New technique for testing drugs to treat cystic fibrosis and epilepsy
Researchers from the University of Southampton, in collaboration with researchers at the University of Quebec at Montreal, have developed a new microsystem for more efficient testing of pharmaceutical drugs to treat diseases such as cystic fibrosis, MG (myasthenia gravis) and epilepsy.A large percentage of pharmaceutical drugs target ion channels, which are proteins found in a cell's membrane, that play a pivotal role in these serious disorders and that are used to test the effectiveness of new drugs. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 30, 2013 Category: Consumer Health News Tags: Pharma Industry / Biotech Industry Source Type: news

FDA Approves New Gene-Sequencing Devices
The FDA approved four "next-generation" gene-sequencing devices with the potential to make faster and more precise diagnoses of cystic fibrosis. (Source: WSJ.com: Health)
Source: WSJ.com: Health - November 20, 2013 Category: Pharmaceuticals Tags: PAID Source Type: news

Medical Breakthrough Gives Couples Who Want Children New Hope
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 20, 2013 Category: Consumer Health News Authors: deanreddington Tags: Health Local News Seen On WBZ-TV Syndicated Local Watch Listen cystic fibrosis Dr. Ian Hardy Fragile X Pompeii Disease Preimplantation Genetic Diagnosis Spinal Muscular Atrophy Tay-Sachs Source Type: news

The thyroid gland and cystic fibrosis
Research in the College of Veterinary Medicine at Kansas State University is leading to a better understanding of the molecular interactions in the thyroid gland related to cystic fibrosis. A genetic disorder, cystic fibrosis affects the function of epithelia, the tissues formed of cells that secrete and absorb an array of substances important for health. The university's Peying Fong, associate professor of anatomy and physiology, has received a $285,000 grant from the Department of Health and Human Services in support of her study, "CFTR Regulation of Thyroid Transport... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 31, 2013 Category: Consumer Health News Tags: Cystic Fibrosis Source Type: news

Queen's University in €6m bid to find new Cystic Fibrosis treatments
(Queen's University Belfast) The new global program, known as CF Matters, aims to develop personalized antibiotic treatments for these chest infections. The work could revolutionize the practice of antibiotic prescription and limit resistance to the drugs globally. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 29, 2013 Category: Global & Universal Source Type: news

Thyroid project sheds light on molecular processes related to cystic fibrosis
(Kansas State University) Veterinary medicine research is leading to a better understanding of the molecular interactions in the thyroid gland related to cystic fibrosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 29, 2013 Category: Global & Universal Source Type: news

Study on transitioning cystic fibrosis care
Children's National pediatrician and researcher, Lisa Tuchman, MD, MPH, co-authored a new study on cystic fibrosis (CF) care that found patients had a less rapid decline in pulmonary function and no other significant health-related changes after transitioning from pediatric to adult care. The findings of this study contradict reports of negative health outcomes after transition from pediatric to adult care for other chronic childhood illnesses such as HIV and sickle cell disease. The study was published online in Pediatrics, the official journal of the American Academy of Pediatrics... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 25, 2013 Category: Consumer Health News Tags: Cystic Fibrosis Source Type: news

Did Insmed Release Shaky Data for its Arikace Drug?
Financial reporters from TheStreet.com question Insmed's analysis of Arikace Cystic Fibrosis study (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - October 24, 2013 Category: Pharmaceuticals Source Type: news

Ivacaftor Treatment of Cystic Fibrosis PatientsIvacaftor Treatment of Cystic Fibrosis Patients
Current cystic fibrosis care is supportive, but recent breakthroughs have occurred with the advent of novel therapeutic strategies that assist the function of mutant CFTR proteins. Therapeutic Advances in Respiratory Disease (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 23, 2013 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Children's National researcher co-authors study on transitioning cystic fibrosis care
(Children's National Medical Center) Children's National pediatrician and researcher, Lisa Tuchman, M.D., M.P.H., co-authored a new study on cystic fibrosis care that found patients had a less rapid decline in pulmonary function and no other significant health-related changes after transitioning from pediatric to adult care. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 23, 2013 Category: Global & Universal Source Type: news

Personal Independence Payment
Opinion piece by a woman with cystic fibrosis on how the reduction of the ability to walk criteria to 20m in the new PIP benefit that is replacing DLA will lead to more people becoming effectively housebound and reduce ability to work. Guardian Benefits and tax credits - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - October 21, 2013 Category: Neurology Source Type: news

How to separate the good from the bad in bacteria
There are good bacteria and there are bad bacteria -- and sometimes both coexist within the same species. Take, for instance, Pseudomonas aeruginosa, a microbe common in soil and water. This bacterium has been found to colonize medical equipment in hospitals and clinics around the world, and can live benignly in healthy individuals. But the bug poses a risk to those with weakened immune systems, and can turn pathogenic in patients with cystic fibrosis, forming thick layers of mucus in the lungs... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 19, 2013 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Just 1 CF Patient per Meeting?
(MedPage Today) -- Cystic fibrosis researcher Paul M. Quinton, PhD, planned to attend his field's major conference this week, but there was just one problem: He has the disease himself. (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - October 18, 2013 Category: Infectious Diseases Source Type: news

Separating the good from the bad in bacteria
(Massachusetts Institute of Technology) New microfluidic technique quickly distinguishes bacteria within the same strain; could improve monitoring of cystic fibrosis and other diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2013 Category: Global & Universal Source Type: news

Ella’s legacy: Turning tragedy into an international advocacy network for PVNH
By Yolaine Dupont Ella She was born in Vancouver, British-Columbia at 39 weeks, weighing 5 lbs. and 7 oz. With a nearly flawless APGAR score, her father’s mouth and nose, along with my eyes and full set of dark hair. Just as I imagined she would be, Ella was picture perfect. Still, I had an uneasy feeling. Ella was frail, and her breathing seemed off. I mentioned it to her doctor and nurse, only to be quickly reassured that all was okay. After five days, I took her home. But that upsetting feeling would not go away. The old expression “Mom knows best” turned out to be true. By Ella’s second mon...
Source: Thrive, Children's Hospital Boston - October 15, 2013 Category: Pediatrics Authors: Guest Blogger Tags: All posts Diseases & conditions Our patients’ stories Research cytomegalovirus our patients' stories PVNH Source Type: news

Flatley Discovery Lab to pursue development of FDL169 for cystic fibrosis treatment
US-based Flatley Discovery Lab plans to develop FDL169, an orally available small molecule, as a clinical candidate for the treatment of cystic fibrosis (CF). (Source: Drug Development Technology)
Source: Drug Development Technology - October 14, 2013 Category: Pharmaceuticals Source Type: news

Celtaxsys begins patient enrolment for first clinical study of cystic fibrosis drug
US-based clinical stage drug discovery and development firm Celtaxsys has started enrolling patients for its first trial of its lead clinical stage drug candidate, CTX-4430, to treat patients with cystic fibrosis (CF) lung disease. (Source: Drug Development Technology)
Source: Drug Development Technology - October 13, 2013 Category: Pharmaceuticals Source Type: news

Synedgen to Report Promising Research at National Cystic Fibrosis...
Potential Treatment to Improve Lung Function and Antibiotic Effectiveness in Patients with Cystic Fibrosis(PRWeb October 09, 2013)Read the full story at http://www.prweb.com/releases/2013/10/prweb11210927.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - October 9, 2013 Category: Pharmaceuticals Source Type: news

Kalydeco: A Price Too High to Pay?
(MedPage Today) -- A MedPage Today/Milwaukee Journal Sentinel report revealed the staggering annual treatment cost for the cystic fibrosis drug ivacaftor (Kalydeco) as part of an investigation of venture philanthrophy -- now a JAMA Viewpoint echoes those findings. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - October 2, 2013 Category: Pediatrics Source Type: news

Scientists are unraveling the secrets of the mechanism that snips our genes
Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing. These conditions are difficult to prevent because scientists are still grasping to understand how the splicing process works. Now, researchers from Brandeis University and the University of Massachusetts Medical School have teamed up to unravel a major component in understanding the process of RNA splicing... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 1, 2013 Category: Consumer Health News Tags: Genetics Source Type: news

Queen's scientist to target Cystic Fibrosis superbug
(Queen's University Belfast) Queen's University Belfast is to lead a £139,000 study into the way cystic fibrosis sufferers are affected by a superbug that destroys lung function. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 1, 2013 Category: Global & Universal Source Type: news

Dartmouth researchers receive $5.9 million grant from NIH for lung research
(The Geisel School of Medicine at Dartmouth) The NIH has awarded a $5.9 million grant to support an Institutional Development Award Lung Biology Center of Biomedical Research Excellence (COBRE) at the Geisel School of Medicine at Dartmouth.For the past 10 years, COBRE funding has supported the Center's work, which has contributed not only to our understanding of cystic fibrosis and to the development of patented and patent-pending therapeutic approaches for treating the disease, but to other chronic lung diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 30, 2013 Category: Global & Universal Source Type: news

Disease-specific human embryonic stem cell lines placed on NIH Stem Cell Registry
Scientists from King's College London have announced that 16 human embryonic stem (hES) cell lines have been approved by the US National Institutes of Health (NIH) and placed on their Stem Cell Registry, making them freely available for federally-funded research in the USA. The stem cell lines, which carry genes for a variety of hereditary disorders such as Huntington's disease, spinal muscular dystrophy and cystic fibrosis, are considered to be ideal research tools for designing models to understand disease progression, and ultimately in helping scientists develop new treatments for patients... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 27, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Ground-breaking MRC-NIHR funded Cystic Fibrosis gene therapy study features on BBC Radio 4
The Chief Investigator for a pioneering clinical trial funded through the MRC-NIHR Efficacy and Mechanism Evaluation programme, Professor Eric Alton, was interviewed on the BBC Radio 4 Today programme (Friday 16 March, 2012). Professor Alton described how it was hoped the ground-breaking, world-leading research study, a cystic fibrosis (CF) gene therapy trial, could eventually lead to a cure... (Source: NIHR Evaluation, Trials and Studies News)
Source: NIHR Evaluation, Trials and Studies News - September 26, 2013 Category: American Health Source Type: news

Funding boost for cystic fibrosis gene therapy trial
A pioneering clinical trial that could lead to a potentially life-changing new treatment for cystic fibrosis (CF) has received a £3.1m funding boost from the Medical Research Council (MRC) and the National Institute for Health Research (NIHR). The research, which has been supported by the Cystic Fibrosis Trust for a decade, had faced an uncertain... (Source: NIHR Evaluation, Trials and Studies News)
Source: NIHR Evaluation, Trials and Studies News - September 20, 2013 Category: American Health Source Type: news

Celtaxsys completes Phase I study of CTX-4430 in cystic fibrosis patients
US-based clinical stage drug firm Celtaxsys has completed the Phase I clinical trial of its lead clinical stage drug candidate, CTX-4430 to treat patients with cystic fibrosis (CF) lung disease. (Source: Drug Development Technology)
Source: Drug Development Technology - September 16, 2013 Category: Pharmaceuticals Source Type: news

Potential new drug target for cystic fibrosis
(European Molecular Biology Laboratory) Scientists at EMBL Heidelberg, Regensburg University, and the University of Lisboa have discovered a promising potential drug target for cystic fibrosis. Their work, published online today in Cell, also uncovers a large set of genes not previously linked to the disease, demonstrating how a new screening technique can help identify new drug targets. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 13, 2013 Category: Global & Universal Source Type: news

Irish-led project has potential to revolutionise cystic fibrosis treatment
New €6m project to design personal antibiotic prescription     (Source: The Irish Times - Health)
Source: The Irish Times - Health - September 13, 2013 Category: Consumer Health News Source Type: news

ChanTest Announces a Global Campaign to Share New Findings and...
ChanTest is a world leader in drug safety and discovery, in areas particularly relevant to Cystic Fibrosis.(PRWeb September 11, 2013)Read the full story at http://www.prweb.com/releases/2013/9/prweb11078923.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - September 12, 2013 Category: Pharmaceuticals Source Type: news

Road traffic pollution increases risk of death for bronchiectasis patients
Living close to a busy road is associated with a higher risk of death in people with bronchiectasis. A new study, presented at the European Respiratory Society (ERS) Annual Congress in Barcelona on 8 September 2013, has added to the growing body of evidence demonstrating the damaging effects of road-side pollution. Bronchiectasis is a condition in which the airways of the lungs become abnormally widened, leading to a build-up of excess mucus. It can be caused by cystic fibrosis (CF), and experts usually categorise the condition as cases either due to CF or not... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 10, 2013 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

Activaero and Chiesi to develop new treatment solution for cystic fibrosis patients
Germany-based Activaero has entered into research collaboration with Italian pharmaceutical firm Chiesi Farmaceutici for the development of an effective solution to treat patients with cystic fibrosis (CF). (Source: Drug Development Technology)
Source: Drug Development Technology - September 9, 2013 Category: Pharmaceuticals Source Type: news

Cystic fibrosis sufferer Natalie McCusker gains top exam results despite needing lung transplant
Natalie McCusker, from Greater Manchester, got four As and a B in her AS-levels while waiting for urgent treatment for cystic fibrosis. (Source: the Mail online | Health)
Source: the Mail online | Health - September 4, 2013 Category: Consumer Health News Source Type: news

Discovery of 105 additional genetic errors that cause cystic fibrosis
Of the over 1,900 errors already reported in the gene responsible for cystic fibrosis (CF), it is unclear how many of them actually contribute to the inherited disease. Now a team of researchers reports significant headway in figuring out which mutations are benign and which are deleterious. In so doing, they have increased the number of known CF-causing mutations from 22 to 127, accounting for 95 percent of the variations found in patients with CF... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 28, 2013 Category: Consumer Health News Tags: Cystic Fibrosis Source Type: news

Sarah Murnaghan, girl who successfully sued for adult lung transplants, goes home
11-year-old was dying of end-stage cystic fibrosis before receiving two adult lung transplants in June (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - August 27, 2013 Category: Consumer Health News Source Type: news

Real Couple, Real Progress
We will be coaching a couple and sharing their progress as they work through 8 relationship-building assignments from "Lifelong Love". Other readers may work through the assignments as they are posted and share their progress on the blog. read more (Source: Psychology Today Parenting Center)
Source: Psychology Today Parenting Center - August 27, 2013 Category: Psychiatry & Psychology Authors: Phyllis R. Koch-Sheras, Ph.D. and Peter L. Sheras, Ph.D, ABPP Tags: Parenting Relationships Self-Help ADHD brief summary brink children with disability couples cystic fibrosis decade deliberation dual career couple good relationship joint vision lucky contest winners match Obsessive Compuls Source Type: news

Gene Study Helps Advance Diagnosis of Cystic Fibrosis
Title: Gene Study Helps Advance Diagnosis of Cystic FibrosisCategory: Health NewsCreated: 8/26/2013 2:36:00 PMLast Editorial Review: 8/27/2013 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - August 27, 2013 Category: Respiratory Medicine Source Type: news

Gene Study Helps Advance Diagnosis of Cystic Fibrosis
Findings may help determine if person has the lung disease or is a carrier, and might aid treatment (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - August 27, 2013 Category: Respiratory Medicine Authors: webmaster at doctorslounge.com Tags: Infections, Nursing, Pulmonology, Research, News, Source Type: news

Transplant gives Sarah chance to live dreams
Sarah Murnaghan fully understands all she's been through: her lifelong battle with cystic fibrosis that led to her deteriorating lungs, the campaign her parents waged that temporarily changed national policy surrounding organ transplants, and the fact that she came so close to death in the days leading up to her two double lung transplants. (Source: WDSU.com - Health)
Source: WDSU.com - Health - August 26, 2013 Category: Consumer Health News Source Type: news

Gene Study Helps Advance Diagnosis of Cystic Fibrosis
Findings may help determine if person has the lung disease or is a carrier, and might aid treatment Source: HealthDay Related MedlinePlus Pages: Cystic Fibrosis, Genes and Gene Therapy (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 26, 2013 Category: Consumer Health News Source Type: news

'Mommy, I knew I was dying'
Sarah Murnaghan's lifelong battle with cystic fibrosis led to her deteriorating lungs, and a temporary national policy change on organ transplants. (Source: CNN.com - Health)
Source: CNN.com - Health - August 26, 2013 Category: Consumer Health News Source Type: news

Scientists Pinpoint 105 Additional Genetic Errors that Cause Cystic Fibrosis - 8/26/13
Of the over 1,900 errors already reported in the gene responsible for cystic fibrosis (CF), it is unclear how many of them actually contribute to the inherited disease. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - August 26, 2013 Category: Research Source Type: news

Scientists pinpoint 105 additional genetic errors that cause cystic fibrosis
(Johns Hopkins Medicine) Of the over 1,900 errors already reported in the gene responsible for cystic fibrosis (CF), it is unclear how many of them actually contribute to the inherited disease. Now a team of researchers reports significant headway in figuring out which mutations are benign and which are deleterious. In so doing, they have increased the number of known CF-causing mutations from 22 to 127, accounting for 95 percent of the variations found in patients with CF. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 25, 2013 Category: Global & Universal Source Type: news

Should adult organs be used in pediatric patients?
Sarah Murnaghan, an 11-year-old with end-stage cystic fibrosis who was at the top of the pediatric organ donor list, took her medical battle to the courtroom to be placed at the top of the adult list so she could receive organs more quickly. After a judge ruled in her favor, she twice underwent a double lung transplant in June; she is now fighting pneumonia in her right lung. "Sound Medicine" host.... (Source: Sound Medicine)
Source: Sound Medicine - August 25, 2013 Category: Global & Universal Authors: Sound Medicine Source Type: news

Different colonization patterns of Aspergillus terreus in patients with cystic fibrosis.
Rougeron A, Giraud S, Razafimandimby B, Meis JF, Bouchara JP, Klaassen CH. (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - August 23, 2013 Category: Respiratory Medicine Source Type: news

Two forms of iron must be targeted to control cystic fibrosis lung infection
The bacterium Pseudomonas aeruginosa needs iron to establish and maintain a biofilm in the lungs of cystic fibrosis patients, and therapies have been proposed to deprive the bacteria of this necessary element. However, these techniques may not work, according to a new study published in mBio®, the online open-access journal of the American Society for Microbiology, because they only target one of the two types of iron that are available in the lung... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 21, 2013 Category: Consumer Health News Tags: Cystic Fibrosis Source Type: news

Target 2 forms of iron to control cystic fibrosis lung infection
(American Society for Microbiology) The bacterium Pseudomonas aeruginosa needs iron to establish and maintain a biofilm in the lungs of cystic fibrosis patients, and therapies have been proposed to deprive the bacteria of this necessary element. However, these techniques may not work, according to a new study published in mBio®, the online open-access journal of the American Society for Microbiology, because they only target one of the two types of iron that are available in the lung. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 20, 2013 Category: Global & Universal Source Type: news

Evolution of hyperswarming bacteria could develop anti-biofilm therapies
(Cell Press) Hyperswarming, pathogenic bacteria have repeatedly evolved in a lab, and the good news is that they should be less of a problem to us than their less mobile kin. That's because those hyperswarmers, adorned with multiple whipping flagella, are also much worse at sticking together on surfaces in hard-to-treat biofilms. They might even help us figure out a way to develop anti-biofilm therapies for use in people with cystic fibrosis or other conditions. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 15, 2013 Category: Infectious Diseases Source Type: news

Study identifies 3 enzymes required for building sugar superstructure involved in muscular dystrophies
For many inherited diseases, such as cystic fibrosis or Huntington disease, the disease-causing genetic mutation damages or removes a protein that has an essential role in the body. This protein defect is the root cause of the disease symptoms. However, for a group of muscular dystrophies known collectively as congenital muscular dystrophies (CMDs), the sequence of the protein that is central to normal function is typically unaffected. Instead, the defects lie in processing proteins - ones that are responsible for modifying the central protein by adding sugar chains (glycans)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 12, 2013 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

Doctor has cystic fibrosis
Dr. Chuck Fox was born with cystic fibrosis and raised with a resilient spirit which helps him beat the odds. (Source: CNN.com - Health)
Source: CNN.com - Health - August 1, 2013 Category: Consumer Health News Source Type: news

Becoming a doctor against all odds
Living with a chronic illness is like walking on a treadmill that never stops, says Chuck Fox, who has cystic fibrosis. (Source: CNN.com - Health)
Source: CNN.com - Health - July 31, 2013 Category: Consumer Health News Source Type: news