Molecules, Vol. 28, Pages 2872: Essential Oils Distilled from Colombian Aromatic Plants and Their Constituents as Penetration Enhancers for Transdermal Drug Delivery
obar
The study aimed to determine the enhanced effects of essential oils (EOs) and plant-derived molecules (PDMs) as penetration enhancers (PEs) for transdermal drug delivery (TDD) of caffeine. A 1% w/w solution of eight EOs and seven PDMs was included in the 1% caffeine carbopol hydrogel. Franz diffusion cell experiments were performed using mice with full-thickness skin. At various times over 24 h, 300 μL of the receptor were withdrawn and replaced with fresh medium. Caffeine was analyzed spectrophotometrically at 272 nm. The skin irritation effects of the hydrogels applied once a day for 21 days were inve...
Source: Molecules - March 22, 2023 Category: Chemistry Authors: Heider Carre ño Elena E. Stashenko Patricia Escobar Tags: Article Source Type: research
Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome
Volume 18, Issue 1, December 2023 . (Source: Epigenetics)
Source: Epigenetics - March 5, 2023 Category: Genetics & Stem Cells Authors: Aleix Noguera-Castells Carlos A. Garc ía-Prieto Damiana Álvarez-Errico Manel Esteller Source Type: research
IJERPH, Vol. 20, Pages 4313: The Management of Obstructive Sleep Apnea Patients during the COVID-19 Pandemic as a Public Health Problem & mdash;Interactions with Sleep Efficacy and Mental Health
IJERPH, Vol. 20, Pages 4313: The Management of Obstructive Sleep Apnea Patients during the COVID-19 Pandemic as a Public Health Problem—Interactions with Sleep Efficacy and Mental Health
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph20054313
Authors:
Anca Diana Maierean
Damiana Maria Vulturar
Ioana Maria Chetan
Carmen-Bianca Crivii
Cornelia Bala
Stefan Cristian Vesa
Doina Adina Todea
With the onset of the COVID-19 outbreak, it was stipulated that patients with obstructive sleep apnea (OSA) may have a greater risk of morbidity and mortality and may even ex...
Source: International Journal of Environmental Research and Public Health - February 28, 2023 Category: Environmental Health Authors: Anca Diana Maierean Damiana Maria Vulturar Ioana Maria Chetan Carmen-Bianca Crivii Cornelia Bala Stefan Cristian Vesa Doina Adina Todea Tags: Article Source Type: research
Molecules, Vol. 28, Pages 2066: Hydrogen/Deuterium Exchange Mass Spectrometry for Probing the Isomeric Forms of Oleocanthal and Oleacin in Extra Virgin Olive Oils
R. I. Cataldi
Reversed-phase liquid chromatography and electrospray ionization with Fourier-transform single and tandem mass spectrometry (RPLC-ESI-FTMS and FTMS/MS) were employed for the structural characterization of oleocanthal (OLEO) and oleacin (OLEA), two of the most important bioactive secoiridoids occurring in extra virgin olive oils (EVOOs). The existence of several isoforms of OLEO and OLEA was inferred from the chromatographic separation, accompanied, in the case of OLEA, by minor peaks due to oxidized OLEO recognized as oleocanthalic acid isoforms. The detailed analysis of the product ion tandem MS spectra ...
Source: Molecules - February 22, 2023 Category: Chemistry Authors: Ramona Abbattista Ilario Losito Graziana Basile Andrea Castellaneta Giovanni Ventura Cosima Damiana Calvano Tommaso R. I. Cataldi Tags: Article Source Type: research
ASO Visual Abstract: Nipple-Sparing Mastectomy After Neoadjuvant Chemotherapy: Definitive Results with a Long-Term Follow-Up
Ann Surg Oncol. 2023 Feb 10. doi: 10.1245/s10434-023-13157-4. Online ahead of print.NO ABSTRACTPMID:36763287 | DOI:10.1245/s10434-023-13157-4 (Source: Ann Oncol)
Source: Ann Oncol - February 10, 2023 Category: Cancer & Oncology Authors: Emanuele Zarba Meli Anna De Santis Giuliana Cortese Elena Manna Tiziana Mastropietro Massimo La Pinta Andrea Loreti Floriana Arelli Paola Scavina Mauro Minelli Angela Damiana Andrulli Leopoldo Costarelli Laura Broglia Tatiana Ponzani Lucio Fortunato Source Type: research
ASO Visual Abstract: Nipple-Sparing Mastectomy After Neoadjuvant Chemotherapy: Definitive Results with a Long-Term Follow-Up
Ann Surg Oncol. 2023 Feb 10. doi: 10.1245/s10434-023-13157-4. Online ahead of print.NO ABSTRACTPMID:36763287 | DOI:10.1245/s10434-023-13157-4 (Source: Ann Oncol)
Source: Ann Oncol - February 10, 2023 Category: Cancer & Oncology Authors: Emanuele Zarba Meli Anna De Santis Giuliana Cortese Elena Manna Tiziana Mastropietro Massimo La Pinta Andrea Loreti Floriana Arelli Paola Scavina Mauro Minelli Angela Damiana Andrulli Leopoldo Costarelli Laura Broglia Tatiana Ponzani Lucio Fortunato Source Type: research
Nipple-Sparing Mastectomy After Neoadjuvant Chemotherapy: Definitive Results with a Long-Term Follow-Up Evaluation
CONCLUSIONS: The study data definitively confirm that NSM is safe even after NACT, with good cosmetic results and complications comparable with those in the primary surgery setting. Tumor stage and age were the only independent factors for local relapse. Patients with pCR enjoyed optimal locoregional control.PMID:36598627 | DOI:10.1245/s10434-022-13035-5 (Source: Cancer Control)
Source: Cancer Control - January 4, 2023 Category: Cancer & Oncology Authors: Emanuele Zarba Meli Anna De Santis Giuliana Cortese Elena Manna Tiziana Mastropietro Massimo La Pinta Andrea Loreti Floriana Arelli Paola Scavina Mauro Minelli Angela Damiana Andrulli Leopoldo Costarelli Laura Broglia Tatiana Ponzani Lucio Fortunato Source Type: research
Nipple-Sparing Mastectomy After Neoadjuvant Chemotherapy: Definitive Results with a Long-Term Follow-Up Evaluation
CONCLUSIONS: The study data definitively confirm that NSM is safe even after NACT, with good cosmetic results and complications comparable with those in the primary surgery setting. Tumor stage and age were the only independent factors for local relapse. Patients with pCR enjoyed optimal locoregional control.PMID:36598627 | DOI:10.1245/s10434-022-13035-5 (Source: Ann Oncol)
Source: Ann Oncol - January 4, 2023 Category: Cancer & Oncology Authors: Emanuele Zarba Meli Anna De Santis Giuliana Cortese Elena Manna Tiziana Mastropietro Massimo La Pinta Andrea Loreti Floriana Arelli Paola Scavina Mauro Minelli Angela Damiana Andrulli Leopoldo Costarelli Laura Broglia Tatiana Ponzani Lucio Fortunato Source Type: research
Nipple-Sparing Mastectomy After Neoadjuvant Chemotherapy: Definitive Results with a Long-Term Follow-Up Evaluation
CONCLUSIONS: The study data definitively confirm that NSM is safe even after NACT, with good cosmetic results and complications comparable with those in the primary surgery setting. Tumor stage and age were the only independent factors for local relapse. Patients with pCR enjoyed optimal locoregional control.PMID:36598627 | DOI:10.1245/s10434-022-13035-5 (Source: Ann Oncol)
Source: Ann Oncol - January 4, 2023 Category: Cancer & Oncology Authors: Emanuele Zarba Meli Anna De Santis Giuliana Cortese Elena Manna Tiziana Mastropietro Massimo La Pinta Andrea Loreti Floriana Arelli Paola Scavina Mauro Minelli Angela Damiana Andrulli Leopoldo Costarelli Laura Broglia Tatiana Ponzani Lucio Fortunato Source Type: research
Reduced platelet glycoprotein Ib α shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen
Haematologica. 2022 Dec 22. doi: 10.3324/haematol.2022.281006. Online ahead of print.NO ABSTRACTPMID:36546455 | DOI:10.3324/haematol.2022.281006 (Source: Haematologica)
Source: Haematologica - December 22, 2022 Category: Hematology Authors: Paola Simeone Rossella Liani Romina Tripaldi Sonia Ciotti Antonio Recchiuti Vittorio Abbonante Benedetta Porro Piero Del Boccio Augusto Di Castelnuovo Paola Lanuti Marina Camera Damiana Pieragostino Melissa Lee-Sundlov Myriam Luongo Raffaella Auciello Giu Source Type: research
Reduced platelet glycoprotein Ib α shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen
Haematologica. 2022 Dec 22. doi: 10.3324/haematol.2022.281006. Online ahead of print.ABSTRACTCardiovascular prevention with low-dose aspirin can be less effective in patients with a faster recovery of platelet cyclooxygenase (COX)-1 activity during the 24 hours dosing interval. We previously showed that incomplete suppression of TXA2 over 24 hours can be rescued by a twice daily aspirin regimen. Here we show that reduced platelet glycoprotein (GP)Ibα shedding characterizes patients with accelerated COX-1 recovery and may contribute to higher thrombopoietin production and higher rates of newly-formed platelets, escaping as...
Source: Haematologica - December 22, 2022 Category: Hematology Authors: Paola Simeone Rossella Liani Romina Tripaldi Sonia Ciotti Antonio Recchiuti Vittorio Abbonante Benedetta Porro Piero Del Boccio Augusto Di Castelnuovo Paola Lanuti Marina Camera Damiana Pieragostino Melissa Lee-Sundlov Myriam Luongo Raffaella Auciello Giu Source Type: research
Reduced platelet glycoprotein Ib α shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen
Haematologica. 2022 Dec 22. doi: 10.3324/haematol.2022.281006. Online ahead of print.ABSTRACTCardiovascular prevention with low-dose aspirin can be less effective in patients with a faster recovery of platelet cyclooxygenase (COX)-1 activity during the 24 hours dosing interval. We previously showed that incomplete suppression of TXA2 over 24 hours can be rescued by a twice daily aspirin regimen. Here we show that reduced platelet glycoprotein (GP)Ibα shedding characterizes patients with accelerated COX-1 recovery and may contribute to higher thrombopoietin production and higher rates of newly-formed platelets, escaping as...
Source: Haematologica - December 22, 2022 Category: Hematology Authors: Paola Simeone Rossella Liani Romina Tripaldi Sonia Ciotti Antonio Recchiuti Vittorio Abbonante Benedetta Porro Piero Del Boccio Augusto Di Castelnuovo Paola Lanuti Marina Camera Damiana Pieragostino Melissa Lee-Sundlov Myriam Luongo Raffaella Auciello Giu Source Type: research
Reduced platelet glycoprotein Ib α shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen
Haematologica. 2022 Dec 22. doi: 10.3324/haematol.2022.281006. Online ahead of print.ABSTRACTCardiovascular prevention with low-dose aspirin can be less effective in patients with a faster recovery of platelet cyclooxygenase (COX)-1 activity during the 24 hours dosing interval. We previously showed that incomplete suppression of TXA2 over 24 hours can be rescued by a twice daily aspirin regimen. Here we show that reduced platelet glycoprotein (GP)Ibα shedding characterizes patients with accelerated COX-1 recovery and may contribute to higher thrombopoietin production and higher rates of newly-formed platelets, escaping as...
Source: Haematologica - December 22, 2022 Category: Hematology Authors: Paola Simeone Rossella Liani Romina Tripaldi Sonia Ciotti Antonio Recchiuti Vittorio Abbonante Benedetta Porro Piero Del Boccio Augusto Di Castelnuovo Paola Lanuti Marina Camera Damiana Pieragostino Melissa Lee-Sundlov Myriam Luongo Raffaella Auciello Giu Source Type: research
Reduced platelet glycoprotein Ib α shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen
Haematologica. 2022 Dec 22. doi: 10.3324/haematol.2022.281006. Online ahead of print.ABSTRACTCardiovascular prevention with low-dose aspirin can be less effective in patients with a faster recovery of platelet cyclooxygenase (COX)-1 activity during the 24 hours dosing interval. We previously showed that incomplete suppression of TXA2 over 24 hours can be rescued by a twice daily aspirin regimen. Here we show that reduced platelet glycoprotein (GP)Ibα shedding characterizes patients with accelerated COX-1 recovery and may contribute to higher thrombopoietin production and higher rates of newly-formed platelets, escaping as...
Source: Haematologica - December 22, 2022 Category: Hematology Authors: Paola Simeone Rossella Liani Romina Tripaldi Sonia Ciotti Antonio Recchiuti Vittorio Abbonante Benedetta Porro Piero Del Boccio Augusto Di Castelnuovo Paola Lanuti Marina Camera Damiana Pieragostino Melissa Lee-Sundlov Myriam Luongo Raffaella Auciello Giu Source Type: research
Reduced platelet glycoprotein Ib α shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen
Haematologica. 2022 Dec 22. doi: 10.3324/haematol.2022.281006. Online ahead of print.ABSTRACTCardiovascular prevention with low-dose aspirin can be less effective in patients with a faster recovery of platelet cyclooxygenase (COX)-1 activity during the 24 hours dosing interval. We previously showed that incomplete suppression of TXA2 over 24 hours can be rescued by a twice daily aspirin regimen. Here we show that reduced platelet glycoprotein (GP)Ibα shedding characterizes patients with accelerated COX-1 recovery and may contribute to higher thrombopoietin production and higher rates of newly-formed platelets, escaping as...
Source: Haematologica - December 22, 2022 Category: Hematology Authors: Paola Simeone Rossella Liani Romina Tripaldi Sonia Ciotti Antonio Recchiuti Vittorio Abbonante Benedetta Porro Piero Del Boccio Augusto Di Castelnuovo Paola Lanuti Marina Camera Damiana Pieragostino Melissa Lee-Sundlov Myriam Luongo Raffaella Auciello Giu Source Type: research
