How Alcohol Affects Blood Pressure: A Detailed Insight
Conclusion In this guide, we’ve explored the complex relationship between alcohol and blood pressure. We’ve seen that alcohol, whether consumed moderately, heavily, or in a binge pattern, can impact blood pressure. We also delved into the biological mechanisms at play, the role of various drinking patterns, and the sobering revelations of recent research. While the pleasure of a drink might be fleeting, its effects on our body, particularly on our blood pressure, can be long-lasting. The key takeaway? Moderation. Even a small reduction in alcohol intake can have significant health benefits, partic...
Source: The EMT Spot - July 18, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

The Diet Linked To Lower Depression Risk
Those that made the change were less depressed and anxious as well as feeling less fatigue. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 18, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Depression Source Type: blogs

Inhibition of Glycolysis as a Treatment for Neurodegeneration
Researchers here discuss a program of drug discovery that led to inhibitors of glycolysis as a potential approach to treatment for neurodegenerative conditions. The researchers note that elevated glycolysis is a characteristic of Alzheimer's disease, for example. There are always many, many mechanisms and altered aspects of cell metabolism one can investigate in aging and age-related disease. The question to ask when looking at any one specific mechanism in isolation is how much of the pathology of the condition lies downstream of this mechanism. It is all to easy to find oneself targeting a side-effect, or a minor mechani...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Small Molecule to Reduce Mitochondrial Generation of Oxidative Stress
Researchers here report on an improved version of compounds known to reduce the generation of oxidizing molecules by mitochondria. Mitochondrial dysfunction can produce sustained oxidative stress that changes cell behavior for the worse, contributing to aspects of aging. That targeting antioxidants to the mitochondria or upregulating natural antioxidant molecules can produce some benefit to health suggests that the size of the contribution is meaningful. The details matter, however, and as cells use mild mitochondrial oxidative stress to trigger beneficial maintenance activities, with the metabolic response to exercise bei...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Yoghurt: A Delicious Solution To High Blood Pressure?
Conclusion In a nutshell, the humble pot of yoghurt could be a powerful tool in the fight against high blood pressure. From its impressive mineral content to the potential blood-pressure-lowering action of its amino acids, yoghurt has proven to be more than just a tasty snack. However, as we’ve learned from Dr. Lee, the type and quantity of yoghurt we consume matters. The takeaway? Dietary choices can significantly impact our health, making conscious consumption essential. Now, you might view that bowl of yoghurt in a new light, not only for its delicious taste but also for its potential health-...
Source: The EMT Spot - July 16, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Primary Hypertension: The Unseen Risk For Healthy People
Conclusion In conclusion, even the healthiest individuals can develop primary hypertension, a condition that affects a significant portion of the U.S. adult population. With its roots often hidden in our genetic makeup and influenced by various lifestyle factors, hypertension can quietly disrupt our wellbeing, earning its nickname as the “silent killer.” Real-life experiences, such as Martin Cassels’, highlight that maintaining an active, healthy lifestyle doesn’t render one immune to this condition. However, it underscores the importance of regular health check-ups and the value of a second o...
Source: The EMT Spot - July 13, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs

The surprising power of lifestyle and diet changes to prevent infertility
An excerpt from What to Eat When You Want to Get Pregnant. I know firsthand how hard infertility can be to talk about. Personally, I struggled conceiving my second daughter, and I am an advocate for taking control of your own fertility through lifestyle and diet changes. Infertility has been seen as a taboo topic Read more… The surprising power of lifestyle and diet changes to prevent infertility originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 12, 2023 Category: General Medicine Authors: Tags: Conditions OB/GYN Source Type: blogs

Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options. The Aging of the Enteric Nervous System https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/ The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Major evidence review supports an “exercise prescription” for most adults to boost mental health and well-being
Conclusion and relevance: Physical activity is highly beneficial for improving symptoms of depression, anxiety and distress across a wide range of adult populations, including the general population, people with diagnosed mental health disorders and people with chronic disease. Physical activity should be a mainstay approach in the management of depression, anxiety and psychological distress. The Study in Context: Can you grow your hippocampus? Yes. Here’s how, and why it matters Three ways to protect your mental health during –and after– COVID-19 Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging ...
Source: SharpBrains - July 6, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning Peak Performance anxiety depression exercise exercise prescription gym improve mental health lift weights medication mental-health-treatment physical-health therapy yoga class Source Type: blogs

Science Snippet: Antioxidants Explained
Many types of fruits, vegetables, and legumes are rich in antioxidants. Credit: iStock. While at the grocery store, you’ve likely noticed foods with labels saying they contain antioxidants, but what does that mean? In short, antioxidants are substances that may prevent or delay some types of cell damage. Many foods, including fruits and vegetables, naturally produce antioxidants like vitamins C and E, beta-carotene, and selenium. Our bodies also naturally produce antioxidant molecules such as alpha-lipoic acid, glutathione, and coenzyme Q10. Antioxidants are united by their ability to donate electrons, whi...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 5, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Science Snippet Source Type: blogs

A Seed and Soil Model for Gut Microbiome Aging to Contribute to Alzheimer's Disease
It is becoming clear that characteristic age-related changes in the composition of the gut microbiome accompany specific age-related diseases, and may well be contributing meaningfully to the development of those conditions. At the very least, the aged gut microbiome creates chronic inflammation, and that unresolved inflammatory signaling is disruptive to cell and tissue function throughout the body. There may be many other meaningfully involved mechanisms, however, such as changes in metabolite production. Many microbial metabolites have a beneficial effect on cell function, such as butyrate, and are known to decline with...
Source: Fight Aging! - July 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Breaking Down Methionine as an Alternative to a Low Methionine Diet
In conclusion, the present study provides evidence that restricting methionine by either a low-methionine diet or E. coli JM109-rMETase has clinical potential to treat old-age-induced obesity. Link: https://doi.org/10.18632/aging.204783 (Source: Fight Aging!)
Source: Fight Aging! - July 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Processed Foods Linked To Increased Blood Pressure, Study Finds
Conclusions This groundbreaking study highlights the link between high consumption of processed foods and increased blood pressure variability, particularly at night. The findings emphasize the crucial role of diet and lifestyle in cardiovascular health. Interestingly, researchers noted an unexpected association: higher consumption of ultra-processed foods was linked to less variation in night-time blood pressure. This puzzling finding suggests a need for further investigation into the effects of ultra-processed foods on our health. In conclusion, the study underscores the importance of prioritizing unproc...
Source: The EMT Spot - July 4, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs

Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers. The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs