Cystic Fibrosis Transmembrane Conductance Regulator ∆F508 Heterozygosity: A Spectrum of Disease Burden
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 19, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

3D Printing and the Cystic Fibrosis Lung
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 19, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Does Improved Lung Health Change the Incidence of Cystic Fibrosis-Related Diabetes?
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 19, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

High Frequency of Atopy with Geographic Variation in Non-Cystic Fibrosis Bronchiectasis
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 19, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Omalizumab Treatment in Patients with Cystic Fibrosis (CF) and Allergic Bronchopulmonary Aspergillosis (ABPA): a Case Series
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 16, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Mother of girl with cystic fibrosis is taking legal action against the NHS after it refused drug
Sarah Burgwin, of Totnes, Devon, said it was 'shameful' that six-year-old Katie Stafford was being denied access to Orkambi, which can improve lung function in sufferers of the disease. (Source: the Mail online | Health)
Source: the Mail online | Health - November 14, 2018 Category: Consumer Health News Source Type: news

Devon mother in fight with NHS for cystic fibrosis drug funding
Sarah Burgwin wants the NHS to pay for Orkambi to treat her six-year-old daughter's cystic fibrosis. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 14, 2018 Category: Consumer Health News Source Type: news

Moths and magnets could save lives
(Rice University) Rice University bioengineers have combined a virus that infects moths with magnetic nanoparticles to create a potential new therapy for inherited genetic diseases like muscular dystrophy, sickle cell, cystic fibrosis, spinal muscular atrophy and some forms of cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 13, 2018 Category: Cancer & Oncology Source Type: news

Researchers identify risk factors of advanced liver disease in cystic fibrosis patients
(Children's Hospital Colorado) Children's Hospital Colorado (Children's Colorado) pediatric gastroenterologist, Michael Narkewicz, MD, recently shared results of the Prospective Study of Ultrasound to Predict Hepatic Cirrhosis in Cystic Fibrosis (PUSH), which sought to determine if liver ultrasounds could identify children and adolescents with cystic fibrosis who are at greater risk of developing advanced liver disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 12, 2018 Category: International Medicine & Public Health Source Type: news

Father with cystic fibrosis finally gets lung transplant after three failed attempts
James Beeching, 34, has had the incurable genetic condition since he was two years old. Three lung transplants fell through before his surgery. He can finally walk his twins to school in Hastings. (Source: the Mail online | Health)
Source: the Mail online | Health - November 7, 2018 Category: Consumer Health News Source Type: news

Most patients with cystic fibrosis may receive insufficient antibiotics to fight lung infections
(Children's National Health System) The majority of patients with cystic fibrosis may not achieve blood concentrations of antibiotics sufficiently high enough to effectively fight bacteria responsible for pulmonary exacerbations, leading to worsening pulmonary function, indicates a study led by researchers at Children's National Health System. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 6, 2018 Category: International Medicine & Public Health Source Type: news

10x Genomics takes gene imaging and analysis tools to the big leagues
10x Genomics Growth: 2,044% Rank: 1 What it does: Sells gene imaging and analysis tools CEO: Serge Saxonov HQ: Pleasanton 2017 Employees: 246 2017 revenue: $71.18 million 2016 revenue: $27.48 million 2015 revenue: $3.32 million In April, scientists at MIT and Harvard’s joint Broad Institute for bi omedical and genomic research made a tiny discovery that could have big implications for patients who suffer from the lung infections and breathing difficulties typical of cystic fibrosis. “Using… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 31, 2018 Category: American Health Authors: Lauren Hepler Source Type: news

10x Genomics takes gene imaging and analysis tools to the big leagues
10x Genomics Growth: 2,044% Rank: 1 What it does: Sells gene imaging and analysis tools CEO: Serge Saxonov HQ: Pleasanton 2017 Employees: 246 2017 revenue: $71.18 million 2016 revenue: $27.48 million 2015 revenue: $3.32 million In April, scientists at MIT and Harvard’s joint Broad Institute for bi omedical and genomic research made a tiny discovery that could have big implications for patients who suffer from the lung infections and breathing difficulties typical of cystic fibrosis. “Using… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 31, 2018 Category: Biotechnology Authors: Lauren Hepler Source Type: news

Mucus, cough and chronic lung disease: New discoveries
(University of Gothenburg) As a cold ends, a severe mucus cough starts. Sound familiar? Two studies now give explanations: First, crucial mechanisms of the mucus in both diseased and healthy airways; second, what happens in such chronic lung diseases as cystic fibrosis and chronic obstructive pulmonary disease (COPD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 24, 2018 Category: International Medicine & Public Health Source Type: news

UAB researchers leading way on drug regimen battling cystic fibrosis
A triple combination drug has been shown to be effective in improving lung function for the majority of patients with cystic fibrosis.   The new therapy can provide therapeutic benefits for 90 percent of all patients with the disease, according to findings published in the New England Journal of Medicine. Researchers from UAB report the medication, which combines an experimental compound known as VX-659 with two existing medicati ons, tezacaftor and ivacaftor, improved lung function by more than… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 19, 2018 Category: American Health Authors: Tyler Patchen Source Type: news

Triple Combo Regimens May Address Cause of Cystic Fibrosis
FRIDAY, Oct. 19, 2018 -- Triple therapy with VX-659 or VX-445 combined with tezacaftor-ivacaftor shows promise for the treatment of adult patients with cystic fibrosis who have mutations in the cystic fibrosis transmembrane conductance regulator... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 19, 2018 Category: Pharmaceuticals Source Type: news

3-Drug Therapy Might Be Cystic Fibrosis 'Breakthrough'
Title: 3-Drug Therapy Might Be Cystic Fibrosis 'Breakthrough'Category: Health NewsCreated: 10/18/2018 12:00:00 AMLast Editorial Review: 10/19/2018 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - October 19, 2018 Category: Respiratory Medicine Source Type: news

3-Drug Therapy Might Be Cystic Fibrosis Advance
In what researchers call “a breakthrough,” two clinical trials have found that two different three-drug treatment plans could help 90 percent of people with cystic fibrosis. “It’s not a cure,” said one of the lead researchers. “But it could be game-changing.” (Source: WebMD Health)
Source: WebMD Health - October 18, 2018 Category: Consumer Health News Source Type: news

3 - Drug Therapy Might Be Cystic Fibrosis ‘ Breakthrough ’
(Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 18, 2018 Category: Respiratory Medicine Tags: Family Medicine, Pharmacy, Pulmonology, Research, News, Source Type: news

' Major Breakthrough' in Cystic Fibrosis Treatment'Major Breakthrough' in Cystic Fibrosis Treatment
Adding a third drug to modulate the CFTR protein improved respiratory function and reduced sweat chloride concentrations in most patients with cystic fibrosis. Phase 3 trials are ongoing.Medscape Medical News (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - October 18, 2018 Category: Primary Care Tags: Pulmonary Medicine News Source Type: news

3-Drug Therapy Might Be Cystic Fibrosis'Breakthrough '
THURSDAY, Oct. 18, 2018 -- In what researchers are calling a " breakthrough, " two preliminary trials have found that either of two triple-drug regimens could potentially benefit 90 percent of people with cystic fibrosis. The trials were short-term,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 18, 2018 Category: General Medicine Source Type: news

A day in the life of a 10-year-old patient at Alder Hey
She has cystic fibrosis and shared a day in her life to show what it's like for her. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 13, 2018 Category: Consumer Health News Source Type: news

I'm Drowning
(MedPage Today) -- A researcher-patient's plea for broader inclusion in cystic fibrosis trials (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - October 11, 2018 Category: American Health Source Type: news

Scientists reveal new cystic fibrosis treatments work best in inflamed airways
(University of North Carolina Health Care) A new UNC School of Medicine study shows that two cystic fibrosis (CF) drugs aimed at correcting the defected CFTR protein seem to be more effective when a patient's airway is inflamed. This is the first study to evaluate the efficacy of these drugs under inflammatory conditions relevant to CF airways. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 11, 2018 Category: Biology Source Type: news

Carriers of cystic fibrosis may be at greater risk for allergic bronchopulmonary aspergillosis
Tue, 10/09/2018 - 11:45News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 9, 2018 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Cystic fibrosis sufferer lifts one million kilograms in 22 hours
Josh Llewellyn-Jones completes the "crazy" challenge to inspire others living with the disorder. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 1, 2018 Category: Consumer Health News Source Type: news

Interventions for the eradication of meticillinresistant Staphylococcus aureus (MRSA) in people with cystic fibrosis
This review concluded that whilst early eradication of respiratory MRSA in cystic fibrosis with oral trimethoprim and sulfamethoxazole combined with rifampicin is possible, the evidence is of low quality to justify use. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 28, 2018 Category: Consumer Health News Source Type: news

Real-life experience of Omalizumab in adult Cystic Fibrosis patients with allergic severe asthma and Allergic Bronchopulmonary Aspergillosis
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - September 27, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Nontuberculous Mycobacteria in Cystic Fibrosis Nontuberculous Mycobacteria in Cystic Fibrosis
In this article, the diagnosis, treatment, and impact of nontuberculous mycobacteria infection among patients with cystic fibrosis is discussed.Seminars in Respiratory and Critical Care Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 20, 2018 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Insuring patient access and affordability for treatments for rare and ultra-rare diseases
(American College of Medical Genetics and Genomics) The last decade has seen tremendous progress in the development of new drugs for patients with genetic disorders, including Cystic Fibrosis, many lysosomal storage disorders (Gaucher disease, Fabry disease and others) and most recently, Duchenne Muscular Dystrophy and Spinal Muscular Atrophy (SMA). The American College of Medical Genetics and Genomics (ACMG) is concerned with the staggering projected cost of these new treatments. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 7, 2018 Category: International Medicine & Public Health Source Type: news

Claire Wineland, who chronicled cystic fibrosis, dies at 21
Claire Wineland used social media platforms to speak about the difficult details of her life and spread awareness about the disease (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - September 4, 2018 Category: Consumer Health News Source Type: news

Claire Wineland, inspirational speaker and social media star, dies one week after lung transplant
Cystic fibrosis did not define Claire Wineland. She did. (Source: CNN.com - Health)
Source: CNN.com - Health - September 4, 2018 Category: Consumer Health News Source Type: news

Claire Wineland: Cystic fibrosis activist dies at 21
Claire Wineland made a name for herself writing and speaking about her life with the disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - September 4, 2018 Category: Consumer Health News Source Type: news

A lung transplant gave her hope for a longer life; now her family prays for 'another miracle'
Claire Wineland, who has cystic fibrosis, needed a double-lung transplant to save her life. But she had a stroke and is now in a medically induced coma. (Source: CNN.com - Health)
Source: CNN.com - Health - August 29, 2018 Category: Consumer Health News Source Type: news

Cystic fibrosis mothers' plea over 'life-changing' drug
Two mothers call on a drug firm and ministers to reach a deal over a 'life-changing' treatment. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - August 28, 2018 Category: Consumer Health News Source Type: news

Cystic fibrosis mum's drug plea for 'deserving' daughter
Ivy, aged three, has cystic fibrosis and her mum wants a £100,000-a-year to help control Ivy's condition. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - August 28, 2018 Category: Consumer Health News Source Type: news

Enzyme ducts in the pancreas are formed like rivers
(University of Copenhagen The Faculty of Health and Medical Sciences) With methods used to analyse road systems and rivers researchers from the University of Copenhagen have studied the formation of the pancreas' network of ducts transporting digestive enzymes in mice. The network resembles the structure of road networks and the formation of rivers. The new results can help the researchers gain a better understanding of disorders like cystic fibrosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 27, 2018 Category: International Medicine & Public Health Source Type: news

Africa:How an App Is Helping to Collect Genetic Data in Ethiopia and Ghana
[The Conversation Africa] Genetic technologies are poised to change the world. Want to eradicate a human disease such as cystic fibrosis or improve a person's ability to run impossible distances or lift unimaginable weights? This may be possible in the future by using something called CRISPR to edit an organism's genetic makeup. How about rapidly sequencing a newborn's genome, similar to an early scene in the 1997 movie Gattaca? Next-generation sequencing may make this fiction a reality. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - August 24, 2018 Category: African Health Source Type: news

Madden Launches DartCF
Dean Madden, Professor of Biochemistry and Cell Biology and Director of the COBRE Institute for Biomolecular Targeting, has received a new NIH program project award to establish the Dartmouth Cystic Fibrosis Research Center (DartCF). This collaborative effort supported by the National Institute of Diabetes and Digestive and Kidney Diseases will […] Read More (Source: News at Dartmouth Medical School)
Source: News at Dartmouth Medical School - August 17, 2018 Category: Hospital Management Authors: Heather Smith Tags: News Source Type: news

Electromed touts SmartVest non-cystic fybrosis bronchiectasis study data
Electromed (NSDQ:ELMD) today released results from an independent clinical study exploring the use of high frequency chest wall oscillation therapy with its SmartVest, touting that it significantly reduced severe exacerbations and hospitalizations for non-cystic fibrosis bronchiectasis patients. Findings from the study were presented at the World Bronchiectasis Conference in Washington D.C., the New Prague, Minn.-based company said. “Preventing exacerbations and maintaining pulmonary function is vital to the health and well-being of bronchiectasis patients. This independent study builds on previously publis...
Source: Mass Device - August 16, 2018 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Electromed Source Type: news

Vertex cystic fibrosis drug gets expanded approval for use in infants
U.S. health regulators have expanded the use of one of Vertex Pharmaceuticals Inc's cystic fibrosis drugs to include patients aged between 12 months and 24 months. (Source: Reuters: Health)
Source: Reuters: Health - August 15, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Cystic fibrosis boy, 8, urges firm to lower Orkambi drug price
Luis Walker, 8, wrote to Vertex Pharmaceuticals saying Orkambi would make him "feel much better". (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - August 15, 2018 Category: Consumer Health News Source Type: news

FDA Approves Kalydeco (ivacaftor) for Cystic Fibrosis in Children Ages 12 to & lt;24 Months with Certain Mutations in the CFTR Gene
BOSTON--(BUSINESS WIRE)--Aug. 15, 2018-- Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced the U.S. Food and Drug Administration (FDA) approved Kalydeco (ivacaftor) to include use in children with cystic fibrosis (CF) ages 12 to... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - August 15, 2018 Category: Drugs & Pharmacology Source Type: news

VIDEO – Taking on Cystic Fibrosis: A Student Story
Dartmouth College undergraduate Sam Neff D '21 fights cystic fibrosis (CF) every day by following a strict treatment regimen, by contributing to CF research in Geisel’s Lung Biology Center, and by participating in a clinical trial at Dartmouth-Hitchcock. (Source: News at Dartmouth Medical School)
Source: News at Dartmouth Medical School - August 14, 2018 Category: Hospital Management Authors: Jennifer Durgin Tags: Multimedia News Research Video cystic fibrosis Dartmouth undergraduate Home-feature Interaction student research Source Type: news

NICE, Vertex continue to spar over drug prices
The U.K.'s National Institute for Health and Care Excellence (NICE) has suspended its review of Vertex's Symkevi for treating cystic fibrosis patients who are homozygous for the F508del mutation, after the biotech did not provide evidence for the agency's appraisal. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - August 13, 2018 Category: Pharmaceuticals Source Type: news

Ambitious 'Human Cell Atlas' Aims To Catalog Every Type Of Cell In The Body
Already the project has revealed a previously unknown type of cell in the windpipe that might play a role in cystic fibrosis — and lead to a new treatment, scientists say.(Image credit: Casey Atkins/Broad Institute) (Source: NPR Health and Science)
Source: NPR Health and Science - August 13, 2018 Category: Consumer Health News Authors: Karen Weintraub Source Type: news

Research shows that cystic fibrosis impacts growth in the womb
(University of Liverpool) New research, published in Thorax, funded by the Cystic Fibrosis Trust has shown that babies with cystic fibrosis (CF) are born weighing less than babies without the condition, even allowing that they are more likely to be born prematurely. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 13, 2018 Category: International Medicine & Public Health Source Type: news

Finally, a potential new approach against KRAS-driven lung cancer
(University of Colorado Anschutz Medical Campus) University of Colorado Cancer Center and M.D. Anderson Cancer Center study shows KRAS-driven lung cancers are also marked by high levels of 'gel-forming mucins,' as seen in some forms of asthma, chronic obstructive pulmonary disease and cystic fibrosis. The study, published Aug. 9 in the journal JCI Insight, also pinpoints a cause of increased mucin production, namely the gene MUC5AC. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 9, 2018 Category: Cancer & Oncology Source Type: news

Boehringer Ingelheim, the UK Cystic Fibrosis Gene Therapy Consortium, Imperial Innovations and Oxford BioMedica announce new partnership to develop first-in-class gene therapy for cystic fibrosis
Boehringer Ingelheim, the UK Cystic Fibrosis Gene Therapy Consortium (GTC) - consisting of Imperial College London and the Universities of Oxford and Edinburgh - Imperial Innovations, and Oxford BioMedica (OXB) announce a global collaboration to develop a first-in-class, long-term therapy for patients with cystic fibrosis (CF). (Source: World Pharma News)
Source: World Pharma News - August 7, 2018 Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news