Impacts of the Covid-19 Epidemic and Associated Lockdown Measures on the Management, Health and Behaviors of Cystic Fibrosis Patients During the 2020 Epidemic
Conditions:   Cystic Fibrosis in Children;   Cystic Fibrosis Interventions:   Behavioral: Questionnaire;   Behavioral: Interview Sponsor:   Centre Hospitalier Intercommunal Creteil Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 9, 2020 Category: Research Source Type: clinical trials

Pharmacokinetics of Omadacycline in Cystic Fibrosis
Condition:   Cystic Fibrosis Interventions:   Drug: Omadacycline Injection [Nuzyra];   Drug: Omadacycline Oral Tablet [Nuzyra] Sponsors:   Paul Beringer;   Paratek Pharmaceuticals Inc Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 7, 2020 Category: Research Source Type: clinical trials

Polyethylene Glycol and Intestinal Inflammation in Cystic Fibrosis
Condition:   Cystic Fibrosis Intervention:   Drug: Treatment with polyethylene glycol (Macrogol 4000) Sponsor:   University Hospital, Bordeaux Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 7, 2020 Category: Research Source Type: clinical trials

Pharmacokinetics of Omadacycline in Cystic Fibrosis
Condition:   Cystic Fibrosis Interventions:   Drug: Omadacycline Injection [Nuzyra];   Drug: Omadacycline Oral Tablet [Nuzyra] Sponsors:   Paul Beringer;   Paratek Pharmaceuticals Inc Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 7, 2020 Category: Research Source Type: clinical trials

Polyethylene Glycol and Intestinal Inflammation in Cystic Fibrosis
Condition:   Cystic Fibrosis Intervention:   Drug: Treatment with polyethylene glycol (Macrogol 4000) Sponsor:   University Hospital, Bordeaux Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 7, 2020 Category: Research Source Type: clinical trials

Pharmacokinetics of Omadacycline in Cystic Fibrosis
Condition:   Cystic Fibrosis Interventions:   Drug: Omadacycline Injection [Nuzyra];   Drug: Omadacycline Oral Tablet [Nuzyra] Sponsors:   Paul Beringer;   Paratek Pharmaceuticals Inc Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 7, 2020 Category: Research Source Type: clinical trials

Polyethylene Glycol and Intestinal Inflammation in Cystic Fibrosis
Condition:   Cystic Fibrosis Intervention:   Drug: Treatment with polyethylene glycol (Macrogol 4000) Sponsor:   University Hospital, Bordeaux Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 3, 2020 Category: Research Source Type: clinical trials

Cystic Fibrosis Remote Monitoring System
Condition:   Cystic Fibrosis Interventions:   Device: InCourage-Connect;   Device: InCourage Sponsors:   Koronis Biomedical Technologies;   Johns Hopkins University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 1, 2020 Category: Research Source Type: clinical trials

Magnetic Resonance Imaging and Neuro-Psychological Testing In Cystic Fibrosis
Condition:   Cystic Fibrosis Intervention:   Diagnostic Test: MRI head Sponsors:   Cardiff and Vale University Health Board;   Cardiff University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 30, 2020 Category: Research Source Type: clinical trials

Efficacy and safety of aerosolized intra-tracheal dornase alfa administration in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS): a structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) may trigger severe pneumonia in coronavirus disease of 2019 (COVID-19) patients through release of damage-associated molecular patterns (DAMPs) and recruitment of neutrophils in the lungs. Activated neutrophils induce inflammation and severe alveolar injury by releasing neutrophil extracellular traps (NETs). The backbones of many DAMPs and NETs are made of extracellular, cell-free DNA decorated with highly toxic compounds such as elastase, myeloperoxidase and citrullinated histones. Dornase alfa is a FDA-approved recombinant human DNAse 1 for th...
Source: Trials - June 19, 2020 Category: Research Source Type: clinical trials

Combined Effect of CFTR Protein Modulator Drugs and Exercise in Cystic Fibrosis
Condition:   Cystic Fibrosis in Children Interventions:   Behavioral: Exercise;   Behavioral: Unsupervised exercise;   Drug: CFTR Modulators Sponsor:   Universidad Europea de Madrid Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 4, 2020 Category: Research Source Type: clinical trials

Patient Outcomes of Clinic Transition From Face to Face Encounter to Telemedicine in Cystic Fibrosis
Condition:   Cystic Fibrosis Intervention:   Sponsor:   University of Virginia Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 27, 2020 Category: Research Source Type: clinical trials

Utility of CD64 and TLR2 Assays to Diagnose Acute Pulmonary Exacerbations in Cystic Fibrosis
Condition:   Cystic Fibrosis Intervention:   Sponsor:   National Jewish Health Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 22, 2020 Category: Research Source Type: clinical trials