The influence of drying and storage conditions on the volatilome and cannabinoid content of Cannabis sativa L. inflorescences
Anal Bioanal Chem. 2024 May 3. doi: 10.1007/s00216-024-05321-w. Online ahead of print.ABSTRACTThe increasing interest in hemp and cannabis poses new questions about the influence of drying and storage conditions on the overall aroma and cannabinoids profile of these products. Cannabis inflorescences are subjected to drying shortly after harvest and then to storage in different containers. These steps may cause a process of rapid deterioration with consequent changes in precious secondary metabolite content, negatively impacting on the product quality and potency. In this context, in this work, the investigation of the effe...
Source: Analytical and Bioanalytical Chemistry - May 3, 2024 Category: Chemistry Authors: Natasha Damiana Spadafora Simona Felletti Tatiana Chenet Tiziana Maria Sirangelo Mirco Cescon Martina Catani Chiara De Luca Claudia Stevanin Alberto Cavazzini Luisa Pasti Source Type: research
The influence of drying and storage conditions on the volatilome and cannabinoid content of Cannabis sativa L. inflorescences
Anal Bioanal Chem. 2024 May 3. doi: 10.1007/s00216-024-05321-w. Online ahead of print.ABSTRACTThe increasing interest in hemp and cannabis poses new questions about the influence of drying and storage conditions on the overall aroma and cannabinoids profile of these products. Cannabis inflorescences are subjected to drying shortly after harvest and then to storage in different containers. These steps may cause a process of rapid deterioration with consequent changes in precious secondary metabolite content, negatively impacting on the product quality and potency. In this context, in this work, the investigation of the effe...
Source: Analytical and Bioanalytical Chemistry - May 3, 2024 Category: Chemistry Authors: Natasha Damiana Spadafora Simona Felletti Tatiana Chenet Tiziana Maria Sirangelo Mirco Cescon Martina Catani Chiara De Luca Claudia Stevanin Alberto Cavazzini Luisa Pasti Source Type: research
Tl(I) and Tl(III)-induce genotoxicity, reticulum stress and autophagy in PC12 Adh cells
Arch Toxicol. 2024 Apr 15. doi: 10.1007/s00204-024-03752-z. Online ahead of print.ABSTRACTThallium (Tl) and its two cationic species, Tl(I) and Tl(III), are toxic for most living beings. In this work, we investigated the effects of Tl (10-100 µM) on the viability and proliferation capacity of the adherent variant of PC12 cells (PC12 Adh cells). While both Tl(I) and Tl(III) halted cell proliferation from 24 h of incubation, their viability was ~ 90% even after 72 h of treatment. At 24 h, increased levels of γH2AX indicated the presence of DNA double-strand breaks. Simultaneously, increased expression of p53 and its phosph...
Source: Archives of Toxicology - April 15, 2024 Category: Toxicology Authors: Damiana M Salvatierra-Fr échou Sandra V Verstraeten Source Type: research
Clipping a Positive Lymph Node Improves Accuracy of Nodal Staging After Neoadjuvant Chemotherapy for Breast Cancer Patients, but Does It Drive Management Changes?
CONCLUSIONS: For a conservative axillary treatment in this setting, TAD is an effective method. It is more accurate than SLN alone and allows management changes. Further studies are warranted.PMID:38427160 | DOI:10.1245/s10434-024-15052-y (Source: Ann Oncol)
Source: Ann Oncol - March 1, 2024 Category: Cancer & Oncology Authors: Leopoldo Costarelli Francesca Arienzo Laura Broglia Massimo La Pinta Paola Scavina Emanuele Zarba Meli Maria Helena Colavito Alessandra Ascarelli Domenico Campagna Tiziana Mastropietro Elena Manna Michela Amato Angela Damiana Andrulli Alfonso Schiavone Ma Source Type: research
Clipping a Positive Lymph Node Improves Accuracy of Nodal Staging After Neoadjuvant Chemotherapy for Breast Cancer Patients, but Does It Drive Management Changes?
CONCLUSIONS: For a conservative axillary treatment in this setting, TAD is an effective method. It is more accurate than SLN alone and allows management changes. Further studies are warranted.PMID:38427160 | DOI:10.1245/s10434-024-15052-y (Source: Ann Oncol)
Source: Ann Oncol - March 1, 2024 Category: Cancer & Oncology Authors: Leopoldo Costarelli Francesca Arienzo Laura Broglia Massimo La Pinta Paola Scavina Emanuele Zarba Meli Maria Helena Colavito Alessandra Ascarelli Domenico Campagna Tiziana Mastropietro Elena Manna Michela Amato Angela Damiana Andrulli Alfonso Schiavone Ma Source Type: research
Molecules, Vol. 29, Pages 868: Matrix Selection Strategies for MALDI-TOF MS/MS Characterization of Cyclic Tetrapyrroles in Blood and Food Samples
io Monopoli
Cyclic tetrapyrrole derivatives such as porphyrins, chlorins, corrins (compounds with a corrin core), and phthalocyanines are a family of molecules containing four pyrrole rings usually coordinating a metal ion (Mg, Cu, Fe, Zn, etc.). Here, we report the characterization of some representative cyclic tetrapyrrole derivatives by MALDI-ToF/ToF MS analyses, including heme b and c, phthalocyanines, and protoporphyrins after proper matrix selection. Both neutral and acidic matrices were evaluated to assess potential demetallation, adduct formation, and fragmentation. While chlorophylls exhibited magnesium demeta...
Source: Molecules - February 15, 2024 Category: Chemistry Authors: Mariachiara Bianco Giovanni Ventura Cosima Damiana Calvano Ilario Losito Tommaso R. I. Cataldi Antonio Monopoli Tags: Article Source Type: research
Asbestos burden in lungs of non-occupationally exposed women from Broni (Pavia, Italy): a postmortem SEM-EDS study
CONCLUSIONS: These results suggest the relevance of the lung clearance of asbestos, regarding mainly chrysotile. As a consequence, although scanning electron microscopy -energy dispersive X-ray spectroscopy (SEM-EDS) is considered the most reliable tool for assessing previous exposure to asbestos, its results should be interpreted with caution, especially in a legal context. In addition, our data confirm the relevance of environmental and household exposure in determining asbestos concentration in lungs and highlight the importance of household exposure.PMID:38249898 | PMC:PMC10797346 | DOI:10.21037/jtd-23-1061 (Source: Jo...
Source: Journal of Thoracic Disease - January 22, 2024 Category: Respiratory Medicine Authors: Silvia Damiana Vison à Silvana Capella Paola Borrelli Simona Villani Cristina Favaron Zhyldyz Kurzhunbaeva Claudio Colosio Elena Belluso Source Type: research
Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice
CONCLUSION: These findings implicate specific roles of integrins in inflammation and tonic pain, as well as in the related central nervous system sequelae.PMID:38073106 | DOI:10.2174/1570159X22999231207105743 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Carmela Belardo Jed Jebali Serena Boccella Rosmara Infantino Antimo Fusco Michela Perrone Roozbe Bonsale Iolanda Manzo Monica Iannotta Damiana Scuteri Franca Ferraraccio Iacopo Panares Giovanna Ferrara Francesca Guida Livio Luongo Enza Palazzo Najet Srair Source Type: research
