New functions and roles of the Na < sup > + < /sup > -H < sup > + < /sup > -exchanger NHE3
Pflugers Arch. 2024 Mar 7. doi: 10.1007/s00424-024-02938-9. Online ahead of print.ABSTRACTThe sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it contributes to hydrogen secretion and sodium (re)absorption. The roles of this transporter have been studied by the use of the respective knockout mice and by using pharmacological inhibitors. Whole-body NHE3 knockout mice suffer from a high mortality rate (with only ∼30% of mice surviving into adulthood), and based on the expression of NHE3 in both intestine and kidney, some conclusions that were originally derived were based on this...
Source: Pflugers Archiv : European Journal of Physiology - March 6, 2024 Category: Physiology Authors: Jessica A Dominguez Rieg Timo Rieg Source Type: research
New functions and roles of the Na < sup > + < /sup > -H < sup > + < /sup > -exchanger NHE3
Pflugers Arch. 2024 Mar 7. doi: 10.1007/s00424-024-02938-9. Online ahead of print.ABSTRACTThe sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it contributes to hydrogen secretion and sodium (re)absorption. The roles of this transporter have been studied by the use of the respective knockout mice and by using pharmacological inhibitors. Whole-body NHE3 knockout mice suffer from a high mortality rate (with only ∼30% of mice surviving into adulthood), and based on the expression of NHE3 in both intestine and kidney, some conclusions that were originally derived were based on this...
Source: Pflugers Archiv : European Journal of Physiology - March 6, 2024 Category: Physiology Authors: Jessica A Dominguez Rieg Timo Rieg Source Type: research
Association between gastrointestinal symptoms and insomnia in patients with type 2 diabetes: The KAMOGAWA‐DM cohort study
ConclusionsGastrointestinal symptoms are strongly associated with sleep disturbances in patients with type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 6, 2024 Category: Endocrinology Authors: Megumi Minamida,
Hiroshi Okada,
Masahide Hamaguchi,
Junya Hironaka,
Yuriko Kondo,
Hanako Nakajima,
Takuro Okamura,
Takafumi Sennmaru,
Naoko Nakanishi,
Emi Ushigome,
Michiaki Fukui Tags: Original Article Source Type: research
Gastrointestinal Characteristics of Constipation from the Perspectives of Microbiome and Metabolome
ConclusionsThe current findings are significant in terms of not only laying a foundation for understanding characteristics of constipation, but also providing accurate diagnosis and treatments of constipation clinically.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 6, 2024 Category: Gastroenterology Source Type: research
Bioinspired composite packed in blunt needles, integrated microextraction and determination of oxycodone and naloxone in saliva by substrate spray mass spectrometry
This article presents a novel substrate-spray mass spectrometry interface based on a polydopamine-cotton (PDA-Cel) composite hosted inside the inner diameter of a 14-gauge blunt needle to determine oxycodone and naloxone in saliva samples. The needle is used as a microextraction device and a substrate for mass spectrometric analysis. The lack of sharpness of the 14-gauge (14G) blunt needles challenges the formation of the electrospray (ESI), and a commercial 10 μL pipette tip is proposed as a simple solution to this shortcoming. Under the optimum parameters, the proposed method was validated, obtaining limits of detection...
Source: Analytica Chimica Acta - March 4, 2024 Category: Chemistry Authors: Jaime Mill án-Santiago Rafael Lucena Soledad C árdenas Source Type: research
Bioinspired composite packed in blunt needles, integrated microextraction and determination of oxycodone and naloxone in saliva by substrate spray mass spectrometry
This article presents a novel substrate-spray mass spectrometry interface based on a polydopamine-cotton (PDA-Cel) composite hosted inside the inner diameter of a 14-gauge blunt needle to determine oxycodone and naloxone in saliva samples. The needle is used as a microextraction device and a substrate for mass spectrometric analysis. The lack of sharpness of the 14-gauge (14G) blunt needles challenges the formation of the electrospray (ESI), and a commercial 10 μL pipette tip is proposed as a simple solution to this shortcoming. Under the optimum parameters, the proposed method was validated, obtaining limits of detection...
Source: Analytica Chimica Acta - March 4, 2024 Category: Chemistry Authors: Jaime Mill án-Santiago Rafael Lucena Soledad C árdenas Source Type: research
Bioinspired composite packed in blunt needles, integrated microextraction and determination of oxycodone and naloxone in saliva by substrate spray mass spectrometry
This article presents a novel substrate-spray mass spectrometry interface based on a polydopamine-cotton (PDA-Cel) composite hosted inside the inner diameter of a 14-gauge blunt needle to determine oxycodone and naloxone in saliva samples. The needle is used as a microextraction device and a substrate for mass spectrometric analysis. The lack of sharpness of the 14-gauge (14G) blunt needles challenges the formation of the electrospray (ESI), and a commercial 10 μL pipette tip is proposed as a simple solution to this shortcoming. Under the optimum parameters, the proposed method was validated, obtaining limits of detection...
Source: Analytica Chimica Acta - March 4, 2024 Category: Chemistry Authors: Jaime Mill án-Santiago Rafael Lucena Soledad C árdenas Source Type: research
Bioinspired composite packed in blunt needles, integrated microextraction and determination of oxycodone and naloxone in saliva by substrate spray mass spectrometry
This article presents a novel substrate-spray mass spectrometry interface based on a polydopamine-cotton (PDA-Cel) composite hosted inside the inner diameter of a 14-gauge blunt needle to determine oxycodone and naloxone in saliva samples. The needle is used as a microextraction device and a substrate for mass spectrometric analysis. The lack of sharpness of the 14-gauge (14G) blunt needles challenges the formation of the electrospray (ESI), and a commercial 10 μL pipette tip is proposed as a simple solution to this shortcoming. Under the optimum parameters, the proposed method was validated, obtaining limits of detection...
Source: Analytica Chimica Acta - March 4, 2024 Category: Chemistry Authors: Jaime Mill án-Santiago Rafael Lucena Soledad C árdenas Source Type: research
Bioinspired composite packed in blunt needles, integrated microextraction and determination of oxycodone and naloxone in saliva by substrate spray mass spectrometry
This article presents a novel substrate-spray mass spectrometry interface based on a polydopamine-cotton (PDA-Cel) composite hosted inside the inner diameter of a 14-gauge blunt needle to determine oxycodone and naloxone in saliva samples. The needle is used as a microextraction device and a substrate for mass spectrometric analysis. The lack of sharpness of the 14-gauge (14G) blunt needles challenges the formation of the electrospray (ESI), and a commercial 10 μL pipette tip is proposed as a simple solution to this shortcoming. Under the optimum parameters, the proposed method was validated, obtaining limits of detection...
Source: Analytica Chimica Acta - March 4, 2024 Category: Chemistry Authors: Jaime Mill án-Santiago Rafael Lucena Soledad C árdenas Source Type: research
Delayed diagnosis in Hirschsprung disease
ConclusionsThe results of our study underline that a significant percentage of patients are basically missed in the neonatal period mostly due to mild symptoms. Overall outcome does not differ from that of patients without diagnostic delay. Nonetheless, we underline the importance of a throughout investigation of all patients with meconium delay/failure and that of adopting a low threshold for performing rectal suction biopsies in constipated children to avoid misdiagnosis to serve the best for our patients. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - March 4, 2024 Category: Surgery Source Type: research
Relationship of Age and Gender to Motility Test Results and Symptoms in Patients with Chronic Constipation
CONCLUSIONS: There are significant age- and gender-related differences in symptoms, CTT, and HR-HRM parameters, rectal sensation, and expulsion, that may influence the multifaceted management of constipation.PMID:38430328 | DOI:10.1007/s10620-024-08314-y (Source: Anal Sci)
Source: Anal Sci - March 2, 2024 Category: Chemistry Authors: George Triadafilopoulos Jerry D Gardner Source Type: research
Cystic fibrosis and fat malabsorption: Pathophysiology of the cystic fibrosis gastrointestinal tract and the impact of highly effective CFTR modulator therapy
Nutr Clin Pract. 2024 Apr;39 Suppl 1:S57-S77. doi: 10.1002/ncp.11122.ABSTRACTCystic fibrosis (CF) is a progressive, genetic, multi-organ disease affecting the respiratory, digestive, endocrine, and reproductive systems. CF can affect any aspect of the gastrointestinal (GI) tract, including the esophagus, stomach, small intestine, colon, pancreas, liver, and gall bladder. GI pathophysiology associated with CF results from CF membrane conductance regulator (CFTR) dysfunction. The majority of people with CF (pwCF) experience exocrine pancreatic insufficiency resulting in malabsorption of nutrients and malnutrition. Additional...
Source: Nutrition in Clinical Practice - March 2, 2024 Category: Nutrition Authors: Catherine M McDonald Elizabeth K Reid John F Pohl Tatiana K Yuzyuk Laura M Padula Kay Vavrina Kimberly Altman Source Type: research
Relationship of Age and Gender to Motility Test Results and Symptoms in Patients with Chronic Constipation
CONCLUSIONS: There are significant age- and gender-related differences in symptoms, CTT, and HR-HRM parameters, rectal sensation, and expulsion, that may influence the multifaceted management of constipation.PMID:38430328 | DOI:10.1007/s10620-024-08314-y (Source: Anal Sci)
Source: Anal Sci - March 2, 2024 Category: Chemistry Authors: George Triadafilopoulos Jerry D Gardner Source Type: research
