Multi-drug resistant infection spreading globally among cystic fibrosis patients
(University of Cambridge) A multi-drug resistant infection that can cause life-threatening illness in people with cystic fibrosis and can spread from patient to patient has spread globally and is becoming increasingly virulent, according to new research published today in the journal Science. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 10, 2016 Category: Infectious Diseases Source Type: news

Pole dancer has just 'months to live' after her body has rejected her second transplant
Kirstie Tancock, 27, from Honiton, Devon, has suffered from cystic fibrosis since she was born. But in a blog, she says she has suffered her second organ rejection and is now too ill to receive a third. (Source: the Mail online | Health)
Source: the Mail online | Health - November 8, 2016 Category: Consumer Health News Source Type: news

To Your Health: NLM update: Cystic fibrosis research institute's potential
Listen to the To Your Health: NLM update on Cystic fibrosis research institute's potential. The transcript is also available. The Cystic Fibrosis Foundation just opened its own research institute to speed the development of medications in a move that will be watched by other disease advocacy organizations, finds a recent article published in Science... (Source: What's New on MedlinePlus)
Source: What's New on MedlinePlus - November 7, 2016 Category: Consumer Health News Source Type: news

Assessing the Airway Microbiota in Cystic Fibrosis
Cystic fibrosis (CF) lung disease is characterized by chronic airway bacterial infections and airway inflammation. Microbiologic cultures of CF airway samples identify a narrow spectrum of pathogenic bacteria. More recently, culture-independent techniques have identified much more diverse microbial communities within the CF airways. The role of these bacterial communities in CF disease progression and pulmonary exacerbations is under investigation. This review discusses advances in molecular approaches for microbiota analysis; challenges in airway sampling; recent findings in airway microbiota in CF, including longitudinal...
Source: Clinical Microbiology Newsletter - November 4, 2016 Category: Microbiology Authors: Jordana E. Hoppe, J. Kirk Harris, Edith T. Zemanick Source Type: news

Fluorescent sensor provides low-cost diagnosis of cystic fibrosis
Scientists have developed a new diagnostic test for cystic fibrosis. The new device provides a cheaper, easier way to detect levels of chloride in sweat, which are elevated in cystic fibrosis patients. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 2, 2016 Category: Science Source Type: news

A lead to overcome resistance to antibiotics
Pseudomonas aeruginosa is a common bacterium in the environment. It can however become a formidable pathogen causing fatal infections, especially in intubated patients, people suffering from cystic fibrosis or severe burns. The presence of certain metals in the natural or human environment of the bacterium makes it more dangerous and, in particular, resistant to antibiotics of last resort. A team of researchers has shown that a specific protein of P. aeruginosa, called Host factor q (Hfq), is essential for reacting to these metals and acquire these new properties. The results single out the Hfq protein as the Achilles heel...
Source: ScienceDaily Headlines - October 5, 2016 Category: Science Source Type: news

Nurse Assist Initiates Nationwide Voluntary Recall of All Unexpired Lots of I.V. Flush Syringes
Nurse Assist, Inc. announced today that it is voluntarily recalling all unexpired lots of I.V. Flush Syringes due to a potential link to Burkholderia cepacia bloodstream infections with the product.  According to the U.S. Centers for Disease Control and Prevention (CDC), the effects of Burkholderia cepacia on people'vary widely, ranging from no symptoms at all to serious respiratory infections, especially in patients with cystic fibrosis.' If a patient is having symptoms, contact your health care provider. (Source: Food and Drug Administration)
Source: Food and Drug Administration - October 5, 2016 Category: Food Science Source Type: news

Curing inherited disease by running a stop sign
(University of Alabama at Birmingham) A study published today by scientists at University of Massachusetts Medical School and the University of Alabama at Birmingham provides insight into the mechanism of action of the drug ataluren, which is showing promise in treating Duchenne muscular dystrophy and cystic fibrosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 4, 2016 Category: Global & Universal Source Type: news

FDA OKs Cystic Fibrosis Drug Orkambi for Younger Patients FDA OKs Cystic Fibrosis Drug Orkambi for Younger Patients
The lumacaftor/ivacaftor combination drug is now approved for children aged 6 to 11 years with two copies of the F508del mutation in the CTFR gene.FDA Approvals (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - September 29, 2016 Category: Drugs & Pharmacology Tags: Pulmonary Medicine News Alert Source Type: news

Cystic Fibrosis: Ensuring adequate nutrition
People with cystic fibrosis (CF) need help to ensure they are getting correct nutrition and the right amount of enzymes. They also need constant reminders. Researchers are now developing a digital support device to promote autonomy, but are finding that this is no easy task. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 28, 2016 Category: Science Source Type: news

FDA Approves Orkambi (lumacaftor/ivacaftor) for Use in Children with Cystic Fibrosis Ages 6 through 11 who have Two Copies of the F508del Mutation
BOSTON--(BUSINESS WIRE) September 28, 2016 -- Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced that the U.S. Food and Drug Administration (FDA) approved Orkambi (lumacaftor/ivacaftor) for use in children with cystic fibrosis (CF)... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - September 28, 2016 Category: Drugs & Pharmacology Source Type: news

Katie Prager dies days after her husband
Katie Prager, the wife in the real "Fault in Our Stars" couple, died Thursday after complications from cystic fibrosis and a lung transplant. She was 26 years old. (Source: CNN.com - Health)
Source: CNN.com - Health - September 24, 2016 Category: Consumer Health News Source Type: news

Katie Prager, wife in real 'Fault in Our Stars' couple, dies
Katie Prager, the wife in the real "Fault in Our Stars" couple, died Thursday after complications from cystic fibrosis and a lung transplant. She was 26 years old. (Source: CNN.com - Health)
Source: CNN.com - Health - September 23, 2016 Category: Consumer Health News Source Type: news

Real-life Fault in Our Stars wife with cystic fibrosis dies
Katie Prager and her husband Dalton Prager met on Facebook in 2009. Dalton Prager died Saturday at a St. Louis hospital from cystic fibrosis, which clogs the lungs with mucus. (Source: the Mail online | Health)
Source: the Mail online | Health - September 23, 2016 Category: Consumer Health News Source Type: news

Real 'Fault in Our Stars' couple: Katie Prager dies
Katie Prager, the wife in the real "Fault in Our Stars" couple, died Thursday after complications from cystic fibrosis and a lung transplant. She was 26 years old. (Source: CNN.com - Health)
Source: CNN.com - Health - September 22, 2016 Category: Consumer Health News Source Type: news

'Fault in our Stars' wife dies 5 days after husband
Katie Prager died after complications from cystic fibrosis and a lung transplant. She was 26 years old. (Source: CNN.com - Health)
Source: CNN.com - Health - September 22, 2016 Category: Consumer Health News Source Type: news

A real 'Fault in Our Stars' couple
Katie and Dalton Prager both had cystic fibrosis. Despite doctors' warnings, they married and became known as the real "Fault in Our Stars" couple. They passed away days apart from each other in September 2016. (Source: CNN.com - Health)
Source: CNN.com - Health - September 22, 2016 Category: Consumer Health News Source Type: news

Dalton and Katie Prager: A love story
Katie and Dalton Prager both had cystic fibrosis. Despite doctors' warnings, they married and became known as the real "Fault in Our Stars" couple. They passed away days apart from each other in September 2016. (Source: CNN.com - Health)
Source: CNN.com - Health - September 22, 2016 Category: Consumer Health News Source Type: news

A low-cost sensor for cystic fibrosis diagnosis
A new, inexpensive method for detecting salt concentrations in sweat or other bodily fluids has been developed by biomaterials scientists. The fluorescent sensor, derived from citric acid molecules, is highly sensitive and highly selective for chloride, the key diagnostic marker in cystic fibrosis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 20, 2016 Category: Science Source Type: news

Gene therapy for cystic fibrosis lung disease
Gene therapy may be a viable approach for treating or preventing lung disease caused by cystic fibrosis (CF), suggests new research. Working with CF pigs, the researchers have shown that two different virus-based vectors can restore a working version of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is faulty in CF to the pigs'airway cells. Moreover, this gene replacement normalized important aspects of the lung biology and improved the ability of airway secretions to kill bacteria. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 20, 2016 Category: Science Source Type: news

Husband in real-life "Fault in Our Stars" couple dies
25-year-old Dalton Prager died from cystic fibrosis, while his wife is in hospice care with the same disease (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - September 20, 2016 Category: Consumer Health News Source Type: news

New clues to cystic fibrosis'gender gap '
There is evidence that women with Cystic Fibrosis die on average two to three years earlier than do men with the devastating lung airway disease. A research team has come up with the first detailed molecular explanation for a factor that may contribute to the so-called cystic fibrosis (CF) " gender gap. " (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 19, 2016 Category: Science Source Type: news

[In Depth] Cystic fibrosis foundation opens drug discovery lab
The Cystic Fibrosis Foundation is once again breaking new ground. In 2000, with little beyond symptomatic relief available for the inherited, life-threatening condition, the Bethesda, Maryland–based foundation hired a biotech company to develop more effective treatments. The move, unprecedented for a disease advocacy organization, paid off in two new drugs, the first to target the molecular root of the disease. But there is still no cure, and cystic fibrosis patients continue to die—467 in the United States alone in 2014. So on 19 September, the foundation is setting another precedent by officially opening its ...
Source: ScienceNOW - September 15, 2016 Category: Science Authors: Bijal P. Trivedi Tags: Biomedicine Source Type: news

What Causes Hyperphosphatemia?
Discussion Constipation is a common problem in general pediatrics and its causes are numerous. It can cause acute and recurrent abdominal pain and is a cause of abdominal distention. Patients who are young, whose presentations are other than routine or who had complications should be invested for underlying causes of their constipation. This patient had undergone some evaluations in the past for constipation but because of the presentation of sepsis a more rigorous evaluation was undertaken. The differential diagnoses of the following can be found here: constipation, acute abdominal pain, recurrent abdominal pain, and abdo...
Source: PediatricEducation.org - September 12, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

New research sheds light'gender gap' in cystic fibrosis
Medical researchers have examined the underpinnings of cystic fibrosis, including its disproportionate effect on women -- due in part to the influence of estrogen on the flow of important chemical ions. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 10, 2016 Category: Science Source Type: news

New research sheds light 'gender gap' in cystic fibrosis
(Arizona State University) In new research appearing in the current issue of Science Advances, Wade Van Horn and colleagues from Vanderbilt and Northwestern Universities examine the underpinnings of cystic fibrosis, including its disproportionate effect on women -- due in part to the influence of estrogen on the flow of important chemical ions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 9, 2016 Category: Global & Universal Source Type: news

Sweat Chloride Test (Cystic Fibrosis)
Title: Sweat Chloride Test (Cystic Fibrosis)Category: Procedures and TestsCreated: 2/11/1999 12:00:00 AMLast Editorial Review: 9/7/2016 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - September 7, 2016 Category: Respiratory Medicine Source Type: news

Burkholderia cepacia: a Complex Problem for More than Cystic Fibrosis Patients
It is always surprising to find that an organism we know only from the clinical laboratory is a “player” in other venues. Therefore, it was with some fascination that we learned that Burkholderia cepacia, long known as a pathogen in cystic fibrosis patients, is also the number one organism isolated from product recalls. We recount the story of this amazing organism, which has a place in th e clinical, agricultural, and pharmaceutical sectors. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - September 3, 2016 Category: Microbiology Authors: Nehemiah J. Landes, Hannah N. Livesay, Fran Schaeffer, Pam Terry, Ernest Trevino, Alice Schauer Weissfeld Source Type: news

Genetic Factors Shed Light on Barrett's Esophagus, Adenocarcinoma Genetic Factors Shed Light on Barrett's Esophagus, Adenocarcinoma
Cystic fibrosis is among factors which may influence the complex relationship of genetics to Barrett's esophagus and adenocarcinoma, according to a large-scale meta-analysis.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 2, 2016 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Palivizumab for prophylaxis against respiratory syncytial virus infection in children with cystic fibrosis
Respiratory syncytial virus infection causes acute lung infection in infants and young children worldwide, resulting in considerable morbidity and mortality. Children with cystic fibrosis are prone to recurrent lung inflammation, bacterial colonisation and subsequent chronic airway disease, putting them at risk for severe respiratory syncytial virus infections requiring intensive care and respiratory support. No treatment currently exists, hence prevention is important. Palivizumab is effective in reducing respiratory syncytial virus hospitalisation rates and is recommended for prophylaxis in high-risk children with other ...
Source: Current Awareness Service for Health (CASH) - September 1, 2016 Category: Consumer Health News Source Type: news

Marijuana: Health effects of recreational and medical use
Marijuana is widely used, especially in adolescents and young adults. In the US, there are about 20 million users (about 7.5% of people aged 12 or older). Marijuana is a mind-altering (psychoactive) drug. Similar to hemp, it comes from the cannabis plant. The plant’s primary drug effects come from the chemical delta-9-tetrahydrocannabinol, or “THC.” Marijuana is smoked, “vaped” (inhaling the vapor), or ingested in foods or teas. Over the last few decades, the concentration of THC in the cannabis plant has been increasing. In addition, the plant extracts are more potent. Short-term effects of m...
Source: New Harvard Health Information - August 19, 2016 Category: Consumer Health News Authors: Wynne Armand, MD Tags: Behavioral Health Brain and cognitive health Drugs and Supplements Pain Management Source Type: news

Vertex Abandons Cystic Fibrosis Combo Trial
Boston-based biotech Vertex Pharmaceuticals will end a late-stage clinical study testing a two-drug combination therapy on cystic fibrosis patients after an independent board concluded the treatment wasn ’t showing meaningful benefit. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - August 17, 2016 Category: Pharmaceuticals Source Type: news

Sharing Mayo Clinic: Double Lung Transplant Recipient Beats Cystic Fibrosis
When Tammy Bolerjack was diagnosed with cystic fibrosis at age 18, she found herself frequently in and out of hospitals for treatments to help her breathe. Running 5K races and half-marathons certainly wasn ’t something she envisioned in her future. Little did she know then that eventually a double lung transplant at Mayo Clinic'sFlorida campus would not [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - August 14, 2016 Category: Databases & Libraries Source Type: news

Life And Love With A Chronic Illness
Time, it is a gift that is unassumingly stolen from us with every breath we take. It silently turns summer into fall, moments into memories, and days into decades. We wish it away while desperately clinging to it -- hoping to grip it tightly within the safety of our entangled fingers. But time is not ours to keep -- it's untamable and the very currency for which we trade to write the story of our unique and beautiful lives. Love And CF Eight years later I can still feel the words brushing against my lips as I said, "to have and to hold from this day forward." Forward. If only we truly understood what "forwa...
Source: Healthy Living - The Huffington Post - August 11, 2016 Category: Consumer Health News Source Type: news

Dr. George Scangos: Not just science for science ’s sake
America ’s biopharmaceutical researchers are working tirelessly to develop new and innovative medicines for patients. For those diseases that have no treatment options, the opportunity to improve patients’ lives provides daily inspiration to researchers.In anew video, George Scangos, Ph.D., chief executive officer at Biogen, says it was early in his career when he was researching treatments for children with cystic fibrosis that he fully understood the magnitude of his work. (Source: The Catalyst)
Source: The Catalyst - August 10, 2016 Category: Pharmaceuticals Tags: Alzheimer's Drug Development MS Source Type: news

PharmaTech LLC Issues Voluntary Nationwide Recall Due to Potential Risk of Product Contamination
PharmaTech, LLC of Davie, FL, is voluntarily recalling all liquid products from October 20, 2015 through July 15, 2016 as a precautionary measure due to a potential risk of product contamination with Burkholderia cepacia.If a product contains B. cepacia, its use could result in infections in patients with compromised immune systems and in patients with chronic lung conditions such as cystic fibrosis. Some of these infections may be serious or even life-threatening in the at risk patient population. (Source: Food and Drug Administration)
Source: Food and Drug Administration - August 9, 2016 Category: Food Science Source Type: news

NHS cut raft of new treatments after HIV drug High Court ruling
Toddlers with cystic fibrosis, children born deaf, adults who have lost their legs, and patients with cancer were among those who will no longer have access to planned new treatments. (Source: the Mail online | Health)
Source: the Mail online | Health - August 4, 2016 Category: Consumer Health News Source Type: news

​Vertex plans to apply for approval of the drug that will replace Orkambi next year
Late Tuesday, Vertex Pharmaceuticals gave the latest sales figures for its newest drug to treat cystic fibrosis, called Orkambi, as well as a timeline for approval of the drug it hopes will replace it in a couple years. Shares of Boston-based Vertex (Nasdaq: VRTX) were trading about flat on Thursday morning after the company’s overall revenue and net income figures beat the bar set by analysts. Total revenue for the three months that ended in June was $432 million. That was made up mostly of sales… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 28, 2016 Category: Pharmaceuticals Authors: Don Seiffert Source Type: news

Boy With Cystic Fibrosis Gets Wish To Be Garbage Man During 'Best Day Ever'
One sweet boy’s dream come true involved a lot of trash ― and that’s a good thing.  Ethan Dean, who has cystic fibrosis, has always been fascinated with waste management. So on Tuesday, the 6-year-old had the opportunity to live out his dreams of becoming a garbage man for a day and helped pick up trash around Sacramento, California, thanks to the Make-A-Wish foundation.  The experience, which was documented on social media with the hashtag #EthanCleansUp, was no disappointment as the boy told KCRA that he had the “best day ever!” The boy, who rode in the garbage truck with Waste Manage...
Source: Healthy Living - The Huffington Post - July 27, 2016 Category: Consumer Health News Source Type: news

Vertex Pharma Loss Narrows as Cystic Fibrosis Drug Sales Grow
Vertex Pharmaceuticals Inc. said its second-quarter loss narrowed, as sales of its cystic fibrosis drugs continued to grow. (Source: WSJ.com: Health)
Source: WSJ.com: Health - July 27, 2016 Category: Pharmaceuticals Tags: PAID Source Type: news

DNA sequencing uncovers latent risk for developing cystic fibrosis
All babies with a known mutation for cystic fibrosis (CF) and second mutation called the 5T allele should receive additional screening in order to better predict the risk of developing CF later in life, new research shows. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 25, 2016 Category: Science Source Type: news

DNA sequencing uncovers latent risk for developing cystic fibrosis
( Children's Hospital Los Angeles ) A study by researchers at Children's Hospital Los Angeles (CHLA), Brigham and Women's Hospital and the California Department of Public Health suggests that all babies with a known mutation for cystic fibrosis (CF) and second mutation called the 5T allele should receive additional screening in order to better predict the risk of developing CF later in life. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 25, 2016 Category: Global & Universal Source Type: news

Children 'going blind and risk dying from cancer' as doctors overlook crucial NF1 signs
Despite being more common than cystic fibrosis and being linked to a number of serious complications, the incurable condition neurofibromatosis (NF1) is not checked for in infancy. (Source: the Mail online | Health)
Source: the Mail online | Health - July 24, 2016 Category: Consumer Health News Source Type: news

DNA-modulating drug attenuates lung inflammation in mice
( JCI Journals ) In this issue of JCI Insight, Jay Kolls and colleagues at the University of Pittsburgh demonstrate that bromodomain and extraterminal domain (BET) inhibitors, a class of drugs that alter DNA architecture and change gene expression, attenuate cystic fibrosis lung inflammation. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 21, 2016 Category: Biology Source Type: news

7 Reasons Why Including Protein in Your Diet is a Must
When we think about protein, images of body builders and athletes come to mind. But protein has important health benefits for everyone, not just for sports enthusiasts eager to build muscle. To understand why this nutrient is so necessary in our diets, it's important to understand more about it. Think back to high school science class. Proteins are molecules that make sure that our bodies' organs and tissues function properly. They are also key components in our skin, eyes, hair, bones and nails. Proteins are made up of smaller molecules called amino acids. When we digest protein, the amino acids are what's left. These un...
Source: Healthy Living - The Huffington Post - July 19, 2016 Category: Consumer Health News Source Type: news

PharmaTech LLC Issues Voluntary Nationwide Recall of Diocto Liquid Distributed by Rugby Laboratories Due to Product Contamination
PharmaTech LLC of Davie, FL, the manufacturer of the Rugby®- branded product, is voluntarily recalling all lots within the expiry of Diocto Liquid, a docusate sodium solution due to a risk of product contamination with Burkholderia cepacia. Use of docusate sodium liquid contaminated with B. cepacia may result in serious infections that could be life-threatening in patients with compromised immune systems and in patients with chronic lung conditions such as cystic fibrosis. (Source: Food and Drug Administration)
Source: Food and Drug Administration - July 16, 2016 Category: Food Science Source Type: news

The adorable moment girl claps after giving HERSELF her cystic fibrosis medicine
Talia Coombs, from Warrington, pushes four plastic syringes filled with medication into her mouth without complaint - before clapping and asking for more. The clip has been seen by 100,000 people. (Source: the Mail online | Health)
Source: the Mail online | Health - July 13, 2016 Category: Consumer Health News Source Type: news

Personalized Medicine: The Way Forward?
This article will look at some of the strategies already available to help healthcare professionals meet individual patient needs, in the multifaceted field of personalized medicine. Personalizing drug therapy for depression Research suggests that around 50 percent of patients with depression do not respond to first-line antidepressants. What can explain this, and how can it be solved? Current treatment is often a case of trial and error. A patient may take one medication after another, often for 12 weeks or more each time, while symptoms remain the same, or worsen. A team from King's College London in the United Kingd...
Source: Healthy Living - The Huffington Post - July 6, 2016 Category: Consumer Health News Source Type: news

Cystic fibrosis sufferer claims POLE VAULTING saved his life 
When Jerry Cahill was diagnosed in New York in 1974, cystic fibrosis sufferers were not expected to live past 16. Even now, the average life expectancy of a CF sufferer is 36. Jerry is 60. (Source: the Mail online | Health)
Source: the Mail online | Health - July 4, 2016 Category: Consumer Health News Source Type: news

Breathing in a Cure: Inhalable Ibuprofen on the Horizon
Ibuprofen: You can buy it at any drug store, and it will help with that stabbing headache or sprained ankle. One of the ways it does so is by reducing inflammation, and it is this property that may also help patients with cystic fibrosis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 2, 2016 Category: Science Source Type: news