Requirements for translation in clinical trials of aromatherapy: the case of the essential oil of bergamot (BEO) for the management of agitation in severe dementia
The objective of the present perspective is to illustrate the long rigorous process leading from preclinical research to clinical translation of the EO of bergamot (BEO) for the management of agitation in dementia. A nanotechnology-based delivery system consisting of odorless alpha-tocopheryl stearate solid lipid nanoparticles (SLN) loaded with EO of bergamot (BEO) (NanoBEO), has been proven active on acute and neuropathic pain models confirming the strong antinociceptive and anti-allodynic efficacy reported for BEO in preclinical studies. In particular, prolonged physicochemical stability of NanoBEO and titration in its m...
Source: Current Pharmaceutical Design - May 17, 2022 Category: Drugs & Pharmacology Authors: Damiana Scuteri Shinobu Sakurada Tsukasa Sakurada Paolo Tonin Giacinto Bagetta Pierluigi Nicotera Maria Tiziana Corasaniti Source Type: research
Requirements for translation in clinical trials of aromatherapy: the case of the essential oil of bergamot (BEO) for the management of agitation in severe dementia
The objective of the present perspective is to illustrate the long rigorous process leading from preclinical research to clinical translation of the EO of bergamot (BEO) for the management of agitation in dementia. A nanotechnology-based delivery system consisting of odorless alpha-tocopheryl stearate solid lipid nanoparticles (SLN) loaded with EO of bergamot (BEO) (NanoBEO), has been proven active on acute and neuropathic pain models confirming the strong antinociceptive and anti-allodynic efficacy reported for BEO in preclinical studies. In particular, prolonged physicochemical stability of NanoBEO and titration in its m...
Source: Current Pharmaceutical Design - May 17, 2022 Category: Drugs & Pharmacology Authors: Damiana Scuteri Shinobu Sakurada Tsukasa Sakurada Paolo Tonin Giacinto Bagetta Pierluigi Nicotera Maria Tiziana Corasaniti Source Type: research
CB < sub > 1 < /sub > R, CB < sub > 2 < /sub > R and TRPV1 expression and modulation in in vivo, animal glaucoma models: A systematic review
This study aimed to explore the available literature on cannabinoid receptor 1 (CB1R), cannabinoid receptor 2 (CB2R), and transient receptor potential vanilloid 1 (TRPV1) expression in the trabecular meshwork (TM), ciliary body (CB), and retina as well as their ocular hypotensive and neuroprotective effects in preclinical, in vivo, animal glaucoma models.MATERIALS AND METHODS: The study adhered to both PRISMA and SYRCLE guidelines. Sixty-nine full-length articles were included in the final analysis.RESULTS: Preclinical studies indicated a widespread distribution of CB1R, CB2R, and TRPV1 in the TM, CB, and retina, although ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2022 Category: Drugs & Pharmacology Authors: Gabriele Gallo Afflitto Francesco Aiello Damiana Scuteri Giacinto Bagetta Carlo Nucci Source Type: research
CB < sub > 1 < /sub > R, CB < sub > 2 < /sub > R and TRPV1 expression and modulation in in vivo, animal glaucoma models: A systematic review
This study aimed to explore the available literature on cannabinoid receptor 1 (CB1R), cannabinoid receptor 2 (CB2R), and transient receptor potential vanilloid 1 (TRPV1) expression in the trabecular meshwork (TM), ciliary body (CB), and retina as well as their ocular hypotensive and neuroprotective effects in preclinical, in vivo, animal glaucoma models.MATERIALS AND METHODS: The study adhered to both PRISMA and SYRCLE guidelines. Sixty-nine full-length articles were included in the final analysis.RESULTS: Preclinical studies indicated a widespread distribution of CB1R, CB2R, and TRPV1 in the TM, CB, and retina, although ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2022 Category: Drugs & Pharmacology Authors: Gabriele Gallo Afflitto Francesco Aiello Damiana Scuteri Giacinto Bagetta Carlo Nucci Source Type: research
Homo-AMPA in the periaqueductal grey modulates pain and rostral ventromedial medulla activity in diabetic neuropathic mice
In this study we evaluated the effect of intra-ventrolateral periaqueductal grey (VL PAG) microinjections of homo-AMPA on pain responses and the activity of pain-responding neurons of the rostral ventromedial medulla (RVM), the "pronociceptive" ON cells, and the "antinociceptive" OFF cells. The study was performed in control and diabetic neuropathic mice. Homo-AMPA decreased mechanical allodynia in diabetic neuropathic mice. Homo-AMPA increased also the latency to tail-flick, decreased the ongoing activity, the pain stimulus-evoked burst of firing, and delayed the onset of the burst of the ON cells in both, control and neu...
Source: Neuropharmacology - April 1, 2022 Category: Drugs & Pharmacology Authors: Enza Palazzo Serena Boccella Ida Marabese Michela Perrone Carmela Belardo Monica Iannotta Damiana Scuteri Emanuela De Dominicis Martina Pagano Rosmara Infantino Giacinto Bagetta Sabatino Maione Source Type: research
Homo-AMPA in the periaqueductal grey modulates pain and rostral ventromedial medulla activity in diabetic neuropathic mice
In this study we evaluated the effect of intra-ventrolateral periaqueductal grey (VL PAG) microinjections of homo-AMPA on pain responses and the activity of pain-responding neurons of the rostral ventromedial medulla (RVM), the "pronociceptive" ON cells, and the "antinociceptive" OFF cells. The study was performed in control and diabetic neuropathic mice. Homo-AMPA decreased mechanical allodynia in diabetic neuropathic mice. Homo-AMPA increased also the latency to tail-flick, decreased the ongoing activity, the pain stimulus-evoked burst of firing, and delayed the onset of the burst of the ON cells in both, control and neu...
Source: Neuropharmacology - April 1, 2022 Category: Drugs & Pharmacology Authors: Enza Palazzo Serena Boccella Ida Marabese Michela Perrone Carmela Belardo Monica Iannotta Damiana Scuteri Emanuela De Dominicis Martina Pagano Rosmara Infantino Giacinto Bagetta Sabatino Maione Source Type: research
Homo-AMPA in the periaqueductal grey modulates pain and rostral ventromedial medulla activity in diabetic neuropathic mice
In this study we evaluated the effect of intra-ventrolateral periaqueductal grey (VL PAG) microinjections of homo-AMPA on pain responses and the activity of pain-responding neurons of the rostral ventromedial medulla (RVM), the "pronociceptive" ON cells, and the "antinociceptive" OFF cells. The study was performed in control and diabetic neuropathic mice. Homo-AMPA decreased mechanical allodynia in diabetic neuropathic mice. Homo-AMPA increased also the latency to tail-flick, decreased the ongoing activity, the pain stimulus-evoked burst of firing, and delayed the onset of the burst of the ON cells in both, control and neu...
Source: Neuropharmacology - April 1, 2022 Category: Drugs & Pharmacology Authors: Enza Palazzo Serena Boccella Ida Marabese Michela Perrone Carmela Belardo Monica Iannotta Damiana Scuteri Emanuela De Dominicis Martina Pagano Rosmara Infantino Giacinto Bagetta Sabatino Maione Source Type: research
Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome
. (Source: Epigenetics)
Source: Epigenetics - March 21, 2022 Category: Genetics & Stem Cells Authors: Carlos A. Garcia-Prieto Damiana Álvarez-Errico Eva Musulen Alberto Bueno-Costa Berta N. Vazquez Alejandro Vaquero Manel Esteller Source Type: research
Pregnancy and post-partum outcomes of obese women after bariatric surgery: A case-control study
CONCLUSIONS: Our findings support the positive impact of BS on several obstetric outcomes, at the expense of a higher frequency of SGA and PTD. BS mothers more frequently achieved the recommended goal of breastfeeding for 6 months compared to obese women.PMID:35279640 | DOI:10.1016/j.ejogrb.2022.03.016 (Source: Reproductive Biology)
Source: Reproductive Biology - March 13, 2022 Category: Reproduction Medicine Authors: Giovanna Savastano Giuseppe Caruso Damiana Pompeo Benedetta Lobozzo Giuseppina Perrone Francesco Pecorini Innocenza Palaia Ludovico Muzii Paola Galoppi Roberto Brunelli Source Type: research
IJERPH, Vol. 19, Pages 3220: Risk-Based Mapping Tools for Surveillance and Control of the Invasive Mosquito Aedes albopictus in Switzerland
Conclusions: The areas identified as suitable for Ae. albopictus establishment are consistent with the actual current findings of tiger mosquito. Our approach provides a useful tool to prompt authorities&rsquo; intervention in the areas where there is higher risk of introduction and establishment of Ae. albopictus. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - March 9, 2022 Category: Environmental Health Authors: Damiana Ravasi Francesca Mangili David Huber Laura Azzimonti Lukas Engeler Nicola Vermes Giacomo Del Rio Valeria Guidi Mauro Tonolla Eleonora Flacio Tags: Article Source Type: research
Pregnancy and post-partum outcomes of obese women after bariatric surgery: A case-control study
Obesity is a huge public health issue affecting around 10-15% of the adult population worldwide [1]. Over the last decades, the prevalence of obesity has continued to increase among women of reproductive age, involving nearly 25% of pregnant women in developed countries [2]. Pregnancy occurs in 18% and 50% of obese and overweight women, respectively [3]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 8, 2022 Category: OBGYN Authors: Giovanna Savastano, Giuseppe Caruso, Damiana Pompeo, Benedetta Lobozzo, Giuseppina Perrone, Francesco Pecorini, Innocenza Palaia, Ludovico Muzii, Paola Galoppi, Roberto Brunelli Source Type: research
Real world considerations for newly approved CGRP receptor antagonists in migraine care
Expert Rev Neurother. 2022 Mar;22(3):221-230. doi: 10.1080/14737175.2022.2049758. Epub 2022 Mar 14.ABSTRACTINTRODUCTION: Migraine is the leading cause of years lived with disability in people under 50. Electrophysiological phenomena at the basis of prodromal and headache attack phases and of chronification processes involve calcitonin-gene related peptide (CGRP) as a fundamental player become a game changer of migraine pharmacotherapy.AREAS COVERED: The purpose of the present review is to retrace fundamental stages of CGRP from its discovery to the role in migraine pathogenesis and therapy to underscore the change of parad...
Source: Expert Review of Neurotherapeutics - March 4, 2022 Category: Neurology Authors: Damiana Scuteri Paolo Tonin Pierluigi Nicotera Giacinto Bagetta Maria Tiziana Corasaniti Source Type: research
