Is Postoperative Radiotherapy Needed in the Management of Adult Craniopharyngiomas?
CONCLUSIONS: Our study underscores the importance of RT for local control and suggests that STR + RT should be considered a viable option in the management of these tumors as it may be associated with improved PFS compared to surgery alone.PMID:35581927 | DOI:10.1017/cjn.2022.28 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - May 18, 2022 Category: Neurology Authors: Julia Khriguian Marwan Tolba Farzin Khosrow-Khavar Sarah Kordlouie Marie-Christine Guiot Bassam Abdulkarim George Shenouda Denis Sirhan Luis Souhami Valerie Panet-Raymond Source Type: research

Is Postoperative Radiotherapy Needed in the Management of Adult Craniopharyngiomas?
CONCLUSIONS: Our study underscores the importance of RT for local control and suggests that STR + RT should be considered a viable option in the management of these tumors as it may be associated with improved PFS compared to surgery alone.PMID:35581927 | DOI:10.1017/cjn.2022.28 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - May 18, 2022 Category: Neurology Authors: Julia Khriguian Marwan Tolba Farzin Khosrow-Khavar Sarah Kordlouie Marie-Christine Guiot Bassam Abdulkarim George Shenouda Denis Sirhan Luis Souhami Valerie Panet-Raymond Source Type: research

Is Postoperative Radiotherapy Needed in the Management of Adult Craniopharyngiomas?
CONCLUSIONS: Our study underscores the importance of RT for local control and suggests that STR + RT should be considered a viable option in the management of these tumors as it may be associated with improved PFS compared to surgery alone.PMID:35581927 | DOI:10.1017/cjn.2022.28 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - May 18, 2022 Category: Neurology Authors: Julia Khriguian Marwan Tolba Farzin Khosrow-Khavar Sarah Kordlouie Marie-Christine Guiot Bassam Abdulkarim George Shenouda Denis Sirhan Luis Souhami Valerie Panet-Raymond Source Type: research

Is Postoperative Radiotherapy Needed in the Management of Adult Craniopharyngiomas?
CONCLUSIONS: Our study underscores the importance of RT for local control and suggests that STR + RT should be considered a viable option in the management of these tumors as it may be associated with improved PFS compared to surgery alone.PMID:35581927 | DOI:10.1017/cjn.2022.28 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - May 18, 2022 Category: Neurology Authors: Julia Khriguian Marwan Tolba Farzin Khosrow-Khavar Sarah Kordlouie Marie-Christine Guiot Bassam Abdulkarim George Shenouda Denis Sirhan Luis Souhami Valerie Panet-Raymond Source Type: research

Is Postoperative Radiotherapy Needed in the Management of Adult Craniopharyngiomas?
CONCLUSIONS: Our study underscores the importance of RT for local control and suggests that STR + RT should be considered a viable option in the management of these tumors as it may be associated with improved PFS compared to surgery alone.PMID:35581927 | DOI:10.1017/cjn.2022.28 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - May 18, 2022 Category: Neurology Authors: Julia Khriguian Marwan Tolba Farzin Khosrow-Khavar Sarah Kordlouie Marie-Christine Guiot Bassam Abdulkarim George Shenouda Denis Sirhan Luis Souhami Valerie Panet-Raymond Source Type: research

Is Postoperative Radiotherapy Needed in the Management of Adult Craniopharyngiomas?
CONCLUSIONS: Our study underscores the importance of RT for local control and suggests that STR + RT should be considered a viable option in the management of these tumors as it may be associated with improved PFS compared to surgery alone.PMID:35581927 | DOI:10.1017/cjn.2022.28 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - May 18, 2022 Category: Neurology Authors: Julia Khriguian Marwan Tolba Farzin Khosrow-Khavar Sarah Kordlouie Marie-Christine Guiot Bassam Abdulkarim George Shenouda Denis Sirhan Luis Souhami Valerie Panet-Raymond Source Type: research

Sleep Disturbances in Pediatric Craniopharyngioma: A Systematic Review
Craniopharyngiomas are rare brain tumors of the sellar region and are the most common non-neuroepithelial intracerebral neoplasm in children. Despite a low-grade histologic classification, craniopharyngiomas can have a severe clinical course due to hypothalamic involvement. The hypothalamus plays a crucial role in regulating vital functions, and it is a critical component of the sleep-wake regulatory system. This systematic review aims to provide an overview of the current knowledge on sleep disorders in patients with craniopharyngioma to unravel their underlying mechanisms and identify possible therapeutic strategies. A c...
Source: Frontiers in Neurology - May 13, 2022 Category: Neurology Source Type: research

A Survey of Patient-Relevant Outcomes in Pediatric Craniopharyngioma: Focus on Hypothalamic Obesity
ConclusionsOnly a minority of individuals with hypothalamic obesity had trialed medication, even though many reported that lifestyle modification was inadequate. Furthermore, social function was significantly impaired overall in survivors compared to a reference cohort, and even more so in individuals with obesity. These findings highlight the opportunity to improve social functioning as an additional potential benefit of improved treatments for hypothalamic obesity. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - May 9, 2022 Category: Endocrinology Source Type: research

Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloid
The mechanism by which adamantinomatous craniopharyngioma (ACP) damages the hypothalamus is still unclear. Cyst fluid rich in lipids and inflammatory factors is a characteristic pathological manifestation of A... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - May 7, 2022 Category: Neurology Authors: Yilamujiang Ainiwan, Yiguang Chen, Chaofu Mao, Junxiang Peng, Siyuan Chen, Songtao Wei, Songtao Qi and Jun Pan Tags: Research Source Type: research

Five-Year Changes in Weight and Diabetes Status After Bariatric Surgery for Craniopharyngioma-Related Hypothalamic Obesity: a Case-Control Study
CONCLUSIONS: Bariatric surgery induced a significant weight loss in the craniopharyngioma group at 1 and 5 years, but less than in common obesity. SG may be more effective than RYGB but this remains to be demonstrated in a larger cohort.PMID:35524022 | DOI:10.1007/s11695-022-06079-9 (Source: Cancer Control)
Source: Cancer Control - May 6, 2022 Category: Cancer & Oncology Authors: Pauline Faucher Claire Carette Anne-Sophie Jannot Blandine Gatta-Cherifi Alexis Van Straaten Marie-Astrid Piquet Gerald Raverot Maud Alligier Thibault Batisse Olivier Ziegler Delphine Drui Marion Bretault Nicolas Farigon Karem Slim Laurent Genser Tigran P Source Type: research

Surgical resection of giant extrasellar thyrotropinoma: Use of orbitozygomatic and endoscopic endonasal approach
CONCLUSION: Operative treatment strategy is presented for a rare large challenging multicompartmental extrasellar TSHoma using endoscopic endonasal and open skull base approaches.PMID:35509589 | PMC:PMC9062941 | DOI:10.25259/SNI_1182_2021 (Source: Surgical Neurology International)
Source: Surgical Neurology International - May 5, 2022 Category: Neurosurgery Authors: Patricio Gimenez Mahmoud Asad Karin Bradley Natasha Thorogood Warren Bennett Kumar Abhinav Source Type: research