GSE206861 Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloid
Conclusion: In this study, a novel animal model of ACP cystic fuid-hypothalamic injury was established. For the frst time, it was found that ACP cystic fuid can trigger infammatory activation of microglia to damage the hypothalamus, which may be related to the upregulation of the CD74–APP interaction and deposition of β-amyloid, implying that there may be a similar mechanism between ACP cystic fuid damage to the hypothalamus and neurodegenerative diseases. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 25, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research

Utility of hospital frailty risk score for predicting postoperative outcomes in craniopharyngioma
ConclusionIn patients undergoing any surgery for craniopharyngioma, frailty is predictive of increased hospital length of stay and overall care costs. HFRS failed to independently predict mortality because the incidence of mortality is too low in this population to analyze. The HFRS is a valuable tool to identify post-operative outcomes following surgery for craniopharyngioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 20, 2022 Category: Cancer & Oncology Source Type: research

Endoscopic endonasal surgery for craniopharyngioma in an 18-month-old boy
Asian J Surg. 2022 Jun 15:S1015-9584(22)00755-2. doi: 10.1016/j.asjsur.2022.06.031. Online ahead of print.NO ABSTRACTPMID:35717300 | DOI:10.1016/j.asjsur.2022.06.031 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - June 18, 2022 Category: Surgery Authors: Yuan Tian Jing Chen Bowen Cai Songping Zheng Source Type: research

Endoscopic endonasal surgery for craniopharyngioma in an 18-month-old boy
Asian J Surg. 2022 Jun 15:S1015-9584(22)00755-2. doi: 10.1016/j.asjsur.2022.06.031. Online ahead of print.NO ABSTRACTPMID:35717300 | DOI:10.1016/j.asjsur.2022.06.031 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - June 18, 2022 Category: Surgery Authors: Yuan Tian Jing Chen Bowen Cai Songping Zheng Source Type: research

Postoperative hypothalamic damage predicts postoperative weight gain in patients with adult-onset craniopharyngioma
CONCLUSIONS: Significant postoperative weight gain is common in patients with adult-onset craniopharyngioma. Postoperative hypothalamic damage can predict clinically meaningful weight gain and HO.PMID:35707874 | DOI:10.1002/oby.23447 (Source: Obesity)
Source: Obesity - June 16, 2022 Category: Eating Disorders & Weight Management Authors: Jie Wu Jun Fu Zhong Jian Huang Shen Hao Xie Bin Tang Xiao Wu Zhi Gao Tong Bo Wen Wu Cheng Bing Pan You Qing Yang Han Ding Shao Yang Li Jia Long Qi Tao Hong Source Type: research

Postoperative hypothalamic damage predicts postoperative weight gain in patients with adult-onset craniopharyngioma
CONCLUSIONS: Significant postoperative weight gain is common in patients with adult-onset craniopharyngioma. Postoperative hypothalamic damage can predict clinically meaningful weight gain and HO.PMID:35707874 | DOI:10.1002/oby.23447 (Source: Obesity)
Source: Obesity - June 16, 2022 Category: Eating Disorders & Weight Management Authors: Jie Wu Jun Fu Zhong Jian Huang Shen Hao Xie Bin Tang Xiao Wu Zhi Gao Tong Bo Wen Wu Cheng Bing Pan You Qing Yang Han Ding Shao Yang Li Jia Long Qi Tao Hong Source Type: research

Neoadjuvant B-RAF and MEK Inhibitor Targeted Therapy for Adult Papillary Craniopharyngiomas: A New Treatment Paradigm
ConclusionOur experience and a review of the literature argue for a change in the current treatment paradigm for Craniopharyngiomas (CPs). In giant and invasive tumors, confirmation of BRAFV600E mutated PCPs by biopsy and BRAF/MEK inhibitor therapy before proposing other treatments may be useful to improve long term outcomes for patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 9, 2022 Category: Endocrinology Source Type: research

Histomorphological spectrum of pediatric supratentorial CNS tumors: A 3-year retrospective study in a tertiary care center
Conclusion: Though posterior fossa neoplasms are more common in children, supratentorial tumors show a rising trend worldwide in the pediatric population. Our study gives an overview of the incidence and histopathological profile of supratentorial CNS tumors. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - June 3, 2022 Category: Neuroscience Authors: Jagadeeswari Rajendran Rama Krishnanswamy Source Type: research

Endoscopic Endonasal Approach to the Third Ventricle Using the Surgical Corridor of the Reverse Third Ventriculostomy: Anatomo-Surgical Nuances
Conclusion The third ventricle can safely be accessed through ERTV either above or below the pituitary gland. ERTV provides a wide exposure of the third ventricle through the tuber cinereum and offers access to the anterior part as far as the anterior commissure and precommissural part of fornix and the whole length of the posterior part. Endoscopic ERTV may be a suitable alternative to transcranial approaches to access the third ventricle in selected patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source...
Source: Journal of Neurological Surgery Part B: Skull Base - June 3, 2022 Category: Neurosurgery Authors: Karadag, Ali Camlar, Mahmut Turkis, Omer Furkan Bayramli, Nijat Middlebrooks, Erik H. Tanriover, Necmettin Tags: Original Article Source Type: research

134 A particular case of craniopharyngioma
In September 2020 an 18-year-old female patient was referred to our clinic for primary amenorrhea, in a panhypopituitarism resulting from a surgically removed craniopharyngioma. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - June 1, 2022 Category: OBGYN Authors: A. Tassi, V. Capodicasa, D. Driul, L. Driul Source Type: research

Pathological and Prognostic Characterization of Craniopharyngioma Based on the Expression of TrkA, β-Catenin, Cell Cycle Markers, and BRAF V600E Mutation
We collected 61 craniopharyngioma (CP) specimens to investigate the expression of TrkA, β-catenin, BRAF gene mutation, and NTRK1 fusion in CP. There were 37 male and 24 female individuals with a median age of 34 years (range, 4–75 years). Histologically, there were 46 cases of adamantinomatous craniopharyngioma (ACP), 14 cases of papillary craniopharyngioma (PCP), and 1 case with a mixed adamantinomatous and papillary pattern. By immunohistochemistry, we found that moderate/high TrkA expression was detected in 47% (28/60) CP and was significantly higher in adult patients (p = 0.018). Interestingly, TrkA is more expresse...
Source: Frontiers in Endocrinology - May 30, 2022 Category: Endocrinology Source Type: research

Complications of Endoscopic Skull Base Surgery for Sellar and Parasellar Tumors in Pediatric Population; Neurosurgical Perspectives
ConclusionESS in children is feasible and relatively safe. More attention and different postoperative management protocols are required in children to avoid complications, especially in craniopharyngiomas. However, the complications can be mostly managed conservatively without permanent neurologic deficits. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - May 27, 2022 Category: Cancer & Oncology Source Type: research

Surgical Strategies and Outcomes for Intracranial Chondromas: A Retrospective Study of 17 Cases and Systematic Review
ConclusionsICDs lack typical imaging features and are often misdiagnosed. The EETA or EEETA helps improve the surgical outcomes and GTR rates of ICDs at different sites. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - May 26, 2022 Category: Cancer & Oncology Source Type: research

Radiation-induced Brain Calcification Leads to L-dopa-resistant Parkinsonism and Cerebellar Ataxia
Intern Med. 2022 May 21. doi: 10.2169/internalmedicine.8400-21. Online ahead of print.ABSTRACTWe experienced a young patient who presented with progressive parkinsonism and cerebellar ataxia. Brain magnetic resonance imaging revealed progressive brain calcification, expanding from the bilateral basal ganglia to the central pons, caused by a delayed reaction to the radiation therapy that she had received to treat craniopharyngioma 14 years earlier. Heterogeneous clinical symptoms due to radiation-induced brain calcification have been described, but parkinsonism has never been reported. While dopamine transporter-single phot...
Source: Internal Medicine - May 22, 2022 Category: Internal Medicine Authors: Tomoyo Shimada Ryota Kamo Kensuke Daida Kenya Nishioka Nobutaka Hattori Taiji Tsunemi Source Type: research