Molecules, Vol. 27, Pages 4987: Analgesic Characteristics of NanoBEO Released by an Airless Dispenser for the Control of Agitation in Severe Dementia

Molecules, Vol. 27, Pages 4987: Analgesic Characteristics of NanoBEO Released by an Airless Dispenser for the Control of Agitation in Severe Dementia Molecules doi: 10.3390/molecules27154987 Authors: Damiana Scuteri Laura Rombolà Takafumi Hayashi Chizuko Watanabe Shinobu Sakurada Kengo Hamamura Tsukasa Sakurada Paolo Tonin Giacinto Bagetta Luigi A. Morrone Maria Tiziana Corasaniti Chronic pain is one of the most common causes of the need for clinical evaluation, acquiring more importance in the elderly with cognitive impairment. Reduced self-reporting capabilities cause unrelieved pain contributing to the development of agitation. Safe and effective pain treatment can afford the management of agitation without the serious increase in death risk associated with neuroleptics. To this aim, the essential oil of bergamot (BEO), proven by rigorous evidence to have strong preclinical anti-nociceptive and anti-allodynic properties, has been engineered (NanoBEO, patent EP 4003294) to allow randomized, double-blind, placebo-controlled trials (BRAINAID, NCT04321889). The present study: (1) assesses the analgesic effects of a single therapeutic dose of NanoBEO, as supplied by an airless dispenser for clinical translation, in models of inflammatory, neuropathic, and sensitization types of pain relevant to clinic; (2) provides a dose–response analysis of the efficacy of NanoBEO on scratching behavior, a typical behavioral disturbance occurring in ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research