Therapeutic progress and future prospects of chronic inflammatory demyelinating polyradiculoneuropathy
AbstractChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare and heterogeneous but treatable immune-mediated neuropathy. The pathogenesis of CIDP is complex interplay of diverse immune mechanisms involving cellular and humoral pathways. The European Academy of Neurology/Peripheral Nerve Society guidelines were reissued in 2021, and the classification and diagnostic criteria were changed. Treatments include immunoglobulin, steroid, and plasmapheresis are effective, including remission induction and maintenance therapy. Maintenance treatments are often required for years, and treatment regimens require ...
Source: Clinical and Experimental Neuroimmunology - April 24, 2024 Category: Neurology Authors: Tomoko Okamoto Tags: INVITED REVIEW Source Type: research
Antigen-specific immunotherapy via delivery of tolerogenic dendritic cells for multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system resulting from loss of immune tolerance. Many disease-modifying therapies for MS have broad immunosuppressive effects on peripheral immune cells, but this can increase risks of infection and attenuate vaccine-elicited immunity. A more targeted approach is to re-establish immune tolerance in an autoantigen-specific manner. This review discusses methods to achieve this, focusing on tolerogenic dendritic cells. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 19, 2024 Category: Allergy & Immunology Authors: Vivien Li, Michele Binder, Anthony W. Purcell, Trevor J. Kilpatrick Tags: Review Article Source Type: research
Diagnostic value of lower extremity ultrasonographic nerve enlargement for differentiating demyelinating Charcot-Marie-Tooth disease from chronic inflammatory demyelinating polyneuropathy
We previously reported that nerve enlargement assessment by nerve ultrasonography of the intermediate upper limb is applicable for distinguishing demyelinating Charcot-Marie-Tooth disease (CMT) from chronic inflammatory demyelinating polyneuropathy (CIDP). However, differences in the severity and distribution patterns of lower extremity nerve enlargement have not been established for either disease. Therefore, we examined the utility of lower extremity nerve ultrasonography for differentiating between CMT and CIDP. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 1, 2024 Category: Neurology Authors: Hiroyuki Naito, Takamichi Sugimoto, Akemi Hironaka, Masahiro Nakamori, Yu Yamazaki, Kazuhide Ochi, Hirofumi Maruyama Source Type: research
Iron metabolism disorder and multiple sclerosis: a comprehensive analysis
ConclusionThis study comprehensively explored the relationship between metabolism and MS through integrated bioinformatics analysis and Mendelian randomization methods. The findings provide important insights for further research into the role of iron metabolism disorder in the pathogenesis of MS and offer crucial theoretical support for the prevention and treatment of related diseases is changed to treatment of MS. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 21, 2024 Category: Allergy & Immunology Source Type: research
Marked hypertrophy trigeminal nerves in CIDP: a rare cause of VI nerve compression
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - March 14, 2024 Category: Neurology Source Type: research
Chronic inflammatory demyelinating polyneuropathy and HEV antibody status: A case-control study from Lazio, Italy
Few studies have pointed to the possible role of infectious diseases in triggering Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). Given the association of Hepatitis E Virus (HEV) with Guillain Barr รจ syndrome, we conducted a case-control study to determine the possible association of HEV infection with CIDP, analyzing possible risk factors for acquiring HEV infection in both CIDP patients and controls. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - March 11, 2024 Category: Neurology Authors: Federica Moret, Enea Spada, Marco Ceccanti, Laura Libonati, Edoardo D'Andrea, Umbertina Villano, Elisabetta Madonna, Paola Chionne, Alberto Carocci, Giulio Pisani, Laura Fionda, Giovanni Antonini, Antonio Petrucci, Roberto Bruni, Anna Rita Ciccaglione, Gl Source Type: research
Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada
CONCLUSION: The multi-step design to derive ICD code definitions provided flexibility to identify existing definitions, to improve their sensitivity and PPV and adapt them to the Canadian context.PMID:38455876 | PMC:PMC10917133 | DOI:10.14745/ccdr.v49i78a01 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Eleni Galanis Azita Goshtasebi Yuen Wai Hung Jonathan Chan Douglas Matsell Kristine Chapman Gilaad Kaplan David Patrick Bei Yuan Zhang Marsha Taylor Dimitra Panagiotoglou Shannon Majowicz Source Type: research
Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada
CONCLUSION: The multi-step design to derive ICD code definitions provided flexibility to identify existing definitions, to improve their sensitivity and PPV and adapt them to the Canadian context.PMID:38455876 | PMC:PMC10917133 | DOI:10.14745/ccdr.v49i78a01 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Eleni Galanis Azita Goshtasebi Yuen Wai Hung Jonathan Chan Douglas Matsell Kristine Chapman Gilaad Kaplan David Patrick Bei Yuan Zhang Marsha Taylor Dimitra Panagiotoglou Shannon Majowicz Source Type: research
Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada
CONCLUSION: The multi-step design to derive ICD code definitions provided flexibility to identify existing definitions, to improve their sensitivity and PPV and adapt them to the Canadian context.PMID:38455876 | PMC:PMC10917133 | DOI:10.14745/ccdr.v49i78a01 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Eleni Galanis Azita Goshtasebi Yuen Wai Hung Jonathan Chan Douglas Matsell Kristine Chapman Gilaad Kaplan David Patrick Bei Yuan Zhang Marsha Taylor Dimitra Panagiotoglou Shannon Majowicz Source Type: research
Autoimmune nodopathy with anti-contactin 1 antibody characterized by cerebellar dysarthria: a case report and literature review
ConclusionApart from peripheral neuropathies, cerebellar dysarthria (central nervous system involvement) should not be ignored in AN patients with CNTN1 antibodies. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 8, 2024 Category: Allergy & Immunology Source Type: research
Physician awareness and understanding of chronic inflammatory demyelinating polyradiculoneuropathy in Japan: a web-based study
Conclusions
Orthopaedists and internists had lower CIDP awareness compared with neurologists, which may lead to inadequate referrals to neurology. Evaluation of IVIg effectiveness for maintenance therapy occurred earlier than the guideline recommendations (6–12 months), risking premature discontinuation. Improving CIDP knowledge among orthopaedists and internists is critical for better diagnosis and collaboration with neurologists. Neurologists should consider slow and careful evaluation of IVIg maintenance therapy.
Trial registration number
UMIN000048516. (Source: BMJ Open)
Source: BMJ Open - March 8, 2024 Category: General Medicine Authors: Takeshita, Y., Imajo, Y., Oh, A., Kikutani, M., Okamatsu, N. Tags: Open access, Neurology Source Type: research
Anti-contactin 1 Antibody-associated Membranous Nephropathy in Chronic Inflammatory Demyelinating Polyneuropathy with Several Autoantibodies
Intern Med. 2024;63(5):699-705. doi: 10.2169/internalmedicine.2126-23.ABSTRACTA 50-year-old man diagnosed with anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) was referred to our department for the evaluation of proteinuria. A kidney biopsy revealed membranous nephropathy (MN). Immunohistochemistry for CNTN1 revealed positive granular staining along the glomerular basement membrane, confirming anti-CNTN1 antibody-associated MN. Immunofluorescence showed a full-house pattern, and several autoantibodies, such as anti-nuclear antibody, anti-double-strand DNA antibody, and ...
Source: Internal Medicine - March 3, 2024 Category: Internal Medicine Authors: Ryutaro Shida Takamasa Iwakura Naro Ohashi Chiemi Ema Taro Aoki Takeshi Tashiro Sayaka Ishigaki Shinsuke Isobe Tomoyuki Fujikura Akihiko Kato Tomohiko Nakamura Yoshihide Fujigaki Akira Shimizu Hideo Yasuda Source Type: research
