New option for H pylori treatment: Voquezna
The Food and Drug Administration (FDA) has approved the following new medication for the treatment of Helicobacter pylori (H. pylori) infection in adults.:- Voquezna Triple Pak(vonoprazan, amoxicillin, clarithromycin)-Voquezna Dual Pak (vonoprazan, amoxicillin)Vonoprazan, which gives the name of the medication, is an oral small molecule potassium-competitive acid blocker.H. pylori eradication rates were84.7% and 78.5% with Voquezna Triple and Dual Pak, respectively.Voquezna Triple Pak is supplied as a carton containing 56-tablets and 56-capsules divided into 14 daily dose blister cards. Each daily blister card contai...
Source: Clinical Cases and Images - Blog - January 13, 2023 Category: Universities & Medical Training Tags: Infectious Diseases Source Type: blogs
MKSAP: 60-year-old woman with H. pylori gastritis
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 60-year-old woman is evaluated 1 month after completing a 14-day course of Helicobacter pylori eradication therapy consisting of amoxicillin, clarithromycin, and omeprazole. Initial upper endoscopy before treatment showe d patchy gastric erythema with no ulcers or erosions, and biopsies revealed H. pylori gastritis. Currently, she […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 16, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Gastroenterology Source Type: blogs
A case report: the antibiotic roxithromycin induces PR in a patient with smoldering myeloma
Well…Well…WELL!!! I’ve got a very interesting item for you today…
Many many many thanks to my blog reader Charlotte for this gem: goo.gl/hMsWov
The link will lead you to a case report about a 86-year-old patient (with IgA lambda smoldering myeloma) who went into partial remission after taking roxithromycin, an antibiotic, for just ONE MONTH. This happened last year in New Zealand.
The patient’s paraprotein, which had been increasing since he was diagnosed in 2008, dropped from 46 g/L to 20 g/L.
That’s a 57% decrease! Wowsie.
And another thing: in addition to his other markers remaining...
Source: Margaret's Corner - July 12, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll myeloma roxithromycin Roxithromycin monotherapy inducing a partial response in a patient with myeloma: a case report Source Type: blogs
LITFL Review 263
Welcome to the 263rd LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chunk of FOAM.
The Most Fair Dinkum Ripper Beauts of the Week
A well-written NY Times essay on how social isolation is killing us made the Internet rounds over the holidays, penned by a medical resident.
The Best of #FOAMed Emergency Medicine
A very interesting and thought provoking post by Josh Fa...
Source: Life in the Fast Lane - January 1, 2017 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs
Longing for the QT
A 58-year-old man presented to the ED with a reported overdose of an unknown medication. The patient was agitated, combative, and altered. Initial vital signs included a heart rate of 115 beats/min, blood pressure of 154/93 mm Hg, respirations of 22/min, and temperature of 99.5°F. The patient was difficult to evaluate because he was agitated, and he was given 5 mg of haloperidol IV and 2 mg of lorazepam IV. The patient continued to be agitated, and was given another 10 mg of haloperidol IV, followed by a repeat dose of 10 mg IV 15 minutes later. The patient then became unresponsive, and his cardiac monitor demonstrated th...
Source: The Tox Cave - March 1, 2016 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Top stories in health and medicine, August 21, 2014
From MedPage Today:
Nutrition Experts Like ‘Outdated’ Foods Initiative. Public health specialists offered high praise for an initiative by a former Trader Joe’s executive that will funnel unwanted produce into stores in low-income areas.
Doctors’ Spouses: What’s Not to Like? When it comes to domestic life for physicians, things have changed since an oversexed and gory 1971 film with Gene Hackman called “Doctors’ Wives” featured as one of its taglines, “Doctors’ wives have everything. Except husbands.”
Clarithromycin May Boost Risk of Cardiac Death. The ant...
Source: Kevin, M.D. - Medical Weblog - August 21, 2014 Category: Journals (General) Authors: MedPage Today Tags: News Heart Orthopedics Source Type: blogs
Increased Heart Risk Linked To Popular Antibiotic
Acute use of the popular macrolide antibiotic clarithromycin has been linked to a small but significant increase in cardiac death. In a report in the BMJ, researchers in Denmark analyzed the effects over a 14-year period of the acute use of penicillin V, roxithromycin, and clarithromycin. Earlier research raised concerns that marcrolide antibiotics in general, and erythromycin and azithromycin in particular, might prolong the QT interval and increase the risk for fatal arrhythmias. In the new study, clarithromycin was associated with a significant increase in the rate of sudden cardiac death compared with the other...
Source: CardioBrief - August 20, 2014 Category: Cardiology Authors: Larry Husten Tags: Heart Rhythms Policy & Ethics Prevention, Epidemiology & Outcomes antibiotics arrhythmias clarithromycin QT interval Source Type: blogs
Certain Antibiotics Linked to Blood Glucose Swings
By Diane Fennell
People with diabetes who take a certain class of antibiotics are more likely to experience severe swings in blood glucose, according to new research from Taiwan.
Previous research and case reports have raised concern about the possibility of severe high and low blood glucose associated with the use of fluoroquinolones, a class of antibiotics that includes ciprofloxacin (brand name Cipro), levofloxacin (Levaquin), and moxifloxacin (Avelox). One drug in this class, gatifloxacin (Tequin), was removed from the US market due to the risk of blood glucose fluctuations.
To assess the risk of severe blood gluc...
Source: Diabetes Self-Management - August 16, 2013 Category: Diabetes Authors: Diane Fennell Source Type: blogs
Berberine Works But May Very Well Be Harmful
I have been getting a lot of email of late about the supplement Berberine, which appears to be the latest miracle cure being sold to those people with diabetes who believe that completely unregulated herbs imported from countries with long histories of food and drug adulteration are somehow safer and "more natural" than the tightly regulated pharamceuticals.Berberine does appear to work to lower blood sugar. The problem is that we really know very little about how it does it or what its long term effects are on the body. I see many mentions on sites promoting berberine supplements of the fact that berberine has a lon...
Source: Diabetes Update - August 14, 2013 Category: Diabetes Authors: Jenny Source Type: blogs
Peptic Ulcer Disease
Pathophysiology of Peptic Ulcer Disease
1) peptic ulcer disease is marked by a break in mucosal lining of stomach and duodenum
2) main causes are infection with Helicobacter pylori and use of NSAIDs
Signs and Symptoms
1) burning epigastric pain relieved by antacids and eating
2) epigastric pain causing patient to wake up in the middle of the night
3) chest pain mimicking angina
4) epigastric tenderness
5) gastrointestinal bleeding (15%) with coffee-ground emesis or vomiting bright red blood or lower gastrointestinal bleeding
6) perforation (8%) with peritonitis and rigid abdomen
7) duodenal obstruction (3%) with nausea and...
Source: Inside Surgery - February 24, 2013 Category: Surgeons Authors: Editor Tags: Gastroenterology Source Type: blogs
