What samples are suitable for monitoring antimicrobial-resistant genes? Using NGS technology, a comparison between eDNA and mrDNA analysis from environmental water
ConclusionTo estimate potential AMR pollution, our findings suggested that eDNA is preferable for detecting pathogen ARGs. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - December 14, 2023 Category: Microbiology Source Type: research
Tolerability outcomes of ATS/IDSA guideline-recommended multi-drug antibiotic treatment for Mycobacterium avium complex pulmonary disease in U.S. Medicare beneficiaries with bronchiectasis
Chest. 2023 Dec 10:S0012-3692(23)05846-4. doi: 10.1016/j.chest.2023.12.006. Online ahead of print.ABSTRACTBACKGROUND: Nontuberculous mycobacteria are environmental organisms that are increasingly causing chronic and debilitating pulmonary infections, of which Mycobacterium avium complex (MAC) is the most common pathogen. MAC pulmonary disease (MAC-PD) is often difficult to treat, often requiring long-term multi-drug antibiotic therapy.RESEARCH QUESTION: Is there an association between various guideline-based 3-drug therapy (GBT) regimens and (1) therapy-associated adverse events; or (2) regimen change/discontinuation, with...
Source: Chest - December 12, 2023 Category: Respiratory Medicine Authors: Jennifer H Ku Emily Henkle Kathleen F Carlson Miguel Marino Sarah K Brode Theodore K Marras Kevin L Winthrop Source Type: research
Adsorption of clarithromycin on polystyrene nanoplastics surface and its combined adverse effect on serum albumin
This study revealed that the CLA-PSNP binds to serum albumin spontaneously and its hydrophobic interactions played a significant role. The conformational changes in the structure of serum albumin were revealed from the findings of synchronous fluorescence spectra, CD spectra, and 3D fluorescence spectra, leading to the disturbance in functional activity. This study focuses valuable insights into the intermolecular interactions between clarithromycin-adsorbed polystyrene nanoplastics and serum albumin and its potential molecular-level biological toxicity.PMID:38086277 | DOI:10.1016/j.colsurfb.2023.113673 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - December 12, 2023 Category: Biotechnology Authors: B S Utkal Laxmi Pani Natarajan Chandrasekaran Source Type: research
Tolerability outcomes of ATS/IDSA guideline-recommended multi-drug antibiotic treatment for Mycobacterium avium complex pulmonary disease in U.S. Medicare beneficiaries with bronchiectasis
Chest. 2023 Dec 10:S0012-3692(23)05846-4. doi: 10.1016/j.chest.2023.12.006. Online ahead of print.ABSTRACTBACKGROUND: Nontuberculous mycobacteria are environmental organisms that are increasingly causing chronic and debilitating pulmonary infections, of which Mycobacterium avium complex (MAC) is the most common pathogen. MAC pulmonary disease (MAC-PD) is often difficult to treat, often requiring long-term multi-drug antibiotic therapy.RESEARCH QUESTION: Is there an association between various guideline-based 3-drug therapy (GBT) regimens and (1) therapy-associated adverse events; or (2) regimen change/discontinuation, with...
Source: Chest - December 12, 2023 Category: Respiratory Medicine Authors: Jennifer H Ku Emily Henkle Kathleen F Carlson Miguel Marino Sarah K Brode Theodore K Marras Kevin L Winthrop Source Type: research
Adsorption of clarithromycin on polystyrene nanoplastics surface and its combined adverse effect on serum albumin
This study revealed that the CLA-PSNP binds to serum albumin spontaneously and its hydrophobic interactions played a significant role. The conformational changes in the structure of serum albumin were revealed from the findings of synchronous fluorescence spectra, CD spectra, and 3D fluorescence spectra, leading to the disturbance in functional activity. This study focuses valuable insights into the intermolecular interactions between clarithromycin-adsorbed polystyrene nanoplastics and serum albumin and its potential molecular-level biological toxicity.PMID:38086277 | DOI:10.1016/j.colsurfb.2023.113673 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - December 12, 2023 Category: Biotechnology Authors: B S Utkal Laxmi Pani Natarajan Chandrasekaran Source Type: research
< i > Mycobacterium ulcerans < /i > - < i > Bordetella trematum < /i > chronic tropical cutaneous ulcer: A four-case series, C ôte d’Ivoire
Conclusions/significanceIn four cases of Buruli ulcer in C ôte d’Ivoire,B.trematum was a co-pathogen which was resistant to rifampicin and clarithromycin, unmatchingM.ulcerans antibiotic susceptibility profile and counteracting the current treatment of Buruli ulcer in West Africa and Australia. Thus, we report here chronic mixedM.ulcerans-B.trematum chronic tropical ulcer as a specific form of Buruli ulcer in West Africa. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 7, 2023 Category: Tropical Medicine Authors: Bi Gor é Oscar Tchan Source Type: research
Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression
by Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa
We previously reported that macrolide antibiotics, such as clarithromycin (CAM), blocked autophagy flux, and simultaneous proteasome and autophagy inhibition by bortezomib (BTZ) plus CAM resulted in enhanced apoptosis induction in multiple myeloma (MM) cells via increased endoplasmic reticulum (ER ) stress loading. However, in actual therapeutic settings, cell adhesion-mediated drug resistance between bone marrow stromal cells (BMSC) and MM cells has been known to be a barrier to treatment. To investigate whether...
Source: PLoS One - December 1, 2023 Category: Biomedical Science Authors: Shota Moriya Source Type: research
