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Opioid-induced Constipation: Old and New Concepts in Diagnosis and Treatment
J Neurogastroenterol Motil. 2024 Apr 30;30(2):131-142. doi: 10.5056/jnm23144.ABSTRACTDaily use of opioid analgesics has significantly increased in recent years due to an increasing prevalence of conditions associated with chronic pain. Opioid-induced constipation (OIC) is one of the most common, under-recognized, and under-treated side effects of opioid analgesics. OIC significantly reduces the quality of life by causing psychological distress, lowering work productivity, and increasing access to healthcare facilities. The economic and social burden of OIC led to the development of precise strategies for daily clinical pra...
Source: Journal of Neurogastroenterology and Motility - April 5, 2024 Category: Gastroenterology Authors: Francesco Squeo Francesca Celiberto Enzo Ierardi Francesco Russo Giuseppe Riezzo Benedetta D'Attoma Alfredo Di Leo Giuseppe Losurdo Source Type: research

Effect of Trimebutine and Rifaximin on Breath Hydrogen and Methane by Glucose Breath Test in Patients With Functional Bloating: A Randomized Double-blind Clinical Trial
CONCLUSION: While the combination therapy was not superior over rifaximin alone for SIBO eradication, it improves the symptom of bloating with numerically reducing the concentration of breath H2/CH4.PMID:38576371 | PMC:PMC10999843 | DOI:10.5056/jnm23029 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 5, 2024 Category: Gastroenterology Authors: Ik Hyun Jo Chang-Nyol Paik Ji Min Lee Do Seon Song Yeon-Ji Kim Source Type: research

Effect of prebiotic oligosaccharides on bowel habit and the gut microbiota in children with functional constipation (Inside study): study protocol for a randomised, placebo-controlled, multi-centre trial
Functional constipation (FC) in children is a common gastrointestinal disorder with a worldwide-pooled prevalence of 9.5%. Complaints include infrequent bowel movements, painful defecation due to hard and/or l... (Source: Trials)
Source: Trials - April 5, 2024 Category: General Medicine Authors: Carrie A. M. Wegh, Margriet H. C. Schoterman, Elaine E. Vaughan, Sofie C. C. van der Zalm, Hauke Smidt, Clara Belzer and Marc A. Benninga Tags: Study protocol Source Type: research

Pancreatic Cancer: Rapid Evidence Review
Am Fam Physician. 2024 Mar;109(3):245-250.ABSTRACTPancreatic cancer is relatively uncommon and carries a poor prognosis because patients often develop signs or symptoms at a late stage of illness. Patients with a family history, especially those with genetic syndromes, are at a significantly increased risk of pancreatic cancer. Modifiable risk factors include smoking, heavy alcohol use, and obesity. Although patients at increased risk should be screened, screening is not recommended for asymptomatic people at average risk. The differential diagnosis for a symptomatic patient is broad, including gastroesophageal reflux dise...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Carl Bryce Merima Bucaj Source Type: research

Pancreatic Cancer: Rapid Evidence Review
Am Fam Physician. 2024 Mar;109(3):245-250.ABSTRACTPancreatic cancer is relatively uncommon and carries a poor prognosis because patients often develop signs or symptoms at a late stage of illness. Patients with a family history, especially those with genetic syndromes, are at a significantly increased risk of pancreatic cancer. Modifiable risk factors include smoking, heavy alcohol use, and obesity. Although patients at increased risk should be screened, screening is not recommended for asymptomatic people at average risk. The differential diagnosis for a symptomatic patient is broad, including gastroesophageal reflux dise...
Source: Pain Physician - April 4, 2024 Category: Anesthesiology Authors: Carl Bryce Merima Bucaj Source Type: research