Community-acquired pneumonia: the best candidates for clarithromycin - Authors' reply
Lancet Respir Med. 2024 Feb 28:S2213-2600(24)00035-3. doi: 10.1016/S2213-2600(24)00035-3. Online ahead of print.NO ABSTRACTPMID:38430925 | DOI:10.1016/S2213-2600(24)00035-3 (Source: Respiratory Care)
Source: Respiratory Care - March 2, 2024 Category: Respiratory Medicine Authors: Evangelos J Giamarellos-Bourboulis Michael S Niederman Source Type: research
The effects of drug-drug interaction on linezolid pharmacokinetics: A systematic review
ConclusionsThis systematic review found that numerous drugs have an impact on the pharmacokinetics of linezolid, and the purported main mechanism may be that linezolid is the substrate of P-glycoprotein. In clinical practice, it is prudent to pay attention to the changes in linezolid pharmacokinetics caused by interactions. Conducting therapeutic drug monitoring (TDM) is beneficial to improve efficacy and reduce adverse reactions of linezolid. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Source Type: research
Macrolide antibiotics (including azithromycin) for cystic fibrosis
CONCLUSIONS: Azithromycin therapy is associated with a small but consistent improvement in respiratory function, a decreased risk of exacerbation and longer time to exacerbation at six months; but evidence for treatment efficacy beyond six months remains limited. Azithromycin appears to have a good safety profile (although a weekly dose was associated with more gastrointestinal side effects, which makes it less acceptable for long-term therapy), with a relatively minimal treatment burden for people with CF, and it is inexpensive. A wider concern may be the emergence of macrolide resistance reported in the most recent study...
Source: Cochrane Database of Systematic Reviews - February 27, 2024 Category: General Medicine Authors: Kevin W Southern Arturo Solis-Moya Dominiki Kurz Sherie Smith Source Type: research
Macrolide antibiotics (including azithromycin) for cystic fibrosis
CONCLUSIONS: Azithromycin therapy is associated with a small but consistent improvement in respiratory function, a decreased risk of exacerbation and longer time to exacerbation at six months; but evidence for treatment efficacy beyond six months remains limited. Azithromycin appears to have a good safety profile (although a weekly dose was associated with more gastrointestinal side effects, which makes it less acceptable for long-term therapy), with a relatively minimal treatment burden for people with CF, and it is inexpensive. A wider concern may be the emergence of macrolide resistance reported in the most recent study...
Source: Cochrane Database of Systematic Reviews - February 27, 2024 Category: General Medicine Authors: Kevin W Southern Arturo Solis-Moya Dominiki Kurz Sherie Smith Source Type: research
Effects of Preoperative Quadruple Therapy for Helicobacter pylori on Bariatric Surgery Metabolic Outcomes
ConclusionsPreoperative treatment with OCAM has been associated to poorer glycemic and weight loss outcomes after BS. More research is needed on the influence of OCAM on gut microbiota, and in turn, the effect of the latter on metabolic and weight loss outcomes after BS.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - February 24, 2024 Category: Surgery Source Type: research
Vonoprazan: A Review in Helicobacter pylori Infection
AbstractTreatment for the eradication ofHelicobacter pylori infection, a leading cause of peptic ulcer disease and an important risk factor for gastric cancer and mucosa-associated lymphoid tissue lymphoma, is indicated whenever infection is identified. However, treatment success rates with current guideline-recommended proton-pump inhibitor (PPI)-based regimens remain suboptimal, with one potential factor associated with treatment failure being inadequate acid suppression. Vonoprazan (Voquezna®) is a first-in-class potassium-competitive acid blocker with the potential to provide potent and sustained acid suppression. Fol...
Source: Drugs - February 23, 2024 Category: Drugs & Pharmacology Source Type: research
Seasonal variation in structural and functional distribution of periphyton in a macrolide antibiotics-contaminated river
Environ Pollut. 2024 Feb 9:123495. doi: 10.1016/j.envpol.2024.123495. Online ahead of print.ABSTRACTPeriphyton, a microbial assemblage of autotrophic and heterotrophic organisms, is vital to aquatic ecosystems. While exposure to macrolide antibiotics has been confirmed to reduce the biodiversity and damage the critical ecological functions in indoor microcosm bioassays, the distribution of periphyton along a macrolide antibiotic pollution gradient in a river has yet to be determined. Herein, we established the spatiotemporal distribution of five major macrolides, i.e., azithromycin (AZI), roxithromycin (ROX), erythromycin ...
Source: Environmental Pollution - February 11, 2024 Category: Environmental Health Authors: Baihuan Zhang Wenqian Yu Jiayi Liang Xiunan Yao Haotian Sun Hisato Iwata Jiahua Guo Source Type: research
Contaminants of emerging concern in water and sediment of the Venice Lagoon, Italy
This study investigates for the first time the contamination of water and sediment of the Venice Lagoon by twenty Contaminants of Emerging Concern (CECs): three hormones, six pharmaceutical compounds (diclofenac and five antibiotics, three of which are macrolides), nine pesticides (methiocarb, oxadiazon, metaflumizone, triallate, and five neonicotinoids), one antioxidant (BHT), and one UV filter (EHMC). Water and sediment samples were collected in seven sites in four seasons, with the aim of investigating the occurrence, distribution, and possible emission sources of the selected CECs in the studied transitional environmen...
Source: Environmental Research - February 8, 2024 Category: Environmental Health Authors: Sarah Pizzini Elisa Giubilato Elisa Morabito Elena Barbaro Alessandro Bonetto Loris Calgaro Matteo Feltracco Elena Semenzin Marco Vecchiato Roberta Zangrando Andrea Gambaro Antonio Marcomini Source Type: research
Success of susceptibility-guided eradication of < em > Helicobacter pylori < /em > in a region with high secondary clarithromycin and levofloxacin resistance rates
CONCLUSION: H. pylori presented high secondary resistance rates to CLA and LFX. For patients with previous treatment failures, treatments should be guided by antibiotic susceptibility tests or regional antibiotic resistance profile.PMID:38312120 | PMC:PMC10835524 | DOI:10.3748/wjg.v30.i2.184 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - February 5, 2024 Category: Gastroenterology Authors: Yan-Meng Wang Mo-Ye Chen Jing Chen Xin-He Zhang Yan Feng Yu-Xi Han Yi-Ling Li Source Type: research
Success of susceptibility-guided eradication of < em > Helicobacter pylori < /em > in a region with high secondary clarithromycin and levofloxacin resistance rates
CONCLUSION: H. pylori presented high secondary resistance rates to CLA and LFX. For patients with previous treatment failures, treatments should be guided by antibiotic susceptibility tests or regional antibiotic resistance profile.PMID:38312120 | PMC:PMC10835524 | DOI:10.3748/wjg.v30.i2.184 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 5, 2024 Category: Gastroenterology Authors: Yan-Meng Wang Mo-Ye Chen Jing Chen Xin-He Zhang Yan Feng Yu-Xi Han Yi-Ling Li Source Type: research
Success of susceptibility-guided eradication of < em > Helicobacter pylori < /em > in a region with high secondary clarithromycin and levofloxacin resistance rates
CONCLUSION: H. pylori presented high secondary resistance rates to CLA and LFX. For patients with previous treatment failures, treatments should be guided by antibiotic susceptibility tests or regional antibiotic resistance profile.PMID:38312120 | PMC:PMC10835524 | DOI:10.3748/wjg.v30.i2.184 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 5, 2024 Category: Gastroenterology Authors: Yan-Meng Wang Mo-Ye Chen Jing Chen Xin-He Zhang Yan Feng Yu-Xi Han Yi-Ling Li Source Type: research
Success of susceptibility-guided eradication of < em > Helicobacter pylori < /em > in a region with high secondary clarithromycin and levofloxacin resistance rates
CONCLUSION: H. pylori presented high secondary resistance rates to CLA and LFX. For patients with previous treatment failures, treatments should be guided by antibiotic susceptibility tests or regional antibiotic resistance profile.PMID:38312120 | PMC:PMC10835524 | DOI:10.3748/wjg.v30.i2.184 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - February 5, 2024 Category: Gastroenterology Authors: Yan-Meng Wang Mo-Ye Chen Jing Chen Xin-He Zhang Yan Feng Yu-Xi Han Yi-Ling Li Source Type: research
Success of susceptibility-guided eradication of < em > Helicobacter pylori < /em > in a region with high secondary clarithromycin and levofloxacin resistance rates
CONCLUSION: H. pylori presented high secondary resistance rates to CLA and LFX. For patients with previous treatment failures, treatments should be guided by antibiotic susceptibility tests or regional antibiotic resistance profile.PMID:38312120 | PMC:PMC10835524 | DOI:10.3748/wjg.v30.i2.184 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 5, 2024 Category: Gastroenterology Authors: Yan-Meng Wang Mo-Ye Chen Jing Chen Xin-He Zhang Yan Feng Yu-Xi Han Yi-Ling Li Source Type: research
