Jay A. Salpekar, Paramjit T. Joshi, David A. Axelson, Gayane Yenokyan, Abanti Sanyal, Benedetto Vitiello, Joan Luby, Karen Dineen Wagner, Mark A. Riddle, Leslie Miller, Adelaide Robb, Dwight Wolf, Boris Birmaher Source Type: research
Preventive Migraine Treatment
This article reviews the evidence base for the preventive treatment of migraine.
Recent Findings:: Evidence-based guidelines for the preventive treatment of migraine have recently been published by the American Academy of Neurology (AAN) and the Canadian Headache Society (CHS), providing valuable guidance for clinicians. Strong evidence exists to support the use of metoprolol, timolol, propranolol, divalproex sodium, sodium valproate, and topiramate for migraine prevention, according to the AAN. Based on best available evidence, adverse event profile, and expert consensus, topiramate, propranolol, nadolol, metoprolol, amit...
Source: CONTINUUM - August 1, 2015 Category: Neurology Tags: Review Articles Source Type: research
Cross section comparative study for comorbid migraine and major depression in epileptic patients: demographic, clinical, electroencahpalograhy and therapeutic implications
Conclusion:
It is important to address comorbidity in treating patients with epilepsy. The diagnosis of atypical migraine symptoms can be quite difficult, in such cases EEG may be useful. Some antiepileptic drugs (AEDs) like divalproex sodium (valproate) and topiramate are effective in preventing migraine attacks, while others including phenytoin, oxcarbazepine, vigabatrin and clonazepam, are not effective in migraine prophylaxis. The antiepileptic drugs most closely associated with depression on initiation of treatment are vigabatrin, phenobarbitone, and topiramate.Further research on the nature and causes of the co-morbi...
Source: Epidemiologic Perspectives and Innovations - July 13, 2015 Category: Epidemiology Authors: Hatem ElmassryNahla NagyNoha SamyMaissa Eid Source Type: research
N,N-Dimethyltryptamine–Induced Psychosis
Conclusions: This case report illustrates an important example of substance-induced psychosis that resolved with antipsychotic treatment in a 42-year-old white man with no past psychiatric history likely attributable to the use of DMT. Given the increasing use of this substance, the emergency department, primary care, and inpatient services are likely to see a significant increase in similar cases. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2015 Category: Neurology Tags: Case Reports Source Type: research
The effect of antidepressants and antipsychotics on weight gain in children and adolescents
In conclusion, prescribing of SSRIs and SNRIs may be associated with improvements in weight status in children and adolescents but trials assessing their use in obesity, outside of established psychiatric illness, are limited and still experimental. Youth prescribed antipsychotic medication should be monitored for exaggerated weight gain and in those where obesity is a pre‐existing concern agents other than olanzapine, clozapine and risperidone may be advantageous. (Source: Obesity Reviews)
Source: Obesity Reviews - May 28, 2015 Category: Eating Disorders and Weight Management Authors: J. Reekie, S. P. M. Hosking, C. Prakash, K.‐T. Kao, M. Juonala, M. A. Sabin Tags: Review Article Source Type: research
Three patients needing high doses of valproic Acid to get therapeutic concentrations.
Authors: Jackson J, McCollum B, Ognibene J, Diaz FJ, de Leon J
Abstract
Valproic acid (VPA) can autoinduce its own metabolism. Cases requiring VPA doses >4000 mg/day to obtain therapeutic plasma concentrations, such as these 3 cases, have never been published. Case 1 received VPA for seizures and schizophrenia and had >50 VPA concentrations in 4 years. A high dose of 5,250 mg/day of VPA concentrate was prescribed for years but this dose led to an intoxication when switched to the enterocoated divalproex sodium formulation, requiring a normal dose of 2000 mg/day. VPA metabolic capacity was signi...
Source: Case Reports in Psychiatry - May 23, 2015 Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
Limbic Encephalitis Exacerbations and Remissions Charted by Microglial PET Scan: A Case Study (P4.104)
CONCLUSIONS: C-11-PK11195 PET imaging can be useful in the diagnosis of limbic encephalitis and for monitoring response to treatment. MALT lymphoma may also be associated with autoimmune or paraneoplastic encephalitis, especially in individuals with other predisposing factors to autoimmune disorders, such as Tourette’s and autoimmune thyroid disease. The reduction in microglial activity with both IVIG and anti-psychotics supports previous findings that anti-psychotics may act through anti-inflammatory pathways.Disclosure: Dr. Shatz has received research support from Janssen Pharmaceutica. Dr. Chugani has nothing to d...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shatz, R., Chugani, H. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Rapidly Progressive and Inflammatory Dementias Source Type: research
Divalproex sodium and quetiapine treatment of a pedophile with bipolar spectrum disorder.
Authors: Wang SC, Kao YC, Liu YP
PMID: 25093789 [PubMed - in process] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - November 16, 2014 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
