Reviewing What is Known of Hair Aging
The aging of hair is a priority for many, but in the grand scheme of things we might perhaps want to suffer that loss in preference to the decline of other bodily systems more essential to life. If that choice in priority of research and development is offered, at least. In fact, while a sizable and vocal industry focuses on the little that can be done today to satisfy the demand for an end to the aging of hair, research and development does occur, but not to the degree one might imagine, and is moving very slowly. The age-related disruption of hair growth and coloration processes is complex and incompletely understood. Ev...
Source: Fight Aging! - December 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Thoughts on Air Pollution and Accelerated Aging
A number of large epidemiological studies demonstrate that particulate air pollution correlates with mortality and incidence of age-related disease, likely via mechanisms involving increased inflammation resulting from the interaction of particulates with lung tissue. While socioeconomic status interacts with both exposure to air pollution and life expectancy, it is nonetheless possible to disentangle these effects in some population studies. While the long-term trend is towards reduced air pollution, it seems likely that chronic inflammation will be controlled and its effects on tissues reversed via novel therapeutics on ...
Source: Fight Aging! - December 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The NIA Interventions Testing Program Shows that Fisetin Does Not Extend Life in Mice
The latest results from the NIA Interventions Testing Program (ITP) were recently published. The ITP conducts the most rigorous of animal life span studies, frequently demonstrating that earlier promising results were incorrect. The most interesting outcome from this batch of different interventions is that fisetin, demonstrated to clear senescent cells in mice and improve health measures, did not extend life. In contrast, dasatinib and quercetin, the most well-studied senolytic, has been shown by other groups to extend life in mice, by 36% in one study. This is puzzling!
We might theorize that either fisetin at th...
Source: Fight Aging! - December 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Collagen, wrinkles, and ageing skin
Collagen is a protein that plays a crucial role in maintaining the structure, firmness, and elasticity of the skin. As we age, several changes occur in the collagen of our skin, contributing to the visible signs of ageing, such as the appearance of wrinkles.
Here are some key aspects of how collagen changes with age:
Decreased Production: The synthesis of collagen decreases with age, leading to a reduction in the overall amount of collagen in the skin. This reduced production is influenced by both genetic and environmental factors, such as sun exposure and lifestyle choices, like smoking and alcohol consumption. a balanced...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 12, 2023 Category: Science Authors: David Bradley Tags: Health and Medicine Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
« Back to ...
Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Twin Study to Assess Short Term Cardiometabolic Health Benefits of a Vegan Diet
If you're familiar with discussion of veganism as a lifestyle choice, nothing in this material will all that surprising. Vegans tend towards lower calorie intake and the benefits resulting from that, and that may be the dominant effect when looking at commonly measured health metrics in vegan study participants. It would be interesting to see more comparison studies in which the vegans were held to the same calorie intake as the omnivore control participants, but, alas, that is logistically harder and thus not the approach chosen by most study organizers.
Although it's well-known that eating less meat improves car...
Source: Fight Aging! - December 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
5 Simple Habits and Routines to Keep You Away from Depression and Stress
One of the major problems facing today’s generation is depression. Excessive workload, changing lifestyle, loneliness, and financial pressure all lead to stress which results in depression. You feel unhappy, non-productive and withdrawn when you are depressed.
Many experts believe that establishing routines filled with healthy habits is a great way to move more efficiently through your day while expending less mental energy and even willpower in the process. Following simple routines like exercising, eating the right food, taking energy supplements, meditating, and getting sufficient sleep can help to manage str...
Source: PickTheBrain | Motivation and Self Improvement - December 7, 2023 Category: Consumer Health News Authors: jaya Tags: career confidence depression featured happiness health and fitness meditation motivation productivity tips self-improvement habits routines stress Source Type: blogs
Klotho as a Biomarker of the Influence of Lifestyle Choice on Health
Klotho is a longevity-associated protein that operates both within the cell and also as a circulating signal protein. It is longevity-associated in the sense that upregulation increases life span and downregulation reduces life span in mice, but also in the sense that measured klotho levels correlate with health and life expectancy in human epidemiological studies. Klotho may largely operate by maintaining kidney function into late life, but researchers have found that it may also help brain cells resist the harmful effects of an aged environment.
In today's open access paper, the authors make the interesting point ...
Source: Fight Aging! - December 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Intermittent Fasting Diet That Most People Can Stick To
The hours of fasting suitable for most people who want to lose weight but keep their energy and mood high. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 5, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Weight Loss Source Type: blogs
A Longevity Industry Feature in Biopharma Dealmakers: Repair Biotechnologies, Deciduous Therapeutics, and More
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. (Source: Fight Aging!)
Source: Fight Aging! - December 4, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Effects of Diet on Life Expectancy
It is somewhat interesting to see a careful analysis of diet and life expectancy, using the sizable UK Biobank population, that does not contain any of the words "calorie", "weight", or "obesity". The effects of calorie intake on health over the long-term are sizable, even if we focus only on mechanisms associated with the gain of weight. Visceral fat is metabolically active, generates an increased burden of senescent cells, and contributes to the chronic inflammation of aging via a range of different mechanisms.
Thus one would assume that buried underneath this set of data on what it is that people eat is a more re...
Source: Fight Aging! - December 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why is the National Academies Appointing Alcohol-Industry Funded Researchers to Serve on Panel to Review the Health Effects of Alcohol?
In conclusion, there is no doubt that Dr. Mukamal should be removed from the National Academies panel in order to preserve the integrity of both the panel and of the National Academies itself.Although Dr. Rimm was not involved in the solicitation of funding, he didserve as a principal investigator of the MACH trial. Thus, he has been funded by the alcohol industry and this conflict of interest should disqualify him from participating in, much less chairing the panel. Dr. Rimmshould be removed from the National Academies panel in order to
preserve the integrity of both the panel and of the National Academies
itself.T...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - November 30, 2023 Category: Addiction Source Type: blogs
Assessing Markers of Cellular Senescence in the CALERIE Study of Calorie Restriction
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice. (Source: Fight Aging!)
Source: Fight Aging! - November 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How Patient Activation Made It Possible to Thrive with Kidney Disease
By DAVE WHITE
It had been 10 years since I’d seen a doctor when I arrived at the Emergency Room at George Washington University Hospital in October 2009. I was able to climb the first flight of stairs, but after I froze on the second, they brought me in on a wheelchair.
That was the first time I heard the dreaded words, “Your kidneys aren’t working.” I was put on dialysis immediately, and my life transformed into a series of tests and procedures. But even after three weeks at the hospital, it didn’t sink in that there was no cure.
I checked most risk factors for kidney disease: I ate the wrong foods, smo...
Source: The Health Care Blog - November 27, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy chronic kidney disease Dave White Patient Activation Measure Patient Activism patient advocacy Source Type: blogs
