Overview of the 2022 WHO Classification of Pituitary Tumors
AbstractThis review summarizes the changes in the 5th Edition of the WHO Classification of Endocrine and Neuroendocrine Tumors that relate to the pituitary gland. The new classification clearly distinguishes anterior lobe (adenohypophyseal) from posterior lobe (neurohypophyseal) and hypothalamic tumors. Other tumors arising in the sellar region are also discussed. Anterior lobe tumors include (i) well-differentiated adenohypophyseal tumors that are now classified as pituitary neuroendocrine tumors (PitNETs; formerly known as pituitary adenomas), (ii) pituitary blastoma, and (iii) the two types of craniopharyngioma. The new...
Source: Endocrine Pathology - March 15, 2022 Category: Pathology Source Type: research

Disease Control after Radiotherapy for Adult Craniopharyngioma: Clinical Outcomes from a Large Single-Institution Series
CONCLUSIONS: Radiotherapy provides excellent disease control with acceptable toxicity among adult patients with craniopharyngioma. These data support the use of fractionated radiotherapy in adult patients with recurrent or gross residual disease after surgery. For inoperable patients or those with moderate or high surgical risk to neurologic and/or vascular structures, we advocate for limited surgical resection and postoperative radiotherapy to balance optimal tumor control with tumor- and treatment-related morbidity.PMID:35278157 | DOI:10.1007/s11060-022-03983-z (Source: Cancer Control)
Source: Cancer Control - March 12, 2022 Category: Cancer & Oncology Authors: Michael S Rutenberg Adam L Holtzman Daniel J Indelicato Soon Huh Dinesh Rao Peter J Fiester Christopher G Morris Daryoush Tavanaiepour Robert J Amdur Source Type: research

Disease Control after Radiotherapy for Adult Craniopharyngioma: Clinical Outcomes from a Large Single-Institution Series
ConclusionsRadiotherapy provides excellent disease control with acceptable toxicity among adult patients with craniopharyngioma. These data support the use of fractionated radiotherapy in adult patients with recurrent or gross residual disease after surgery. For inoperable patients or those with moderate or high surgical risk to neurologic and/or vascular structures, we advocate for limited surgical resection and postoperative radiotherapy to balance optimal tumor control with tumor- and treatment-related morbidity. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 12, 2022 Category: Cancer & Oncology Source Type: research

18F-Choline PET Detected the Third Ventricle Craniopharyngioma
We report a case of the third ventricular craniopharyngioma detected using 18F-choline PET/CT in a 43-year-old man. MRI of the brain revealed an intense gadolinium enhancement focus in the same area. Histology revealed characteristics of papillary craniopharyngioma. Our findings suggest that craniopharyngioma should be included in the differential diagnosis of 18F-choline‚Äďavid brain lesions. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - March 10, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Sella bugged!!! - Abscess inside a Craniopharyngioma - Case report with literature review.
Conclusion This is the first report of a pediatric case with secondary abscess in craniopharyngioma. Operative management of such a case includes controlled drainage of pus without dissemination into the surrounding arachnoid space. The tumour and abscess have to be addressed as separate surgical entities; infection control and wherever complete resection is not feasible, partial safe resection followed by radiotherapy is a viable option. (Source: Pediatric Neurosurgery)
Source: Pediatric Neurosurgery - March 9, 2022 Category: Neurosurgery Source Type: research

Craniopharyngioma and Metabolic Syndrome: A 5-Year Follow-Up Single-Center Experience
Patients with craniopharyngioma often have comorbidities, such as obesity and hypopituitarism. These two conditions affect each other and worsen the quality of life of patients, which lead to a higher risk of morbidity and mortality. In addition, abdominal obesity, measured as waist circumference (WC), is together with other parameters [arterial hypertension, hyperglycemia, hypertriglyceridemia, and reduced levels of high-density lipoprotein (HDL) cholesterol], one of the components of metabolic syndrome (MS). Each one of these morbidities occurs in patients with craniopharyngioma more frequently than in the remaining popu...
Source: Frontiers in Neurology - March 9, 2022 Category: Neurology Source Type: research

Quadriparesis Due to Delayed Tension Pneumoventricle
Conclusions: The probable mechanisms of tPV and the importance of early recognition and treatment are discussed. A review of the literature of this uncommon entity has also been performed. (Source: The Neurologist)
Source: The Neurologist - March 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

Endoscopic Endonasal Excision of a Complex Craniopharyngioma Operated Multiple Times by Transcranial Route
Conclusion: This case demonstrates the surgical technique and various operative nuances of endoscopic endonasal resection of a complex craniopharyngioma. (Source: Neurology India)
Source: Neurology India - February 28, 2022 Category: Neurology Authors: Biren K Patel HR Darshan Anand Binu HV Easwer Prakash Nair Source Type: research

Determinants of Short-Term Weight Gain Following Surgical Treatment for Craniopharyngioma in Adults
CONCLUSION: Patients with CP experience greater postoperative weight gain than those with NFPA. Hypothalamic damage itself as well as steroid replacement may contribute to the postoperative weight gain in patients with CP.PMID:35184516 | DOI:10.3340/jkns.2021.0067 (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - February 21, 2022 Category: Neurosurgery Authors: A Ram Hong Jung Hee Kim Seung Shin Park Sung Hye Kong Hyung Jin Choi Yong Hwy Kim Chan Soo Shin Source Type: research

Skull Base Tumors: Neuropathology and Clinical Implications
Tumors that arise in and around the skull base comprise a wide range of common and rare entities. Recent studies have advanced our understanding of their pathogenesis, which in some cases, have significantly influenced clinical practice. The genotype of meningiomas is strongly associated with their phenotype, including histologic subtype and tumor location, and clinical outcome. A single molecular alteration, NAB2-STAT6 fusion, has redefined the category of solitary fibrous tumors to include the previous entity hemangiopericytomas. Schwannomas, both sporadic and familial, are characterized by near ubiquitous alterations in...
Source: Neurosurgery - February 15, 2022 Category: Neurosurgery Tags: NEUROPATHOLOGY REVIEW SERIES Source Type: research

Identification and Characterization of TF-lncRNA Regulatory Networks Involved in the Tumorigenesis and Development of Adamantinomatous Craniopharyngioma
In this study, we introduced an integrated algorithm for identifying lncRNAs and TFs regulating the ACP-related pathway. This is the first comprehensive study to systematically investigate the potential TF and lncRNA regulatory network in ACP. The resulting data serve as a valuable resource for understanding the mechanisms underlying ACP-related lncRNAs and TFs.PMID:35155179 | PMC:PMC8827039 | DOI:10.3389/fonc.2021.739714 (Source: Cancer Control)
Source: Cancer Control - February 14, 2022 Category: Cancer & Oncology Authors: Dingkang Xu Yufeng Guo Shixiong Lei Abao Guo Dengpan Song Qiang Gao Shengqi Zhao Kaiwen Yin Qingjie Wei Longxiao Zhang Xiaoxuan Wang Jie Wang Qi Zhang Fuyou Guo Source Type: research

Clinical Outcomes of Transcranial and Endoscopic Endonasal Surgery for Craniopharyngiomas: A Single-Institution Experience
ConclusionThese data support the view that EES is a safe and effective minimally invasive surgery compared to TCS. Compared to TCS, EES has fewer surgical complications and a lower recurrence rate. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 10, 2022 Category: Cancer & Oncology Source Type: research

Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update
Sleep disorders (SDs) represent an important issue in patients with craniopharyngioma (CP). Nearly 70% of these patients complain of sleep-wake cycle alterations and/or excessive diurnal somnolence due to sleep-related breathing disorders, such as obstructive sleep apnea (OSA) and/or central hypersomnia, including secondary narcolepsy. SDs may severely reduce quality of life, increase disease-related cardiorespiratory and cardiovascular morbidity, and finally play a major role in increased long-term mortality reported on patients with CP. A major risk factor for SDs is represented by the hypothalamic syndrome, which may de...
Source: Frontiers in Neurology - February 9, 2022 Category: Neurology Source Type: research