Molecules, Vol. 27, Pages 6593: Two Ways to Achieve the Same Goal & mdash;Two Validated Quantitative NMR Strategies for a Low-Abundance Natural Product in Standardized Extracts: The Case of Hepatodamianol in Turnera diffusa
Molecules, Vol. 27, Pages 6593: Two Ways to Achieve the Same Goal—Two Validated Quantitative NMR Strategies for a Low-Abundance Natural Product in Standardized Extracts: The Case of Hepatodamianol in Turnera diffusa
Molecules doi: 10.3390/molecules27196593
Authors:
Aída Parra-Naranjo
Cecilia Delgado-Montemayor
Ricardo Salazar-Aranda
Rocío Castro-Ríos
Alma L. Saucedo
Noemí Waksman-Minsky
The quantification of low-abundance secondary metabolites in plant extracts is an analytical problem that can be addressed by different analytical platforms, the most common being those based on chromatograph...
Source: Molecules - October 5, 2022 Category: Chemistry Authors: A ída Parra-Naranjo Cecilia Delgado-Montemayor Ricardo Salazar-Aranda Roc ío Castro-Ríos Alma L. Saucedo Noem í Waksman-Minsky Tags: Article Source Type: research
Molecules, Vol. 27, Pages 4987: Analgesic Characteristics of NanoBEO Released by an Airless Dispenser for the Control of Agitation in Severe Dementia
a Tiziana Corasaniti
Chronic pain is one of the most common causes of the need for clinical evaluation, acquiring more importance in the elderly with cognitive impairment. Reduced self-reporting capabilities cause unrelieved pain contributing to the development of agitation. Safe and effective pain treatment can afford the management of agitation without the serious increase in death risk associated with neuroleptics. To this aim, the essential oil of bergamot (BEO), proven by rigorous evidence to have strong preclinical anti-nociceptive and anti-allodynic properties, has been engineered (NanoBEO, patent EP 4003294) to...
Source: Molecules - August 5, 2022 Category: Chemistry Authors: Damiana Scuteri Laura Rombol à Takafumi Hayashi Chizuko Watanabe Shinobu Sakurada Kengo Hamamura Tsukasa Sakurada Paolo Tonin Giacinto Bagetta Luigi A. Morrone Maria Tiziana Corasaniti Tags: Article Source Type: research
Inhibition of the carnitine acylcarnitine carrier by carbon monoxide reveals a novel mechanism of action with non-metal-containing proteins
Free Radic Biol Med. 2022 Jul 2;188:395-403. doi: 10.1016/j.freeradbiomed.2022.06.244. Online ahead of print.ABSTRACTBoth toxic and physiological effects of CO are mostly caused by well described interactions with heme-groups of proteins. Interactions of CO with non-heme proteins have also been unveiled. Besides interaction of CO with mitochondrial heme containing respiratory complexes, a BK channel and the phosphate carrier which do not contain metal cofactors, have been identified as CO targets. However, the molecular mechanisms of interaction with non-metal-containing proteins are not understood. We show in this work th...
Source: Free Radical Biology and Medicine - July 6, 2022 Category: Biology Authors: Annamaria Tonazzi Nicola Giangregorio Lara Console Cosima Damiana Calvano Mario Prejan ò Mariafrancesca Scalise Giovanna Incampo Tiziana Marino Nino Russo Tommaso R I Cataldi Cesare Indiveri Source Type: research
Inhibition of the carnitine acylcarnitine carrier by carbon monoxide reveals a novel mechanism of action with non-metal-containing proteins
Free Radic Biol Med. 2022 Jul 2:S0891-5849(22)00471-3. doi: 10.1016/j.freeradbiomed.2022.06.244. Online ahead of print.ABSTRACTBoth toxic and physiological effects of CO are mostly caused by well described interactions with heme-groups of proteins. Interactions of CO with non-heme proteins have also been unveiled. Besides interaction of CO with mitochondrial heme containing respiratory complexes, a BK channel and the phosphate carrier which do not contain metal cofactors, have been identified as CO targets. However, the molecular mechanisms of interaction with non-metal-containing proteins are not understood. We show in th...
Source: Free Radical Biology and Medicine - July 6, 2022 Category: Biology Authors: Annamaria Tonazzi Nicola Giangregorio Lara Console Cosima Damiana Calvano Mario Prejan ò Mariafrancesca Scalise Giovanna Incampo Tiziana Marino Nino Russo Tommaso R I Cataldi Cesare Indiveri Source Type: research
Inhibition of the carnitine acylcarnitine carrier by carbon monoxide reveals a novel mechanism of action with non-metal-containing proteins
Free Radic Biol Med. 2022 Jul 2:S0891-5849(22)00471-3. doi: 10.1016/j.freeradbiomed.2022.06.244. Online ahead of print.ABSTRACTBoth toxic and physiological effects of CO are mostly caused by well described interactions with heme-groups of proteins. Interactions of CO with non-heme proteins have also been unveiled. Besides interaction of CO with mitochondrial heme containing respiratory complexes, a BK channel and the phosphate carrier which do not contain metal cofactors, have been identified as CO targets. However, the molecular mechanisms of interaction with non-metal-containing proteins are not understood. We show in th...
Source: Free Radical Biology and Medicine - July 6, 2022 Category: Biology Authors: Annamaria Tonazzi Nicola Giangregorio Lara Console Cosima Damiana Calvano Mario Prejan ò Mariafrancesca Scalise Giovanna Incampo Tiziana Marino Nino Russo Tommaso R I Cataldi Cesare Indiveri Source Type: research
IJERPH, Vol. 19, Pages 8141: High Incidence of Partial Biotinidase Deficiency in the First 3 Years of a Regional Newborn Screening Program in Italy
Vincenzo De-Laurenzi
Ines Bucci
Biotinidase deficiency (BD) is an autosomal recessive inherited disorder in which the enzyme biotinidase is totally or partially defective and the vitamin biotin is not recycled. BD meets the major criteria for a population screening program. Newborn bloodspot screening (NBS) allows early diagnosis of BD, thus preventing the high morbidity and mortality associated with untreated disease. Both profound and partial BD variant can be detected by NBS test, and serum enzyme activity and/or mutational analysis are required for definitive diagnosis. In Italy, BD is included in the screening p...
Source: International Journal of Environmental Research and Public Health - July 2, 2022 Category: Environmental Health Authors: Daniela Semeraro Sara Verrocchio Giulia Di Dalmazi Claudia Rossi Damiana Pieragostino Ilaria Cicalini Rossella Ferrante Silvia Di Michele Liborio Stuppia Cristiano Rizzo Francesca Romana Lepri Antonio Novelli Carlo Dionisi-Vici Vincenzo De-Laurenzi Ines B Tags: Article Source Type: research
Dementia therapeutics and cognitive rehabilitation
Curr Opin Pharmacol. 2022 May 29;65:102237. doi: 10.1016/j.coph.2022.102237. Online ahead of print.NO ABSTRACTPMID:35649319 | DOI:10.1016/j.coph.2022.102237 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 1, 2022 Category: Drugs & Pharmacology Authors: Damiana Scuteri Giacinto Bagetta Pierluigi Nicotera Source Type: research
Dementia therapeutics and cognitive rehabilitation
Curr Opin Pharmacol. 2022 May 29;65:102237. doi: 10.1016/j.coph.2022.102237. Online ahead of print.NO ABSTRACTPMID:35649319 | DOI:10.1016/j.coph.2022.102237 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 1, 2022 Category: Drugs & Pharmacology Authors: Damiana Scuteri Giacinto Bagetta Pierluigi Nicotera Source Type: research
Dementia therapeutics and cognitive rehabilitation
Curr Opin Pharmacol. 2022 May 29;65:102237. doi: 10.1016/j.coph.2022.102237. Online ahead of print.NO ABSTRACTPMID:35649319 | DOI:10.1016/j.coph.2022.102237 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 1, 2022 Category: Drugs & Pharmacology Authors: Damiana Scuteri Giacinto Bagetta Pierluigi Nicotera Source Type: research
Hypoglycemic, Hypolipidemic, and Anti-Inflammatory Effects of Beta-Pinene in Diabetic Rats
Evid Based Complement Alternat Med. 2022 May 17;2022:8173307. doi: 10.1155/2022/8173307. eCollection 2022.ABSTRACTBACKGROUND: Diabetes is a metabolic disease linked to multiple comorbidities, such as low-grade inflammation. β-pinene, a monoterpene commonly found in aromatic plants, is endowed with anti-inflammatory effect and this fact lead us to investigate the possible hypoglycemic, hypolipidemic and anti-inflammatory effects of the monoterpene in the alloxan-induced diabetes experimental model.METHODS: Male Wistar rats (200-250 g) were treated orally with β-pinene (25, 50, 100, and 200 mg/kg) or glibenclamide (5 mg/kg...
Source: Evidence-based Complementary and Alternative Medicine - May 27, 2022 Category: Complementary Medicine Authors: Enaide Soares Santos Geraldo Lucas Abrantes Coelho Yan Kau ê Saraiva Fontes Loula B árbara Lourenço Saraiva Landim C ícera Norma Fernandes Lima Sara Tavares de Sousa Machado Maria Janice Pereira Lopes Acl éssia Damiana Soares Gomes Jos é Galberto Ma Source Type: research
Risk stratification for hospital-acquired venous thromboembolism in medical patients (RISE): Protocol for a prospective cohort study
In this study, we aim to prospectively validate the simplified Geneva score and to examine the predictive performance of a novel and objective definition of in-hospital immobilization using accelerometry. Methods and analysisRISE is a multicenter prospective cohort study. The goal is to recruit 1350 adult inpatients admitted for medical illness in three Swiss tertiary care hospitals. We collect data on demographics, comorbidities, VTE risk and thromboprophylaxis. Mobility from admission to discharge is objectively measured using a wrist-worn accelerometer. Participants are followed for 90 days for the occurrence of symptom...
Source: PLoS One - May 24, 2022 Category: Biomedical Science Authors: Damien Choffat Source Type: research
