Tirzepatide for Maintenance of Weight Reduction in Adults with Obesity —Reply
In Reply The authors raise 5 issues related to our trial of tirzepatide. First, the glucagon-like peptide-1 (GLP-1) receptor agonist class has been available for the treatment of type 2 diabetes since 2005 and for the treatment of obesity since 2014, and has been the subject of increasing worldwide use. Although nausea, diarrhea, constipation, and vomiting are the most common adverse effects of this class of medication, appropriate clinical treatment of patients can reduce these common adverse effects and increase tolerability. Such treatment includes slow titration or downtitration of the medication or symptomatic managem...
Source: JAMA - Journal of the American Medical Association - April 17, 2024 Category: General Medicine Source Type: research
Capsules for the Diagnosis and Treatment of Gastrointestinal Motility Disorders- A Game Changer
AbstractPurpose of ReviewOver the last few decades, there have been remarkable strides in endoscopy and radiological imaging that have advanced gastroenterology. However, the management of neurogastroenterological disorders has lagged behind, in part handicapped by the use of catheter-based manometry that is both non-physiological and uncomfortable. The advent of capsule technology has been a game changer for both diagnostic and therapeutic applications.Recent FindingsHere, we discuss several capsule devices that are available or under investigation. There are three technologies that are FDA approved. Wireless motility cap...
Source: Current Gastroenterology Reports - April 17, 2024 Category: Gastroenterology Source Type: research
Characterization of Initial Gastrointestinal Evaluation of Children with Autism Spectrum Disorder: A Descriptive Study
J Autism Dev Disord. 2024 Apr 15. doi: 10.1007/s10803-024-06318-1. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is a multifactorial, pervasive neurodevelopmental disorder affecting 1 in 36 children in the United States. Given the rising prevalence and significant economic and social costs associated with ASD, it is critical that continued efforts be made towards better understanding the underlying etiology as well as management of the condition and its commonly associated comorbidities. It has been estimated that upwards of 70% of children with ASD have a positive history of gastrointestinal (GI) symptoms. ...
Source: Journal of Autism and Developmental Disorders - April 15, 2024 Category: Psychiatry Authors: Mojdeh Mostafavi Wael Sayej Source Type: research
Comparative study of laparoscopic ventral mesh rectopexy versus perineal stapler resection for external full-thickness rectal prolapse in elderly patients: enhanced outcomes and reduced recurrence rates —a retrospective cohort study
ConclusionsLVMR is safe for EFTRP treatment in elderly patients with low recurrence, and improved postoperative functional outcomes.Trial registrationClinical Trial.gov (NCT05915936), retrospectively registered on June 14, 2023. (Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - April 15, 2024 Category: Surgery Source Type: research
CFP/Yit: An Inbred Mouse Strain with Slow Gastrointestinal Transit
ConclusionsThis study indicates that CFP mice exhibit slow transit in the stomach, cecum, and colon. As a novel mouse model, CFP mice can contribute to the study of gastrointestinal physiology and disease. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 15, 2024 Category: Gastroenterology Source Type: research
Dysgeusia increases the risk for death and other side effects during antineoplastic systemic treatment for solid tumors: a cross-sectional study
CONCLUSIONS: Dysgeusia during CT increases the risk of other adverse effects and negatively impacts prognosis.PMID:38615256 | DOI:10.4317/medoral.26389 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - April 14, 2024 Category: ENT & OMF Authors: P-G Silva G-A Barreto A-C Carlos M-M Borges C-E Malta J-V Barbosa A-A Crispim S-F Jua çaba L-F Gonzaga-Silva Source Type: research
Knowledge-based, computerized, patient clinical decision support system for perioperative pain, nausea and constipation management: a clinical feasibility study
We report the development and feasibility validation of a knowledge-based CDSS aiming at optimizing the management of perioperative pain, postoperative nausea and vomiting (PONV), and laxative medications. This novel CDSS uses patient adaptive testing through a smartphone display, literature-based rules, and individual medical prescriptions to produce direct medical advice for the patient user. Our objective was to test the feasibility of the clinical use of our CDSS in the perioperative setting. This was a prospective single arm, single center, cohort study conducted in Strasbourg University Hospital. The primary outcome ...
Source: Journal of Clinical Monitoring and Computing - April 12, 2024 Category: Information Technology Source Type: research
Costs associated with adverse events during treatment episodes for adult attention-deficit/hyperactivity disorder
Conclusions: This study found that AEs occurring during ADHD treatment episodes are associated with significant healthcare costs. This highlights the potential of treatments with favorable safety profiles to alleviate the burden experienced by patients and the healthcare system.PMID:38602691 | DOI:10.1080/13696998.2024.2342749 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 11, 2024 Category: Health Management Authors: Jeff Schein Martin Cloutier Rebecca Bungay Marjolaine Gauthier-Loiselle Ann Childress Source Type: research
Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review
Z Gastroenterol. 2024 Apr 11. doi: 10.1055/a-2279-5045. Online ahead of print.ABSTRACTPhytotherapeutics are gaining influence in the treatment of gastroenterological diseases. Their popularity and growing evidence of efficacy contribute to their integration into medical guidelines. A systematic screening identified recommended phytotherapeutic approaches. Based on current scientific data, some recommendations for the use of phytotherapeutic agents are given. For irritable bowel syndrome the use of peppermint oil is "strongly recommended", especially for pain and flatulence. Other phytotherapeutics such as STW-5, Tibetan Pa...
Source: Zeitschrift fur Gastroenterologie - April 11, 2024 Category: Gastroenterology Authors: Sandra Utz Miriam Bittel Jost Langhorst Source Type: research
Costs associated with adverse events during treatment episodes for adult attention-deficit/hyperactivity disorder
Conclusions: This study found that AEs occurring during ADHD treatment episodes are associated with significant healthcare costs. This highlights the potential of treatments with favorable safety profiles to alleviate the burden experienced by patients and the healthcare system.PMID:38602691 | DOI:10.1080/13696998.2024.2342749 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 11, 2024 Category: Health Management Authors: Jeff Schein Martin Cloutier Rebecca Bungay Marjolaine Gauthier-Loiselle Ann Childress Source Type: research
Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review
Z Gastroenterol. 2024 Apr 11. doi: 10.1055/a-2279-5045. Online ahead of print.ABSTRACTPhytotherapeutics are gaining influence in the treatment of gastroenterological diseases. Their popularity and growing evidence of efficacy contribute to their integration into medical guidelines. A systematic screening identified recommended phytotherapeutic approaches. Based on current scientific data, some recommendations for the use of phytotherapeutic agents are given. For irritable bowel syndrome the use of peppermint oil is "strongly recommended", especially for pain and flatulence. Other phytotherapeutics such as STW-5, Tibetan Pa...
Source: Zeitschrift fur Gastroenterologie - April 11, 2024 Category: Gastroenterology Authors: Sandra Utz Miriam Bittel Jost Langhorst Source Type: research
