Papillary craniopharyngioma: a type of tumor primarily impairing the hypothalamus. A comprehensive anatomo-clinical characterization of 350 well-described cases
This study systematically analyzes the clinical-anatomical correlation between tumor topography and symptoms related to hypothalamic dysfunction in the largest series of PCPs ever gathered. Methods: From 5,346 CP reports published from 1856 to 2021, we selected 350 well-described cases of the squamous-papillary type. Clinical presentation, tumor topography, severity of hypothalamic adhesion, patient outcome and tumor recurrence were thoroughly analyzed. Results: PCPs predominantly occur in adult (96.3%), male (61.7%) patients presenting with headache (63.4%), visual alterations (56.2%) and psychiatric disturbances (50.4%)....
Source: Neuroendocrinology - December 28, 2021 Category: Endocrinology Source Type: research

Papillary Craniopharyngioma: A Type of Tumor Primarily Impairing the Hypothalamus – A Comprehensive Anatomo-Clinical Characterization of 350 Well-Described Cases
Conclusions: This systematic review evidences that PCP topography is a major determinant of hypothalamic-related symptoms, type of hypothalamic attachments, and tumor recurrence rate. Accurate preoperative definition of PCP-hypothalamus relationships is essential for the judicious, safe management of these complex lesions.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 28, 2021 Category: Endocrinology Source Type: research

Radiotherapy of benign intracranial tumours
We present the updated recommendations of the French Society for Radiation Oncology on benign intracranial tumours. Most of them are meningiomas, vestibular schwannomas, pituitary adenomas, craniopharyngiomas, and glomus tumours. Some grow very slowly, and can be observed without specific treatment, especially if they are asymptomatic. Symptomatic or growing tumours are treated by surgery, which is the reference treatment. When surgery is not possible, due to the location of the lesion, or general conditions, radiotherapy can be applied, as it is if there is a postoperative growing residual tumour, or a local relapse. Ind...
Source: Cancer Radiotherapie - December 26, 2021 Category: Cancer & Oncology Authors: G Dissaux S Josset F Thillays F Lucia V Bourbonne O Pradier D Pasquier J Biau Source Type: research

Clinical Implication of Individually Tailored Segmentation Method for Distorted Hypothalamus in Craniopharyngioma
ConclusionsAdult-onset CP patients showed negative associations between postoperative HT volume and preoperative/postoperative body weight using a new method of HT volume measurement based on T2-weighted images. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - December 20, 2021 Category: Endocrinology Source Type: research

Characterization of novel CTNNB1 mutation in Craniopharyngioma by whole-genome sequencing
Craniopharyngioma (CP) is rare histologically benign but clinically challenging tumor because of its intimate relationship with the critical structure in the central brain. CP can be divided into two major his... (Source: Molecular Cancer)
Source: Molecular Cancer - December 18, 2021 Category: Cancer & Oncology Authors: Juan He, Zhen Zeng, Yuelong Wang, Jiaojiao Deng, Xin Tang, Fujun Liu, Jianhan Huang, Hongxu Chen, Ruichao Liang, Xin Zan, Zhiyong Liu, Aiping Tong, Gang Guo, Jianguo Xu, Xiaofeng Zhu, Liangxue Zhou & hellip; Tags: Research Source Type: research

High prevalence of early endocrine disorders after childhood brain tumors in a large cohort
CONCLUSIONS: We found a high incidence of early onset endocrine disorders. An endocrine consultation and nutritional evaluation should be mandatory for all patients with a brain tumor, especially when the tumor is suprasellar or after hypothalamus/pituitary irradiation.PMID:34918112 | DOI:10.1210/clinem/dgab893 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 17, 2021 Category: Endocrinology Authors: Laura Gabriela Gonz ález Briceño Dulanjalee Kariyawasam Dinane Samara-Boustani Elisa Giani Jacques Beltrand St éphanie Bolle Brice Fresneau St éphanie Puget Christian Sainte-Rose Claire Alapetite Graziella Pinto Marie-Liesse Piketty S éverine Brabant Source Type: research

High prevalence of early endocrine disorders after childhood brain tumors in a large cohort
CONCLUSIONS: We found a high incidence of early onset endocrine disorders. An endocrine consultation and nutritional evaluation should be mandatory for all patients with a brain tumor, especially when the tumor is suprasellar or after hypothalamus/pituitary irradiation.PMID:34918112 | DOI:10.1210/clinem/dgab893 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 17, 2021 Category: Endocrinology Authors: Laura Gabriela Gonz ález Briceño Dulanjalee Kariyawasam Dinane Samara-Boustani Elisa Giani Jacques Beltrand St éphanie Bolle Brice Fresneau St éphanie Puget Christian Sainte-Rose Claire Alapetite Graziella Pinto Marie-Liesse Piketty S éverine Brabant Source Type: research

Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients
ConclusionsNST could serve as a novel useful marker for regional nuchal adipose tissue. NST is highly associated with body mass and waist-to-height ratio, and easily measurable in routine MRI monitoring of brain tumor patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - December 16, 2021 Category: Endocrinology Source Type: research

90-Day Bundled Payment Simulation, Health Care Utilization, and Complications following Craniopharyngioma Resection in Adult Patients
Conclusion ENEC following surgery incurred almost two times the overall median payments at 90 days, 6 months, 1 year. and 2 years compared with those without complications. Bundled payment model may not be a feasible option in this patient population. Type of complications and readmission rates should be considered to optimize payment model prediction following craniopharyngioma resection. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - December 16, 2021 Category: Neurosurgery Authors: Dietz, Nicholas Sharma, Mayur John, Kevin Wang, Dengzhi Ugiliweneza, Beatrice Mokshagundam, Sriprakash Bjurstr öm, Martin F. Boakye, Maxwell Williams, Brian J. Andaluz, Norberto Tags: Original Article Source Type: research

Pituitary MRI standard and advanced sequences: role in the diagnosis and characterization of pituitary adenomas
J Clin Endocrinol Metab. 2021 Dec 15:dgab901. doi: 10.1210/clinem/dgab901. Online ahead of print.ABSTRACTPituitary adenomas (PAs) represent the most frequently found lesions in the sellar region; however, several other lesions may be encountered in this region, such as meningiomas, craniopharyngiomas and aneurysms. High-quality imaging is fundamental for diagnosis, characterization and guidance of treatment planning of PAs. Sellar magnetic resonance imaging (MRI) is considered the imaging modality of choice for the evaluation of lesions in the sella turcica. The sellar MRI standard protocol includes coronal and sagittal T1...
Source: The Journal of Clinical Endocrinology and Metabolism - December 15, 2021 Category: Endocrinology Authors: M ônica R Gadelha Monique Alvares Barbosa Elisa Baranski Lamback Luiz Eduardo Wildemberg Leandro Kasuki Nina Ventura Source Type: research

Pituitary MRI standard and advanced sequences: role in the diagnosis and characterization of pituitary adenomas
J Clin Endocrinol Metab. 2021 Dec 15:dgab901. doi: 10.1210/clinem/dgab901. Online ahead of print.ABSTRACTPituitary adenomas (PAs) represent the most frequently found lesions in the sellar region; however, several other lesions may be encountered in this region, such as meningiomas, craniopharyngiomas and aneurysms. High-quality imaging is fundamental for diagnosis, characterization and guidance of treatment planning of PAs. Sellar magnetic resonance imaging (MRI) is considered the imaging modality of choice for the evaluation of lesions in the sella turcica. The sellar MRI standard protocol includes coronal and sagittal T1...
Source: The Journal of Clinical Endocrinology and Metabolism - December 15, 2021 Category: Endocrinology Authors: M ônica R Gadelha Monique Alvares Barbosa Elisa Baranski Lamback Luiz Eduardo Wildemberg Leandro Kasuki Nina Ventura Source Type: research

Expression of Insulin-like Growth Factor Type 1 Receptor is Linked to Inflammation in Adamantinomatous Craniopharyngioma
Conclusions High expression of IG F1R might promote inflammation of ACP, which might be an unfavorable factor for pituitary function and prognosis. The high expression of IGF1R in tumor cell stem-like cells might inhibit the expression of p-ERK and promote the generation of inflammatory factors. Insulin-like growth factor type 1 rec eptor plays a stemness maintenance role in ACP and regulates the production of inflammatory factors through a p-ERK pathway, which suggests that targeting IGF1R and p-ERK might provide a new direction for alleviating tumor inflammation. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 13, 2021 Category: Endocrinology Source Type: research

A Novel Immune Classification for Predicting Immunotherapy Responsiveness in Patients With Adamantinomatous Craniopharyngioma
Adamantinomatous craniopharyngioma (ACP) is the most common tumor of the sellar region in children. The aggressive behavior of ACP challenges the treatment for it. However, immunotherapy is rarely studied in ACP. In this research, we performed unsupervised cluster analysis on the 725 immune-related genes and arrays of 39 patients with ACP patients in GSE60815 and GSE94349 databases. Two novel immune subtypes were identified, namely immune resistance (IR) subtype and immunogenic (IG) subtype. Interestingly, we found that the ACPs with IG subtype (34.78%, 8/23) were more likely to respond to immunotherapy than the ACPs with ...
Source: Frontiers in Neurology - December 13, 2021 Category: Neurology Source Type: research

Cyst Type Differentiates Rathke Cleft Cysts From Cystic Pituitary Adenomas
ConclusionWhen applied to the diagnosis of RCC versus cystic pituitary adenoma, higher cystic lesion types (Type 2 & 4), presence of fluid-fluid level, symptomatic hyperprolactinemia, and obesity were predictors of cystic pituitary adenoma. Further validation is needed, but this classification scheme may prove to be a useful tool for the management of patients with common sellar pathology. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - December 10, 2021 Category: Cancer & Oncology Source Type: research

Expanded Transsphenoidal Trans-Lamina Terminalis Approach to Tumors Extending Into the Third Ventricle: Technique Notes and a Single Institute Experience
ConclusionThe expanded TLTA provides a feasible suprachiasm corridor to remove tumors extending into the third ventricle, especially for craniopharyngiomas. Sound understanding of the major strengths and limitations of this approach, as well as strategies for complication avoidance, is necessary for its safe and effective application. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - December 8, 2021 Category: Cancer & Oncology Source Type: research