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Target 2 forms of iron to control cystic fibrosis lung infection
(American Society for Microbiology) The bacterium Pseudomonas aeruginosa needs iron to establish and maintain a biofilm in the lungs of cystic fibrosis patients, and therapies have been proposed to deprive the bacteria of this necessary element. However, these techniques may not work, according to a new study published in mBio®, the online open-access journal of the American Society for Microbiology, because they only target one of the two types of iron that are available in the lung. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 20, 2013 Category: Global & Universal Source Type: news

Evolution of hyperswarming bacteria could develop anti-biofilm therapies
(Cell Press) Hyperswarming, pathogenic bacteria have repeatedly evolved in a lab, and the good news is that they should be less of a problem to us than their less mobile kin. That's because those hyperswarmers, adorned with multiple whipping flagella, are also much worse at sticking together on surfaces in hard-to-treat biofilms. They might even help us figure out a way to develop anti-biofilm therapies for use in people with cystic fibrosis or other conditions. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 15, 2013 Category: Infectious Diseases Source Type: news

Study identifies 3 enzymes required for building sugar superstructure involved in muscular dystrophies
For many inherited diseases, such as cystic fibrosis or Huntington disease, the disease-causing genetic mutation damages or removes a protein that has an essential role in the body. This protein defect is the root cause of the disease symptoms. However, for a group of muscular dystrophies known collectively as congenital muscular dystrophies (CMDs), the sequence of the protein that is central to normal function is typically unaffected. Instead, the defects lie in processing proteins - ones that are responsible for modifying the central protein by adding sugar chains (glycans)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 12, 2013 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

Doctor has cystic fibrosis
Dr. Chuck Fox was born with cystic fibrosis and raised with a resilient spirit which helps him beat the odds. (Source: CNN.com - Health)
Source: CNN.com - Health - August 1, 2013 Category: Consumer Health News Source Type: news

Becoming a doctor against all odds
Living with a chronic illness is like walking on a treadmill that never stops, says Chuck Fox, who has cystic fibrosis. (Source: CNN.com - Health)
Source: CNN.com - Health - July 31, 2013 Category: Consumer Health News Source Type: news

IV Antibiotics and Aspergillus in Sputum From Adults With CFIV Antibiotics and Aspergillus in Sputum From Adults With CF
Does a reduced oral colony count of Aspergillus translate into improved outcomes for adults with cystic fibrosis? Thorax (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 31, 2013 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Cystic fibrosis wonder drug can give my girl a future
FOR the first time since Maisie Black was a baby her parents are daring to hope she will enjoy a long and full life. (Source: Daily Express - Health)
Source: Daily Express - Health - July 29, 2013 Category: Consumer Health News Source Type: news

A Big Step Forward in Cystic FibrosisA Big Step Forward in Cystic Fibrosis
A study offers new evidence on the efficacy of a drug approved last year by the FDA to treat cystic fibrosis in patients carrying the G551D gene mutation. Medscape Pulmonary Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 15, 2013 Category: Consumer Health News Tags: Pulmonary Medicine Viewpoint Source Type: news

Next Generation Diagnostics of Cystic FibrosisNext Generation Diagnostics of Cystic Fibrosis
The authors present a novel and efficient strategy for the complete molecular characterization of the cystic fibrosis transmembrane regulator gene, based on multiplexed targeted resequencing. Journal of Medical Genetics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 15, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

New Avenue For Improved Treatment Of Cystic Fibrosis
Cystic fibrosis is caused by a mutation in the gene that encodes a particular protein, known as the cystic fibrosis transmembrane conductance regulator (or CFTR). Although this discovery was made 25 years ago and the lives of those with the disease have been extended, there is still no effective cure for the disease. Now new information about the nature of the most common form of mutation in the CFTR gene, gathered by a research team led by Dr. Gergely Lukacs of the Department of Physiology at McGill University, offers exciting new avenues for improving the treatment of the disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 10, 2013 Category: Consumer Health News Tags: Cystic Fibrosis Source Type: news

Deciphering The Cellular 'Roadmap' Of Disease-Related Proteins
University of Toronto researchers are helping demystify an important class of proteins associated with disease, a discovery that could lead to better treatments for cancer, cystic fibrosis and many other conditions. Igor Stagljar, Professor in the Faculty of Medicine's Donnelly Centre for Cellular and Biomolecular Research, and his team developed the first roadmap for ATP-binding cassette (ABC) transporter proteins. These proteins are crucial components of every cell, and are also involved in tumor resistance... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 9, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Clinical Notes: Qsymia Reaches Retail Outlets
(MedPage Today) -- The maker of Qsymia said sales of the obesity drug from brick-and-mortar drugstores had begun. Also this week: a once-daily treatment for cystic fibrosis lung infections is effective. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - July 7, 2013 Category: Cardiology Source Type: news

Scientists decipher cellular 'roadmap' of disease-related proteins
(University of Toronto) University of Toronto researchers are helping demystify an important class of proteins associated with disease, a discovery that could lead to better treatments for cancer, cystic fibrosis and many other conditions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 7, 2013 Category: Global & Universal Source Type: news

Communication Between Bacteria Helps Them Resist Antibiotics
New research from Western University unravels a novel means of communication that allows bacteria such as Burkholderia cenocepacia (B. cenocepacia) to resist antibiotic treatment. B. cenocepacia is an environmental bacterium that causes devastating infections in patients with cystic fibrosis (CF) or with compromised immune systems. Dr. Miguel Valvano and first author Omar El-Halfawy, PhD candidate, show that the more antibiotic resistant cells within a bacterial population produce and share small molecules with less resistant cells, making them more resistant to antibiotic killing... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 6, 2013 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Alendronate Boosts Bone Density in Young With Cystic FibrosisAlendronate Boosts Bone Density in Young With Cystic Fibrosis
In young cystic fibrosis (CF) patients with low bone density who do not respond sufficiently to calcium and calcifediol alone, adding alendronate may help, a randomized trial has shown. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 5, 2013 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Manchester Researchers Discover Half Of All Adults With Cystic Fibrosis Affected By Airborne Fungus
Experts believe a pioneering breakthrough by a Manchester hospital research team could pave the way for doctors to better understand and treat adults with Cystic Fibrosis (CF), helping them live longer and healthier lives. CF is the commonest inherited genetic disease in Europe and the US affecting tens of thousands of people. Although significant advances in care have improved - with some patients now surviving into their 40's and 50's - it remains incurable... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 4, 2013 Category: Consumer Health News Tags: Cystic Fibrosis Source Type: news

Bacteria communicate to help each other resist antibiotics
(University of Western Ontario) New research from Western University (Canada) unravels a novel means of communication that allows bacteria such as Burkholderia cenocepacia (B. cenocepacia) to resist antibiotic treatment. B. cenocepacia is an environmental bacterium that causes devastating infections in patients with cystic fibrosis. Dr. Miguel Valvano and first author Omar El-Halfawy, show that the more antibiotic resistant cells within a bacterial population produce and share small molecules with less resistant cells, making them more resistant to antibiotic killing. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 3, 2013 Category: Global & Universal Source Type: news

Pennsylvania girl who got lung transplants recovering from more surgery
(Reuters) - A 10-year-old Pennsylvania girl with cystic fibrosis who sparked a national debate about child access to organ donations that led to two lung transplant operations was in recovery on Tuesday after surgery to repair her diaphragm, her family said. (Source: Reuters: Health)
Source: Reuters: Health - July 3, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Newspath July 2013 - Diagnostics in Cystic Fibrosis
Cystic fibrosis affects roughly one in every 2,800 United States newborns each year, making it the most common life-threatening autosomal recessive disease in America. (Source: NewsPath - Pathology News for the Medical Community)
Source: NewsPath - Pathology News for the Medical Community - July 2, 2013 Category: Pathology Source Type: news

Arikace Noninferior for Pseudomonas in Cystic FibrosisArikace Noninferior for Pseudomonas in Cystic Fibrosis
Insmed Inc's experimental lung infection drug fared no better than a competing drug developed by Novartis AG in a lung function test. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 1, 2013 Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news

Replacing Organs without Organ Donors
The recent plight of cystic fibrosis sufferer 10-year Sarah Murnagham created somewhat of a controversy about organ donation. She required hospitalization due to her failing lungs, and it wasn't clear she would be able to get a new pair from a donor in time to save her life. Although she did get lungs in time, not everyone does. There are less organs than people that need them....Read Full Post (Source: About.com Biotech Biomedical)
Source: About.com Biotech Biomedical - July 1, 2013 Category: Biotechnology Source Type: news

How Common Are Gastric Ulcers?
Discussion The exact cause of gastric and upper intestinal inflammation and ulceration are not entirely understood. Imbalances between irritative factors and mucosal defenses underlie it. Gastric acid production is at adult levels by 3-4 years. Actual ulceration is associated with a lower acid secretion for gastric ulcerations but are increased in duodenal ulcerations in both adults and children. In adults changes to the mucus layer of the stomach and duodenum and bicarbonate secretion play a part in upper GI inflammation and ulcerations. Genetic studies have been linked to differences in both acid production, and mucosal ...
Source: PediatricEducation.org - July 1, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Casting Doubts On The Molecular Mechanism Of 'Read-Through' Drug PTC124/Ataluren
A drug developed to treat genetic diseases such as Duchenne muscular dystrophy and cystic fibrosis may need a radical rethink. In a new study published in the open access journal PLOS Biology, researchers question the mechanistic basis of the drug called PTC124 (also known as Ataluren), casting doubt as to whether it has the molecular effects that are claimed for it. This may have implications for its effectiveness in treating genetic diseases. An estimated 10% of all human genetic diseases are caused by nonsense mutations... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 27, 2013 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

Nanotech roundup: ultra-colour TV, nano-flowers and Trojan blood cells | Ros Daw
In this month's roundup we describe the use of quantum dots in LCD TVs to enhance colour, nanoscale flower arrangements and nanoparticles hidden in blood cellsTV in nanotechnicolourThe next generation of LCD televisions from Sony use quantum dots to improve the colour performance of their screens. Quantum dots are light-emitting nanoparticles. New Scientist reports that Sony's Triluminos sets, which use tubes of quantum dots stimulated by blue light-emitting diodes, are now available in stores.Meanwhile, 3M has developed quantum dot films, also stimulated by blue LEDs, that are designed to improve colour intensity with red...
Source: Guardian Unlimited Science - June 25, 2013 Category: Science Authors: Ros Daw Tags: Blogposts guardian.co.uk Nanotechnology Television Physics Chemistry Science Source Type: news

Fatal Pulmonary Mycobacterium abscessus Infection in an Immunosuppressed Patient
We present a case of M. abscessus pulmonary infection in a patient with a history of glomerulonephritis, hepatitis B infection, cystic fibrosis, type II diabetes, and obesity as underlying compromising conditions. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - June 22, 2013 Category: Microbiology Authors: Matilde María Palanca Giménez, Esther López Pérez, Pilar Sanz Poveda, Elena Abarca Cidón Source Type: news

Clinical Use of Exhaled VOCs in Pulmonary DiseasesClinical Use of Exhaled VOCs in Pulmonary Diseases
Are there different 'breath-prints' for asthma, lung cancer, COPD, and cystic fibrosis? Respiratory Research (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 21, 2013 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

10-year-old girl gets adult lungs
Sarah Murnaghan, a 10-year-old Pennsylvania girl with cystic fibrosis whose family fought to have her prioritized for adult organs, got a new set of lungs Wednesday, her family said. (Source: CNN.com - Health)
Source: CNN.com - Health - June 18, 2013 Category: Consumer Health News Source Type: news

Girl gets adult lungs
Sarah Murnaghan, a 10-year-old Pennsylvania girl with cystic fibrosis whose family fought to have her prioritized for adult organs, got a new set of lungs Wednesday, her family said. (Source: CNN.com - Health)
Source: CNN.com - Health - June 13, 2013 Category: Consumer Health News Source Type: news

10-year-old girl gets long-awaited lung transplant
Sarah Murnaghan, a 10-year-old Pennsylvania girl with cystic fibrosis whose family fought to have her prioritized for adult organs, got a new set of lungs Wednesday, her family said. (Source: CNN.com - Health)
Source: CNN.com - Health - June 13, 2013 Category: Consumer Health News Source Type: news

Girl's long-awaited lung transplant complete
Sarah Murnaghan, a 10-year-old Pennsylvania girl with cystic fibrosis whose family fought to have young children prioritized for adult organs, received new lungs Wednesday, her family told CNN. Her surgery took about six hours, and there were no comp... (Source: WDSU.com - Health)
Source: WDSU.com - Health - June 13, 2013 Category: Consumer Health News Source Type: news

Mother says Pennsylvania girl's lung transplant a success
(Reuters) - A 10-year-old Pennsylvania girl with cystic fibrosis who only became eligible for an adult organ transplant because of a federal judge's order is out of surgery after a double-lung transplant on Wednesday and doing well, her mother said. (Source: Reuters: Health)
Source: Reuters: Health - June 13, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

National Briefing | Mid-Atlantic: Pennsylvania: Girl Gets Adult Lungs
Sarah Murnaghan, 10, who has cystic fibrosis, underwent successful surgery at Children’s Hospital of Philadelphia, a family spokeswoman said.     (Source: NYT Health)
Source: NYT Health - June 13, 2013 Category: Consumer Health News Authors: By THE ASSOCIATED PRESS Tags: Murnaghan, Sarah Pennsylvania Transplants Children's Hospital of Philadelphia Lungs Source Type: news

Pennsylvania girl gets lung transplant after judge's order
(Reuters) - A 10-year-old Pennsylvania girl with cystic fibrosis, who only became eligible for an adult organ transplant because of a judge's order, on Wednesday received a double-lung transplant from an adult donor, her family said. (Source: Reuters: Health)
Source: Reuters: Health - June 13, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Girl gets long-awaited lung transplant
Sarah Murnaghan, a 10-year-old Pennsylvania girl with cystic fibrosis whose family fought to have her prioritized for adult organs, got a new set of lungs Wednesday, her family said. (Source: CNN.com - Health)
Source: CNN.com - Health - June 13, 2013 Category: Consumer Health News Source Type: news

Video: 10-year-old who sued for adult lung gets transplant
Sarah Murnaghan, a 10-year-old Pennsylvania girl with cystic fibrosis, will receive a new set of adult lungs. The transplant comes just days after a federal judge granted her family's request to suspend a rule that blocked her from being put on a waiting list for an adult lung because of her age. Marlie Hall speaks to Sarah's mother Janet Murnaghan. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - June 12, 2013 Category: Consumer Health News Source Type: news

Pennsylvania girl gets lung transplant after judge's order
(Reuters) - A 10-year-old Pennsylvania girl with cystic fibrosis, who only became eligible for an adult organ transplant because of a judge's order, on Wednesday received a double-lung transplant from an adult donor, her family said. (Source: Reuters: Health)
Source: Reuters: Health - June 12, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Mother loses son, fights for other
Milagros Martinez endured losing one of her sons to cystic fibrosis before he could get a lung transplant. (Source: CNN.com - Health)
Source: CNN.com - Health - June 12, 2013 Category: Consumer Health News Source Type: news

Girl to get long-awaited lung transplant
Sarah Murnaghan, a 10-year-old Pennsylvania girl with cystic fibrosis whose family fought to have her prioritized for adult organs, is getting a new set of lungs Wednesday, her family said. (Source: CNN.com - Health)
Source: CNN.com - Health - June 12, 2013 Category: Consumer Health News Source Type: news

Girl who needed judge's order to be on transplant list to get new lung
(Reuters) - A lung donor has been found for a 10-year-old girl with cystic fibrosis who only became eligible for an adult organ transplant because of a judge's order, her mother said on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - June 12, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

CHCF Innovation Fund invests $1M in Asthmapolis
The California Health Care Foundation’s CHCF Innovation Fund announced this week that it has invested a total of slightly more than $1 million in Madison, Wisconsin-based Asthmapolis, which offers a FDA-cleared inhaler sensor and app for people with asthma, COPD, or cystic fibrosis. CHCF has made two investments in Asthmapolis over the years but the bulk of [...] (Source: mobihealthnews)
Source: mobihealthnews - June 11, 2013 Category: Information Technology Authors: Brian Dolan Tags: Uncategorized Amerigroup Florida Asthmapolis California Health Care Foundation CHCF City of Louisville digital health investments Dignity Health FDA cleared smartphone apps iPhone medical apps mobile asthma management The Social Capi Source Type: news

Vote Aids Children Under 12 Seeking Lung Transplant
Officials with the Organ Procurement and Transplantation Network voted in an emergency meeting to create a new avenue for children seeking lung transplants.     (Source: NYT Health)
Source: NYT Health - June 11, 2013 Category: Consumer Health News Authors: By ABBY GOODNOUGH Tags: Cystic Fibrosis Murnaghan, Sarah Organ Procurement and Transplantation Network Decisions and Verdicts Transplants Sebelius, Kathleen Health and Human Services Department Lungs Acosta, Javier Children and Childhood Source Type: news

Nebulizer to treat cystic fibrosis
Scientific observation of surfers with cystic fibrosis (CF) has led to the discovery that the inhaled mist of seawater has a therapeutic effect on the lung problems associated with the disease. These findings are now being used by pharmaceutical company Parion Sciences and product development firm Cambridge Consultants in a revolutionary new aerosol delivery system, which enables CF sufferers to get the benefits of saltwater treatment at home while they sleep. “We have seen evidence that routine exposure to salt water reduces the number of lung infections in CF patients and leads to fewer hospital admissions –...
Source: Articles from MedicalDesign.com - June 10, 2013 Category: Medical Equipment Tags: Products Source Type: news

Mom lost son, fights to save other
Milagros Martinez endured losing one of her sons to cystic fibrosis before he could get a lung transplant. Now she's hoping her younger boy, Javier Acosta, 11, will get such an operation in time. (Source: CNN.com - Health)
Source: CNN.com - Health - June 10, 2013 Category: Consumer Health News Source Type: news

Mother who lost one son fights for young son
Milagros Martinez endured losing one of her sons to cystic fibrosis before he could get a lung transplant. Now she's hoping her younger boy, Javier Acosta, 11, will get such an operation in time. (Source: WDSU.com - Health)
Source: WDSU.com - Health - June 9, 2013 Category: Consumer Health News Source Type: news

Mother pleads for child's lung transplant
The case of Millie Martinez's son Javier, who has cystic fibrosis, highlights the issue of organ donor policy when it comes to children (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - June 8, 2013 Category: Consumer Health News Source Type: news

Mom lost one son, fights to save other
Milagros Martinez endured losing one of her sons to cystic fibrosis before he could get a lung transplant. Now she's hoping her younger boy, Javier Acosta, 11, will get such an operation in time. (Source: CNN.com - Health)
Source: CNN.com - Health - June 8, 2013 Category: Consumer Health News Source Type: news

Cystic Fibrosis: New Assay May Help Individualize CareCystic Fibrosis: New Assay May Help Individualize Care
A simple cell culture assay may facilitate personalized diagnosis and treatment of patients with cystic fibrosis. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 6, 2013 Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news

Cystic Fibrosis: Bisphosphonate Ups Bone Density in ChildrenCystic Fibrosis: Bisphosphonate Ups Bone Density in Children
Osteoporosis drug increased bone mineral density in children with cystic fibrosis in a randomized controlled trial, with some participants reaching normal density for their age. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 6, 2013 Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news

Video: Judge grants exception for 10-year-old's lung transplant
A 10-year-old girl with cystic fibrosis that desperately needs a lung transplant now has a better chance of getting one, thanks to a judge's decision. CBS News' Terrell Brown reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - June 6, 2013 Category: Consumer Health News Source Type: news

Osteoporosis Drug Aids Young People With Cystic Fibrosis Not Helped By Standard Treatments
The first randomised trial to investigate the treatment of low bone density in young people with cystic fibrosis (CF), published Online First in The Lancet Respiratory Medicine, provides compelling evidence that alendronate (a drug that curbs bone loss) is safe and can help increase bone mineral density (BMD) in young patients with CF after standard treatment with calcium and vitamin D has failed. Improvements in treatments have increased the life expectancy of people with CF to about 40 years, putting them at high risk of long-term complications such as osteoporosis and bone fractures... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 6, 2013 Category: Consumer Health News Tags: Cystic Fibrosis Source Type: news